In order to predict electromechanical equipments' nonlinear and non-stationary condition effectively, max Lyapunov exponent is introduced to the fault trend prediction of large rotating mechanical equipments based on...In order to predict electromechanical equipments' nonlinear and non-stationary condition effectively, max Lyapunov exponent is introduced to the fault trend prediction of large rotating mechanical equipments based on chaos theory. The predict method of chaos time series and two methods of proposing f and F are dis- cussed. The arithmetic of max prediction time of chaos time series is provided. Aiming at the key part of large rotating mechanical equipments-bearing, used this prediction method the simulation experiment is carried out. The result shows that this method has excellent performance for condition trend prediction.展开更多
National Quality Supervision & Inspection Center for Refractories Business scope: Selective examination for national quality supervision; Identification of production license; Arbitration inspection and technical ac...National Quality Supervision & Inspection Center for Refractories Business scope: Selective examination for national quality supervision; Identification of production license; Arbitration inspection and technical achievements evaluation; Commodities inspection and otherquality inspections .展开更多
Scissors and locks are famous products from Wenzhou. Now scissors from the city including multi-purpose, tailoring, tourist and special-purpose ones and exquisite fruit and artistic knives have entered the world marke...Scissors and locks are famous products from Wenzhou. Now scissors from the city including multi-purpose, tailoring, tourist and special-purpose ones and exquisite fruit and artistic knives have entered the world market. At the展开更多
With the projected global surge in hydrogen demand, driven by increasing applications and the imperative for low-emission hydrogen, the integration of machine learning(ML) across the hydrogen energy value chain is a c...With the projected global surge in hydrogen demand, driven by increasing applications and the imperative for low-emission hydrogen, the integration of machine learning(ML) across the hydrogen energy value chain is a compelling avenue. This review uniquely focuses on harnessing the synergy between ML and computational modeling(CM) or optimization tools, as well as integrating multiple ML techniques with CM, for the synthesis of diverse hydrogen evolution reaction(HER) catalysts and various hydrogen production processes(HPPs). Furthermore, this review addresses a notable gap in the literature by offering insights, analyzing challenges, and identifying research prospects and opportunities for sustainable hydrogen production. While the literature reflects a promising landscape for ML applications in hydrogen energy domains, transitioning AI-based algorithms from controlled environments to real-world applications poses significant challenges. Hence, this comprehensive review delves into the technical,practical, and ethical considerations associated with the application of ML in HER catalyst development and HPP optimization. Overall, this review provides guidance for unlocking the transformative potential of ML in enhancing prediction efficiency and sustainability in the hydrogen production sector.展开更多
The research and application on small denture machining equipment are great breakthrough for modern dental restoration technology. In this paper, a small denture machining equipment made of two spindles with four-axis...The research and application on small denture machining equipment are great breakthrough for modern dental restoration technology. In this paper, a small denture machining equipment made of two spindles with four-axis was designed based on machining characteristics and functional analysis. Position accuracy and re-position accuracy were measured by accuracy instrument. In order to test its machining capacity, some typical microstcucture parts, such as straight channel, hemispherical surface, and molars coronal, were selected for high speed milling. It was obtained that the denture machining equipment met the machining requirements with high quality and efficiency, according to the acquisition and analysis of form and position errors, surface roughness, and 3-D profile.展开更多
As a newly invented parallel kinematic machine(PKM), Exechon has found its potential application in machining and assembling industries due to high rigidity and high dynamics. To guarantee the overall performance, t...As a newly invented parallel kinematic machine(PKM), Exechon has found its potential application in machining and assembling industries due to high rigidity and high dynamics. To guarantee the overall performance, the loading conditions and deflections of the key components must be revealed to provide basic mechanic data for component design. For this purpose, a kinetostatic model is proposed with substructure synthesis technique. The Exechon is divided into a platform subsystem, a fixed base subsystem and three limb subsystems according to its structure. By modeling the limb assemblage as a spatial beam constrained by two sets of lumped virtual springs representing the compliances of revolute joint, universal joint and spherical joint, the equilibrium equations of limb subsystems are derived with finite element method(FEM). The equilibrium equations of the platform are derived with Newton's 2nd law. By introducing deformation compatibility conditions between the platform and limb, the governing equilibrium equations of the system are derived to formulate an analytical expression for system's deflections. The platform's elastic displacements and joint reactions caused by the gravity are investigated to show a strong position-dependency and axis-symmetry due to its kinematic and structure features. The proposed kinetostatic model is a trade-off between the accuracy of FEM and concision of analytical method, thus can predict the kinetostatics throughout the workspace in a quick and succinct manner. The proposed modeling methodology and kinetostatic analysis can be further expanded to other PKMs with necessary modifications, providing useful information for kinematic calibration as well as component strength calculations.展开更多
The milling-head machine tool is a sophisticated and high-quality machine tool of which the spindle system is made up of special multi-element structure. Two special mechanical configurations make the cutting performa...The milling-head machine tool is a sophisticated and high-quality machine tool of which the spindle system is made up of special multi-element structure. Two special mechanical configurations make the cutting performance of the machine tool decline. One is the milling head spindle supported on two sets of complex bearings. The mechanical dynamic rigidity of milling head structure is researched on designed digital prototype with finite element analysis(FEA) and modal synthesis analysis ( MSA ) for identifying the weak structures. The other is the ram structure hanging on milling head. The structure is researched to get dynamic performance on cutting at different ram extending positions. The analysis results on spindle and ram are used to improve the mechanical configurations and structure in design. The machine tool is built up with modified structure and gets better dynamic rigidity than it was before.展开更多
Finding energetic materials with tailored properties is always a significant challenge due to low research efficiency in trial and error.Herein,a methodology combining domain knowledge,a machine learning algorithm,and...Finding energetic materials with tailored properties is always a significant challenge due to low research efficiency in trial and error.Herein,a methodology combining domain knowledge,a machine learning algorithm,and experiments is presented for accelerating the discovery of novel energetic materials.A high-throughput virtual screening(HTVS)system integrating on-demand molecular generation and machine learning models covering the prediction of molecular properties and crystal packing mode scoring is established.With the proposed HTVS system,candidate molecules with promising properties and a desirable crystal packing mode are rapidly targeted from the generated molecular space containing 25112 molecules.Furthermore,a study of the crystal structure and properties shows that the good comprehensive performances of the target molecule are in agreement with the predicted results,thus verifying the effectiveness of the proposed methodology.This work demonstrates a new research paradigm for discovering novel energetic materials and can be extended to other organic materials without manifest obstacles.展开更多
Rapid and precise location of the faults of on-board equipment of train control system is a significant factor to ensure reliable train operation.Text data of the fault tracking table of on-board equipment are taken a...Rapid and precise location of the faults of on-board equipment of train control system is a significant factor to ensure reliable train operation.Text data of the fault tracking table of on-board equipment are taken as samples,and an on-board equipment fault diagnosis model is designed based on the combination of convolutional neural network(CNN)and particle swarm optimization-support vector machines(PSO-SVM).Due to the characteristics of high dimensionality and sparseness of fault text data,CNN is used to achieve feature extraction.In order to decrease the influence of the imbalance of the fault sample data category on the classification accuracy,the PSO-SVM algorithm is introduced.The fully connected classification part of CNN is replaced by PSO-SVM,the extracted features are classified precisely,and the intelligent diagnosis of on-board equipment fault is implemented.According to the test analysis of the fault text data of on-board equipment recorded by a railway bureau and comparison with other models,the experimental results indicate that this model can obviously upgrade the evaluation indexes and can be used as an effective model for fault diagnosis for on-board equipment.展开更多
Carbon dots(CDs)have wide application potentials in optoelectronic devices,biology,medicine,chemical sensors,and quantum techniques due to their excellent fluorescent properties.However,synthesis of CDs with controlla...Carbon dots(CDs)have wide application potentials in optoelectronic devices,biology,medicine,chemical sensors,and quantum techniques due to their excellent fluorescent properties.However,synthesis of CDs with controllable spectrum is challenging because of the diversity of the CD components and structures.In this report,machine learning(ML)algorithms were applied to help the synthesis of CDs with predictable photoluminescence(PL)under the excitation wavelengths of 365 and 532 nm.The combination of precursors was used as the variable.The PL peaks of the strongest intensity(λ_(s))and the longest wavelength(λ_(l))were used as target functions.Among six investigated ML models,the random forest(RF)model showed outstanding)performance in the prediction of the PL peaks.展开更多
The determination of maintenance mode of complex equipment in nuclear power plant is an essential work for reliability analysis and maintenance decision. Currently, the main decision method of maintenance mode is reli...The determination of maintenance mode of complex equipment in nuclear power plant is an essential work for reliability analysis and maintenance decision. Currently, the main decision method of maintenance mode is reliability centered maintenance( RCM) logic decision-making process, but the process is a qualitative analysis process. Based on a comprehensive analysis of factors affecting equipment reliability and maintenance work, it adopts a fuzzy synthesis decision method to establish a maintenance decision model,which uses the maximum subordination principle and expert assessment method to determine the maintenance mode of complex equipment. Combined with a concrete example of generators in nuclear power plant,a description of maintenance decision method was proposed in the application of complex equipment. The research shows that the method is feasible and reliable.展开更多
This paper realizes a sign language-to-speech conversion system to solve the communication problem between healthy people and speech disorders. 30 kinds of different static sign languages are firstly recognized by com...This paper realizes a sign language-to-speech conversion system to solve the communication problem between healthy people and speech disorders. 30 kinds of different static sign languages are firstly recognized by combining the support vector machine (SVM) with a restricted Boltzmann machine (RBM) based regulation and a feedback fine-tuning of the deep model. The text of sign language is then obtained from the recognition results. A context-dependent label is generated from the recognized text of sign language by a text analyzer. Meanwhile,a hiddenMarkov model (HMM) basedMandarin-Tibetan bilingual speech synthesis system is developed by using speaker adaptive training.The Mandarin speech or Tibetan speech is then naturally synthesized by using context-dependent label generated from the recognized sign language. Tests show that the static sign language recognition rate of the designed system achieves 93.6%. Subjective evaluation demonstrates that synthesized speech can get 4.0 of the mean opinion score (MOS).展开更多
This paper presents dimensional synthesis design theory for a novel planar 3-DOF (degrees of freedom) parallel machine tool. Closed-form solutions are developed for both the inverse and direct kinematics. The formula...This paper presents dimensional synthesis design theory for a novel planar 3-DOF (degrees of freedom) parallel machine tool. Closed-form solutions are developed for both the inverse and direct kinematics. The formulation of the dexterity and the definitions of the theoretical workspace and the valid workspace are used to analyze the effects of the design parameters on the dexterity and workspace. The analysis results are used to propose an approach to satisfy the platform motion requirement while realizing orientation capability, dexterity and valid workspace. A design example is given to illustrate the effectiveness of this approach.展开更多
Ionizable lipid (IL), the most important component of lipid nanoparticles (LNPs) for messenger RNA (mRNA) delivery, is closely related to the mRNA expression and targeted property of LNPs. Recently, a pioneering resea...Ionizable lipid (IL), the most important component of lipid nanoparticles (LNPs) for messenger RNA (mRNA) delivery, is closely related to the mRNA expression and targeted property of LNPs. Recently, a pioneering research led by Li et al.1 published in Nature Materials reported a novel approach to the high-throughput screening of novel ILs for mRNA delivery via combinatorial chemistry and machine learning (ML) (Fig. 1). 119-23, a newly structured IL, was finally designed by this strategy, which outperformed commercial ILs (MC3 and SM102) in transfecting muscle cells and immune cells in several tissues. This study should accelerate the design and optimization of potent ILs, advancing the development of LNPs for efficient mRNA delivery.展开更多
The generation and development of microcracks of SiCp/Al materials in the machining process were researched, and the forming causes and mechanism of the cut surface morphology for ap=0.2 mm or ap=0.4 mm and at 2 m/min...The generation and development of microcracks of SiCp/Al materials in the machining process were researched, and the forming causes and mechanism of the cut surface morphology for ap=0.2 mm or ap=0.4 mm and at 2 m/min~10 m/min were systematically analyzed. The supporting and "floor"roles of aluminum are wake at a shallower cutting depth and a lower speed, the SiC particles are shed under the role of cutting force, and the microcrack size of cut surface is larger. With the increase in the cutting depth and the cutting speed, the cutting temperature increases, the supporting and "floor" roles of aluminum are enhanced, the shedding and fracture of the reinforcement particles are flexible under the action of the cutting force, the fracture of cutting transforms from brittle to ductile, and the expansion of microcrack on the entire surface tends to balance with a smaller size. A curve between the cutting force and the cutting speed was plotted, a microcrack form of the cut surface was given, and some theoretical basis is provided for the mechanical processing and the surface quality.展开更多
Designer chromosomes are artificially synthesized chromosomes.Nowadays,these chromosomes have numerous applications ranging from medical research to the development of biofuels.However,some chromosome fragments can in...Designer chromosomes are artificially synthesized chromosomes.Nowadays,these chromosomes have numerous applications ranging from medical research to the development of biofuels.However,some chromosome fragments can interfere with the chemical synthesis of designer chromosomes and eventually limit the widespread use of this technology.To address this issue,this study aimed to develop an interpretable machine learning framework to predict and quantify the synthesis difficulties of designer chromosomes in advance.Through the use of this framework,six key sequence features leading to synthesis difficulties were identified,and an e Xtreme Gradient Boosting model was established to integrate these features.The predictive model achieved high-quality performance with an AUC of 0.895 in cross-validation and an AUC of 0.885 on an independent test set.Based on these results,the synthesis difficulty index(S-index)was proposed as a means of scoring and interpreting synthesis difficulties of chromosomes from prokaryotes to eukaryotes.The findings of this study emphasize the significant variability in synthesis difficulties between chromosomes and demonstrate the potential of the proposed model to predict and mitigate these difficulties through the optimization of the synthesis process and genome rewriting.展开更多
The influence of different technological parameter on material remove rate and surface quality of ZrO2 ceramics is studied using the cutting machining method of electroplate diamond wire saw with ultrasonic vibration....The influence of different technological parameter on material remove rate and surface quality of ZrO2 ceramics is studied using the cutting machining method of electroplate diamond wire saw with ultrasonic vibration.Experimental results show that,compared with the same experiment condition without ultrasonic vibration,this cutting method has the advantages of high material remove rate,good surface quality,little brokenness and so on.展开更多
基金Sponsored by Key Funding Project for Science and Technology under the Beijing Municipal Education Commission(KZ200910772001)
文摘In order to predict electromechanical equipments' nonlinear and non-stationary condition effectively, max Lyapunov exponent is introduced to the fault trend prediction of large rotating mechanical equipments based on chaos theory. The predict method of chaos time series and two methods of proposing f and F are dis- cussed. The arithmetic of max prediction time of chaos time series is provided. Aiming at the key part of large rotating mechanical equipments-bearing, used this prediction method the simulation experiment is carried out. The result shows that this method has excellent performance for condition trend prediction.
文摘National Quality Supervision & Inspection Center for Refractories Business scope: Selective examination for national quality supervision; Identification of production license; Arbitration inspection and technical achievements evaluation; Commodities inspection and otherquality inspections .
文摘Scissors and locks are famous products from Wenzhou. Now scissors from the city including multi-purpose, tailoring, tourist and special-purpose ones and exquisite fruit and artistic knives have entered the world market. At the
基金express their gratitude to the Higher Institution Centre of Excellence (HICoE) fund under the project code (JPT.S(BPKI)2000/016/018/015JId.4(21)/2022002HICOE)Universiti Tenaga Nasional (UNITEN) for funding the research through the (J510050002–IC–6 BOLDREFRESH2025)Akaun Amanah Industri Bekalan Elektrik (AAIBE) Chair of Renewable Energy grant,and NEC Energy Transition Grant (202203003ETG)。
文摘With the projected global surge in hydrogen demand, driven by increasing applications and the imperative for low-emission hydrogen, the integration of machine learning(ML) across the hydrogen energy value chain is a compelling avenue. This review uniquely focuses on harnessing the synergy between ML and computational modeling(CM) or optimization tools, as well as integrating multiple ML techniques with CM, for the synthesis of diverse hydrogen evolution reaction(HER) catalysts and various hydrogen production processes(HPPs). Furthermore, this review addresses a notable gap in the literature by offering insights, analyzing challenges, and identifying research prospects and opportunities for sustainable hydrogen production. While the literature reflects a promising landscape for ML applications in hydrogen energy domains, transitioning AI-based algorithms from controlled environments to real-world applications poses significant challenges. Hence, this comprehensive review delves into the technical,practical, and ethical considerations associated with the application of ML in HER catalyst development and HPP optimization. Overall, this review provides guidance for unlocking the transformative potential of ML in enhancing prediction efficiency and sustainability in the hydrogen production sector.
基金National Key Technology R&D Program,China(No.2009BAI81B02)PhD Programs Foundation of Ministry of Education of China(No.20070287055)Anhui Natural Science Foundation,China(No.1308085QE93)
文摘The research and application on small denture machining equipment are great breakthrough for modern dental restoration technology. In this paper, a small denture machining equipment made of two spindles with four-axis was designed based on machining characteristics and functional analysis. Position accuracy and re-position accuracy were measured by accuracy instrument. In order to test its machining capacity, some typical microstcucture parts, such as straight channel, hemispherical surface, and molars coronal, were selected for high speed milling. It was obtained that the denture machining equipment met the machining requirements with high quality and efficiency, according to the acquisition and analysis of form and position errors, surface roughness, and 3-D profile.
基金Supported by State Key Laboratory for Manufacturing Systems Engineering,Xi’an Jiaotong University(Grant No.sklms2015004)Open Research Fund of Key Laboratory of High Performance Complex Manufacturing,Central South University(Grant No.Kfkt2013-12)+2 种基金Open Fund of Shanghai Key Laboratory of Digital Manufacture for Thin-walled Structures(Grant No.2014001)Innovation Research Fund for Postgraduates of Anhui University of Technology(Grant No.2014054)Engineering and Physical Science Research Council in the United Kingdom(Grant No.EP/K004964/1)
文摘As a newly invented parallel kinematic machine(PKM), Exechon has found its potential application in machining and assembling industries due to high rigidity and high dynamics. To guarantee the overall performance, the loading conditions and deflections of the key components must be revealed to provide basic mechanic data for component design. For this purpose, a kinetostatic model is proposed with substructure synthesis technique. The Exechon is divided into a platform subsystem, a fixed base subsystem and three limb subsystems according to its structure. By modeling the limb assemblage as a spatial beam constrained by two sets of lumped virtual springs representing the compliances of revolute joint, universal joint and spherical joint, the equilibrium equations of limb subsystems are derived with finite element method(FEM). The equilibrium equations of the platform are derived with Newton's 2nd law. By introducing deformation compatibility conditions between the platform and limb, the governing equilibrium equations of the system are derived to formulate an analytical expression for system's deflections. The platform's elastic displacements and joint reactions caused by the gravity are investigated to show a strong position-dependency and axis-symmetry due to its kinematic and structure features. The proposed kinetostatic model is a trade-off between the accuracy of FEM and concision of analytical method, thus can predict the kinetostatics throughout the workspace in a quick and succinct manner. The proposed modeling methodology and kinetostatic analysis can be further expanded to other PKMs with necessary modifications, providing useful information for kinematic calibration as well as component strength calculations.
基金supported by Funding Project for Academic Human Resources Development in Institutions of Higher Learning under the Jurisdiction of Beijing Municipality,China.
文摘The milling-head machine tool is a sophisticated and high-quality machine tool of which the spindle system is made up of special multi-element structure. Two special mechanical configurations make the cutting performance of the machine tool decline. One is the milling head spindle supported on two sets of complex bearings. The mechanical dynamic rigidity of milling head structure is researched on designed digital prototype with finite element analysis(FEA) and modal synthesis analysis ( MSA ) for identifying the weak structures. The other is the ram structure hanging on milling head. The structure is researched to get dynamic performance on cutting at different ram extending positions. The analysis results on spindle and ram are used to improve the mechanical configurations and structure in design. The machine tool is built up with modified structure and gets better dynamic rigidity than it was before.
基金the Science Challenge Project(TZ2018004)the National Natural Science Foundation of China(21875228 and 21702195)for financial support。
文摘Finding energetic materials with tailored properties is always a significant challenge due to low research efficiency in trial and error.Herein,a methodology combining domain knowledge,a machine learning algorithm,and experiments is presented for accelerating the discovery of novel energetic materials.A high-throughput virtual screening(HTVS)system integrating on-demand molecular generation and machine learning models covering the prediction of molecular properties and crystal packing mode scoring is established.With the proposed HTVS system,candidate molecules with promising properties and a desirable crystal packing mode are rapidly targeted from the generated molecular space containing 25112 molecules.Furthermore,a study of the crystal structure and properties shows that the good comprehensive performances of the target molecule are in agreement with the predicted results,thus verifying the effectiveness of the proposed methodology.This work demonstrates a new research paradigm for discovering novel energetic materials and can be extended to other organic materials without manifest obstacles.
基金Gansu Province Higher Education Innovation Fund Project(No.2020B-104)“Innovation Star”Project for Outstanding Postgraduates of Gansu Province(No.2021CXZX-606)。
文摘Rapid and precise location of the faults of on-board equipment of train control system is a significant factor to ensure reliable train operation.Text data of the fault tracking table of on-board equipment are taken as samples,and an on-board equipment fault diagnosis model is designed based on the combination of convolutional neural network(CNN)and particle swarm optimization-support vector machines(PSO-SVM).Due to the characteristics of high dimensionality and sparseness of fault text data,CNN is used to achieve feature extraction.In order to decrease the influence of the imbalance of the fault sample data category on the classification accuracy,the PSO-SVM algorithm is introduced.The fully connected classification part of CNN is replaced by PSO-SVM,the extracted features are classified precisely,and the intelligent diagnosis of on-board equipment fault is implemented.According to the test analysis of the fault text data of on-board equipment recorded by a railway bureau and comparison with other models,the experimental results indicate that this model can obviously upgrade the evaluation indexes and can be used as an effective model for fault diagnosis for on-board equipment.
基金supported by the National Natural Science Foundation of China(No.22175095).
文摘Carbon dots(CDs)have wide application potentials in optoelectronic devices,biology,medicine,chemical sensors,and quantum techniques due to their excellent fluorescent properties.However,synthesis of CDs with controllable spectrum is challenging because of the diversity of the CD components and structures.In this report,machine learning(ML)algorithms were applied to help the synthesis of CDs with predictable photoluminescence(PL)under the excitation wavelengths of 365 and 532 nm.The combination of precursors was used as the variable.The PL peaks of the strongest intensity(λ_(s))and the longest wavelength(λ_(l))were used as target functions.Among six investigated ML models,the random forest(RF)model showed outstanding)performance in the prediction of the PL peaks.
文摘The determination of maintenance mode of complex equipment in nuclear power plant is an essential work for reliability analysis and maintenance decision. Currently, the main decision method of maintenance mode is reliability centered maintenance( RCM) logic decision-making process, but the process is a qualitative analysis process. Based on a comprehensive analysis of factors affecting equipment reliability and maintenance work, it adopts a fuzzy synthesis decision method to establish a maintenance decision model,which uses the maximum subordination principle and expert assessment method to determine the maintenance mode of complex equipment. Combined with a concrete example of generators in nuclear power plant,a description of maintenance decision method was proposed in the application of complex equipment. The research shows that the method is feasible and reliable.
基金supported by the National Natural Science Foundation of China(No.81400680,No.31500723)the National Science Foundation of Tianjin(No.17JCQNJC12800)+1 种基金Tianjin Science and Technology Plan Project(No.14RCGFSY00147)International S&T Cooperation Program of China(No.2015DFG31850)
基金The research leading to these results was partly funded by the National Natural Science Foundation of China (Grant No. 61263036, 61262055), Gansu Science Fund for Distinguished Young Scholars (Grant No. 1210RJDA007) and Natural Science Foundation of Gansu (Grant No. 1506RJYA126).
文摘This paper realizes a sign language-to-speech conversion system to solve the communication problem between healthy people and speech disorders. 30 kinds of different static sign languages are firstly recognized by combining the support vector machine (SVM) with a restricted Boltzmann machine (RBM) based regulation and a feedback fine-tuning of the deep model. The text of sign language is then obtained from the recognition results. A context-dependent label is generated from the recognized text of sign language by a text analyzer. Meanwhile,a hiddenMarkov model (HMM) basedMandarin-Tibetan bilingual speech synthesis system is developed by using speaker adaptive training.The Mandarin speech or Tibetan speech is then naturally synthesized by using context-dependent label generated from the recognized sign language. Tests show that the static sign language recognition rate of the designed system achieves 93.6%. Subjective evaluation demonstrates that synthesized speech can get 4.0 of the mean opinion score (MOS).
基金Supported by the National High- Tech Developm entProgram (No.86 3- 5 11- 943- 0 0 1) and the NationalNatural Science Foundation of China(No.5 980 5 0 11)
文摘This paper presents dimensional synthesis design theory for a novel planar 3-DOF (degrees of freedom) parallel machine tool. Closed-form solutions are developed for both the inverse and direct kinematics. The formulation of the dexterity and the definitions of the theoretical workspace and the valid workspace are used to analyze the effects of the design parameters on the dexterity and workspace. The analysis results are used to propose an approach to satisfy the platform motion requirement while realizing orientation capability, dexterity and valid workspace. A design example is given to illustrate the effectiveness of this approach.
基金National Key Research and Development Program of China(2023YFC3403200)Sichuan Science and Technology Program(No.2023YFG0207,China).
文摘Ionizable lipid (IL), the most important component of lipid nanoparticles (LNPs) for messenger RNA (mRNA) delivery, is closely related to the mRNA expression and targeted property of LNPs. Recently, a pioneering research led by Li et al.1 published in Nature Materials reported a novel approach to the high-throughput screening of novel ILs for mRNA delivery via combinatorial chemistry and machine learning (ML) (Fig. 1). 119-23, a newly structured IL, was finally designed by this strategy, which outperformed commercial ILs (MC3 and SM102) in transfecting muscle cells and immune cells in several tissues. This study should accelerate the design and optimization of potent ILs, advancing the development of LNPs for efficient mRNA delivery.
文摘The generation and development of microcracks of SiCp/Al materials in the machining process were researched, and the forming causes and mechanism of the cut surface morphology for ap=0.2 mm or ap=0.4 mm and at 2 m/min~10 m/min were systematically analyzed. The supporting and "floor"roles of aluminum are wake at a shallower cutting depth and a lower speed, the SiC particles are shed under the role of cutting force, and the microcrack size of cut surface is larger. With the increase in the cutting depth and the cutting speed, the cutting temperature increases, the supporting and "floor" roles of aluminum are enhanced, the shedding and fracture of the reinforcement particles are flexible under the action of the cutting force, the fracture of cutting transforms from brittle to ductile, and the expansion of microcrack on the entire surface tends to balance with a smaller size. A curve between the cutting force and the cutting speed was plotted, a microcrack form of the cut surface was given, and some theoretical basis is provided for the mechanical processing and the surface quality.
基金supported by the National Natural Science Foundation of China(21621004,31861143017,21907074)the National Key Research and Development Program of China(2019YFA0906600)。
文摘Designer chromosomes are artificially synthesized chromosomes.Nowadays,these chromosomes have numerous applications ranging from medical research to the development of biofuels.However,some chromosome fragments can interfere with the chemical synthesis of designer chromosomes and eventually limit the widespread use of this technology.To address this issue,this study aimed to develop an interpretable machine learning framework to predict and quantify the synthesis difficulties of designer chromosomes in advance.Through the use of this framework,six key sequence features leading to synthesis difficulties were identified,and an e Xtreme Gradient Boosting model was established to integrate these features.The predictive model achieved high-quality performance with an AUC of 0.895 in cross-validation and an AUC of 0.885 on an independent test set.Based on these results,the synthesis difficulty index(S-index)was proposed as a means of scoring and interpreting synthesis difficulties of chromosomes from prokaryotes to eukaryotes.The findings of this study emphasize the significant variability in synthesis difficulties between chromosomes and demonstrate the potential of the proposed model to predict and mitigate these difficulties through the optimization of the synthesis process and genome rewriting.
基金Sponsored by Department of Education University Research Project of Liaoning Province(LN566)
文摘The influence of different technological parameter on material remove rate and surface quality of ZrO2 ceramics is studied using the cutting machining method of electroplate diamond wire saw with ultrasonic vibration.Experimental results show that,compared with the same experiment condition without ultrasonic vibration,this cutting method has the advantages of high material remove rate,good surface quality,little brokenness and so on.