Objective:To investigate the effect of adjuvant oral immunoglobulin therapy on the illness of children with rotavirus enteritis.Methods: A total of 170 children with rotavirus enteritis who were treated in the hospita...Objective:To investigate the effect of adjuvant oral immunoglobulin therapy on the illness of children with rotavirus enteritis.Methods: A total of 170 children with rotavirus enteritis who were treated in the hospital between May 2016 and December 2017 were divided into control group (n=85) and immunoglobulin group (n=85) by random number table method. Control group received clinical routine therapy for rotavirus enteritis, immunoglobulin group received the oral immunoglobulin combined with routine therapy, and the treatment lasted for 7d. The differences in the contents of inflammatory factors, immunoglobulins and complements in serum as well as the levels of intestinal flora count in feces sample tissue were compared between the two groups before and after treatment.Results: Before treatment, the differences in the contents of inflammatory factors, immunoglobulins and complements in serum as well as the levels of intestinal flora count in feces samples were not statistically significant between the two groups of patients. After 7d of treatment, inflammatory factors IL-2, IL-6, IL-15 and TNF-α contents in serum of immunoglobulin group were lower than those of control group;IgG, IgA, IgM, C3 and C4 contents were higher than those of control group;bifidobacterium and lactobacillus count levels in feces samples were higher than those of control group whereas E. coli count level was lower than that of control group.Conclusion: Adjuvant oral immunoglobulin therapy can help to relieve the inflammatory response, enhance the immune function and balance the intestinal flora distribution in children with rotavirus enteritis.展开更多
Objective: To observe clinical efficacy of Ribavirin combined with Clostridium butyricum powder on child patients with rotavirus enteritis and analyze serum IL-6, IL-8, TNF-αconcentration and change of T lymphocyte s...Objective: To observe clinical efficacy of Ribavirin combined with Clostridium butyricum powder on child patients with rotavirus enteritis and analyze serum IL-6, IL-8, TNF-αconcentration and change of T lymphocyte subsets. Methods: A total of 90 patients with rotavirus enteritis were randomly divided into control group (n=45) and observation group (n=45). The control group was given conventional therapy combined with Ribavirin. The observation group was treated with Clostridium butyricum powder on the basis of control group. The changes of T lymphocyte subsets and inflammatory factors were measured before and after treatment in all subjects. Results: There was no significant difference in serum T lymphocyte subsets between the control group and the observation group before treatment. After treatment, the levels of serum CD3+, CD4+ and CD4+/CD8+ in both groups were higher than those before treatment, while CD8+ level was lower than that before treatment. The levels of serum CD3+, CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group after treatment, while the CD8+ level was lower than that in control group in the corresponding period. There was no significant difference in the concentration of inflammatory factors between the control group and the observation group before treatment. After treatment, the levels of IL-6, IL-8 and TNF-α in the two groups were lower than those before treatment. The observation group was significantly lower than control group in corresponding period after treatment and difference was statistically significant. Conclusion: On the basis of conventional therapy and Ribavirin treatment, combined with Clostridium butyricum Powder for children with rotavirus enteritis can reduce concentration of inflammatory factors in peripheral blood and decrease expression of CD8+ T lymphocyte subsets level and improve the level of CD3+, CD4+ level. It is a potent effective drug for treatment of children with rotavirus enteritis.展开更多
[Objectives]To explore the clinical effect of Modified Gegen Qinlian Decoction combined with western medicine on children with rotavirus enteritis with damp-heat syndrome and its influence on myocardial enzymes.[Metho...[Objectives]To explore the clinical effect of Modified Gegen Qinlian Decoction combined with western medicine on children with rotavirus enteritis with damp-heat syndrome and its influence on myocardial enzymes.[Methods]One hundred and eighty children with rotavirus enteritis with damp-heat syndrome were randomly divided into control group and observation group,with 90 cases in each group.The control group was given western medicine symptomatic treatment,and the observation group was given Modified Gegen Qinlian Decoction treatment on the basis of the control group.Both groups were treated for 5 d.The clinical efficacy,symptom disappearance time,myocardial zymogram indicator level and TCM syndrome scores were compared between the two groups.[Results]After 5 d of treatment,the total effective rate of the observation group was 94.44%,which was significantly higher than that of the control group(84.44%)(P<0.05).The time of diarrhea,fever,vomiting,dehydration and fecal RV turning negative in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After 5 d of treatment,the serum levels of creatine kinase(CK),creatine kinase isoenzyme(CK-MB),aspartate aminotransferase(AST),lactate dehydrogenase(LDH)and α-hydroxybutyrate dehydrogenase(α-HBDH)in the two groups were lower than those before treatment.The levels of the above five myocardial enzymes in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 5 d of treatment,the scores of defecation frequency,abdominal distention,thirst,dysphoria,fatigue and anorexia in the two groups were lower than those before treatment.The scores of the above five TCM syndromes in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).[Conclusions]Modified Gegen Qinlian Decoction combined with western medicine can quickly relieve the symptoms and signs of children with rotavirus enteritis with damp-heat syndrome,shorten the course of disease,and reduce myocardial injury.展开更多
文摘Objective:To investigate the effect of adjuvant oral immunoglobulin therapy on the illness of children with rotavirus enteritis.Methods: A total of 170 children with rotavirus enteritis who were treated in the hospital between May 2016 and December 2017 were divided into control group (n=85) and immunoglobulin group (n=85) by random number table method. Control group received clinical routine therapy for rotavirus enteritis, immunoglobulin group received the oral immunoglobulin combined with routine therapy, and the treatment lasted for 7d. The differences in the contents of inflammatory factors, immunoglobulins and complements in serum as well as the levels of intestinal flora count in feces sample tissue were compared between the two groups before and after treatment.Results: Before treatment, the differences in the contents of inflammatory factors, immunoglobulins and complements in serum as well as the levels of intestinal flora count in feces samples were not statistically significant between the two groups of patients. After 7d of treatment, inflammatory factors IL-2, IL-6, IL-15 and TNF-α contents in serum of immunoglobulin group were lower than those of control group;IgG, IgA, IgM, C3 and C4 contents were higher than those of control group;bifidobacterium and lactobacillus count levels in feces samples were higher than those of control group whereas E. coli count level was lower than that of control group.Conclusion: Adjuvant oral immunoglobulin therapy can help to relieve the inflammatory response, enhance the immune function and balance the intestinal flora distribution in children with rotavirus enteritis.
文摘Objective: To observe clinical efficacy of Ribavirin combined with Clostridium butyricum powder on child patients with rotavirus enteritis and analyze serum IL-6, IL-8, TNF-αconcentration and change of T lymphocyte subsets. Methods: A total of 90 patients with rotavirus enteritis were randomly divided into control group (n=45) and observation group (n=45). The control group was given conventional therapy combined with Ribavirin. The observation group was treated with Clostridium butyricum powder on the basis of control group. The changes of T lymphocyte subsets and inflammatory factors were measured before and after treatment in all subjects. Results: There was no significant difference in serum T lymphocyte subsets between the control group and the observation group before treatment. After treatment, the levels of serum CD3+, CD4+ and CD4+/CD8+ in both groups were higher than those before treatment, while CD8+ level was lower than that before treatment. The levels of serum CD3+, CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group after treatment, while the CD8+ level was lower than that in control group in the corresponding period. There was no significant difference in the concentration of inflammatory factors between the control group and the observation group before treatment. After treatment, the levels of IL-6, IL-8 and TNF-α in the two groups were lower than those before treatment. The observation group was significantly lower than control group in corresponding period after treatment and difference was statistically significant. Conclusion: On the basis of conventional therapy and Ribavirin treatment, combined with Clostridium butyricum Powder for children with rotavirus enteritis can reduce concentration of inflammatory factors in peripheral blood and decrease expression of CD8+ T lymphocyte subsets level and improve the level of CD3+, CD4+ level. It is a potent effective drug for treatment of children with rotavirus enteritis.
文摘[Objectives]To explore the clinical effect of Modified Gegen Qinlian Decoction combined with western medicine on children with rotavirus enteritis with damp-heat syndrome and its influence on myocardial enzymes.[Methods]One hundred and eighty children with rotavirus enteritis with damp-heat syndrome were randomly divided into control group and observation group,with 90 cases in each group.The control group was given western medicine symptomatic treatment,and the observation group was given Modified Gegen Qinlian Decoction treatment on the basis of the control group.Both groups were treated for 5 d.The clinical efficacy,symptom disappearance time,myocardial zymogram indicator level and TCM syndrome scores were compared between the two groups.[Results]After 5 d of treatment,the total effective rate of the observation group was 94.44%,which was significantly higher than that of the control group(84.44%)(P<0.05).The time of diarrhea,fever,vomiting,dehydration and fecal RV turning negative in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After 5 d of treatment,the serum levels of creatine kinase(CK),creatine kinase isoenzyme(CK-MB),aspartate aminotransferase(AST),lactate dehydrogenase(LDH)and α-hydroxybutyrate dehydrogenase(α-HBDH)in the two groups were lower than those before treatment.The levels of the above five myocardial enzymes in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 5 d of treatment,the scores of defecation frequency,abdominal distention,thirst,dysphoria,fatigue and anorexia in the two groups were lower than those before treatment.The scores of the above five TCM syndromes in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).[Conclusions]Modified Gegen Qinlian Decoction combined with western medicine can quickly relieve the symptoms and signs of children with rotavirus enteritis with damp-heat syndrome,shorten the course of disease,and reduce myocardial injury.