Factors Influence Hanoians’ Choice of Non-Motorized Transport Mode to Access Bus Stations

Hanoi’s rapid urbanization has led to a surge in private vehicle ownership, particularly motorcycles, amidst inadequate public transportation infrastructure. Despite government efforts, many still prefer motorized transport, citing mobility and safety concerns, exacerbated by insufficient pedestrian infrastructure. This study examines the motivations behind this reliance on motorized vehicles, particularly motorcycles, in Hanoi. Findings reveal safety and convenience as primary factors driving motorized transport use, especially for accessing bus stations. Economic incentives could promote non-motorized travel and public transport adoption. Policy implications highlight the importance of addressing economic factors and improving access infrastructure to manage motorized vehicle reliance and foster sustainable urban mobility in Hanoi.

Monoamine Oxidase-B Inhibitor Rasagiline Effects on Motor and Non-Motor Symptoms in Individuals with Parkinson’s Disease: A Systematic Review and Meta-Analysis

Objective: In the manuscript titled Monoamine Oxidase-B Inhibitor Rasagiline Effects on Motor and Non-Motor Symptoms in Individuals with Parkinsons Disease: A Systematic Review and Meta-Analysis, the objective was to conduct a systematic review with meta-analysis to investigate the effects that Rasagiline has on motor and non-motor symptoms in individuals with PD. Introduction: Rasagiline is a second-generation monoamine oxidase-B (MAO-B) inhibitor used both as monotherapy and adjunctive therapy for Parkinsons Disease (PD). Methods: A systematic literature search and meta-analysis were performed with randomized control trials that investigated the effects of Rasagiline on motor and non-motor symptoms in individuals with PD. The systematic search was conducted in PubMed, Cochrane, and EBSCO databases. Methodological quality was assessed using the Cochrane Grading Recommendations Assessment, Development and Evaluation approach. Results: Fourteen studies were included in our review. There were trivial to small and statistically significant improvements in motor symptoms for individuals with PD treated with Rasagiline compared to placebo. Non-motor symptoms showed no significant improvement with Rasagiline compared to placebo in five of six meta-analyses. Results were based on very low to moderate certainty of evidence. Conclusion: 1 mg/day Rasagiline significantly improved Parkinsonian motor symptoms in individuals with PD compared with placebo. For all outcomes, the 1 mg/day Rasagiline group was favored over the placebo group.

Modeling Bicycle Conflict on Non-Motorized Paths on Suburban College Campuses

Bicycling is an important way for college students and employees to get around campuses. With a rise in bicycling on campuses there comes a rise in bicycle collisions with pedestrians walking to and from classes and work. The literature review showed many papers involving bicycle conflict modeling but on roads with motor vehicles. While some aspects of this research can be applied to non-motorized paths, there is a lack of research strictly focusing on only bicycles and pedestrians. This study aims to fill this knowledge gap by developing a model to identify locations on roads and paths (hotspots) on college campuses that are likely to have a bicycle collision and predict the likelihood of a serious bicycle crash on a non-motorized path based on the characteristics of the path. This study identifies those interactions between bicyclists and pedestrians on non-motorized paths on a suburban college campus in Newark, USA. Findings suggest that pedestrian density of a path is a major factor in the maximum speed bicyclists can achieve. The wider the path is, the higher the maximum speed is that a bicyclist can obtain. This is because a wider path width decreases the pedestrian density. The grade of the path has little effect on bicycle speeds. The results of the models were displayed on a GIS map that is visually appealing to a viewer. The paths were color coded based on their level of safety, so it is easy to observe problematic areas of the network. This technique can be applied to the entire campus network of non-motorized paths to study the whole system. This can then be used by planners and designers to identify areas that need upgrading and improve the overall safety of the non-motorized path system.

Temporal Stability and Transferability of Non-Motorized and Total Trip Generation Models

Transportation systems provide a means for moving people and the goods from which they are spatially separated. Of the two means of surface transportation, the motorized mode is used extensively for utilitarian travel in developed countries. The increasing reliance on motorized travel has contributed to increased traffic congestion, air pollution, and greenhouse emissions. Non-motorized travel has recently received significant attention as a means to reduce congestion and environmental problems and improve human health. However, non-motorized modeling is generally underdeveloped. This study investigated some changes in non-motorized and total travel and the characteristics of the traveling public in 1990, 1995, 2001, and 2009 using a national travel survey. The study also investigated the temporal transferability of linear-regression trip generation models for non-motorized and total travel under such changes. High-income households made fewer non-motorized trips in 1990 and 1995 compared to 2001 and 2009. Persons aged 50 and over showed an increased demand for non-motorized travel, whereas children aged 0 - 15 showed a decreasing preference for non-motorized travel over time. Regarding temporal stability, only the coefficient for single-adult households with no children was stable across all of the analysis years. For both non-motorized and total travel, most model parameter estimates were stable short term but not long term. In general, the total travel models transferred better than non-motorized models, both short term and long term. Despite not finding universal stability in model parameter estimates, the models were marginally able to replicate travel in 2009 relative to the locally estimated 2009 model.

Connected and Autonomous Vehicles (CAVs) Challenges with Non-motorized Amenities Environments

With the deployment of Connected and Automated Vehicles in the coming decades,road transportation will experience a significant upheaval.CAVs(Connected and Autonomous Vehicles)have been a main emphasis of Transportation and the automotive sector,and the future of transportation system analysis is widely anticipated.The examination and future devel­opment of CAVs technology has been the subject of numerous researches.However,as three essential kinds of road users,pedestrians,bicyclists,and motorcyclists have experienced little to no handling.We explored the influ­ence of CAVs on non-motorized mobility in this article and seven various issues that CAVs face in the environment.

Redesign of Motorized and Non-motorized Transport in Cities and Sustainable Mobility

Redesign of motorized and non-motorized transport in cities and sustainable mobility possibilities and utilization of already occupied areas for motorized and non-motorized transport in cities. Reserved area for public transport may be the redesign much more to take advantage of without taking up new space in cities. Redesigned solutions shown in the work of public mass transport and the redesign of non-motorized transport, bicycle and pedestrian paths point to the improved use and safety of movement of passengers, cyclists and pedestrians. This paper presents five redesigned concept designs as improving existing forms of transport and movement of cyclists and pedestrians in cities. Redesigned conceptual designs of motorized and non-motorized transport in cities should serve as ideas for the growing problems of urban development in the segment of insufficient surface for pedestrians and cyclists, as well as sustainable mobility transport people in the city.

Effects of a Cocktail Supplement of Ginkgo Biloba and Acai Extract on Cognitive Symptoms of Parkinson’s Disease

Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, including cognitive impairment. Current treatments often involve synthetic drugs with significant side effects and potential for dependency. This study investigates the effects of a natural supplement combination of Ginkgo Biloba and Acai Extract on cognitive symptoms in a 77-year-old male with PD. The participant underwent a three-month supplementation regimen, with cognitive function assessed using the Montreal Cognitive Assessment (MoCA) test before and after the intervention. The results indicated an improvement in cognitive scores, suggesting that the combination of Ginkgo Biloba and Acai Extract may offer a promising alternative or adjunct to conventional PD treatments. This study highlights the potential of natural supplements in managing PD symptoms and calls for further research with larger sample sizes to confirm these findings. Human data was performed in accordance with the Declaration of Helsinki by the Roxbury District IRB Board (IRB Number: IRB00011767).

Investigation and Optimization of Priority for Non-motor Vehicles in the Old Urban Area of Nanchang

Under the background of"people-oriented"thought and"green transportation",the idea of"priority for non-motor vehicles"came into being,which can improve the riding environment of non-motor vehicle riders to a certain extent.According to the current situation of priority for non-motor vehicles in the old urban area of Nanchang,through field investigation,questionnaire investigation and interview,this study summarized the existing problems,and put forward optimization suggestions for these problems,in order to provide reference for areas with similar conditions.

Non-Motor Symptoms in Parkinson’s Disease Patients—An Observational Study

Background: Parkinson’s disease (PD) remains a challenge for neurologists, particularly in its advanced stages when non-motor symptoms become a burden for the patient. While motor symptoms may be satisfactorily controlled with levodopa therapy or continuous levodopa/carbidopa intestinal gel (LCIG) administration, autonomic, sleep and mental disorders are hard to treat. During the last years, researchers have shifted their interest more to non-motor symptoms, PD being now considered a complex multiorgan impairment. Objective: The aim of this study was to describe non-motor symptoms in 40 Romanian patients diagnosed with PD, under conventional and LCIG administration treatment. Methods: A cross-sectional observational study was conducted, consisting of two groups of 20 patients each: the first group comprised PD patients who received conventional Levodopa treatment, while the second group was formed of patients receiving LCIG therapy. Various data concerning patient’s age, gender, duration of illness, comorbidities, motor and non-motor symptoms were recorded. The data were processed in SPSS v.20. Results: Subjects under continuous LCIG administration, although showing amelioration of motor symptoms, complained more frequently of constipation, mental, and sleeping disorders (statistically significant). Regarding anosmia, orthostatic hypotension, hypersalivation, urinary incontinence and restless legs syndrome, no statistical significant difference was observed between the two groups (p > 0.05). Conclusion: Nowadays, more research is conducted on non-motor symptoms in PD patients, as therapeutic measures try to limit these burdens, in order to improve patient’s quality of life.

Non-motor signs and symptoms in Parkinson’s disease

Motor symptoms are cardinal clinical features of Parkinson’s disease (PD). Progress in drug therapy and rehabilitation has been presenting beneficial effect for motor symptoms. However, non-motor symptoms and signs in PD have been accumulated growing attentions and its amelioration may also give beneficial effect for PD patients’ and their care givers’ quality of life. In this mini-review, I overviewed non-motor symptoms and signs in PD.

Genetic factors associated with non-motor symptoms in Parkinson’s disease

Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease. It is a complex syndrome with heterogeneous aetiologies, pathogenesis and manifestations. Patients with PD may present with motor symptoms and various non-motor symptoms (NMSs). NMSs have been reported in almost every diagnosed case of PD and usually precede motor symptoms. Multiple factors have been proved to be associated with the occurrence of NMSs in PD, among which genetic differentiation is a featured one. With the development of sequencing techniques, an increasing number of NMS-related genetic factors have been identified. This article reviews some of the latest discoveries in this regard.

Sex modulates the outcome of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease

There are many documented sex differences in the clinical course,symptom expression profile,and treatment response of Parkinson’s disease,creating additional challenges for patient management.Although subthalamic nucleus deep brain stimulation is an established therapy for Parkinson’s disease,the effects of sex on treatment outcome are still unclear.The aim of this retrospective observational study,was to examine sex differences in motor symptoms,nonmotor symptoms,and quality of life after subthalamic nucleus deep brain stimulation.Outcome measures were evaluated at 1 and 12 months post-operation in 90 patients with Parkinson’s disease undergoing subthalamic nucleus deep brain stimulation aged 63.00±8.01 years(55 men and 35 women).Outcomes of clinical evaluations were compared between sexes via a Student’s t-test and within sex via a paired-sample t-test,and generalized linear models were established to identify factors associated with treatment efficacy and intensity for each sex.We found that subthalamic nucleus deep brain stimulation could improve motor symptoms in men but not women in the on-medication condition at 1 and 12 months post-operation.Restless legs syndrome was alleviated to a greater extent in men than in women.Women demonstrated poorer quality of life at baseline and achieved less improvement of quality of life than men after subthalamic nucleus deep brain stimulation.Furthermore,Hoehn-Yahr stage was positively correlated with the treatment response in men,while levodopa equivalent dose at 12 months post-operation was negatively correlated with motor improvement in women.In conclusion,women received less benefit from subthalamic nucleus deep brain stimulation than men in terms of motor symptoms,non-motor symptoms,and quality of life.We found sex-specific factors,i.e.,Hoehn-Yahr stage and levodopa equivalent dose,that were related to motor improvements.These findings may help to guide subthalamic nucleus deep brain stimulation patient selection,prognosis,and stimulation programming for optimal therapeutic efficacy in Parkinson’s disease.

The Effects of Exercise on People with Parkinson’s Disease—Review

Quality of life encompasses physical, psychological and social aspects of health. Apart from motor symptoms (physical aspects), Parkinson’s disease (PD) is also closely related with various non-motor symptoms (psychological and social aspects) that can undermine quality of life greatly, even in early stages of the disease. Most research studies in this field focus on analysis of motor symptoms in PD sufferers. Although benefits of physical activity for the psychosocial quality of life are well-known, they have been mostly neglected in case of the people suffering from PD. Numerous studies clearly show that training programs can ameliorate the quality of life as far as non-motor functions in PD sufferers are concerned. The only psychological aspects of the disease related to the effects of exercise that have been researched so far are depression and cognitive functions. Depression is the most common denominator of poor quality of life, while dementia often accompanies the Parkinson’s disease. Studies have shown positive effects of exercise on the social life of those suffering from the disease, especially in case of group exercise. Studying psychological and social aspects of such chronic conditions as PD is of utmost importance for monitoring the patient’s adjustment to the disease, functioning with it, as well as the overall well-being and satisfaction with life. Thus far, the results have been pointing towards improvement of the quality of life. Exercise is a readily available method of treatment in case of PD, especially if applied in the early stages of the disease. In addition to reviewing the existing studies on the relation between exercise and quality of life of the patients, this paper will also focus on the way the psychological and social aspects of PD are influenced by exercise.

Zishenpingchan granules for the treatment of Parkinson＇s disease：a randomized,double-blind,placebo-controlled clinical trial

Levodopa preparations remain the preferred drug for Parkinson＇s disease.However,long-term use of levodopa may lead to a series of motor complications.Previous studies have shown that the combination of levodopa and Zishenpingchan granules（consisting of Radix Rehmanniae preparata,Lycium barbarum,Herba Taxilli,Rhizoma Gastrodiae,Stiff Silkorm,Curcuma phaeocaulis,Radix Paeoniae Alba,Rhizoma Arisaematis,Scorpio and Centipede） can markedly improve dyskinesia and delay the progression of Parkinson＇s disease,with especially dramatic improvements of non-motor symptoms.However,the efficacy of this combination has not been confirmed by randomized controlled trials.The current study was approved by the Hospital Ethics Committee and was registered in the Chinese Clinical Trial Register（registration number：Chi CTR-INR-1701194）.From December 2014 to December 2016,128 patients（72 males and 56 females,mean age of 65.78 ± 6.34 years） with Parkinson＇s disease were recruited from the Department of Neurology of Longhua Hospital and Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine in China.Patients were equally allocated into treatment and control groups.In addition to treatment with dopamine,patients in treatment and control groups were given Zishenpingchan granules or placebo,respectively,for 24 weeks.Therapeutic efficacy was assessed using the Unified Parkinson＇s Disease Rating Scale,on-off phenomenon,Hoehn-Yahr grade,Scales for Outcomes in Parkinson＇s disease–Autonomic,Parkinson＇s disease sleep scale,Hamilton Anxiety Scale,Hamilton Depression Scale,Mini-Mental State Examination,and the Parkinson＇s Disease Quality of Life Questionnaire.Artificial neural networks were used to determine weights at which to scale these parameters.Our results demonstrated that Zishenpingchan granules significantly reduced the occurrence of motor complications,and were useful for mitigating dyskinesia and non-motor symptoms of Parkinson＇s disease.This combination of Chinese and Western medicine has the potential to reduce levodopa dosages,and no obvious side effects were found.These findings indicate that Zishenpingchan granules can mitigate symptoms of Parkinson＇s disease,reduce toxic side effects of dopaminergic agents,and exert synergistic and detoxifying effects.

Clinical features and relative factors of constipation in a cohort of Chinese patients with Parkinson's disease

BACKGROUND Constipation as a most common non-motor symptom of Parkinson's disease(PD),has a higher prevalence compared to the general population.The etiologies of constipation in PD are diverse.In addition to physical weakness and other factors of disease,the lifestyles and eating habits are also important factors.Therefore,the prevalence and influencing factors of constipation may vary among different populations.AIM To determine the prevalence of constipation and analyze relative factors in a cohort of Chinese patients with PD.METHODS All the patients diagnosed with PD according to the movement disorders society criteria were consecutively collected by a self-developed questionnaire.Rome III diagnostic criteria were used to assess functional constipation and Wexner score was used to estimate the severity of constipation.Non-motor symptoms(NMS)were assessed with the non-motor symptoms assessment scale(NMSS).Unified Parkinson's disease Rating Scale III(UPDRS III)was used to evaluate the severity of motor symptoms.The modified Hoehn-Yahr stage was used to evaluate the severity of PD.Cognitive function was assessed using Montreal cognitive assessment(MoCA).Depression and anxiety were rated with the Hamilton depression scale(HAMD)and the Hamilton anxiety scale(HAMA).Quality of life was assessed using the Parkinson’s disease Questionnaire-39 items(PDQ-39).RESULTS Of 166 patients enrolled,87(52.41%)were accompanied with constipation,and 30(34.48%)experienced constipation for 6.30±5.06 years before motor symptoms occurred.Age,Hoehn-Yahr stage,disease duration,levodopa medication times,incidence of motor complications,the scores of UPDRS total,UPDRS III,NMSS,HAMD,HAMA,and PDQ-39 in the constipation group were higher than those in the non-constipation group(P<0.05),but there was no difference in the scores of MoCA,clinical types,or medications between the two groups(P>0.05).There was a higher incidence of depression in patients with constipation(P<0.05),but there were no difference in the incidence of anxiety and cognitive impairment between the two groups(P>0.05).As Hoehn-Yahr stages increased,the severity of constipation increased(P<0.05),but not the incidence of constipation(P>0.05).Pearson correlation analysis showed that constipation was moderately positively correlated with age,Hoehn-Yahr stage,and scores of NMSS,UPDRS III,UPDRS total,PDQ-39,HAMD,and HAMA(r=0.255,0.172,0.361,0.194,0.221,0.237,0.238,and 0.207,P<0.05).Logistic regression analysis showed that only NMSS score was an independent risk factor for constipation(P<0.001).CONCLUSION Our findings confirm that constipation has a relatively high frequency in patients with PD.PD patients with constipation have a higher incidence of depression,which leads to worse quality of life.

Evaluation of urban redevelopment impact on non-motorized traffic

As an important component of city evolution, urban land redevelopment has an impact on transportation system. The current traffic impact analysis （TIA） is lack of a comprehensive component for non-motorized transportation under redevelopment. For a better guidance of land redevelopment and non-motorized transportation planning, it is necessary to evaluate the negative impact of redevelopment on non-motorized traffic in the TIA. In this paper, an evaluation framework for the impact analysis is built up. We organized the pro- cedures and components of impact evaluation, and proposed the corresponding qualitative and quantitative evaluation indicators for non-motorized traffic under redevelopment. Level of service （LOS） and its criterion are employed for external impact evaluation, and level of safety, convenience, independence, and comfort which are four aspects of quality of service （QOS） are proposed to analyze the internal impact. The framework is applied to a redevelopment study in Shanghai, China. The case study results indicate that the rede- velopment from a residential area to a mixed commercial area has a significant impact on non-motorized traffic. The potential negative impact from both external and internal traffic can be minimized by reasonable improvements in the internal land use design.

Magnetic resonance morphometry of the loss of gray matter volume in Parkinson's disease patients

Voxel-based morphometry can be used to quantitatively compare structural differences and func-tional changes of gray matter in subjects. In the present study, we compared gray matter images of 32 patients with Parkinson’s disease and 25 healthy controls using voxel-based morphometry based on 3.0 T high-field magnetic resonance T1-weighted imaging and clinical neurological scale scores. Results showed that the scores in Mini-Mental State Examination and Montreal Cognitive Assessment were lower in patients compared with controls. In particular, the scores of visuospatial/executive function items in Montreal Cognitive Assessment were significantly reduced, but mean scores of non-motor symptoms significantly increased, in patients with Parkinson’s dis-ease. In addition, gray matter volume was significantly diminished in Parkinson’s disease patients compared with normal controls, including bilateral temporal lobe, bilateral occipital lobe, bilateral parietal lobe, bilateral frontal lobe, bilateral insular lobe, bilateral parahippocampal gyrus, bilateral amygdale, right uncus, and right posterior lobe of the cerebel um. These findings indicate that voxel-based morphometry can accurately and quantitatively assess the loss of gray matter volume in patients with Parkinson＇s disease, and provide essential neuroimaging evidence for multisystem pathological mechanisms involved in Parkinson’s disease.

Prion-like propagation of α-synuclein in gutbrain axis

Parkinson disease(PD) is a progressive degenerative disease of the nervous system,which is characterized by movement disorders,such as static tremor,rigidity,and bradykinesia in advanced patients.Gastrointestinal(GI) dysfunction,such as gastric dysmotility,constipation,and anorectic dysfunction,is common non-motor symptom in the early stage of PD.The progression of PD includes the degenerative loss of dopaminergic neurons and aggregation ofα-synuclein in the substantia nigra.Interestingly,both of them are also present in the enteric nervous system of PD patients.In this review,we describe the relationship between non-motor symptoms particularly GI dysfunction and the pathogenesis of PD,aiming to show the powerful evidences about the prion-like propagation of α-synuclein and support the hypothesis of gut-brain axis in PD.We then summarize the mechanism of the gut-brain axis and confirmα-synuclein as a potential target for drug design or new clinical treatment.

Effects of Physical Activity Levels on Fatigue Perception in Patients with Parkinson’s Disease and Neurologically Healthy Individuals

Background: Recent researches involving fatigue and Parkinson’s disease (PD) sought to verify its incidence and the impacts of fatigue on quality life of patients with PD. Despite the importance of regular physical activity practice, there are only few studies that verified the influence of the levels of physical activity on fatigue in patients with PD. Objective: The aim of this study was to compare perception of fatigue between individuals with PD and neurologically healthy individuals (control group), considering the physical activity levels;and to verify the relation between physical activity levels and fatigue dimensions for individuals with PD and control group. Methods: Eighty individuals (40 patients with PD and 40 control individuals) participated in this study. Physical activity levels were evaluated through Modified Baecke Questionnaire for Older Adults. Multidimensional Fatigue Inventory (MFI) was used in order to evaluate fatigue dimensions (general, physical and mental fatigue, reduced motivation and activity). MANOVA two-way and Pearson linear correlation test were performed to analyze the data. Results: Patients with PD presented higher levels of fatigue, in all dimensions evaluated by MFI, comparing to control individuals. There was no association between physical activity levels and perception of fatigue for patients with PD and control individuals. Conclusion: Patients with PD showed increased perception of fatigue when compared to control individuals, due to PD characteristics. In addition, the perception of fatigue’s symptom was not influenced and had no relation by the level of physical activity.

Bivariate macro-level safety analysis of non-motorized vehicle crashes and crash-involved road users

The high risk of injury resulting from non-motorized vehicle(NMV)crashes has created the goal of using the 3E strategy to comprehensively improve NMV safety.Traditional safety improvement methods identify hot zones generally by crash frequency or density,which is effective for roadway engineering improvements but neglects characteristics related to other improvements such as safety education.As safety education would be more effective if targeted at the residences of crash-involved road users,the traditional approach to hot zones may therefore provide biased results for such alternative countermeasures.After confirming that 77.17%of NMV crashes occurred outside the involved riders’areas of residence,this study compared the differences between the locations of crashes and the residences of NMV crash-involved riders in safety influencing factors and hot zone identification.A Poisson lognormal bivariate conditional autoregressive(PLN-BCAR)model was developed to account for potential correlations between crashes and involved riders.The model was compared with the univariate Poisson lognormal conditional autoregressive(UPLN-CAR)model and the bivariate Poisson lognormal conditional autoregressive(BPLNCAR)model;the PLN-BCAR model outperformed the other two models in its better interpretation of the influencing factors and its more efficient parameter estimation.Model results indicated that crashes were mainly associated with roadway and land use characteristics,while involved road users were mainly associated with socioeconomic and land use characteristics.The potential for safety improvement method was adopted to identify hot zones for countermeasure implementation.Results showed over 60%of the identified hot zones were inconsistent:they needed improvement in either engineering or education but not both.These findings can help target the type of improvement to better utilize resources for NMV safety.