Helicobacter pylori (HP) infection is a global problem that affects about half of the world’s population and requires sufficient attention in clinical and scientific work. Due to differences in economic and medical c...Helicobacter pylori (HP) infection is a global problem that affects about half of the world’s population and requires sufficient attention in clinical and scientific work. Due to differences in economic and medical conditions among countries around the world, there is currently no unified treatment plan for anti-HP. In China, empirical quadruple therapy is mainly used. With the abuse of antibiotics, many patients face the problem of secondary eradication after failure, and the resistance rate of HP is gradually increasing. After eradication failure, drug sensitivity cultivation is carried out to choose sensitive antibiotics for treatment. A new strategy is currently needed to address how to improve the eradication rate of HP during the first eradication. This article aims to discuss the first-line treatment plans and research progress for eradicating HP based on drug sensitivity testing before eradication. Compared with traditional empirical therapies, treatment based on drug sensitivity results can effectively improve the eradication rate of HP, and reduce drug resistance rates, and adverse reactions, among other benefits. .展开更多
We show an example of a bounded potential on the half-line obtained as the image of an Inverse Transformation Operator of the Bessel singular potential of the Reduced Radial Schrödinger Equation, and show us ...We show an example of a bounded potential on the half-line obtained as the image of an Inverse Transformation Operator of the Bessel singular potential of the Reduced Radial Schrödinger Equation, and show us the Estimates of the A(α) amplitude.展开更多
目的:探讨成人脊柱畸形(adult spinal deformity,ASD)矫形术后早期躯体重心线(W-line)与近端交界区失败(proximal junctional failure,PJF)的相关性。方法:回顾性分析2014年6月~2019年3月在我院行手术治疗的99例ASD患者的临床资料,其中...目的:探讨成人脊柱畸形(adult spinal deformity,ASD)矫形术后早期躯体重心线(W-line)与近端交界区失败(proximal junctional failure,PJF)的相关性。方法:回顾性分析2014年6月~2019年3月在我院行手术治疗的99例ASD患者的临床资料,其中男19例,女80例。均行单纯后路长节段(固定椎体≥4个)固定融合手术,术后随访至少满2年。测量并记录所有患者术前、术后3个月及末次随访时的脊柱-骨盆参数。在脊柱全长侧位X线片上,将经外耳道口垂线定义为W-line,根据W-line不同位置分为A组、B组及C组。测量术后3个月时W-line到S1后上角水平距离(WSD)及W-line到股骨头中心连线中点的水平距离(WHD),将W-line位置进行数值转化(the numeric value of W-line,N-W-line):N-W-line=WHD/WSD。W-line位于参考点前方数值为正,反之为负。采用受试者工作特征(receiver operating characteristic,ROC)曲线分析得出N-W-line临界值。三组患者参数进行方差分析,应用Kaplan-Meier曲线分析非PJF生存时间。结果:ROC曲线分析得出术后3个月N-W-line临界值为±0.78[敏感度=75%,特异度=75.9%,曲线下面积(the area under the curve,AUC)=0.736,P=0.003]。A组32例,N-W-line>0.78;B组49例,-0.78≤N-W-line≤0.78;C组18例,N-W-line<-0.78。A组患者骨盆入射角(pelvic incidence,PI)最小(P<0.05),术后3个月矢状面平衡距(P<0.001)、T1骨盆角(P<0.001)及骨盆腰椎匹配度(P<0.001)均显著小于其他两组患者。但随访中,A、B及C组分别有12例、3例及1例患者出现PJF,A组患者PJF发生率显著高于其他两组(12/32 vs 3/49 vs 1/18,P<0.001)。此外,A组患者非PJF生存时间显著低于其他两组患者(P=0.005,Log-rank检验)。B、C组患者W-line位置逐渐前移,脊柱-骨盆矢状位参数逐渐增大,但术后PJF发生率显著降低。结论:ASD患者矫形术后早期W-line位置可有效预测PJF发生。矫形手术后W-line偏后或过度偏前,术后随访中PJF发生率显著增加,矫形术后躯干呈轻度前屈为最佳。展开更多
Seven polycyclic aromatic hydrocarbons （PAHs） in atmospheric particulates were determinated by high performance liquid chromatography （HPLC） with fluorescence detector using direction injection and an on-line enri...Seven polycyclic aromatic hydrocarbons （PAHs） in atmospheric particulates were determinated by high performance liquid chromatography （HPLC） with fluorescence detector using direction injection and an on-line enrichment trap column. The method simplified the sample pretreatment, saved time and increased the efficiency. With the on-line trap column, PAHs were separated availably even underground injecting 1.0 ml sample with relatively high column efficiency. The recoveries of the seven PAHs were from 85% to 120% for spiked atmospheric particulate sample. The limit of detection was 15.3-39.6 ng/L （S/N=3.3）. There were good linear correlations between the peak areas and concentrations of the seven kinds of PAHs in the range of 1-50 ng/ml with the correlation coefficients over 0.9970. Furthermore, it also indicated that the method is available to determine PAHs in atmospheric particulates well.展开更多
Based on the fact that on-line chat has become the most developing language form in the information age, this article point out the stylistic features of on-line English chat. Though in written language form, such lan...Based on the fact that on-line chat has become the most developing language form in the information age, this article point out the stylistic features of on-line English chat. Though in written language form, such language is spoken language in nature, thus it is worthwhile to analyze this special phaenomenon in lexical and grammatical level.展开更多
The IAP (Institute of Atmospheric Physics) land-surface model (IAP94) is described. This model is a comprehensive one with detailed description for the processes of vegetation, snow and soil. Particular attention has ...The IAP (Institute of Atmospheric Physics) land-surface model (IAP94) is described. This model is a comprehensive one with detailed description for the processes of vegetation, snow and soil. Particular attention has been paid to the cases with three water phases in the surface media. On the basis of the mixture theory and the theory of fluid dynamics of porous media, the system of universal conservational equations for water and heat of soil, snow and vegetation canopy has been constructed. On this background, all important factors that may affect the water and heat balance in media can be considered naturally, and each factor and term possess distinct physical meaning. In the computation of water content and temperature, the water phase change and the heat transportation by water flow are taken into account. Moreover, particular attention has been given to the water vapor diffusion in soil for arid or semi-arid cases, and snow compaction. In the treatment of surface turbulent fluxes, the difference between aerodynamic and thermal roughness is taken into account. The aerodynamic roughness of vegetation is calculated as a function of canopy density, height and zero-plane displacement. An extrapolation of log linear and exponential relationship is used when calculating the wind profile within canopy. The model has been validated against field measurements in off-line simulations. The desirable model′s performance leads to the conclusion that the IAP94 is able to reproduce the main physical mechanisms governing the energy and water balances in the global land surface. Part II of the present study will concern the validation in a 3-D experiment coupled with the IAP Two-Level AGCM.展开更多
Gastric cancer remains one among the leading causes of cancer-related deaths, regardless of its decreasing incidence and newly available treatment options. Most patients present at an advanced stage and are treated wi...Gastric cancer remains one among the leading causes of cancer-related deaths, regardless of its decreasing incidence and newly available treatment options. Most patients present at an advanced stage and are treated with upfront systemic chemotherapy. Those patients receiving first-line therapy may initially respond to treatment, but many of them relapse over time. In such condition, second-line treatment for disease progression remains the only available option. Although there exists no standard approach in the second-line setting, several phase Ⅲ trials have shown modest survival benefit in patients receiving irinotecan, taxane and ramucirumab over the best supportive care or active agents. This review analyzes the currently available treatment regimens and future directions of research in the second-line setting for metastatic gastric cancer with the best available evidence. Additionally, the prognostic factors that influence patient survival in those receiving second-line therapy are discussed.展开更多
文摘Helicobacter pylori (HP) infection is a global problem that affects about half of the world’s population and requires sufficient attention in clinical and scientific work. Due to differences in economic and medical conditions among countries around the world, there is currently no unified treatment plan for anti-HP. In China, empirical quadruple therapy is mainly used. With the abuse of antibiotics, many patients face the problem of secondary eradication after failure, and the resistance rate of HP is gradually increasing. After eradication failure, drug sensitivity cultivation is carried out to choose sensitive antibiotics for treatment. A new strategy is currently needed to address how to improve the eradication rate of HP during the first eradication. This article aims to discuss the first-line treatment plans and research progress for eradicating HP based on drug sensitivity testing before eradication. Compared with traditional empirical therapies, treatment based on drug sensitivity results can effectively improve the eradication rate of HP, and reduce drug resistance rates, and adverse reactions, among other benefits. .
文摘We show an example of a bounded potential on the half-line obtained as the image of an Inverse Transformation Operator of the Bessel singular potential of the Reduced Radial Schrödinger Equation, and show us the Estimates of the A(α) amplitude.
文摘目的:探讨成人脊柱畸形(adult spinal deformity,ASD)矫形术后早期躯体重心线(W-line)与近端交界区失败(proximal junctional failure,PJF)的相关性。方法:回顾性分析2014年6月~2019年3月在我院行手术治疗的99例ASD患者的临床资料,其中男19例,女80例。均行单纯后路长节段(固定椎体≥4个)固定融合手术,术后随访至少满2年。测量并记录所有患者术前、术后3个月及末次随访时的脊柱-骨盆参数。在脊柱全长侧位X线片上,将经外耳道口垂线定义为W-line,根据W-line不同位置分为A组、B组及C组。测量术后3个月时W-line到S1后上角水平距离(WSD)及W-line到股骨头中心连线中点的水平距离(WHD),将W-line位置进行数值转化(the numeric value of W-line,N-W-line):N-W-line=WHD/WSD。W-line位于参考点前方数值为正,反之为负。采用受试者工作特征(receiver operating characteristic,ROC)曲线分析得出N-W-line临界值。三组患者参数进行方差分析,应用Kaplan-Meier曲线分析非PJF生存时间。结果:ROC曲线分析得出术后3个月N-W-line临界值为±0.78[敏感度=75%,特异度=75.9%,曲线下面积(the area under the curve,AUC)=0.736,P=0.003]。A组32例,N-W-line>0.78;B组49例,-0.78≤N-W-line≤0.78;C组18例,N-W-line<-0.78。A组患者骨盆入射角(pelvic incidence,PI)最小(P<0.05),术后3个月矢状面平衡距(P<0.001)、T1骨盆角(P<0.001)及骨盆腰椎匹配度(P<0.001)均显著小于其他两组患者。但随访中,A、B及C组分别有12例、3例及1例患者出现PJF,A组患者PJF发生率显著高于其他两组(12/32 vs 3/49 vs 1/18,P<0.001)。此外,A组患者非PJF生存时间显著低于其他两组患者(P=0.005,Log-rank检验)。B、C组患者W-line位置逐渐前移,脊柱-骨盆矢状位参数逐渐增大,但术后PJF发生率显著降低。结论:ASD患者矫形术后早期W-line位置可有效预测PJF发生。矫形手术后W-line偏后或过度偏前,术后随访中PJF发生率显著增加,矫形术后躯干呈轻度前屈为最佳。
基金Project supported by the National Natural Science Foundation of China (No.20437020)Major Research Program of Chinese Academy of Sciences (No.KZCX3-SW-432).
文摘Seven polycyclic aromatic hydrocarbons （PAHs） in atmospheric particulates were determinated by high performance liquid chromatography （HPLC） with fluorescence detector using direction injection and an on-line enrichment trap column. The method simplified the sample pretreatment, saved time and increased the efficiency. With the on-line trap column, PAHs were separated availably even underground injecting 1.0 ml sample with relatively high column efficiency. The recoveries of the seven PAHs were from 85% to 120% for spiked atmospheric particulate sample. The limit of detection was 15.3-39.6 ng/L （S/N=3.3）. There were good linear correlations between the peak areas and concentrations of the seven kinds of PAHs in the range of 1-50 ng/ml with the correlation coefficients over 0.9970. Furthermore, it also indicated that the method is available to determine PAHs in atmospheric particulates well.
文摘Based on the fact that on-line chat has become the most developing language form in the information age, this article point out the stylistic features of on-line English chat. Though in written language form, such language is spoken language in nature, thus it is worthwhile to analyze this special phaenomenon in lexical and grammatical level.
文摘The IAP (Institute of Atmospheric Physics) land-surface model (IAP94) is described. This model is a comprehensive one with detailed description for the processes of vegetation, snow and soil. Particular attention has been paid to the cases with three water phases in the surface media. On the basis of the mixture theory and the theory of fluid dynamics of porous media, the system of universal conservational equations for water and heat of soil, snow and vegetation canopy has been constructed. On this background, all important factors that may affect the water and heat balance in media can be considered naturally, and each factor and term possess distinct physical meaning. In the computation of water content and temperature, the water phase change and the heat transportation by water flow are taken into account. Moreover, particular attention has been given to the water vapor diffusion in soil for arid or semi-arid cases, and snow compaction. In the treatment of surface turbulent fluxes, the difference between aerodynamic and thermal roughness is taken into account. The aerodynamic roughness of vegetation is calculated as a function of canopy density, height and zero-plane displacement. An extrapolation of log linear and exponential relationship is used when calculating the wind profile within canopy. The model has been validated against field measurements in off-line simulations. The desirable model′s performance leads to the conclusion that the IAP94 is able to reproduce the main physical mechanisms governing the energy and water balances in the global land surface. Part II of the present study will concern the validation in a 3-D experiment coupled with the IAP Two-Level AGCM.
文摘Gastric cancer remains one among the leading causes of cancer-related deaths, regardless of its decreasing incidence and newly available treatment options. Most patients present at an advanced stage and are treated with upfront systemic chemotherapy. Those patients receiving first-line therapy may initially respond to treatment, but many of them relapse over time. In such condition, second-line treatment for disease progression remains the only available option. Although there exists no standard approach in the second-line setting, several phase Ⅲ trials have shown modest survival benefit in patients receiving irinotecan, taxane and ramucirumab over the best supportive care or active agents. This review analyzes the currently available treatment regimens and future directions of research in the second-line setting for metastatic gastric cancer with the best available evidence. Additionally, the prognostic factors that influence patient survival in those receiving second-line therapy are discussed.
