期刊文献+
共找到4,866篇文章
< 1 2 244 >
每页显示 20 50 100
Application of Grey System GM (1,1) model and unary linear regression model in coal consumption of Jilin Province 被引量:1
1
作者 TIAN Songlin LU Laijun 《Global Geology》 2015年第1期26-31,共6页
The data on the coal production and consumption in Jilin Province for the last ten years were collected,and the Grey System GM( 1,1) model and unary linear regression model were applied to predict the coal consumption... The data on the coal production and consumption in Jilin Province for the last ten years were collected,and the Grey System GM( 1,1) model and unary linear regression model were applied to predict the coal consumption of Jilin Production in 2014 and 2015. Through calculation,the predictive value on the coal consumption of Jilin Province was attained,namely consumption of 2014 is 114. 84 × 106 t and of 2015 is 117. 98 ×106t,respectively. Analysis of error data indicated that the predicted accuracy of Grey System GM( 1,1) model on the coal consumption in Jilin Province improved 0. 21% in comparison to unary linear regression model. 展开更多
关键词 grey system GM 1 1 model unary linear regression model model test PREDICTION coal con-sumption Jilin Province
下载PDF
PROGRESS OF GREY SYSTEM MODELS 被引量:14
2
作者 刘思峰 胡明礼 +1 位作者 Forrest Jeffrey 杨英杰 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2012年第2期103-111,共9页
The progress of grey system models is reviewed, and the general grey numbers, the grey sequence op- erators and several most commonly used grey system models are introduced, such as the absolute degree of grey inciden... The progress of grey system models is reviewed, and the general grey numbers, the grey sequence op- erators and several most commonly used grey system models are introduced, such as the absolute degree of grey incidence model, the grey cluster model based on endpoint triangular whitenization functions, the grey cluster model based on center-point triangular whitenization functions, the grey prediction model of the model GM ( 1,1), and the weighted multi-attribute grey target decision model. 展开更多
关键词 grey system theory general grey numbers grey sequence operators grey system models
下载PDF
Study on the Yield Prediction Model of Processing Tomato Based on the Grey System Theory 被引量:1
3
作者 袁莉 姜波 《Agricultural Science & Technology》 CAS 2011年第5期632-633,642,共3页
[Objective] The research aimed to study the yield prediction model of processing tomato based on the grey system theory.[Method] The variation trend of processing tomato yield was studied by using the grey system theo... [Objective] The research aimed to study the yield prediction model of processing tomato based on the grey system theory.[Method] The variation trend of processing tomato yield was studied by using the grey system theory,and GM(1,1)grey model of processing tomato yield prediction was established.The processing tomato yield in Xinjiang during 2001-2009 was as the example to carry out the instance analysis.[Result] The model had the high forecast accuracy and strong generalization ability,and was reliable for the prediction of recent processing tomato yield.[Conclusion] The research provided the reference for the macro-control of tomato industry,the processing and storage of tomato in Xinjiang. 展开更多
关键词 grey system theory grey prediction model Processing tomato yield
下载PDF
Prediction model of interval grey number based on DGM(1,1) 被引量:19
4
作者 Bo Zeng Sifeng Liu Naiming Xie 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2010年第4期598-603,共6页
In grey system theory,the studies in the field of grey prediction model are focused on real number sequences,rather than grey number ones.Hereby,a prediction model based on interval grey number sequences is proposed.B... In grey system theory,the studies in the field of grey prediction model are focused on real number sequences,rather than grey number ones.Hereby,a prediction model based on interval grey number sequences is proposed.By mining the geometric features of interval grey number sequences on a two-dimensional surface,all the interval grey numbers are converted into real numbers by means of certain algorithm,and then the prediction model is established based on those real number sequences.The entire process avoids the algebraic operations of grey number,and the prediction problem of interval grey number is usefully solved.Ultimately,through an example's program simulation,the validity and practicability of this novel model are verified. 展开更多
关键词 grey system theory prediction model interval grey number grey number band grey number layer DGM(1 1 model.
下载PDF
A New Modified GM (1,1) Model: Grey Optimization Model 被引量:12
5
作者 Xiao Xinping College of Scienced, Wuhan University of Technologyl 430063, P R. China Deng Julong Dept. of Control, Huazhong University of Science and Technology, Wuhan 430074,P. R. China 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2001年第2期1-5,共5页
Based on the optimization method, a new modified GM (1,1) model is presented, which is characterized by more accuracy prediction for the grey modeling.
关键词 GM (1 1) grey optimization model Optimization method.
下载PDF
Effects of neuregulin-1 on autonomic nervous system remodeling post-myocardial infarction in a rat model 被引量:7
6
作者 Xin Lai Liang Zhong +7 位作者 Hai-xia Fu Song Dang Xin Wang Ning Zhang Gao-ke Feng Zi-qiang Liu Xi Wang Long Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第11期1905-1910,共6页
Sympathetic nerve and vagus nerve remodeling play an important part in cardiac function post-myocardial infarction (MI). Increasing evidence indicates that neuregulin-1 (NRG-1) improves cardiac function following ... Sympathetic nerve and vagus nerve remodeling play an important part in cardiac function post-myocardial infarction (MI). Increasing evidence indicates that neuregulin-1 (NRG-1) improves cardiac function following heart failure. Since its impact on cardiac function and neural remodeling post-MI is poorly understood, we aimed to investigate the role of NRG-1 in autonomic nervous system remodeling post-MI. Forty-five Sprague-Dawley rats were equally randomized into three groups: sham (with the left anterior descending coronary artery exposed but without ligation), MI (left anterior descending coronary artery ligation), and MI plus NRG-1 (left anterior descending coronary artery ligation followed by intraperitoneal injection of NRG-1 (10 lag/kg, once daily for 7 days)). At 4 weeks after MI, echocardi- ography was used to detect the rat cardiac function by measuring the left ventricular end-systolic inner diameter, left ventricular diastolic diameter, left ventricular end-systolic volume, left ventricular end-diastolic volume, left ventricular ejection fraction, and left ventricular fractional shortening, mRNA and protein expression levels of tyrosine hydroxylase, growth associated protein-43 (neuronal specific pro- tein), nerve growth factor, choline acetyltransferase (vagus nerve marker), and vesicular acetylcholine transporter (cardiac vagal nerve fiber marker) in ischemic myocardia were detected by real-time PCR and western blot assay to assess autonomous nervous remodeling. After MI, the rat cardiac function deteriorated significantly, and it was significantly improved after NRG-1 injection. Compared with the MI group, mRNA and protein levels of tyrosine hydroxylase and growth associated protein-43, as well as choline acetyltransferase mRNA level significantly decreased in the MI plus NRG-1 group, while mRNA and protein levels of nerve growth factor and vesicular acetylcholine transporters, as well as choline acetyltransferase protein level slightly decreased. Our results indicate that NRG- 1 can improve cardiac function and regulate sympathetic and vagus nerve remodeling post-MI, thus reaching a new balance of the autonomic nervous system to protect the heart from injury. 展开更多
关键词 nerve remodeling myocardial infarction NEUREGULIN-1 sympathetic nerve vagus nerve animal model real-time PCR westernblot assay cardiac function ECHOCARDIOGRAPHY
下载PDF
Multi-variable grey model (MGM(1,n,q)) based on genetic algorithm and its application in urban water consumption 被引量:3
7
作者 Yan Han Shi Guoxu 《Agricultural Science & Technology》 CAS 2007年第1期14-20,共7页
Urban water consumption has some characteristics of grey because it is influenced by economy, population, standard of living and so on. The multi-variable grey model (MGM(1,n)), as the expansion and complement of GM(1... Urban water consumption has some characteristics of grey because it is influenced by economy, population, standard of living and so on. The multi-variable grey model (MGM(1,n)), as the expansion and complement of GM(1,1) model, reveals the relationship between restriction and stimulation among variables, and the genetic algorithm has the whole optimal and parallel characteristics. In this paper, the parameter q of MGM(1,n) model was optimized, and a multi-variable grey model (MGM(1,n,q)) was built by using the genetic algorithm. The model was validated by examining the urban water consumption from 1990 to 2003 in Dalian City. The result indicated that the multi-variable grey model (MGM(1,n,q)) based on genetic algorithm was better than MGM(1,n) model, and the MGM(1,n) model was better than MGM(1,1) model. 展开更多
关键词 grey system MGM 1 N q) genetic algorithm urban water consumption
下载PDF
Prediction of leaching rate in heap leaching process by grey dynamic model GDM(1,1) 被引量:1
8
作者 刘金枝 吴爱祥 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2008年第4期541-548,共8页
The method of developing GM(1,1) model is extended on the basis of grey system theory. Conditions for the transfer function that improve smoothness of original data sequence and decrease the revert error are given. ... The method of developing GM(1,1) model is extended on the basis of grey system theory. Conditions for the transfer function that improve smoothness of original data sequence and decrease the revert error are given. The grey dynamic model is first combined with the transfer function to predict the leaching rate in heap leaching process. The results show that high prediction accuracy can be expected by using the proposed method. This provides a new approach to realize prediction and control of the future behavior of leaching kinetics. 展开更多
关键词 leaching rate PREDICTION grey theory dynamic model
下载PDF
Establishment of a humanized ST6GAL1 mouse model for influenza research
9
作者 Lyu Chao Han Feng +10 位作者 Gao Qian Lv Limin Lu Ziwei Lu Shuangshuang Li Xiaoyan Hu Yuechao Yang Mengjie Zhao Yingze Liu Jun Lu Xuancheng Duo Shuguang 《Animal Models and Experimental Medicine》 CAS CSCD 2024年第3期337-346,共10页
Background:This study aimed to construct and characterize a humanized influenza mouse model expressing hST6GAL1.Methods:Humanized fragments,consisting of the endothelial cell-specific K18 promoter,human ST6GAL1-encodi... Background:This study aimed to construct and characterize a humanized influenza mouse model expressing hST6GAL1.Methods:Humanized fragments,consisting of the endothelial cell-specific K18 promoter,human ST6GAL1-encoding gene,and luciferase gene,were microinjected into the fertilized eggs of mice.The manipulated embryos were transferred into the oviducts of pseudopregnant female mice.The offspring were identified using PCR.Mice exhibiting elevated expression of the hST6GAL1 gene were selectively bred for propagation,and in vivo analysis was performed for screening.Expression of the humanized gene was tested by performing immunohistochemical(IHC)analysis.Hematologic and biochemical analyses using the whole blood and serum of humanized hST6GAL1 mice were performed.Results:Successful integration of the human ST6GAL1 gene into the mouse genome led to the overexpression of human SiaT ST6GAL1.Seven mice were identified as carrying copies of the humanized gene,and the in vivo analysis indicated that hST6GAL1gene expression in positive mice mirrored influenza virus infection characteristics.The IHC results revealed that hST6GAL1 was expressed in the lungs of humanized mice.Moreover,the hematologic and biochemical parameters of the positive mice were within the normal range.Conclusion:A humanized influenza mouse model expressing the hST6GAL1 gene was successfully established and characterized. 展开更多
关键词 hST6GAL1 humanized mice influenza animal model
下载PDF
Expression of L amino acid transport system 1 and analysis of iodine-123-methyltyrosine tumor uptake in a pancreatic xenotransplantation model using fused high-resolution-micro-SPECT-MRI 被引量:1
10
作者 Corinna von Forstner Maaz Zuhayra +5 位作者 Ole Ammerpohl Sanjay Tiwari Olav Jansen Holger Kalthoff Eberhard Henze Jan-Hendrik Egberts 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2011年第1期30-37,共8页
BACKGROUND:The specificity in discriminating pancreatitis is limited in the positron emission tomography(PET)using Fluorine-18-fluorodeoxyglucose.Furthermore,PET is not widely available compared to the single photon e... BACKGROUND:The specificity in discriminating pancreatitis is limited in the positron emission tomography(PET)using Fluorine-18-fluorodeoxyglucose.Furthermore,PET is not widely available compared to the single photon emission computed tomography(SPECT).Since amino acids play a minor role in metabolism of inflammatory cells,the potential of the SPECT tracer,3-[ 123 I]iodo-L-α-methyltyrosine(123I-IMT),for detecting pancreatic cancer was examined in xenotransplantation models of human pancreatic carcinoma in mice. METHODS: 123 I-IMT was injected to eight mice inoculated with subcutaneous or orthotopic pancreatic tumors.Fused high-resolution-micro-SPECT(Hi-SPECT)and magnetic resonance imaging were performed.The gene expression level of L amino acid transport-system 1(LAT1)was analyzed and correlated with tumor uptake of 123 I-IMT. RESULTS:A high uptake of 123 I-IMT was detected in all tumor-bearing mice.The median tumor-to-background ratio (T/B)was 12.1(2.0-13.2)for orthotopic and 8.4(1.8-11.1)for subcutaneous xenotransplantation,respectively.Accordingly, the LAT1 expression in transplanted Colo357 cells was increased compared to non-malignant controls.CONCLUSIONS:Our mouse model could show a high 123 I-IMT uptake in pancreatic cancer.Fused MRI scans facilitate precise evaluation of uptake in the specific regions of interest.Further studies are required to confirm these findings in tumors derived from other human pancreatic cancer cells.Since amino acids play a minor role in the metabolism of inflammatory cells,the potential for application of 123 I-IMT to distinguish pancreatic tumor from inflammatory pancreatitis warrants further investigation. 展开更多
关键词 pancreatic ductal adenocarcinoma iodine-123-methyltyrosine high-resolution-micro-SPECT L amino acid transport-system 1 xenotransplantation model
下载PDF
The Non-Equidistant Grey GRM (1, 1) Model and Its Application 被引量:1
11
作者 Ruibiao Zou Zouxin Mou Wei Yi 《International Journal of Modern Nonlinear Theory and Application》 2012年第2期51-54,共4页
Applying the modeling method of Grey system and accumulated generating operation of reciprocal number for the problem of lower precision as well as lower adaptability in non-equidistant GM (1, 1) model, the calculatio... Applying the modeling method of Grey system and accumulated generating operation of reciprocal number for the problem of lower precision as well as lower adaptability in non-equidistant GM (1, 1) model, the calculation formulas were deduced and a non-equidistant GRM (1, 1) model generated by accumulated generating operation of reciprocal number was put forward .The grey GRM (1, 1) model can be used in non-equal interval & equal interval time series and has the characteristic of high precision as well as high adaptability. Example validates the practicability and reliability of the proposed model. 展开更多
关键词 BACKGROUND Value grey model GRM (1 1) Generated by Accumulated GENERATING Operation of Reciprocal Number Non-Equal INTERVAL ACCUMULATION Generation Operation grey system
下载PDF
Tidal modeling based on satellite altimetry observations of TOPEX/ Poseidon, Jason1, Jason2, and Jason3 with high prediction capability: A case study of the Baltic Sea
12
作者 Alireza A.Ardalan Asiyeh Hashemifaraz 《Geodesy and Geodynamics》 EI CSCD 2024年第4期404-418,共15页
This research aims to optimize the utilization of long-term sea level data from the TOPEX/Poseidon,Jason1,Jason2,and Jason3 altimetry missions for tidal modeling.We generate a time series of along-track observations a... This research aims to optimize the utilization of long-term sea level data from the TOPEX/Poseidon,Jason1,Jason2,and Jason3 altimetry missions for tidal modeling.We generate a time series of along-track observations and apply a developed method to produce tidal models with specific tidal constituents for each location.Our tidal modeling methodology follows an iterative process:partitioning sea surface height(SSH)observations into analysis/training and prediction/validation parts and ultimately identi-fying the set of tidal constituents that provide the best predictions at each time series location.The study focuses on developing 1256 time series along the altimetry tracks over the Baltic Sea,each with its own set of tidal constituents.Verification of the developed tidal models against the sSH observations within the prediction/validation part reveals mean absolute error(MAE)values ranging from 0.0334 m to 0.1349 m,with an average MAE of 0.089 m.The same validation process is conducted on the FES2014 and EOT20 global tidal models,demonstrating that our tidal model,referred to as BT23(short for Baltic Tide 2023),outperforms both models with an average MAE improvement of 0.0417 m and 0.0346 m,respectively.In addition to providing details on the development of the time series and the tidal modeling procedure,we offer the 1256 along-track time series and their associated tidal models as supplementary materials.We encourage the satellite altimetry community to utilize these resources for further research and applications. 展开更多
关键词 Satellitealtimetry Baltic Sea Ocean tide modeling Jason3 Jason2 Jason1 TOPEX/POSEIDON EOT20 FES2014
下载PDF
Grey GM(1,1) Model with Function-Transfer Method for Wear Trend Prediction and its Application 被引量:11
13
作者 LUO You xin 1 , PENG Zhu 2 , ZHANG Long ting 1 , GUO Hui xin 1 , CAI An hui 1 1Department of Mechanical Engineering, Changde Teachers University, Changde 415003, P.R. China 2 Engineering Technology Board, Changsha Cigare 《International Journal of Plant Engineering and Management》 2001年第4期203-212,共10页
Trend forecasting is an important aspect in fault diagnosis and work state supervision. The principle, where Grey theory is applied in fault forecasting, is that the forecast system is considered as a Grey system; the... Trend forecasting is an important aspect in fault diagnosis and work state supervision. The principle, where Grey theory is applied in fault forecasting, is that the forecast system is considered as a Grey system; the existing known information is used to infer the unknown information's character, state and development trend in a fault pattern, and to make possible forecasting and decisions for future development. It involves the whitenization of a Grey process. But the traditional equal time interval Grey GM (1,1) model requires equal interval data and needs to bring about accumulating addition generation and reversion calculations. Its calculation is very complex. However, the non equal interval Grey GM (1,1) model decreases the condition of the primitive data when establishing a model, but its requirement is still higher and the data were pre processed. The abrasion primitive data of plant could not always satisfy these modeling requirements. Therefore, it establishes a division method suited for general data modeling and estimating parameters of GM (1,1), the standard error coefficient that was applied to judge accuracy height of the model was put forward; further, the function transform to forecast plant abrasion trend and assess GM (1,1) parameter was established. These two models need not pre process the primitive data. It is not only suited for equal interval data modeling, but also for non equal interval data modeling. Its calculation is simple and convenient to use. The oil spectrum analysis acted as an example. The two GM (1,1) models put forward in this paper and the new information model and its comprehensive usage were investigated. The example shows that the two models are simple and practical, and worth expanding and applying in plant fault diagnosis. 展开更多
关键词 grey GM (1 1) model fault diagnosis function transfer method trend prediction
下载PDF
Prediction of syphilis incident rate and number in China based on the GM(1,1)grey model 被引量:1
14
作者 Run-Hua Li Jing Huang +1 位作者 Shun-Ying Luo Mei-Ying Zhang 《Food Therapy and Health Care》 2020年第4期170-175,共6页
Objective:To explore the feasibility of using grey model GM(1,1)model to predict syphilis,and to provide a theoretical basis for the health sector to develop corresponding strategies.Methods:GM(1,1)model was used to c... Objective:To explore the feasibility of using grey model GM(1,1)model to predict syphilis,and to provide a theoretical basis for the health sector to develop corresponding strategies.Methods:GM(1,1)model was used to construct and simulate the incident rate and case number of syphilis in China from 2009 to 2018 to predict the change trend.Results:The GM(1,1)prediction model of syphilis incident rate was x^(1)(k+1)=929.367901 e(0.029413k)-906.297901.The GM(1,1)prediction model for the number of syphilis patients was x^(1)(k+1)=1060.278025 e(0.034280k)-1029.639925.For syphilis incidence model,the posterior difference ratio was 0.19819 and the probability of small error was 1.For the syphilis incident number model,the posterior difference ratio was 0.18450 and the probability of small error was 1.The above models have good fitting accuracy with excellent grade level and can be predicted by extrapolation and predicted that the syphilis incidence in 2019-2021 may be 36.15 per 100,000,37.23 per 100,000 and 38.34 per 100,000,respectively.From 2019 to 2021,the number of incident syphilis cases in China may be 503,406,520,962 and 539,130,respectively.Conclusion:The GM(1,1)model can well fit and predict the change trend of syphilis incidence in time series.The prediction model showed that the incidence of syphilis may continue to increase and the number of syphilis cases per year may continue to increase substantially.More effort is needed to strengthen the prevention and treatment of venereal disease,reduce venereal harm to the population and improve the early detection rate of syphilis. 展开更多
关键词 SYPHILIS grey model PREDICTION
下载PDF
An approach to estimate tree height using PolInSAR data constructed by the Sentinel-1 dual-pol SAR data and RVoG model
15
作者 Yin Zhang Ding-Feng Duan 《Journal of Electronic Science and Technology》 EI CAS CSCD 2024年第3期69-79,共11页
We estimate tree heights using polarimetric interferometric synthetic aperture radar(PolInSAR)data constructed by the dual-polarization(dual-pol)SAR data and random volume over the ground(RVoG)model.Considering the Se... We estimate tree heights using polarimetric interferometric synthetic aperture radar(PolInSAR)data constructed by the dual-polarization(dual-pol)SAR data and random volume over the ground(RVoG)model.Considering the Sentinel-1 SAR dual-pol(SVV,vertically transmitted and vertically received and SVH,vertically transmitted and horizontally received)configuration,one notes that S_(HH),the horizontally transmitted and horizontally received scattering element,is unavailable.The S_(HH)data were constructed using the SVH data,and polarimetric SAR(PolSAR)data were obtained.The proposed approach was first verified in simulation with satisfactory results.It was next applied to construct PolInSAR data by a pair of dual-pol Sentinel-1A data at Duke Forest,North Carolina,USA.According to local observations and forest descriptions,the range of estimated tree heights was overall reasonable.Comparing the heights with the ICESat-2 tree heights at 23 sampling locations,relative errors of 5 points were within±30%.Errors of 8 points ranged from 30%to 40%,but errors of the remaining 10 points were>40%.The results should be encouraged as error reduction is possible.For instance,the construction of PolSAR data should not be limited to using SVH,and a combination of SVH and SVV should be explored.Also,an ensemble of tree heights derived from multiple PolInSAR data can be considered since tree heights do not vary much with time frame in months or one season. 展开更多
关键词 Constructed polarimetric SAR data Dual polarization Sentinel-1 SAR data Polarimetric interferometric SAR Random volume over the ground model Tree height estimation
下载PDF
Numerical Models and Methods of Atmospheric Parameters Originating in the Formation of the Earth’s Climatic Cycle
16
作者 Wend Dolean Arsène Ilboudo Kassoum Yamba +1 位作者 Windé Nongué Daniel Koumbem Issaka Ouédraogo 《Atmospheric and Climate Sciences》 2024年第2期277-286,共10页
Atmospheric models are physical equations based on the ideal gas law. Applied to the atmosphere, this law yields equations for water, vapor (gas), ice, air, humidity, dryness, fire, and heat, thus defining the model o... Atmospheric models are physical equations based on the ideal gas law. Applied to the atmosphere, this law yields equations for water, vapor (gas), ice, air, humidity, dryness, fire, and heat, thus defining the model of key atmospheric parameters. The distribution of these parameters across the entire planet Earth is the origin of the formation of the climatic cycle, which is a normal climatic variation. To do this, the Earth is divided into eight (8) parts according to the number of key parameters to be defined in a physical representation of the model. Following this distribution, numerical models calculate the constants for the formation of water, vapor, ice, dryness, thermal energy (fire), heat, air, and humidity. These models vary in complexity depending on the indirect trigonometric direction and simplicity in the sum of neighboring models. Note that the constants obtained from the equations yield 275.156˚K (2.006˚C) for water, 273.1596˚K (0.00963˚C) for vapor, 273.1633˚K (0.0133˚C) for ice, 0.00365 in/s for atmospheric dryness, 1.996 in<sup>2</sup>/s for humidity, 2.993 in<sup>2</sup>/s for air, 1 J for thermal energy of fire, and 0.9963 J for heat. In summary, this study aims to define the main parameters and natural phenomena contributing to the modification of planetary climate. . 展开更多
关键词 Atmospheric Parameter 1 Climatic Cycle 2 Numerical models 3
下载PDF
成纤维细胞生长因子受体1 抑制剂对胶原诱导关节炎模型大鼠骨破坏的影响
17
作者 韩海慧 孟晓辉 +3 位作者 徐博 冉磊 施杞 肖涟波 《中国组织工程研究》 CAS 北大核心 2025年第5期968-977,共10页
背景:课题组前期的研究表明靶向成纤维细胞生长因子受体1(fibroblast growth factor receptor 1,FGFR1)可能是治疗类风湿性关节炎的有效靶点。目的:探讨FGFR1抑制剂(PD173074)对胶原诱导关节炎模型大鼠骨破坏的影响。方法:将25只雌性SD... 背景:课题组前期的研究表明靶向成纤维细胞生长因子受体1(fibroblast growth factor receptor 1,FGFR1)可能是治疗类风湿性关节炎的有效靶点。目的:探讨FGFR1抑制剂(PD173074)对胶原诱导关节炎模型大鼠骨破坏的影响。方法:将25只雌性SD大鼠随机分为5组,正常对照组、模型组、甲氨蝶呤组、PD173074低剂量组、PD173074高剂量组。除正常对照组外,其余各组大鼠建立Ⅱ型胶原诱导关节炎模型。造模成功后正常组及模型组大鼠腹腔注射无菌PBS,甲氨蝶呤组药物注射剂量为1.04 mg/kg,PD173074低剂量组和高剂量组药物注射剂量分别为5,20 mg/kg,1次/周。给药4周后取材,观察大鼠临床症状以及关节肿胀情况,踝关节Micro-CT三维重建及分析,观察踝关节病理变化,检测关节周围血管生成情况及核因子κB受体活化因子配体的表达,检测关节滑膜中p-FGFR1、血管内皮生长因子A、抗酒石酸酸性磷酸酶的表达,观察肝、脾、肾病理变化并计算肝、脾、肾指数。结果与结论:①PD173074能够减轻模型大鼠踝关节临床症状及关节肿胀,延缓骨质丢失,改善骨结构,减轻关节滑膜侵袭以及软骨骨侵蚀,降低关节周围破骨细胞数量,抑制关节滑膜组织中的血管生成,降低核因子κB受体活化因子配体的表达,抑制FGFR1磷酸化蛋白、抗酒石酸酸性磷酸酶和血管内皮生长因子A的蛋白表达。②大鼠肝、脾、肾病理观察表明经过PD173074治疗后无明显的毒副作用。③研究证明了FGFR1抑制剂能够延缓Ⅱ型胶原诱导关节炎模型大鼠关节炎症及骨破坏的进展,并抑制血管的生成。初步验证了PD173074在Ⅱ型胶原诱导关节炎模型中的治疗作用,其可能是通过抑制FGFR1磷酸化发挥作用,为寻找类风湿性关节炎新的治疗靶点提供了方向。 展开更多
关键词 类风湿关节炎 PD173074 成纤维细胞生长因子受体1 胶原诱导型关节炎 动物模型 骨破坏 血管生成
下载PDF
Application of Modelica Based Multi- Domain Modeling and Simulation for Gravity-1
18
作者 ZHANG Chi BU Xiangwei +3 位作者 XU Lijie WU Kao HOU Shiyuan XU Guoguang 《Aerospace China》 2024年第1期47-55,共9页
In the R&D phase of Gravity-1(YL-1), a multi-domain modeling and simulation technology based on Modelica language was introduced, which was a recent attempt in the practice of modeling and simulation method for la... In the R&D phase of Gravity-1(YL-1), a multi-domain modeling and simulation technology based on Modelica language was introduced, which was a recent attempt in the practice of modeling and simulation method for launch vehicles in China. It realizes a complex coupling model within a unified model for different domains, so that technologists can work on one model. It ensured the success of YL-1 first launch mission, supports rapid iteration, full validation, and tight design collaboration. 展开更多
关键词 modelICA Gravity-1 simulation modeling launch vehicle model
下载PDF
Grey GRM(1, 1) Model Based on Reciprocal Accumulated Generating and Its Application
19
作者 Ruibiao Zou Haiyan Wu 《Applied Mathematics》 2012年第6期554-556,共3页
Aiming the problem of low accuracy during establishing grey model in which monotonically decreasing sequence data and traditional modeling methods are used, this paper applied the reciprocal accumulated generating and... Aiming the problem of low accuracy during establishing grey model in which monotonically decreasing sequence data and traditional modeling methods are used, this paper applied the reciprocal accumulated generating and the approach optimizing grey derivative which is based on three points to deduce the calculation formulas for model parameters, established grey GRM(1, 1) model based on reciprocal accumulated generating. It provides a new method for the grey modeling. The example validates the practicability and reliability of the proposed model. 展开更多
关键词 Reciprocal Accumulated GENERATING grey GRM model DATA PROCESSING grey modelING
下载PDF
GREY DISPLACEMENT INPUT-OUTPUT MODELS OF MINERAL PROCESSING-METALLURGY SYSTEM
20
作者 Han Xuli Li Songren(Department of Mineral Engineering, Central South University of Technology, Changsha, 410083) 《中国有色金属学会会刊:英文版》 CSCD 1995年第1期11-14,共4页
GREYDISPLACEMENTINPUT-OUTPUTMODELSOFMINERALPROCESSING-METALLURGYSYSTEMHan;XuliLi;Songren(DepartmentofMineral... GREYDISPLACEMENTINPUT-OUTPUTMODELSOFMINERALPROCESSING-METALLURGYSYSTEMHan;XuliLi;Songren(DepartmentofMineralEngineering,Centr... 展开更多
关键词 MINERAL processing-metallurgy system INPUT-OUTPUT grey theory economic model
下载PDF
上一页 1 2 244 下一页 到第
使用帮助 返回顶部