1,4-Addition reaction of Grignard's reagent to 5-methoxy-2(5H)-furanone 1 was accomplished. which provided a new possible route for synthesizing beta -alkyl-Y-alkyloxy-Y-butyrolactone. A novel concise method of pr...1,4-Addition reaction of Grignard's reagent to 5-methoxy-2(5H)-furanone 1 was accomplished. which provided a new possible route for synthesizing beta -alkyl-Y-alkyloxy-Y-butyrolactone. A novel concise method of preparing fused heterocyclic compounds was offered by 1,3-dipolar cycloaddition reaction of silyl nitronates to 1.展开更多
facile one-step method is presented for the synthesis of indolizines in moder-ate to high yields by reaction of pyridinium, quinolinium and isoquinolinium ylideswith acrylonitrile, methyl acrylate and diethyl maleate ...facile one-step method is presented for the synthesis of indolizines in moder-ate to high yields by reaction of pyridinium, quinolinium and isoquinolinium ylideswith acrylonitrile, methyl acrylate and diethyl maleate respectively in the presenceof tetrakis-pyridino-cobalt(Ⅱ)dichromate (TPCD) in DMF.展开更多
1 Introduction Fullerene has received considerable attention and a great researching interest due to its unique structure and interesting properties[1―3]. Many functional groups have been introduced, often region- or...1 Introduction Fullerene has received considerable attention and a great researching interest due to its unique structure and interesting properties[1―3]. Many functional groups have been introduced, often region- or stereo-selectively, for tuning the physical properties of C60and for constructing supramoleculararchitectures^[4-6].展开更多
Several isoxazoline compounds were obtained by the 1,3-dipolar cycloaddition of benzonitrile oxide to 5-(R)-(l-menthyloxy)-2(5H)-furanone. The reaction condition was investigated preliminarily, the structures of thes...Several isoxazoline compounds were obtained by the 1,3-dipolar cycloaddition of benzonitrile oxide to 5-(R)-(l-menthyloxy)-2(5H)-furanone. The reaction condition was investigated preliminarily, the structures of these compounds have been established via the analysis of NMR data(involved NOEID or HMBC) and the reaction seems occurred regioselectively.展开更多
1, 3 Dipolar cycloaddition reaction between vinyl acetate and 3-hydroxypyridiniun betaine was performed under solid-liquid phase transfer catalytic condition, This reaction has been successfully used on the synthesis ...1, 3 Dipolar cycloaddition reaction between vinyl acetate and 3-hydroxypyridiniun betaine was performed under solid-liquid phase transfer catalytic condition, This reaction has been successfully used on the synthesis of an analogue of Bao-Gong-Teng A.展开更多
5-(1-Menthyloxy)-2(5-H)-furanone is used as s chiral dipolarophile for thermal asymmetric 1,3-dipolar cycloaddition reaction with C-phenyl-N-phenyl nitrone to give the diastereomerically pure cycloaddition product.
The 1.3-dipolar cycloaddition reaction of 2-trifluoromethyl- oxazolone and the activated carbon-carbon multiple bond was studied and gave a convenient way to synthesize 2-trifluoromethylpyrrole derivatives.
Comprehensive Summary,The Pd-catalyzed dipolar cycloaddition represents a significant synthetic strategy for the construction of useful heterocyclic compounds.This study developed the dipolar[4+2]and[6+2]cycloaddition...Comprehensive Summary,The Pd-catalyzed dipolar cycloaddition represents a significant synthetic strategy for the construction of useful heterocyclic compounds.This study developed the dipolar[4+2]and[6+2]cycloaddition reactions of benzo[d]isothiazole 1,1-dioxides(BDs)leading to the synthesis of BD-fused 1,3-oxazinane and 1,3-oxazocane derivatives,respectively.In particular,the synthesis of BD-fused 1,3-oxazinanes demonstrated regio-and enantioselective characteristics,resulting in products with good yields,enantioselectivity and regioselectivity(if applicable).Furthermore,the[6+2]cycloaddition reaction developed in this work represented the first strategy for the synthesis of medium-sized ring compounds based on BDs.展开更多
基金This work was supported by the NNSFC (No.29672004).
文摘1,4-Addition reaction of Grignard's reagent to 5-methoxy-2(5H)-furanone 1 was accomplished. which provided a new possible route for synthesizing beta -alkyl-Y-alkyloxy-Y-butyrolactone. A novel concise method of preparing fused heterocyclic compounds was offered by 1,3-dipolar cycloaddition reaction of silyl nitronates to 1.
文摘facile one-step method is presented for the synthesis of indolizines in moder-ate to high yields by reaction of pyridinium, quinolinium and isoquinolinium ylideswith acrylonitrile, methyl acrylate and diethyl maleate respectively in the presenceof tetrakis-pyridino-cobalt(Ⅱ)dichromate (TPCD) in DMF.
基金Supported by the National Natural Science Foundation of China(No.20402002)the Natural Science Foundation of Fujian Province,China (No.211J01031)+1 种基金the Project of Fujian Provincial Department of Education,China(No.JA11044)the Program for Excellent Young Researchers in Universities of Fujian Province,China(No.JA10056)
文摘1 Introduction Fullerene has received considerable attention and a great researching interest due to its unique structure and interesting properties[1―3]. Many functional groups have been introduced, often region- or stereo-selectively, for tuning the physical properties of C60and for constructing supramoleculararchitectures^[4-6].
文摘Several isoxazoline compounds were obtained by the 1,3-dipolar cycloaddition of benzonitrile oxide to 5-(R)-(l-menthyloxy)-2(5H)-furanone. The reaction condition was investigated preliminarily, the structures of these compounds have been established via the analysis of NMR data(involved NOEID or HMBC) and the reaction seems occurred regioselectively.
基金the Natural Science Foundation of Guangdong province (No. 970154).
文摘1, 3 Dipolar cycloaddition reaction between vinyl acetate and 3-hydroxypyridiniun betaine was performed under solid-liquid phase transfer catalytic condition, This reaction has been successfully used on the synthesis of an analogue of Bao-Gong-Teng A.
文摘5-(1-Menthyloxy)-2(5-H)-furanone is used as s chiral dipolarophile for thermal asymmetric 1,3-dipolar cycloaddition reaction with C-phenyl-N-phenyl nitrone to give the diastereomerically pure cycloaddition product.
文摘The 1.3-dipolar cycloaddition reaction of 2-trifluoromethyl- oxazolone and the activated carbon-carbon multiple bond was studied and gave a convenient way to synthesize 2-trifluoromethylpyrrole derivatives.
基金supported by the NSFC(22071210,22101033,22201023,22271242)the Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology(BM2012110)+1 种基金the Natural Science Foundation of Jiangsu Province(BK20210849)the Innovation&Entrepreneurship Talents Plan of Jiangsu Province(JSSCRC2021536).
文摘Comprehensive Summary,The Pd-catalyzed dipolar cycloaddition represents a significant synthetic strategy for the construction of useful heterocyclic compounds.This study developed the dipolar[4+2]and[6+2]cycloaddition reactions of benzo[d]isothiazole 1,1-dioxides(BDs)leading to the synthesis of BD-fused 1,3-oxazinane and 1,3-oxazocane derivatives,respectively.In particular,the synthesis of BD-fused 1,3-oxazinanes demonstrated regio-and enantioselective characteristics,resulting in products with good yields,enantioselectivity and regioselectivity(if applicable).Furthermore,the[6+2]cycloaddition reaction developed in this work represented the first strategy for the synthesis of medium-sized ring compounds based on BDs.
