N-hydroxysuccinimide (HOSU) active esters have gained wide application in peptide synthesis, especially in the synthesis of longer peptides by segment conden sation, for they can avoid racemization during coupling pro...N-hydroxysuccinimide (HOSU) active esters have gained wide application in peptide synthesis, especially in the synthesis of longer peptides by segment conden sation, for they can avoid racemization during coupling processes. However, the HOSU active ester method is prone to side reactions, forming undesirable by-products such as succinimide-oxycarbonyl-alanine N-hydroxysuccinimide ester (Ⅰ) in activating steps and compound (Ⅱ) in the coupling steps sterically hindered by amino acids (proline, valine, isoleucine, etc.).展开更多
文摘N-hydroxysuccinimide (HOSU) active esters have gained wide application in peptide synthesis, especially in the synthesis of longer peptides by segment conden sation, for they can avoid racemization during coupling processes. However, the HOSU active ester method is prone to side reactions, forming undesirable by-products such as succinimide-oxycarbonyl-alanine N-hydroxysuccinimide ester (Ⅰ) in activating steps and compound (Ⅱ) in the coupling steps sterically hindered by amino acids (proline, valine, isoleucine, etc.).
