4-(1-Pyrrolyl)butanenitrile(4), the key intermediate for the synthesis of 1,2,3,4-tetrahydro-1-indolizinone, was prepared with Clauson-Kass reation. When pyrrole reacted with 4-bromobutanenitrile in PEG-400 dimethyl e...4-(1-Pyrrolyl)butanenitrile(4), the key intermediate for the synthesis of 1,2,3,4-tetrahydro-1-indolizinone, was prepared with Clauson-Kass reation. When pyrrole reacted with 4-bromobutanenitrile in PEG-400 dimethyl ether catalyzed by NaOH, 3-(1-pyrrolyl)butanenitrile was obtained. The nitriles were converted into the corresponding ketones by Hoesch reaction. Some of the ketone derivatives were prepared.展开更多
A β-cyclodextrin derivative, perbenzyl-β-cyclodextrin, was prepared and used as a chiral stationary phase for capillary gas chromatography. Using FID detector and the column temperature between 70 and 80℃, the chir...A β-cyclodextrin derivative, perbenzyl-β-cyclodextrin, was prepared and used as a chiral stationary phase for capillary gas chromatography. Using FID detector and the column temperature between 70 and 80℃, the chiral separations of racemic 3-phenyl-1, 2-epoxyethane and 1-phenyl-1-propanol on a 14m×0.23mm I. D. fused silica column with the β-cyclodextrin derivative were carried out and the optical purities of optically active 1-phenyl-1-propanol samples prepared by asymmetric synthesis were determined.展开更多
Aminoquinoline reacted with 5 bismethylthiomethylene or 5 methylthioalkylidene isopropylidene malonates under microwave irradiation as one pot reaction to afford a new convenient synthesis of 3 substituted 1(1H) pyrim...Aminoquinoline reacted with 5 bismethylthiomethylene or 5 methylthioalkylidene isopropylidene malonates under microwave irradiation as one pot reaction to afford a new convenient synthesis of 3 substituted 1(1H) pyrimidine [1,2 a] quinoline 1 ones. [WT5HZ]展开更多
文摘4-(1-Pyrrolyl)butanenitrile(4), the key intermediate for the synthesis of 1,2,3,4-tetrahydro-1-indolizinone, was prepared with Clauson-Kass reation. When pyrrole reacted with 4-bromobutanenitrile in PEG-400 dimethyl ether catalyzed by NaOH, 3-(1-pyrrolyl)butanenitrile was obtained. The nitriles were converted into the corresponding ketones by Hoesch reaction. Some of the ketone derivatives were prepared.
文摘A β-cyclodextrin derivative, perbenzyl-β-cyclodextrin, was prepared and used as a chiral stationary phase for capillary gas chromatography. Using FID detector and the column temperature between 70 and 80℃, the chiral separations of racemic 3-phenyl-1, 2-epoxyethane and 1-phenyl-1-propanol on a 14m×0.23mm I. D. fused silica column with the β-cyclodextrin derivative were carried out and the optical purities of optically active 1-phenyl-1-propanol samples prepared by asymmetric synthesis were determined.
文摘Aminoquinoline reacted with 5 bismethylthiomethylene or 5 methylthioalkylidene isopropylidene malonates under microwave irradiation as one pot reaction to afford a new convenient synthesis of 3 substituted 1(1H) pyrimidine [1,2 a] quinoline 1 ones. [WT5HZ]
