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Localized wave solutions and interactions of the (2+1)-dimensional Hirota-Satsuma-Ito equation
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作者 巩乾坤 王惠 王云虎 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第4期409-416,共8页
This paper studies the(2+1)-dimensional Hirota-Satsuma-Ito equation.Based on an associated Hirota bilinear form,lump-type solution,two types of interaction solutions,and breather wave solution of the(2+1)-dimensional ... This paper studies the(2+1)-dimensional Hirota-Satsuma-Ito equation.Based on an associated Hirota bilinear form,lump-type solution,two types of interaction solutions,and breather wave solution of the(2+1)-dimensional Hirota-Satsuma-Ito equation are obtained,which are all related to the seed solution of the equation.It is interesting that the rogue wave is aroused by the interaction between one-lump soliton and a pair of resonance stripe solitons,and the fusion and fission phenomena are also found in the interaction between lump solitons and one-stripe soliton.Furthermore,the breather wave solution is also obtained by reducing the two-soliton solutions.The trajectory and period of the one-order breather wave are analyzed.The corresponding dynamical characteristics are demonstrated by the graphs. 展开更多
关键词 lump solution rogue wave solution breather wave solution (2+1)-dimensional Hirota-Satsuma-Ito equation
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DOA estimation of high-dimensional signals based on Krylov subspace and weighted l_(1)-norm
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作者 YANG Zeqi LIU Yiheng +4 位作者 ZHANG Hua MA Shuai CHANG Kai LIU Ning LYU Xiaode 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第3期532-540,F0002,共10页
With the extensive application of large-scale array antennas,the increasing number of array elements leads to the increasing dimension of received signals,making it difficult to meet the real-time requirement of direc... With the extensive application of large-scale array antennas,the increasing number of array elements leads to the increasing dimension of received signals,making it difficult to meet the real-time requirement of direction of arrival(DOA)estimation due to the computational complexity of algorithms.Traditional subspace algorithms require estimation of the covariance matrix,which has high computational complexity and is prone to producing spurious peaks.In order to reduce the computational complexity of DOA estimation algorithms and improve their estimation accuracy under large array elements,this paper proposes a DOA estimation method based on Krylov subspace and weighted l_(1)-norm.The method uses the multistage Wiener filter(MSWF)iteration to solve the basis of the Krylov subspace as an estimate of the signal subspace,further uses the measurement matrix to reduce the dimensionality of the signal subspace observation,constructs a weighted matrix,and combines the sparse reconstruction to establish a convex optimization function based on the residual sum of squares and weighted l_(1)-norm to solve the target DOA.Simulation results show that the proposed method has high resolution under large array conditions,effectively suppresses spurious peaks,reduces computational complexity,and has good robustness for low signal to noise ratio(SNR)environment. 展开更多
关键词 direction of arrival(DOA) compressed sensing(CS) Krylov subspace l_(1)-norm dimensionality reduction
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3-Dimensional Kinematic Comparison of Arm Movements between an Individual with NGLY1 Deficiency and a Neurotypical Individual
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作者 Charles S. Layne Christopher A. Malaya +6 位作者 Brock Futrell Dacia Martinez Diaz Christian Alfaro Hannah E. Gustafson Subhalakshmi Chandrasekaran Rhea M. Phatak Bernhard Suter 《Case Reports in Clinical Medicine》 2024年第4期122-146,共25页
NGLY1 Deficiency is an ultra-rare autosomal recessively inherited disorder. Characteristic symptoms include among others, developmental delays, movement disorders, liver function abnormalities, seizures, and problems ... NGLY1 Deficiency is an ultra-rare autosomal recessively inherited disorder. Characteristic symptoms include among others, developmental delays, movement disorders, liver function abnormalities, seizures, and problems with tear formation. Movements are hyperkinetic and may include dysmetric, choreo-athetoid, myoclonic and dystonic movement elements. To date, there have been no quantitative reports describing arm movements of individuals with NGLY1 Deficiency. This report provides quantitative information about a series of arm movements performed by an individual with NGLY1 Deficiency and an aged-matched neurotypical participant. Three categories of arm movements were tested: 1) open ended reaches without specific end point targets;2) goal-directed reaches that included grasping an object;3) picking up small objects from a table placed in front of the participants. Arm movement kinematics were obtained with a camera-based motion analysis system and “initiation” and “maintenance” phases were identified for each movement. The combination of the two phases was labeled as a “complete” movement. Three-dimensional analysis techniques were used to quantify the movements and included hand trajectory pathlength, joint motion area, as well as hand trajectory and joint jerk cost. These techniques were required to fully characterize the movements because the NGLY1 individual was unable to perform movements only in the primary plane of progression instead producing motion across all three planes of movement. The individual with NGLY1 Deficiency was unable to pick up objects from a table or effectively complete movements requiring crossing the midline. The successfully completed movements were analyzed using the above techniques and the results of the two participants were compared statistically. Almost all comparisons revealed significant differences between the two participants, with a notable exception of the 3D initiation area as a percentage of the complete movement. The statistical tests of these measures revealed no significant differences between the two participants, possibly suggesting a common underlying motor control strategy. The 3D techniques used in this report effectively characterized arm movements of an individual with NGLY1 deficiency and can be used to provide information to evaluate the effectiveness of genetic, pharmacological, or physical rehabilitation therapies. 展开更多
关键词 NGLY1 Deficiency Developmental Disorders KINEMATICS 3 Dimensional Analyses
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MOLECULES AND NEW INTERACTIONAL STRUCTURES FOR A(2+1)-DIMENSIONAL GENERALIZED KONOPELCHENKO-DUBROVSKY-KAUP-KUPERSHMIDT EQUATION 被引量:1
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作者 李岩 姚若侠 夏亚荣 《Acta Mathematica Scientia》 SCIE CSCD 2023年第1期80-96,共17页
Soliton molecules(SMs)of the(2+1)-dimensional generalized KonopelchenkoDubrovsky-Kaup-Kupershmidt(gKDKK)equation are found by utilizing a velocity resonance ansatz to N-soliton solutions,which can transform to asymmet... Soliton molecules(SMs)of the(2+1)-dimensional generalized KonopelchenkoDubrovsky-Kaup-Kupershmidt(gKDKK)equation are found by utilizing a velocity resonance ansatz to N-soliton solutions,which can transform to asymmetric solitons upon assigning appropriate values to some parameters.Furthermore,a double-peaked lump solution can be constructed with breather degeneration approach.By applying a mixed technique of a resonance ansatz and conjugate complexes of partial parameters to multisoliton solutions,various kinds of interactional structures are constructed;There include the soliton molecule(SM),the breather molecule(BM)and the soliton-breather molecule(SBM).Graphical investigation and theoretical analysis show that the interactions composed of SM,BM and SBM are inelastic. 展开更多
关键词 (2+1)-dimensional generalized Konopelchenko-Dubrovsky-Kaup-Kupershmidt equation soliton molecules velocity resonance nonelastic interaction
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Interaction solutions and localized waves to the(2+1)-dimensional Hirota-Satsuma-Ito equation with variable coefficient
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作者 闫鑫颖 刘锦洲 辛祥鹏 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第7期199-205,共7页
This article investigates the Hirota-Satsuma-Ito equation with variable coefficient using the Hirota bilinear method and the long wave limit method.The equation is proved to be Painlevé integrable by Painlevé... This article investigates the Hirota-Satsuma-Ito equation with variable coefficient using the Hirota bilinear method and the long wave limit method.The equation is proved to be Painlevé integrable by Painlevé analysis.On the basis of the bilinear form,the forms of two-soliton solutions,three-soliton solutions,and four-soliton solutions are studied specifically.The appropriate parameter values are chosen and the corresponding figures are presented.The breather waves solutions,lump solutions,periodic solutions and the interaction of breather waves solutions and soliton solutions,etc.are given.In addition,we also analyze the different effects of the parameters on the figures.The figures of the same set of parameters in different planes are presented to describe the dynamical behavior of solutions.These are important for describing water waves in nature. 展开更多
关键词 (2+1)-dimensional variable coefficient Hirota-Satsuma-Ito equation Hirota bilinear method long wave limit method N-soliton solutions
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Interaction solutions for the second extended(3+1)-dimensional Jimbo–Miwa equation
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作者 马红彩 毛雪 邓爱平 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第6期112-121,共10页
Based on the Hirota bilinear method,the second extended(3+1)-dimensional Jimbo–Miwa equation is established.By Maple symbolic calculation,lump and lump-kink soliton solutions are obtained.The interaction solutions be... Based on the Hirota bilinear method,the second extended(3+1)-dimensional Jimbo–Miwa equation is established.By Maple symbolic calculation,lump and lump-kink soliton solutions are obtained.The interaction solutions between the lump and multi-kink soliton,and the interaction between the lump and triangular periodic soliton are derived by combining a multi-exponential function or trigonometric sine and cosine functions with quadratic functions.Furthermore,periodiclump wave solution is derived via the ansatz including hyperbolic and trigonometric functions.Finally,3D plots,2D curves,density plots,and contour plots with particular choices of the suitable parameters are depicted to illustrate the dynamical features of these solutions. 展开更多
关键词 Hirota bilinear method second extended(3+1)-dimensional Jimbo–Miwa equation lump solution interaction solution
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Lie symmetry analysis and invariant solutions for the(3+1)-dimensional Virasoro integrable model
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作者 胡恒春 李雅琦 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第4期249-254,共6页
Lie symmetry analysis is applied to a(3+1)-dimensional Virasoro integrable model and the corresponding similarity reduction equations are obtained with the different infinitesimal generators.Invariant solutions with a... Lie symmetry analysis is applied to a(3+1)-dimensional Virasoro integrable model and the corresponding similarity reduction equations are obtained with the different infinitesimal generators.Invariant solutions with arbitrary functions for the(3+1)-dimensional Virasoro integrable model,including the interaction solution between a kink and a soliton,the lump-type solution and periodic solutions,have been studied analytically and graphically. 展开更多
关键词 (3+1)-dimensional Virasoro integrable model Lie symmetry invariant solutions
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Resonant interactions among two-dimensional nonlinear localized waves and lump molecules for the(2+1)-dimensional elliptic Toda equation
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作者 庞福忠 葛根哈斯 赵雪梅 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第5期200-217,共18页
The(2+1)-dimensional elliptic Toda equation is a high-dimensional generalization of the Toda lattice and a semidiscrete Kadomtsev–Petviashvili I equation.This paper focuses on investigating the resonant interactions ... The(2+1)-dimensional elliptic Toda equation is a high-dimensional generalization of the Toda lattice and a semidiscrete Kadomtsev–Petviashvili I equation.This paper focuses on investigating the resonant interactions between two breathers,a breather/lump and line solitons as well as lump molecules for the(2+1)-dimensional elliptic Toda equation.Based on the N-soliton solution,we obtain the hybrid solutions consisting of line solitons,breathers and lumps.Through the asymptotic analysis of these hybrid solutions,we derive the phase shifts of the breather,lump and line solitons before and after the interaction between a breather/lump and line solitons.By making the phase shifts infinite,we obtain the resonant solution of two breathers and the resonant solutions of a breather/lump and line solitons.Through the asymptotic analysis of these resonant solutions,we demonstrate that the resonant interactions exhibit the fusion,fission,time-localized breather and rogue lump phenomena.Utilizing the velocity resonance method,we obtain lump–soliton,lump–breather,lump–soliton–breather and lump–breather–breather molecules.The above works have not been reported in the(2+1)-dimensional discrete nonlinear wave equations. 展开更多
关键词 (2+1)-dimensional elliptic Toda equation resonant interaction lump molecules
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Hyper Catastrophe on 4-Dimensional Canards
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作者 Kiyoyuki Tchizawa Shuya Kanagawa 《Advances in Pure Mathematics》 2024年第4期196-203,共8页
When discovering the potential of canards flying in 4-dimensional slow-fast system with a bifurcation parameter, the key notion “symmetry” plays an important role. It is of one parameter on slow vector field. Then, ... When discovering the potential of canards flying in 4-dimensional slow-fast system with a bifurcation parameter, the key notion “symmetry” plays an important role. It is of one parameter on slow vector field. Then, it should be determined to introduce parameters to all slow/fast vectors. It is, however, there might be no way to explore for another potential in this system, because the geometrical structure is quite different from the system with one parameter. Even in this system, the “symmetry” is also useful to obtain the potentials classified by R. Thom. In this paper, via the coordinates changing, the possible way to explore for the potential will be shown. As it is analyzed on “hyper finite time line”, or done by using “non-standard analysis”, it is called “Hyper Catastrophe”. In the slow-fast system which includes a very small parameter , it is difficult to do precise analysis. Thus, it is useful to get the orbits as a singular limit. When trying to do simulations, it is also faced with difficulty due to singularity. Using very small time intervals corresponding small , we shall overcome the difficulty, because the difference equation on the small time interval adopts the standard differential equation. These small intervals are defined on hyper finite number N, which is nonstandard. As and the intervals are linked to use 1/N, the simulation should be done exactly. 展开更多
关键词 Canards Flying 4-dimensional Slow-Fast System Hyper Catastrophe
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Erratum to: Experimental Study on the Wavelengths of Two-Dimensional and Three-Dimensional Freak Waves [China Ocean Engineering, 2023, 37(1), 154−164. https://doi.org/10.1007/s13344-023-0013-7]
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作者 CUI Cheng PAN Wen-bo 《China Ocean Engineering》 SCIE EI CSCD 2023年第2期353-353,共1页
In the original publication of the article(Cui and Pan,2023),the organization“National Engineering Research Center for Port Hydraulic Construction Technology,M.O.T.,Tianjin Research Institute of Water Transport Engin... In the original publication of the article(Cui and Pan,2023),the organization“National Engineering Research Center for Port Hydraulic Construction Technology,M.O.T.,Tianjin Research Institute of Water Transport Engineering,Tianjin 300456,China”should be corrected as:“National Engineering Research Center of Port Hydraulic Construction Technology,Tianjin Research Institute for Water Transport Engineering,M.O.T.,Tianjin 300456,China”. 展开更多
关键词 TIANJIN (1) corrected
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Identifying the enhancement mechanism of Al/MoO_(3) reactive multilayered films on the ignition ability of semiconductor bridge using a one-dimensional gas-solid two-phase flow model
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作者 Jianbing Xu Yuxuan Zhou +3 位作者 Yun Shen Yueting Wang Yinghua Ye Ruiqi Shen 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期168-179,共12页
Energetic Semiconductor bridge(ESCB)based on reactive multilayered films(RMFs)has a promising application in the miniature and intelligence of initiator and pyrotechnics device.Understanding the ignition enhancement m... Energetic Semiconductor bridge(ESCB)based on reactive multilayered films(RMFs)has a promising application in the miniature and intelligence of initiator and pyrotechnics device.Understanding the ignition enhancement mechanism of RMFs on semiconductor bridge(SCB)during the ignition process is crucial for the engineering and practical application of advanced initiator and pyrotechnics devices.In this study,a one-dimensional(1D)gas-solid two-phase flow ignition model was established to study the ignition process of ESCB to charge particles based on the reactivity of Al/MoO_(3) RMFs.In order to fully consider the coupled exothermic between the RMFs and the SCB plasma during the ignition process,the heat release of chemical reaction in RMFs was used as an internal heat source in this model.It is found that the exothermal reaction in RMFs improved the ignition performance of SCB.In the process of plasma rapid condensation with heat release,the product of RMFs enhanced the heat transfer process between the gas phase and the solid charge particle,which accelerated the expansion of hot plasma,and heated the solid charge particle as well as gas phase region with low temperature.In addition,it made up for pressure loss in the gas phase.During the plasma dissipation process,the exothermal chemical reaction in RMFs acted as the main heating source to heat the charge particle,making the surface temperature of the charge particle,gas pressure,and gas temperature rise continuously.This result may yield significant advantages in providing a universal ignition model for miniaturized ignition devices. 展开更多
关键词 Ignition enhancement mechanism 1D gas-solid two-phase flow Al/MoO_(3)reactive multilayered films Semiconductor bridge Miniaturized ignition device
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糖尿病视网膜病变患者SDF-1、HO-1及MDA水平变化及与IL-6、TNF-α、CRP的相关性 被引量:1
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作者 赵玉杰 王敏 +3 位作者 刘钰凤 刘学晶 钟胜楠 李莹 《分子诊断与治疗杂志》 2024年第3期539-542,552,共5页
目的 分析糖尿病视网膜病变(DR)患者基质细胞衍生因子(SDF-1)、血红素加氧酶-1(HO-1)及丙二醛(MDA)水平变化及与白介素-6(IL-6)、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)的相关性。方法 选取2020年5月至2023年1月解放军总医院收治的131... 目的 分析糖尿病视网膜病变(DR)患者基质细胞衍生因子(SDF-1)、血红素加氧酶-1(HO-1)及丙二醛(MDA)水平变化及与白介素-6(IL-6)、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)的相关性。方法 选取2020年5月至2023年1月解放军总医院收治的131例DR患者为DR组,另选取同期在本院住院的2型糖尿病患者100例为非DR组。比较两组SDF-1、HO-1、MDA水平;比较两组IL-6、TNF-α、CRP水平;比较不同分期DR患者SDF-1、HO-1、MDA水平;采用Logistic回归分析影响DR发生的相关因素,分析DR组患者SDF-1、HO-1、MDA水平与IL-6、TNF-α、CRP的相关性。结果 DR组SDF-1、HO-1水平比非DR组低,MDA水平比非DR组高,差异有统计学意义(P<0.05);DR组IL-6、TNF-α、CRP水平均比非DR组高,差异有统计学意义(P<0.05);SDF-1、HO-1水平:Ⅰ~Ⅱ期>Ⅲ~Ⅳ期>Ⅴ~Ⅵ期,MDA水平:Ⅰ~Ⅱ期<Ⅲ~Ⅳ期<Ⅴ~Ⅵ期,差异有统计学意义(P<0.05);经Logistic多因素分析显示,性别为女、BMI≥24 km/m2、合并患有高血压、高血脂、IL-6>1.17 mg/mL、TNF-α>30 ng/L、CRP>10 ng/mL、SDF-1>2 ng/mL、HO-1<125 ng/mL、MDA>4.06μmol/mL均是影响DR发生的独立危险因素(P<0.05);血清炎性因子IL-6、TNF-α、CRP与SDF-1、HO-1呈负相关,与MDA呈正相关,且均为中度相关(P<0.05)。结论 SDF-1、HO-1、MDA、IL-6、CRP、TNF-α水平与DR的发生、发展有一定关系,通过检测上述指标水平可为进一步探讨DR的发病机制和治疗方法提供新的思路。 展开更多
关键词 糖尿病视网膜病变 SDF-1 HO-1 MDA IL-6 CRP TNF-α
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山姜素调节VEGF/SphK1/S1P信号通路对膝骨关节炎大鼠血管生成的影响 被引量:1
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作者 罗锟 王智 王柯 《天津医药》 CAS 2024年第5期480-485,共6页
目的探讨山姜素(APT)调节血管内皮生长因子/鞘氨醇激酶1/1磷酸鞘氨醇(VEGF/SphK1/S1P)信号通路对膝骨关节炎(KOA)大鼠血管生成的影响。方法采用改良的Videman法构建KOA大鼠模型,将90只大鼠分为对照组(Control组)、模型组(Model组)、山... 目的探讨山姜素(APT)调节血管内皮生长因子/鞘氨醇激酶1/1磷酸鞘氨醇(VEGF/SphK1/S1P)信号通路对膝骨关节炎(KOA)大鼠血管生成的影响。方法采用改良的Videman法构建KOA大鼠模型,将90只大鼠分为对照组(Control组)、模型组(Model组)、山姜素低剂量组(L-APT组)、山姜素高剂量组(H-APT组)、山姜素高剂量组+慢病毒阴性对照组(APT+NC组)、山姜素高剂量组+过表达SphK1慢病毒组(APT+SphK1组),每组15只。HE染色观察大鼠软骨组织病理变化;酶联免疫吸附试验测定软骨组织白细胞介素(IL)-1β、肿瘤坏死因子α(TNF-α)、IL-6、基质金属蛋白酶-13(MMP-13)水平;TUNEL检测软骨组织细胞凋亡情况;免疫组化检测血管内皮生长因子(VEGF)、CD31蛋白表达情况;Western blot检测血管内皮生长因子受体2(VEGFR2)、磷酸化VEGFR2(p-VEGFR2)、SphK1、S1P蛋白水平。结果与Control组比较,Model组大鼠出现病理损伤,细胞凋亡率、IL-1β、TNF-α、IL-6、MMP-13、VEGF阳性表达、CD31阳性表达和p-VEGFR2、SphK1、S1P蛋白表达水平增加(P<0.05);与Model组比较,L-APT组、H-APT组病理损伤明显减轻,细胞凋亡率、IL-1β、TNF-α、IL-6、MMP-13、VEGF阳性表达、CD31阳性表达和pVEGFR2、SphK1、S1P蛋白表达水平降低(P<0.05);与APT+NC组比较,APT+SphK1组软骨组织病理损伤加重,细胞凋亡率、IL-1β、TNF-α、IL-6、MMP-13、VEGF阳性表达、CD31阳性表达和p-VEGFR2、SphK1、S1P蛋白表达水平增加(P<0.05)。结论APT通过抑制VEGF/SphK1/S1P信号通路抑制KOA大鼠血管生成。 展开更多
关键词 骨关节炎 新生血管化 病理性 血管内皮生长因子类 山姜素 鞘氨醇激酶1 1磷酸鞘氨醇
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青藤碱可有效抑制白细胞介素1β介导的髓核细胞凋亡 被引量:2
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作者 王倩 卢子昂 +3 位作者 李利和 吕超亮 王盟 张存鑫 《中国组织工程研究》 CAS 北大核心 2024年第2期224-230,共7页
背景:椎间盘退变是导致脊柱退行性疾病的基础,然而目前尚无有效的治疗药物。目的:探讨青藤碱是否可以抑制白细胞介素1β诱导的髓核细胞凋亡及其分子机制。方法:采用胰酶联合Ⅱ型胶原酶消化法体外培养大鼠髓核细胞,并绘制细胞生长曲线,采... 背景:椎间盘退变是导致脊柱退行性疾病的基础,然而目前尚无有效的治疗药物。目的:探讨青藤碱是否可以抑制白细胞介素1β诱导的髓核细胞凋亡及其分子机制。方法:采用胰酶联合Ⅱ型胶原酶消化法体外培养大鼠髓核细胞,并绘制细胞生长曲线,采用CCK-8法筛选合适的青藤碱药物浓度。将髓核细胞分为对照组、青藤碱组、白细胞介素1β组、青藤碱+白细胞介素1β组、锌原卟啉(血红素氧合酶1抑制剂)组、锌原卟啉+青藤碱组、锌原卟啉+白细胞介素1β组、青藤碱+锌原卟啉+白细胞介素1β组。分别检测各组髓核细胞增殖活性、活性氧含量、凋亡率及血红素氧合酶1的表达情况。结果与结论:①体外培养的大鼠髓核细胞呈现多角形、三角形、短楔形等形态,其呈现“S”型曲线生长,接种第1-3天生长缓慢,第4-6天生长迅速,第七八天生长速度缓慢,进入“平台期”,细胞数量不再增加;②当青藤碱的浓度≤80μmol/L时,髓核细胞的增殖活性不会受到显著影响(P>0.05);③白细胞介素1β可以显著降低髓核细胞的增殖活性,增加活性氧含量,导致细胞凋亡(P<0.01);④当采用青藤碱干预后,不仅可以促进血红素氧合酶1的表达(P<0.05),而且可以抑制白细胞介素1β诱导的髓核细胞增殖活性降低、活性氧含量和凋亡率增加(P<0.05),其作用可被锌原卟啉逆转(P<0.01)。 展开更多
关键词 青藤碱 白细胞介素1Β 血红素氧合酶1 髓核细胞 细胞增殖 细胞凋亡 活性氧 椎间盘 椎间盘退变
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口服葡萄糖耐量试验1h血糖对糖尿病前期的诊断和鉴别价值 被引量:1
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作者 韩福禄 姚兴伟 +6 位作者 栗晓彬 李洪敏 张梅 武玉鑫 宋天佳 杨琦 刘尚建 《郑州大学学报(医学版)》 CAS 北大核心 2024年第2期201-205,共5页
目的:探讨口服葡萄糖耐量试验(OGTT)1 h血糖对糖尿病前期的诊断和鉴别价值。方法:收集2019年6月至2022年6月于北京中医药大学东直门医院门诊及住院行OGTT的受试者1 206例,其中血糖正常412例,糖尿病前期358例,糖尿病436例。比较3组OGTT... 目的:探讨口服葡萄糖耐量试验(OGTT)1 h血糖对糖尿病前期的诊断和鉴别价值。方法:收集2019年6月至2022年6月于北京中医药大学东直门医院门诊及住院行OGTT的受试者1 206例,其中血糖正常412例,糖尿病前期358例,糖尿病436例。比较3组OGTT不同时点血糖与空腹血糖(FPG)、空腹胰岛素(FINS)、稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛β细胞分泌功能指数(HOMA-β)水平;采用ROC曲线分析OGTT 1 h血糖对糖尿病前期的诊断和鉴别价值。结果:3组OGTT各时点血糖均为糖尿病组>糖尿病前期组>血糖正常组(P<0.05)。FPG、HOMA-IR糖尿病组>糖尿病前期组>血糖正常组,FINS、HOMA-β糖尿病组<糖尿病前期组<血糖正常组(P<0.05)。ROC曲线分析结果显示,OGTT 1 h血糖诊断糖尿病前期的AUC(95%CI)为0.758(0.724~0.792),以敏感度最大选取最佳切点值,该值为9.35 mmol/L,此时敏感度为0.701,特异度为0.709;OGTT 1 h血糖对糖尿病和糖尿病前期鉴别的AUC(95%CI)为0.956(0.942~0.969),以敏感度最大选取最佳切点值,该值为12.55 mmol/L,此时敏感度为0.901,特异度为0.908。结论:OGTT 1 h血糖对糖尿病前期具有一定的诊断和鉴别价值。 展开更多
关键词 糖尿病 糖尿病前期 口服葡萄糖耐量试验1 h血糖
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miR-141-3p对腰椎间盘突出症大鼠背根神经节炎症及下肢疼痛的抑制和改善作用 被引量:3
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作者 许刚 张长春 +2 位作者 朱坤 叶雨辰 周平辉 《中国组织工程研究》 CAS 北大核心 2024年第16期2593-2598,共6页
背景:研究表明,胰岛素样生长因子1/血小板源性生长因子有抑制纤维环细胞凋亡的作用。miR-141-3p微小RNA在骨髓基质细胞中随着年龄的增加而增加,且与炎症信号通路的活化存在一定关系,提示其可能成为腰椎间盘突出症的治疗靶点。目的:探究m... 背景:研究表明,胰岛素样生长因子1/血小板源性生长因子有抑制纤维环细胞凋亡的作用。miR-141-3p微小RNA在骨髓基质细胞中随着年龄的增加而增加,且与炎症信号通路的活化存在一定关系,提示其可能成为腰椎间盘突出症的治疗靶点。目的:探究miR-141-3p通过调控胰岛素样生长因子1/血小板源性生长因子对腰椎间盘突出症大鼠背根神经节炎症及下肢疼痛的影响。方法:选取50只SPF级SD雄性大鼠,随机分为正常组、模型组、miR-NC组、miR-141-3p inhibitor组、miR-141-3p mimics组,每组10只。除正常组外,其余大鼠采用自体髓核移植法进行腰椎间盘突出症建模。建模成功后,对miR-NC组、miR-141-3p inhibitor组和miR-141-3p mimics组大鼠鞘内分别注射10μL 20μmol/L miR-NC,miR-141-3p inhibitor,miR-141-3p mimics,均每天注射1次,连续注射28 d;正常组、模型组同期同位置注射同体积生理盐水。采用热缩足潜伏期阈值评价大鼠下肢疼痛,实时荧光定量PCR检测背根神经节组织miR-141-3p mRNA表达,ELISA法检测背根神经节组织炎症因子,免疫印迹法检测背根神经节组织胰岛素样生长因子1/血小板源性生长因子蛋白表达,并分析miR-141-3p与胰岛素样生长因子1/血小板源性生长因子的相关性。结果与结论:miR-NC组各项指标与模型组比较,差异均无显著性意义。①大鼠热缩足潜伏期阈值:模型组明显低于正常组(P<0.05),miR-141-3p inhibitor组明显低于miR-NC组(P<0.05),miR-141-3p mimics组明显高于miR-141-3p inhibitor组(P<0.05)。②背根神经节组织miR-141-3p mRNA表达:模型组明显低于正常组(P<0.05),miR-141-3p inhibitor组明显低于miR-NC组(P<0.05),miR-141-3p mimics组明显高于miR-141-3p inhibitor组(P<0.05)。③背根神经节组织肿瘤坏死因子α、白细胞介素1β、白细胞介素1含量:模型组明显高于正常组(P<0.05),miR-141-3p inhibitor组明显高于miR-NC组(P<0.05),miR-141-3p mimics组明显低于miR-141-3p inhibitor组(P<0.05)。④背根神经节组织胰岛素样生长因子1、血小板源性生长因子蛋白表达:模型组明显低于正常组(P<0.05),miR-141-3p inhibitor组明显低于miR-NC组(P<0.05),miR-141-3p mimics组明显高于miR-141-3p inhibitor组(P<0.05)。⑤胰岛素样生长因子1与miR-141-3p呈正相关(r=0.904,P<0.001),血小板源性生长因子与miR-141-3p呈正相关(r=0.879,P<0.001)。⑥结论:miR-141-3p可显著改善腰椎间盘突出症大鼠下肢疼痛,抑制背根神经节炎症,其机制可能与促进胰岛素样生长因子1/血小板源性生长因子表达有关。 展开更多
关键词 miR-141-3p IGF-1/PDGF 腰椎间盘突出症 背根神经节炎症 下肢疼痛
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软骨细胞中SIRT1基因敲减后作用状态不明确信号通路及对相关疾病或功能的影响 被引量:1
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作者 叶海明 曾晖 +3 位作者 杨琪 张耕 翁鉴 于斐 《中国组织工程研究》 CAS 北大核心 2024年第20期3123-3129,共7页
背景:沉默信息调节因子1以去乙酰化的方式调控软骨细胞中相关蛋白的功能,参与软骨细胞增殖分化,促进软骨缺损修复。目的:利用高通量技术筛选软骨细胞中沉默信息调节因子1基因敲减后作用状态不明确的信号通路以及产生变化的疾病或功能。... 背景:沉默信息调节因子1以去乙酰化的方式调控软骨细胞中相关蛋白的功能,参与软骨细胞增殖分化,促进软骨缺损修复。目的:利用高通量技术筛选软骨细胞中沉默信息调节因子1基因敲减后作用状态不明确的信号通路以及产生变化的疾病或功能。方法:取处于对数生长期的小鼠ATDC5软骨细胞,分2组转染:对照组转染沉默信息调节因子1基因敲减阴性对照慢病毒,实验组转染沉默信息调节因子1基因敲减慢病毒。转染72 h后,利用小鼠基因表达谱芯片GeneChip®Mouse Genome 4302.0 Array检测mRNA的基因层面变化情况,应用生物信息学技术筛选激活或抑制不明确的信号通路以及这些信号通路相关因子,并分析疾病或功能模块的富集情况。结果与结论:①沉默信息调节因子1基因敲减后,小鼠ATDC5软骨细胞中激活或抑制状态不明确的信号通路有245条;②根据-log(P-value)排序选择排前20的激活或抑制状态不明确信号通路中的因子情况进行报道,包括IGFBP4、TGFBR1、CTGF、COL4A5、LHX2、IL1RL1、KLF6等;③根据-log(P-value)进行排序,细胞生长和增殖、生物体存活和细胞死亡与存活等14个疾病和功能密切相关模块明显变化;根据差异基因数量排序,生物体损伤和异常、癌症和细胞死亡与存活3个疾病和功能密切相关模块明显变化;根据-log(P-value)与差异基因数量综合排序,固有免疫应答这一疾病和功能模块被显著激活。 展开更多
关键词 高通量测序 沉默信息调节因子1 软骨缺损 信号通路 疾病或功能
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脓毒症患者连续性血液净化治疗前后PCT Trx-1D-Lac表达及意义 被引量:1
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作者 曾广志 唐海莲 +2 位作者 陈海玉 曾慧志 梅林 《河北医学》 2024年第1期50-55,共6页
目的:探讨脓毒症患者连续性血液净化(CBP)治疗前后血清降钙素原(PCT)、硫氧还蛋白-1(Trx-1)、D-乳酸(D-Lac)水平变化,分析其对CBP疗效的预测价值及临床意义。方法:选取2021年1月至2022年12月本院100例脓毒症患者作为观察组,另遵循1∶1... 目的:探讨脓毒症患者连续性血液净化(CBP)治疗前后血清降钙素原(PCT)、硫氧还蛋白-1(Trx-1)、D-乳酸(D-Lac)水平变化,分析其对CBP疗效的预测价值及临床意义。方法:选取2021年1月至2022年12月本院100例脓毒症患者作为观察组,另遵循1∶1配对原则,选取100例健康体检者作为对照组。统计两组血清PCT、Trx-1、D-Lac水平。观察组接受CBP治疗,依据治疗效果分为存活亚组、死亡亚组。比较不同亚组血清PCT、Trx-1、D-Lac水平、急性生理学与慢性健康状况Ⅱ评分(APACHEⅡ)及治疗前后其变化差值。Pearson分析各血清指标水平变化差值与APACHEⅡ评分相关性。采用受试者工作特征曲线(ROC)及曲线下面积(AUC)分析各血清指标水平变化差值对疗效的预测价值。采用卡普兰-迈耶(Kaplan-Meier)分析不同血清表达者28d内生存状况。结果:观察组血清PCT、Trx-1、D-Lac水平高于对照组(P<0.05);治疗1周后,死亡亚组血清PCT、Trx-1、D-Lac水平及APACHEⅡ评分高于存活亚组,且变化差值小于存活亚组(P<0.05);各血清指标水平变化差值与APACHEⅡ评分呈正相关(P<0.05);各血清指标水平变化差值联合预测CBP疗效的AUC分别大于单一指标预测、各血清指标联合预测(P<0.05);PCT、Trx-1、D-Lac水平变化差值高表达者死亡风险分别是低表达的4.828、3.600、2.318倍,且生存率高于低表达者(P<0.05)。结论:脓毒症患者CBP治疗前后血清PCT、Trx-1、D-Lac水平变化可反映病情严重程度,且与28d内生存情况密切相关,联合检测其变化差值对CBP疗效具有一定预测价值。 展开更多
关键词 脓毒症 连续性血液净化 降钙素原 硫氧还蛋白-1 D-乳酸
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铁死亡加持PD-1/PD-L1抑制剂杀伤肿瘤细胞综述 被引量:1
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作者 杨洋 耿依珂 于丽 《中国免疫学杂志》 CAS CSCD 北大核心 2024年第2期421-423,427,共4页
恶性肿瘤发生发展的每一环节都与免疫调节息息相关,近年铁死亡及PD-1/PD-L1抑制剂杀伤肿瘤细胞方面的研究是一大热点,因其精准治疗肿瘤的效果被越来越多地应用于临床治疗。但目前尚无将PD-1/PD-L1抑制剂与铁死亡治疗肿瘤细胞结合的研究... 恶性肿瘤发生发展的每一环节都与免疫调节息息相关,近年铁死亡及PD-1/PD-L1抑制剂杀伤肿瘤细胞方面的研究是一大热点,因其精准治疗肿瘤的效果被越来越多地应用于临床治疗。但目前尚无将PD-1/PD-L1抑制剂与铁死亡治疗肿瘤细胞结合的研究,本文将对铁死亡的相关机制、铁死亡与肿瘤的关系和PD-1/PD-L1免疫治疗肿瘤等方面进行综述。 展开更多
关键词 铁死亡 PD-1 PD-L1 肿瘤 综述
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二甲双胍联合维生素D对糖尿病合并骨质疏松症患者血清胰岛素样生长因子1及骨代谢标志物水平的影响 被引量:1
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作者 董娟 李悦芃 +2 位作者 张任飞 赵籥陶 邱蕾 《中国医药》 2024年第2期226-230,共5页
目的 探讨二甲双胍联合维生素D对糖尿病合并骨质疏松症患者血清胰岛素样生长因子1(IGF-1)及骨代谢标志物水平的影响。方法 选取北京医院2020年3月至2023年3月收治的160例2型糖尿病(T_(2)DM)合并骨质疏松症患者作为研究对象,按照随机数... 目的 探讨二甲双胍联合维生素D对糖尿病合并骨质疏松症患者血清胰岛素样生长因子1(IGF-1)及骨代谢标志物水平的影响。方法 选取北京医院2020年3月至2023年3月收治的160例2型糖尿病(T_(2)DM)合并骨质疏松症患者作为研究对象,按照随机数字表法分为对照组和观察组,各80例。对照组给予维生素D联合运动干预和控制饮食等常规血糖控制方法治疗,观察组在上述治疗的基础上外加二甲双胍治疗,2组均治疗6个月。比较2组患者治疗前后空腹血糖、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、血钙、血磷、骨钙素、总Ⅰ型胶原氨基端延长肽(T-PⅠNP)、IGF-1、高敏C反应蛋白(hs-CRP)、维生素D_(3)水平以及总有效率。结果 治疗后,2组空腹血糖、2 hPG、HbA1c、血磷、hs-CRP水平均低于治疗前,且观察组均低于对照组(均P<0.05);2组血钙、骨钙素、T-PⅠNP、骨密度、IGF-1、维生素D_(3)水平均高于治疗前、且观察组均高于对照组[(2.82±0.20)mmol/L比(2.40±0.15)mmol/L、(19.9±2.4)ng/L比(13.6±2.1)ng/L、(48±4)μg/L比(37±4)μg/L、(0.98±0.16)g/cm^(2)比(0.78±0.15)g/cm^(2)、(206±35)μg/L比(137±25)μg/L、(37±3)μg/L比(29±3)μg/L](均P<0.05)。观察组总有效率高于对照组(P<0.001)。结论 二甲双胍联合维生素D治疗T_(2)DM合并骨质疏松症效果较好,可更好地控制血糖水平,上调血清IGF-1水平,改善机体骨代谢。 展开更多
关键词 糖尿病 二甲双胍 维生素D 骨质疏松症 胰岛素样生长因子1
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