以2-(胺甲基)苯酚和取代苯甲醛为原料,首次以FeCl3·6H2 O为催化剂合成了一系列2,3-二取代-1,3-苯并噁嗪,所合成化合物的结构用IR、1 H NMR、13 C NMR进行了分析与鉴定.采用离体法初步测试了目标化合物的杀菌活性,大部分化合物具有...以2-(胺甲基)苯酚和取代苯甲醛为原料,首次以FeCl3·6H2 O为催化剂合成了一系列2,3-二取代-1,3-苯并噁嗪,所合成化合物的结构用IR、1 H NMR、13 C NMR进行了分析与鉴定.采用离体法初步测试了目标化合物的杀菌活性,大部分化合物具有良好的杀菌活性,化合物3c对灰霉病菌的抑制率为86.8%,3f对纹枯病菌的抑制率为87.7%.展开更多
Reaction of 2,4-di-Eert-butyl-phenol,ethylenediamine and formaldehyde （37% solution in water）in 2:1:5molar ratio in methanol afforded the 1,2-bis[3-（6,8-di-tert-butyl-3,4-dihydro-2[H]-1,3-benzoxazine）-yl]ethane in...Reaction of 2,4-di-Eert-butyl-phenol,ethylenediamine and formaldehyde （37% solution in water）in 2:1:5molar ratio in methanol afforded the 1,2-bis[3-（6,8-di-tert-butyl-3,4-dihydro-2[H]-1,3-benzoxazine）-yl]ethane in high yields.This compound was fully characterized by elemental analysis,1H NMR,MS,and IR spectroscopies.The crystal structure of the title compound was determined by X-ray diffraction method.It crystallizes in triclinic,space group P（1）,a=0.5727（2）,b=0.9268（3）,c=1.4666（4）nm,a=88.12（1）°,β=88.54（1）°,γ=80.82（1）°,V=0.7679（4）nm3,Z=1,DC=1.126Mg·m-3,F（000）=286,μ（MoKα）=0.69cm-1,R=0.048,wR=0.140.This compound had a centrosymmetrical structure.展开更多
Benzoxazinone usually exists in many kinds of plants.It is applied in prepharmacy synthesis,and bioactivity studies,and has been prepared from O-aminophenol and chrol-with alkine and solvent by refluxing for a long ti...Benzoxazinone usually exists in many kinds of plants.It is applied in prepharmacy synthesis,and bioactivity studies,and has been prepared from O-aminophenol and chrol-with alkine and solvent by refluxing for a long time.In this work,2,2’-diphenyl-1,4-benzoxazin-3(4H)-one was solvent-free synthesized under microwave irradiation.The configuration and conformation of the product were determined by 1H NMR,IR,MS,elementary analysis and X-ray crystal analysis.The results of X-ray crystal analysis show that the compound crystallizes in a triclinic system,space group %P%1,cell parameter %a%=0.840 7(1)nm,%b%=0.845 1(1)nm,%c%=2.254 1(3)nm,%α%=96.111(3)°,%β%=97.196(3)°,%γ%=90.229(3)°,%V%= 1^579 6(4)nm3,%Z%=4,%D%c =1.267 Mg/m3,%F%(000)= 632.0,%μ%= 0.08 mm-1.In the compound,oxazinone ring is shown chair conformation,two benzene rings is placed in two sides of oxazinone ring distortedly.In crystal state,a centrosymmetric dimmer is formed %via% hydrogen bonds generated from amides of two near molecules.The benzene rings in a same chemical environment are paralleled by a distance of 0.260 9 nm.It displays aromatic π-π stacking interactions.展开更多
文摘以2-(胺甲基)苯酚和取代苯甲醛为原料,首次以FeCl3·6H2 O为催化剂合成了一系列2,3-二取代-1,3-苯并噁嗪,所合成化合物的结构用IR、1 H NMR、13 C NMR进行了分析与鉴定.采用离体法初步测试了目标化合物的杀菌活性,大部分化合物具有良好的杀菌活性,化合物3c对灰霉病菌的抑制率为86.8%,3f对纹枯病菌的抑制率为87.7%.
基金supported by the Program for Changjiang Scholars and Innovative Research Team in University(IRT1061)the Program for Innovative Research Team in Science and Technology in University of Henan Province(15IRTSTHN003)+1 种基金the Young Backbone Teachers Training Fund of the Education Department of Henan Province(2013GGJS-059)Henan Normal University(2011-8)
文摘Reaction of 2,4-di-Eert-butyl-phenol,ethylenediamine and formaldehyde （37% solution in water）in 2:1:5molar ratio in methanol afforded the 1,2-bis[3-（6,8-di-tert-butyl-3,4-dihydro-2[H]-1,3-benzoxazine）-yl]ethane in high yields.This compound was fully characterized by elemental analysis,1H NMR,MS,and IR spectroscopies.The crystal structure of the title compound was determined by X-ray diffraction method.It crystallizes in triclinic,space group P（1）,a=0.5727（2）,b=0.9268（3）,c=1.4666（4）nm,a=88.12（1）°,β=88.54（1）°,γ=80.82（1）°,V=0.7679（4）nm3,Z=1,DC=1.126Mg·m-3,F（000）=286,μ（MoKα）=0.69cm-1,R=0.048,wR=0.140.This compound had a centrosymmetrical structure.
文摘Benzoxazinone usually exists in many kinds of plants.It is applied in prepharmacy synthesis,and bioactivity studies,and has been prepared from O-aminophenol and chrol-with alkine and solvent by refluxing for a long time.In this work,2,2’-diphenyl-1,4-benzoxazin-3(4H)-one was solvent-free synthesized under microwave irradiation.The configuration and conformation of the product were determined by 1H NMR,IR,MS,elementary analysis and X-ray crystal analysis.The results of X-ray crystal analysis show that the compound crystallizes in a triclinic system,space group %P%1,cell parameter %a%=0.840 7(1)nm,%b%=0.845 1(1)nm,%c%=2.254 1(3)nm,%α%=96.111(3)°,%β%=97.196(3)°,%γ%=90.229(3)°,%V%= 1^579 6(4)nm3,%Z%=4,%D%c =1.267 Mg/m3,%F%(000)= 632.0,%μ%= 0.08 mm-1.In the compound,oxazinone ring is shown chair conformation,two benzene rings is placed in two sides of oxazinone ring distortedly.In crystal state,a centrosymmetric dimmer is formed %via% hydrogen bonds generated from amides of two near molecules.The benzene rings in a same chemical environment are paralleled by a distance of 0.260 9 nm.It displays aromatic π-π stacking interactions.
