This review is briefly to recall the history of research and development (R&D) of Chinese materia medica (CMM) and to discuss the challenges of Chinese traditional and herbal medicines (CTHM) facing the modern sci...This review is briefly to recall the history of research and development (R&D) of Chinese materia medica (CMM) and to discuss the challenges of Chinese traditional and herbal medicines (CTHM) facing the modern science and technology. The R&D of CTHM is thought to be an important pathway for new drug discovery. Since1949, about 140 approved new drugs have been developed, among which about 80 originated directly or indirectly from medicinal plants. CTHM has gained interest from the international medical, biomedical, and pharmaceutical institutions as a valuable source of potential medicines. For the modernization of CMM and innovative research of CTHM, there are following challenges to be faced: (1) to evaluate the efficacy, pharmacological properties, action mechanism, and active chemical constituents; (2) to develop new methodologies for the quality and safety of CTHM; (3) to apply new '-omics' techniques to accelerate drug discoveries developed from CTHM; and (4) to apply international practices including good agricultural practice, good manufacturing practice, good laboratory practice, and good clinical practice in the R&D of CTHM.展开更多
目的:分析国家重点研发计划中医药现代化研究重点专项(以下简称专项)的研究进展。方法:基于中国知网(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)和Web of Science核心合集数据库(WoSC...目的:分析国家重点研发计划中医药现代化研究重点专项(以下简称专项)的研究进展。方法:基于中国知网(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)和Web of Science核心合集数据库(WoSCC),检索2017—2023年专项资助发表的论文,利用文献计量学和CiteSpace软件对论文作者、机构、研究热点等进行分析。结果:共检索到中文文献2701篇,涉及核心作者108位、形成2个较大的研究团队,中国中医科学院发文量最多,研究热点包括用药规律、中医证候等中医药临床评价和机制研究,主要研究疾病包括心血管病、恶性肿瘤等。英文文献732篇,其中中国科学院发文量最多,药物效用机制、药物代谢动力学等药理学研究是研究热点。结论:在专项支持下,中医药基础研究和基于循证医学评价的临床研究不断深入,在中医药防治重大疾病研究方面取得了重要进展。未来应加强科技成果转化,深化人工智能技术在中医药现代化研究中的应用。展开更多
Objective To develop the internationalization and modernization of Hainan’s TCM industry,explore the development direction and fill in the research gap.Methods Design qualitative approaches,including fieldwork,semi-s...Objective To develop the internationalization and modernization of Hainan’s TCM industry,explore the development direction and fill in the research gap.Methods Design qualitative approaches,including fieldwork,semi-structured interviews,and policy analysis,were employed to identify development challenges for the cooperation between Hainan and Macao region in TCM industry.Ten interviews with key TCM industry stakeholders in Hainan and Macao region were conducted in 2020.These stakeholders are from schools,hospitals,companies,and governments.Hainan Province is the only free trade port with Chinese characteristics.Macao region is an international free trade port that has special economic relations with European and Portuguese-speaking countries.Therefore,this study focuses on the cooperation in the traditional Chinese medicine(TCM)industry between Hainan and Macao region.Besides,it investigates the traditional Chinese medicine industry in Hainan and Macao region according to the SWOT model.Results and Conclusion The study revealed strengths,weaknesses,opportunities,and threats for cooperation between Hainan and Macao region in TCM industry.Cooperation between Hainan and Macao region can be taken as a priority outline and a standard for the internationalization and modernization of Hainan’s TCM industry.展开更多
文摘This review is briefly to recall the history of research and development (R&D) of Chinese materia medica (CMM) and to discuss the challenges of Chinese traditional and herbal medicines (CTHM) facing the modern science and technology. The R&D of CTHM is thought to be an important pathway for new drug discovery. Since1949, about 140 approved new drugs have been developed, among which about 80 originated directly or indirectly from medicinal plants. CTHM has gained interest from the international medical, biomedical, and pharmaceutical institutions as a valuable source of potential medicines. For the modernization of CMM and innovative research of CTHM, there are following challenges to be faced: (1) to evaluate the efficacy, pharmacological properties, action mechanism, and active chemical constituents; (2) to develop new methodologies for the quality and safety of CTHM; (3) to apply new '-omics' techniques to accelerate drug discoveries developed from CTHM; and (4) to apply international practices including good agricultural practice, good manufacturing practice, good laboratory practice, and good clinical practice in the R&D of CTHM.
文摘目的:分析国家重点研发计划中医药现代化研究重点专项(以下简称专项)的研究进展。方法:基于中国知网(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)和Web of Science核心合集数据库(WoSCC),检索2017—2023年专项资助发表的论文,利用文献计量学和CiteSpace软件对论文作者、机构、研究热点等进行分析。结果:共检索到中文文献2701篇,涉及核心作者108位、形成2个较大的研究团队,中国中医科学院发文量最多,研究热点包括用药规律、中医证候等中医药临床评价和机制研究,主要研究疾病包括心血管病、恶性肿瘤等。英文文献732篇,其中中国科学院发文量最多,药物效用机制、药物代谢动力学等药理学研究是研究热点。结论:在专项支持下,中医药基础研究和基于循证医学评价的临床研究不断深入,在中医药防治重大疾病研究方面取得了重要进展。未来应加强科技成果转化,深化人工智能技术在中医药现代化研究中的应用。
基金University of Macao’s internal research grants(EF013/ICMS-WYT/2019/GPU)Major basic and applied basic research projects of Guangdong Province of China(2019B030302005).
文摘Objective To develop the internationalization and modernization of Hainan’s TCM industry,explore the development direction and fill in the research gap.Methods Design qualitative approaches,including fieldwork,semi-structured interviews,and policy analysis,were employed to identify development challenges for the cooperation between Hainan and Macao region in TCM industry.Ten interviews with key TCM industry stakeholders in Hainan and Macao region were conducted in 2020.These stakeholders are from schools,hospitals,companies,and governments.Hainan Province is the only free trade port with Chinese characteristics.Macao region is an international free trade port that has special economic relations with European and Portuguese-speaking countries.Therefore,this study focuses on the cooperation in the traditional Chinese medicine(TCM)industry between Hainan and Macao region.Besides,it investigates the traditional Chinese medicine industry in Hainan and Macao region according to the SWOT model.Results and Conclusion The study revealed strengths,weaknesses,opportunities,and threats for cooperation between Hainan and Macao region in TCM industry.Cooperation between Hainan and Macao region can be taken as a priority outline and a standard for the internationalization and modernization of Hainan’s TCM industry.
