1,2-Disubstituted benzimidazoles are selectively synthesized in high yields under extremely mild conditions via the condensation of o-phenylenediamine derivatives with aldehyde derivatives using catalytic amount of i...1,2-Disubstituted benzimidazoles are selectively synthesized in high yields under extremely mild conditions via the condensation of o-phenylenediamine derivatives with aldehyde derivatives using catalytic amount of iron（Ⅲ） phosphate under solventfree conditions. The use of readily available iron（Ⅲ） phosphate as a reusable and recyelable catalyst makes this process quite simple, convenient, and environment-friendly.展开更多
We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of （bromoethynyl）benzene with Grignard reagents. The reaction of （bromoethynyl）benzene （1 mmol） wit...We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of （bromoethynyl）benzene with Grignard reagents. The reaction of （bromoethynyl）benzene （1 mmol） with Grignard reagent （1.3 mmol） mediated by NiCl2 （4 mol%） and （p-CH3Ph）3P （8 mol%） in THF could produce 1,2-disubstituted acetylenes in good yields at room temperature.展开更多
文摘1,2-Disubstituted benzimidazoles are selectively synthesized in high yields under extremely mild conditions via the condensation of o-phenylenediamine derivatives with aldehyde derivatives using catalytic amount of iron（Ⅲ） phosphate under solventfree conditions. The use of readily available iron（Ⅲ） phosphate as a reusable and recyelable catalyst makes this process quite simple, convenient, and environment-friendly.
基金financially supported by the Fundamental Research Funds for the Central Universities,Southwest University for Nationalities (No.12NZYTH03)the Natural Science Foundation of Southwest University for Nationalities (No.381010)+1 种基金the Project of Postgraduate Degree Construction,Southwest University for Nationalities (No.2013XWD-S0703)the State Administration of Foreign Experts Affairs project (No.2012-10)
文摘We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of （bromoethynyl）benzene with Grignard reagents. The reaction of （bromoethynyl）benzene （1 mmol） with Grignard reagent （1.3 mmol） mediated by NiCl2 （4 mol%） and （p-CH3Ph）3P （8 mol%） in THF could produce 1,2-disubstituted acetylenes in good yields at room temperature.
