A highly efficient method for the synthesis of unsymmetrical multi-substituted 1,2,3-triazoles via a direct Pd-NHC system catalyzed C（5）-arylation of 1,4-disubstituted triazoles, which are readily accessible via ＂c...A highly efficient method for the synthesis of unsymmetrical multi-substituted 1,2,3-triazoles via a direct Pd-NHC system catalyzed C（5）-arylation of 1,4-disubstituted triazoles, which are readily accessible via ＂click＂ chemistry has been developed. It is important to note that C--H bond functionalizations of 1,2,3-triazoles with a variety of differently substituted aryl iodides and bromides as electrophiles can be conveniently achieved through this catalytic system at significantly milder reaction temperatures of 100 ℃ under air.展开更多
A facile synthesis of 1,4-disubstituted 1,2,3-triazoles was achieved from nitrobenzenes and terminal alkynes under mild conditions. The reactions were successful for nitrobenzenes and terminal alkynes bearing various ...A facile synthesis of 1,4-disubstituted 1,2,3-triazoles was achieved from nitrobenzenes and terminal alkynes under mild conditions. The reactions were successful for nitrobenzenes and terminal alkynes bearing various functionalities, from which the 1,2,3-triazole derivatives were smoothly synthesized through a four-step one-pot sequence.展开更多
文摘A highly efficient method for the synthesis of unsymmetrical multi-substituted 1,2,3-triazoles via a direct Pd-NHC system catalyzed C（5）-arylation of 1,4-disubstituted triazoles, which are readily accessible via ＂click＂ chemistry has been developed. It is important to note that C--H bond functionalizations of 1,2,3-triazoles with a variety of differently substituted aryl iodides and bromides as electrophiles can be conveniently achieved through this catalytic system at significantly milder reaction temperatures of 100 ℃ under air.
基金the National Natural Science Foundation of China (Nos. 21262020 and 51464021)the Science and Technology Planning Project of Yunnan Province (No. KKSY201207140) for the financial support
文摘A facile synthesis of 1,4-disubstituted 1,2,3-triazoles was achieved from nitrobenzenes and terminal alkynes under mild conditions. The reactions were successful for nitrobenzenes and terminal alkynes bearing various functionalities, from which the 1,2,3-triazole derivatives were smoothly synthesized through a four-step one-pot sequence.
