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DNA测序鉴定HLA新等位基因B*35:03:07 被引量:4
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作者 翟培聪 刘艳 +4 位作者 张毅 聂向民 宋永红 庄云龙 朱传福 《中国实验血液学杂志》 CAS CSCD 北大核心 2012年第4期1010-1013,共4页
本研究旨在分析鉴定中国人群HLA-B位点一个新等位基因。应用PCR-序列特异性寡核苷酸探针(PCR-SSOP)技术检测到一个与HLA-B*35:03:01相关的未知基因,应用DNA序列分析技术鉴定并分析该基因与同源性最高的HLA等位基因的序列差异。结果表明... 本研究旨在分析鉴定中国人群HLA-B位点一个新等位基因。应用PCR-序列特异性寡核苷酸探针(PCR-SSOP)技术检测到一个与HLA-B*35:03:01相关的未知基因,应用DNA序列分析技术鉴定并分析该基因与同源性最高的HLA等位基因的序列差异。结果表明,先证者HLA-B位点有1个等位基因的核苷酸序列与所有已知基因序列均不相同,与同源性最高的HLA-B*35:03:01相比,第3外显子387位碱基由C→G,并导致相应的105位密码子编码的氨基酸由CCC变为CCG,编码的氨基酸没有改变,仍为苯丙氨酸。结论:被测样本含有HLA-B新等位基因,WHO HLA因子命名委员会将其正式命名为HLA-B*35:03:07。 展开更多
关键词 DNA测序 新等位基因 HLA—B*35:03:07
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Affine bracket algebra theory and algorithms and their applications in mechanical theorem proving 被引量:1
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作者 Ning ZHANG~(1+) Hong-bo LI~2 1 China Institute for Actuarial Science (CIAS),Central University of Finance and Economics,Beijing 100081,China 2 Academy of Mathematics and Systems Science,Chinese Academy Sciences,Beijing 100080,China 《Science China Mathematics》 SCIE 2007年第7期941-950,共10页
This paper discusses two problems:one is some important theories and algorithms of affine bracket algebra;the other is about their applications in mechanical theorem proving.First we give some efficient algorithms inc... This paper discusses two problems:one is some important theories and algorithms of affine bracket algebra;the other is about their applications in mechanical theorem proving.First we give some efficient algorithms including the boundary expanding algorithm which is a key feature in application.We analyze the characteristics of the boundary operator and this is the base for the implementation of the system.We also give some new theories or methods about the exact division,the representations and structure of affine geometry and so on.In practice,we implement the mechanical auto-proving system in Maple 10 based on the above algorithms and theories.Also we test about more than 100 examples and compare the results with the methods before. 展开更多
关键词 mechanical theorem proving geometric invariance bracket algebra affine geometry affine bracket algebra 68T15 03b35
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Complex brackets and balanced complex 1st-order difference polynomials in 4-dimensional Minkowski space 被引量:1
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作者 HUANG Lei LI HongBo 《Science China Mathematics》 SCIE 2008年第12期2137-2148,共12页
This paper investigates complex brackets and balanced complex 1st-order difference (BCD) polynomials. Then we propose an algorithm of O(n log n) complexity to check the equality of brackets. It substitutes exponential... This paper investigates complex brackets and balanced complex 1st-order difference (BCD) polynomials. Then we propose an algorithm of O(n log n) complexity to check the equality of brackets. It substitutes exponential algorithms before. Also, BCD polynomials have some usages in geometric calculation. 展开更多
关键词 conformal geometric algebra (CGA) null bracket algebra (NBA) geometric invariant mechanical proving normal forms 68T15 03b35
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