Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health challenge.Identifying optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent priorities.Mitochondria are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell death.Mitophagy,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these events.Recent evidence has highlighted the significant role of mitophagy in acute central nervous system injuries.In this review,we provide a comprehensive overview of the process,classification,and related mechanisms of mitophagy.We also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate mitophagy.In the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

Controlling chaos to unstable periodic orbits and equilibrium state solutions for the coupled dynamos system

In the case where the knowledge of goal states is not known, the controllers are constructed to stabilize unstable steady states for a coupled dynamos system. A delayed feedback control technique is used to suppress chaos to unstable focuses and unstable periodic orbits. To overcome the topological limitation that the saddle-type steady state cannot be stabilized, an adaptive control based on LaSalle＇s invariance principle is used to control chaos to unstable equilibrium （i.e. saddle point, focus, node, etc.）. The control technique does not require any computer analysis of the system dynamics, and it operates without needing to know any explicit knowledge of the desired steady-state position.

Controlling chaos in power system based on finite-time stability theory

Recent investigations show that a power system is a highly nonlinear system and can exhibit chaotic behaviour leading to a voltage collapse, which severely threatens the secure and stable operation of the power system. Based on the finite-time stability theory, two control strategies are presented to achieve finite-time chaos control. In addition, the problem of how to stabilize an unstable nonzero equilibrium point in a finite time is solved by coordinate transformation for the first time. Numerical simulations are presented to demonstrate the effectiveness and the robustness of the proposed scheme. The research in this paper may help to maintain the secure operation of power systems.

CONTROLLING EROSION OF SAFE BASIN IN NONLINEAR PARAMETRICALLY EXCITED SYSTEMS

This paper considers the dynamical behavior of a Duffing-Mathieu type system with a cubic single-well potential during the principal parametric resonance. Both the cases of constant and time-dependent excitation amplitude are used to observe the variation of the extent and the rate of the erosion in safe basins. It is evident that the appearance of fractal basin boundaries heralds the onset of the losing of structural integrity. The minimum value of control parameter to prevent the basin from erosion is given along with the excitation amplitude varying. The results show the time-dependence of excitation amplitude can be used to control the extent and the rate of the erosion and delay the first occurrence of heteroclinic tangency.

Controlling and synchronizing spatiotemporal chaos of the coupled Bragg acousto-optical bistable map system using nonlinear feedback

In this paper we present the control and synchronization of a coupled Bragg acousto-optic bistable map system using nonlinear feedback technology. This nonlinear feedback technology is useful to control a temporally chaotic system as well as a spatiotemporally chaotic system. It can be extended to synchronize the spatiotemporal chaos. It can work in a wide range of the controlled and synchronized signals, so it can decrease the sensitivity down to a noise level. The synchronization can be obtained by the analysis of the largest conditional Lyapunov exponent spectrum, and easily implemented in practical systems just by adjusting the coupled strength without any pre-knowledge of the dynamic system required.

BASIC CHARACTERISTICS AND CONTROLLING FACTORS OF ANASTOMSING FLUVIAL SYSTEMS

Although anastomosing fluvial rivers are given much attention recently by some research workers because the result channel sandstone of which is one typical primary reservoirs of petroleum and natural gas, of which the flood plains and the interchannel wetlands are pay zones where coals had formed, the comprehension of anastomosing river is some extent limited at present. Some researchers regard that the anastomosing river river and the anabranched river are the same kind of rivers. In this paper, the sedimentary, geomorphic and hydraulic characteristics and the main controlling factors of anastomosing fluvial system are summarized systematically. Some of the characteristics are compared with others fluvial rivers. Humid climate is suitable to form anastomosing channel systems, in arid semiarid regions anastomosing river maybe develop if many befitting factors combine together. The authors of the paper think that anastomosing river is one typical channel pattern and is dissimilar to anabranched channel pattern.

Controlling Non-Point Source Pollution in Australian Agricultural Systems

The Australian farming sector is continuing to intensify, particularly within 300 km of the east and southern coastlines. In the future there will be fewer and larger farms, which will use more fertilizer, support more stock, grow more monoculture crops, and utilise more marginal soils. This is likely to increase the major environmental impacts of soil degradation, salt, nutrient and sediment contamination of waterways, and greenhouse gas emissions. Australian national water policy continues to focus on land, stream and groundwater salinity issues, although there is now a greater recognition of the importance of nitrogen and phosphorus losses from agriculture. The general philosophy of policy for dealing with non- point source pollution has been towards a voluntary rather than regulatory approach, with state and national governments supporting a range of programs to encourage sustainable agricultural practices. A catchment (watershed) based approach, through the use of integrated catchment management plans, is the primary way that non-point source pollution is addressed at the farm and local level. At an industry level, cotton, grains, meat, sugarcane and dairy amongst others, as well as the Australian fertilizer industry, have responded to non-point source issues by investing in research and development, and developing codes of practice aimed at abating these environmental impacts. Understanding the economic, social, political and cultural contexts of farming as well as the environmental impacts of agriculture are very important in determining the appropriateness of policy responses for Australian farming systems.

Electronically Controlling the System of Preheating Intake Air by Flame for Diesel Engine Cold-Start

In order to improve the cold start performance of heavy duty diesel engine, electronically controlling the preheating of intake air by flame was researched. According to simulation and thermodynamic analysis about the partial working processes of the diesel engine, the amount of heat energy, enough to make the fuel self ignite at the end of compression process at different temperatures of coolant and intake air, was calculated. Several HY20 preheating plugs were used to heat up the intake air. Meanwhile, an electronic control system based on 8 bit micro controller unit (MCS 8031) was designed to automatically control the process of heating intake air. According to the various temperatures of coolant and ambient air, one plug or two plugs can automatically be selected to heat intake air. The demo experiment validated that the total system could operate successfully and achieve the scheduled function.

Design and development of expert system for controlling sintering process

The general structure of expert system for controlling sintering process has been proposed. It includes knowledge base, inference engine, data acquisition system, learning system, knowledge base management system, explanation system and so on. The control functions consist of sintering chemical composition control centered on basicity and sintering process state control centered on permeability. The adaptive prediction of sintering chemical composition, the control strategy centered on basicity, the control strategy centered on permeability, the judgement of permeability and the prediction of burn through point were studied. The software of system, which includes about 1 000 expert rules, was successfully applied in off line control of sintering process in a sintering plant.

An adaptive strategy for controlling chaotic system

This paper presents an adaptive strategy for controlling chaotic systems. By employing the phase space reconstruction technique in nonlinear dynamical systems theory, the proposed strategy transforms the nonlinear system into canonical form, and employs a nonlinear observer to estimate the uncertainties and disturbances of the nonlinear system, and then establishes a state-error-like feedback law. The developed control scheme allows chaos control in spite of modeling errors and parametric variations. The effectiveness of the proposed approach has been demonstrated through its applications to two well-known chaotic systems : Duffing oscillator and Rǒssler chaos.

A hierarchical architecture of centralized monitoring and controlling system and its high-performance and interoperability protocol

This paper describes a hierarchical architecture and a high-performance and interoperability protocol for centralized monitoring and controlling systems (CMCS) . The protocol we proposed can interoperate different monitoring and controlling systems constructed by different companies, each with different functions and communication protocols. The protocol reduces the amount of traffic and has real-time and high-perfor-mance advantages. The protocol was implemented in CMCS for telecommunication power supply and air-condi-tioner used by the Telecommunication Bureau of Zhejiang Province. This paper deals with the hierarchical architecture and function of CMCS and packet format, command ID, and SDL description of its protocol. We also discuss the properties of the interoperability and performance of the protocol in this paper.

Paleozoic Composite Petroleum System of North Africa:Hydrocarbon Distribution and Main Controlling Factors

North Africa, which is one of the main oil and gas producing regions in the world, is best known for its subsalt Paleozoic-Triassic reservoirs and Paleozoic source rocks. Hydrocarbon abundance varies greatly from one structural domain to another areally and from one stratigraphic interval to another vertically. Analyses of the essential elements and geological processes of the Paleozoic petroleum system indicate that the distribution of the Lower Silurian shale source rocks, the development of a thick Mesozoic overburden, the presence of the Upper Triassic-Lower Jurassic evaporite seal are the most important factors goveming the distribution of the Paleozoic-sourced hydrocarbons in North Africa. The Mesozoic sequence plays a critical role for hydrocarbons to accumulate by enabling the maturation of the Paleozoic source rocks during the Mesozoic-Paleogene times and preserving the accumulated hydrocarbons. Basins and surrounding uplifts, particularly the latter, with a thick Mesozoic sequence and a regional evaporite seal generally have abundant hydrocarbons. Basins where only a thin Mesozoic overburden was developed tend to have a very poor to moderate hydrocarbon prospectivity.

Characteristics of boundary fault systems and its hydrocarbon controlling on hydrocarbon accumulation in Awati Sag,Tarim Basin,China

Based on the interpretation of two-dimensional seismic data, this paper analyzes the characteristics of three boundary fault systems including the Shajingzi fault, the Aqia fault and the Tumuxiuke fault around the Awati sag of the Tarim Basin, and studies its controlling on hydrocarbon accumulation. Neotectonic movement is ubiquitous in oil and gas bearing basins in China, such as Neogene intense activities of large boundary thrusting faults of the Awati sag: Shajingzi fault, Aqia fault and Tumuxiuke fault. Based on a large number of seismic data, it is showed that they have section wise characteristics in the direction of fault strike, and active periods and associated structures formed of different sections are different. Usually, large anticlinal structures are formed in the upper wall, and faulted anticline controlled by companion faults are formed in the bottom wall. Large faults cut the strata from Cambrian up to Neogene. For the anticline in the upper wall, fault activities caused by neotectonic movement played a destructive role in hydrocarbon accumulation, thus the preservation condition is critical for reservoir formation. In this sense, attention should be paid to formations in the upper walls of Aqia fault and Tumuxiuke fault under the Cambrian salt bed, whose plastic deformation could help to heal faults. Companion faults in the bottom wall cut down to the Cambrian and up to the Triassic serving as the pathway for hydrocarbon migration, and associated structures in the bottom wall are noteworthy exploration targets.

Rotational Friction Damper’s Performance for Controlling Seismic Response of High Speed Railway Bridge-Track System

CRTS-II slab ballastless track on bridge is a unique system in China high speed railway.The application of longitudinal continuous track system has obviously changed dynamic characteristics of bridge structure.The bridge system and CRTS-II track system form a complex nonlinear system.To investigate the seismic response of high speed railway(HSR)simply supported bridge-track system,nonlinear models of three-span simply supported bridge with piers of different height and CRTS-II slab ballastless track system are established.By seismic analysis,it is found that shear alveolar in CRTS-II track system is more prone to be damaged than bridge components,such as piers,girders and bearings.The result shows that the inconsistent displacement of bridge girders is the main cause of the CRTS-II track system’s damage.Then the rotational friction damper(RFD)is adopted,which utilizes the device’s rotation and friction to dissipate seismic energy.The hysteretic behavior of RFD is studied by numerical and experimental methods.Results prove that RFD can provide good hysteretic energy dissipation ability with stable performance.Furthermore,the analysis of RFD’s influence on seismic response of HSR bridge-track system shows that RFD with larger sliding force is more effective in controlling excessive inconsistent displacement where RFD is installed,though response of other bridge spans could slightly deteriorated.

Controlling hyperchaotic complex systems with unknown parameters based on adaptive passive method

The aim of this paper is to study the control of hyperchaofic complex nonlinear systems with unknown parameters using passive control theory. An approach is stated to design the passive controller and estimate the unknown parameters based on the property of the passive system. The feasibility and effectiveness of the proposed approach is demonstrated through its application to the hyperchaotic complex Lu system, as an example. The estimated values of the unknown parameters are calculated. The analytical form of the complex controller is derived and used in the numerical simulation to control the hyperchaotic attractors of this example. Block diagrams of this example using Matlab/Simulink are constructed after and before the control to ensure the validity of the analytical results. Other examples of hyperchaotic complex nonlinear systems can be similarly treated.

Controlling the probability density of quantum systems

A new method to design a quantum controller which directly controls the probability density function（PDF） of quantum systems is proposed.Based on the quantum model from the PDF perspective,two specific control algorithms are proposed with uniform and non-uniform fields,respectively.Then a detailed control algorithm with convergence analysis is given for the small error case.By appropriately estimating the selected Lyapunov function,more accurate control effect is achieved.The proposed scheme provides a constructive method to find appropriate parameters for controller design.

Separate Dimming Controlling and Data Transmission for an Indoor Visible Light Communication System

Simultaneous dimming controlling and data transmission are usually required in a white LED based indoor visible light communication system.However,the diming controlling of LED normally interferes the data transmission due to the modulation nonlinearity of LED.In order to solve this problem,a scheme by separating the LEDs for the functions of dimming control and data transmission respectively is proposed in this paper.In the scheme,the LEDs used for dimming control function are driven by a dc amplified circuit,and the LEDs for data transmission are driven by a digital modulation circuit respectively.In this way,the modulation distortion to the data signal caused by the modulation nonlinearity can be avoided even if the dimming is at high level dc driven current.The proof-of-concept experiment of a 2.5Mbit/s visible light communication system demonstrates that the dimming controlling and data transmission can be realized simultaneously in a simple way,and the data transmission is not affected by the dimming controlling function.Compared to previous methods,the scheme in this paper is simpler and cost effective,and makes sense when high rate data is transmitted in a visible light communication system.

EXPERT SYSTEM FOR CONTROLLING THE STATE OF SINTERING PROCESS

In order to control sintering process,improve permeability and stabilize burn through point, a control scheme which combines thermal state with permeability state is proposed, and an expert system for controlling sintering process state is developed, the software which includes about 1000 expert rules is successfully applied to off line control of sintering process.

Finite-time Prescribed Performance Time-Varying Formation Control for Second-Order Multi-Agent Systems With Non-Strict Feedback Based on a Neural Network Observer

This paper studies the problem of time-varying formation control with finite-time prescribed performance for nonstrict feedback second-order multi-agent systems with unmeasured states and unknown nonlinearities.To eliminate nonlinearities,neural networks are applied to approximate the inherent dynamics of the system.In addition,due to the limitations of the actual working conditions,each follower agent can only obtain the locally measurable partial state information of the leader agent.To address this problem,a neural network state observer based on the leader state information is designed.Then,a finite-time prescribed performance adaptive output feedback control strategy is proposed by restricting the sliding mode surface to a prescribed region,which ensures that the closed-loop system has practical finite-time stability and that formation errors of the multi-agent systems converge to the prescribed performance bound in finite time.Finally,a numerical simulation is provided to demonstrate the practicality and effectiveness of the developed algorithm.