Owing to the persisting hype in pushing toward global carbon neutrality,the study scope of atmospheric science is rapidly expanding.Among numerous trending topics,energy meteorology has been attracting the most attent...Owing to the persisting hype in pushing toward global carbon neutrality,the study scope of atmospheric science is rapidly expanding.Among numerous trending topics,energy meteorology has been attracting the most attention hitherto.One essential skill of solar energy meteorologists is solar power curve modeling,which seeks to map irradiance and auxiliary weather variables to solar power,by statistical and/or physical means.In this regard,this tutorial review aims to deliver a complete overview of those fundamental scientific and engineering principles pertaining to the solar power curve.Solar power curves can be modeled in two primary ways,one of regression and the other of model chain.Both classes of modeling approaches,alongside their hybridization and probabilistic extensions,which allow accuracy improvement and uncertainty quantification,are scrutinized and contrasted thoroughly in this review.展开更多
Eddy current dampers (ECDs) have emerged as highly desirable solutions for vibration control due to theirexceptional damping performance and durability. However, the existing constitutive models present challenges tot...Eddy current dampers (ECDs) have emerged as highly desirable solutions for vibration control due to theirexceptional damping performance and durability. However, the existing constitutive models present challenges tothe widespread implementation of ECD technology, and there is limited availability of finite element analysis (FEA)software capable of accurately modeling the behavior of ECDs. This study addresses these issues by developing anewconstitutivemodel that is both easily understandable and user-friendly for FEAsoftware. By utilizing numericalresults obtained from electromagnetic FEA, a novel power law constitutive model is proposed to capture thenonlinear behavior of ECDs. The effectiveness of the power law constitutive model is validated throughmechanicalproperty tests and numerical seismic analysis. Furthermore, a detailed description of the application process ofthe power law constitutive model in ANSYS FEA software is provided. To facilitate the preliminary design ofECDs, an analytical derivation of energy dissipation and parameter optimization for ECDs under harmonicmotionis performed. The results demonstrate that the power law constitutive model serves as a viable alternative forconducting dynamic analysis using FEA and optimizing parameters for ECDs.展开更多
Background:This study aimed to construct and characterize a humanized influenza mouse model expressing hST6GAL1.Methods:Humanized fragments,consisting of the endothelial cell-specific K18 promoter,human ST6GAL1-encodi...Background:This study aimed to construct and characterize a humanized influenza mouse model expressing hST6GAL1.Methods:Humanized fragments,consisting of the endothelial cell-specific K18 promoter,human ST6GAL1-encoding gene,and luciferase gene,were microinjected into the fertilized eggs of mice.The manipulated embryos were transferred into the oviducts of pseudopregnant female mice.The offspring were identified using PCR.Mice exhibiting elevated expression of the hST6GAL1 gene were selectively bred for propagation,and in vivo analysis was performed for screening.Expression of the humanized gene was tested by performing immunohistochemical(IHC)analysis.Hematologic and biochemical analyses using the whole blood and serum of humanized hST6GAL1 mice were performed.Results:Successful integration of the human ST6GAL1 gene into the mouse genome led to the overexpression of human SiaT ST6GAL1.Seven mice were identified as carrying copies of the humanized gene,and the in vivo analysis indicated that hST6GAL1gene expression in positive mice mirrored influenza virus infection characteristics.The IHC results revealed that hST6GAL1 was expressed in the lungs of humanized mice.Moreover,the hematologic and biochemical parameters of the positive mice were within the normal range.Conclusion:A humanized influenza mouse model expressing the hST6GAL1 gene was successfully established and characterized.展开更多
This study aims to thoroughly investigate the axial power peaking factors (PPF) within the low-enriched uranium (LEU) core of the Ghana Research Reactor-1 (GHARR-1). This study uses advanced simulation tools, like the...This study aims to thoroughly investigate the axial power peaking factors (PPF) within the low-enriched uranium (LEU) core of the Ghana Research Reactor-1 (GHARR-1). This study uses advanced simulation tools, like the MCNPX code for analysing neutron behavior and the PARET/ANL code for understanding power variations, to get a clearer picture of the reactor’s performance. The analysis covers the initial six years of GHARR-1’s operation and includes projections for its whole 60-year lifespan. We closely observed the patterns of both the highest and average PPFs at 21 axial nodes, with measurements taken every ten years. The findings of this study reveal important patterns in power distribution within the core, which are essential for improving the safety regulations and fuel management techniques of the reactor. We provide a meticulous approach, extensive data, and an analysis of the findings, highlighting the significance of continuous monitoring and analysis for proactive management of nuclear reactors. The findings of this study not only enhance our comprehension of nuclear reactor safety but also carry significant ramifications for sustainable energy progress in Ghana and the wider global context. Nuclear engineering is essential in tackling global concerns, such as the demand for clean and dependable energy sources. Research on optimising nuclear reactors, particularly in terms of safety and efficiency, is crucial for the ongoing advancement and acceptance of nuclear energy.展开更多
Atmospheric models are physical equations based on the ideal gas law. Applied to the atmosphere, this law yields equations for water, vapor (gas), ice, air, humidity, dryness, fire, and heat, thus defining the model o...Atmospheric models are physical equations based on the ideal gas law. Applied to the atmosphere, this law yields equations for water, vapor (gas), ice, air, humidity, dryness, fire, and heat, thus defining the model of key atmospheric parameters. The distribution of these parameters across the entire planet Earth is the origin of the formation of the climatic cycle, which is a normal climatic variation. To do this, the Earth is divided into eight (8) parts according to the number of key parameters to be defined in a physical representation of the model. Following this distribution, numerical models calculate the constants for the formation of water, vapor, ice, dryness, thermal energy (fire), heat, air, and humidity. These models vary in complexity depending on the indirect trigonometric direction and simplicity in the sum of neighboring models. Note that the constants obtained from the equations yield 275.156˚K (2.006˚C) for water, 273.1596˚K (0.00963˚C) for vapor, 273.1633˚K (0.0133˚C) for ice, 0.00365 in/s for atmospheric dryness, 1.996 in<sup>2</sup>/s for humidity, 2.993 in<sup>2</sup>/s for air, 1 J for thermal energy of fire, and 0.9963 J for heat. In summary, this study aims to define the main parameters and natural phenomena contributing to the modification of planetary climate. .展开更多
The China Fusion Engineering Test Reactor plans to build a 200 k V/25 A acceleration grid power supply(AGPS)for the negative-ion-based neutral beam injector prototype system.The AGPS uses a rectifier-inverter-isolated...The China Fusion Engineering Test Reactor plans to build a 200 k V/25 A acceleration grid power supply(AGPS)for the negative-ion-based neutral beam injector prototype system.The AGPS uses a rectifier-inverter-isolated step-up structure.There is a DC bus between the rectifier and the inverter.In order to limit DC bus voltage ripple and transient fluctuations,a large number of capacitors are used,which degrades the reliability of the power supply and occupies a large amount of space.This work finds that due to the difference in the turn-off time of the rectifier and the inverter,the capacitance mainly depends on the rectifier current when the inverter is turned off.On this basis,an active power filter(APF)scheme is proposed to absorb the current.To enhance the dynamic response ability of the APF,model predictive control is adopted.In this paper,the circuit structure of the APF is introduced,the prediction model is deduced,the corresponding control strategy and signal detection method are proposed,and the simulation and experimental results show that APF can track the transient current of the DC bus and reduce the voltage fluctuation significantly.展开更多
Photovoltaic(PV) power generation is characterized by randomness and intermittency due to weather changes.Consequently, large-scale PV power connections to the grid can threaten the stable operation of the power syste...Photovoltaic(PV) power generation is characterized by randomness and intermittency due to weather changes.Consequently, large-scale PV power connections to the grid can threaten the stable operation of the power system. An effective method to resolve this problem is to accurately predict PV power. In this study, an innovative short-term hybrid prediction model(i.e., HKSL) of PV power is established. The model combines K-means++, optimal similar day approach,and long short-term memory(LSTM) network. Historical power data and meteorological factors are utilized. This model searches for the best similar day based on the results of classifying weather types. Then, the data of similar day are inputted into the LSTM network to predict PV power. The validity of the hybrid model is verified based on the datasets from a PV power station in Shandong Province, China. Four evaluation indices, mean absolute error, root mean square error(RMSE),normalized RMSE, and mean absolute deviation, are employed to assess the performance of the HKSL model. The RMSE of the proposed model compared with those of Elman, LSTM, HSE(hybrid model combining similar day approach and Elman), HSL(hybrid model combining similar day approach and LSTM), and HKSE(hybrid model combining K-means++,similar day approach, and LSTM) decreases by 66.73%, 70.22%, 65.59%, 70.51%, and 18.40%, respectively. This proves the reliability and excellent performance of the proposed hybrid model in predicting power.展开更多
Parkinson’s disease(PD)relates to defective mitochondrial quality control in the dopaminergic motor network.Genetic studies have revealed that PINK1 and Parkin mutations are indicative of a heightened propensity to P...Parkinson’s disease(PD)relates to defective mitochondrial quality control in the dopaminergic motor network.Genetic studies have revealed that PINK1 and Parkin mutations are indicative of a heightened propensity to PD onset,pinpointing mitophagy and inflammation as the culprit pathways involved in neuronal loss in the substantia nigra(SNpc).In a reciprocal manner,LRRK2 functions in the regulation of basal flux and inflammatory responses responsible for PINK1/Parkin-dependent mitophagy activation.Pharmacological intervention in these diseasemodifying pathways may facilitate the development of novel PD therapeutics,despite the current lack of an established drug evaluation model.As such,we reviewed the feasibility of employing the versatile global Pink1knockout(KO)rat model as a self-sufficient,spontaneous PD model for investigating both disease etiology and drug pharmacology.These rats retain clinical features encompassing basal mitophagic flux changes with PD progression.We demonstrate the versatility of this PD rat model based on the incorporation of additional experimental insults to recapitulate the proinflammatory responses observed in PD patients.展开更多
This paper presents an approach for estimating power of the score test, based on an asymptotic approximation to the power of the score test under contiguous alternatives. The method is applied to the problem of power ...This paper presents an approach for estimating power of the score test, based on an asymptotic approximation to the power of the score test under contiguous alternatives. The method is applied to the problem of power calculations for the score test of heteroscedasticity in European rabbit data (Ratkowsky, 1983). Simulation studies are presented which indicate that the asymptotic approximation to the finite-sample situation is good over a wide range of parameter configurations.展开更多
The classical minimization of power losses in transmission lines is dominated by artificial intelligence techniques, which do not guarantee global optimum amidst local minima. Revolutionary and evolutionary techniques...The classical minimization of power losses in transmission lines is dominated by artificial intelligence techniques, which do not guarantee global optimum amidst local minima. Revolutionary and evolutionary techniques are encumbered with sophisticated transformations, which weaken the techniques. Power loss minimization is crucial to the efficient design and operation of power transmission lines. Minimization of losses is one way to meet steady grid supply, especially at peak demand. Thus, this paper has presented a gradient technique to obtain optimal variables and values from the power loss model, which efficiently minimizes power losses by modifying the traditional power loss model that combines Ohm and Corona losses. Optimality tests showed that the unmodified model does not support the minimization of power losses on transmission lines as the Hessian matrix portrayed the maximization of power losses. However, the modified model is consistent with the gradient method of optimization, which yielded optimum variables and values from the power loss model developed in this study. The unmodified (modified) models for Bujagali-Kawanda 220 kV and Masaka West-Mbarara North 132 kV transmission lines in Uganda showed maximum power losses of 0.406 (0.391) and 0.452 (0.446) kW/km/phase respectively. These results indicate that the modified model is superior to the unmodified model in minimizing power losses in the transmission lines and should be implemented for the efficient design and operation of power transmission lines within and outside Uganda for the same transmission voltages.展开更多
At present,the database cache model of power information system has problems such as slow running speed and low database hit rate.To this end,this paper proposes a database cache model for power information systems ba...At present,the database cache model of power information system has problems such as slow running speed and low database hit rate.To this end,this paper proposes a database cache model for power information systems based on deep machine learning.The caching model includes program caching,Structured Query Language(SQL)preprocessing,and core caching modules.Among them,the method to improve the efficiency of the statement is to adjust operations such as multi-table joins and replacement keywords in the SQL optimizer.Build predictive models using boosted regression trees in the core caching module.Generate a series of regression tree models using machine learning algorithms.Analyze the resource occupancy rate in the power information system to dynamically adjust the voting selection of the regression tree.At the same time,the voting threshold of the prediction model is dynamically adjusted.By analogy,the cache model is re-initialized.The experimental results show that the model has a good cache hit rate and cache efficiency,and can improve the data cache performance of the power information system.It has a high hit rate and short delay time,and always maintains a good hit rate even under different computer memory;at the same time,it only occupies less space and less CPU during actual operation,which is beneficial to power The information system operates efficiently and quickly.展开更多
The morbidity problem of the GM(1,1) power model in parameter identification is discussed by using multiple and rotation transformation of vectors. Firstly we consider the morbidity problem of the special matrix and...The morbidity problem of the GM(1,1) power model in parameter identification is discussed by using multiple and rotation transformation of vectors. Firstly we consider the morbidity problem of the special matrix and prove that the condition number of the coefficient matrix is determined by the ratio of lengths and the included angle of the column vector, which could be adjusted by multiple and rotation transformation to turn the matrix to a well-conditioned one. Then partition the corresponding matrix of the GM(1,1) power model in accordance with the column vector and regulate the matrix to a well-conditioned one by multiple and rotation transformation of vectors, which completely solve the instability problem of the GM(1,1) power model. Numerical results show that vector transformation is a new method in studying the stability problem of the GM(1,1) power model.展开更多
To accommodate wind power as safely as possible and deal with the uncertainties of the output power of winddriven generators,a min-max-min two-stage robust optimization model is presented,considering the unit commitme...To accommodate wind power as safely as possible and deal with the uncertainties of the output power of winddriven generators,a min-max-min two-stage robust optimization model is presented,considering the unit commitment,source-network load collaboration,and control of the load demand response.After the constraint functions are linearized,the original problem is decomposed into the main problem and subproblem as a matrix using the strong dual method.The minimum-maximum of the original problem was continuously maximized using the iterative method,and the optimal solution was finally obtained.The constraint conditions expressed by the matrix may reduce the calculation time,and the upper and lower boundaries of the original problem may rapidly converge.The results of the example show that the injected nodes of the wind farms in the power grid should be selected appropriately;otherwise,it is easy to cause excessive accommodation of wind power at some nodes,leading to a surge in reserve costs and the load demand response is continuously optimized to reduce the inverse peak regulation characteristics of wind power.Thus,the most economical optimization scheme for the worst scenario of the output power of the generators is obtained,which proves the economy and reliability of the two-stage robust optimization method.展开更多
The in-core self-powered neutron detector(SPND)acts as a key measuring device for the monitoring of parameters and evaluation of the operating conditions of nuclear reactors.Prompt detection and tolerance of faulty SP...The in-core self-powered neutron detector(SPND)acts as a key measuring device for the monitoring of parameters and evaluation of the operating conditions of nuclear reactors.Prompt detection and tolerance of faulty SPNDs are indispensable for reliable reactor management.To completely extract the correlated state information of SPNDs,we constructed a twin model based on a generalized regression neural network(GRNN)that represents the common relationships among overall signals.Faulty SPNDs were determined because of the functional concordance of the twin model and real monitoring sys-tems,which calculated the error probability distribution between the model outputs and real values.Fault detection follows a tolerance phase to reinforce the stability of the twin model in the case of massive failures.A weighted K-nearest neighbor model was employed to reasonably reconstruct the values of the faulty signals and guarantee data purity.The experimental evaluation of the proposed method showed promising results,with excellent output consistency and high detection accuracy for both single-and multiple-point faulty SPNDs.For unexpected excessive failures,the proposed tolerance approach can efficiently repair fault behaviors and enhance the prediction performance of the twin model.展开更多
基金supported by the National Natural Science Foundation of China(project no.42375192),and the China Meteorological Administration Climate Change Special Program(CMA-CCSPproject no.QBZ202315)+2 种基金supported by the National Natural Science Foundation of China(project no.42030608)supported by the National Research,Development and Innovation Fund,project no.OTKA-FK 142702by the Hungarian Academy of Sciences through the Sustainable Development and Technologies National Programme(FFT NP FTA)and the János Bolyai Research Scholarship.
文摘Owing to the persisting hype in pushing toward global carbon neutrality,the study scope of atmospheric science is rapidly expanding.Among numerous trending topics,energy meteorology has been attracting the most attention hitherto.One essential skill of solar energy meteorologists is solar power curve modeling,which seeks to map irradiance and auxiliary weather variables to solar power,by statistical and/or physical means.In this regard,this tutorial review aims to deliver a complete overview of those fundamental scientific and engineering principles pertaining to the solar power curve.Solar power curves can be modeled in two primary ways,one of regression and the other of model chain.Both classes of modeling approaches,alongside their hybridization and probabilistic extensions,which allow accuracy improvement and uncertainty quantification,are scrutinized and contrasted thoroughly in this review.
文摘Eddy current dampers (ECDs) have emerged as highly desirable solutions for vibration control due to theirexceptional damping performance and durability. However, the existing constitutive models present challenges tothe widespread implementation of ECD technology, and there is limited availability of finite element analysis (FEA)software capable of accurately modeling the behavior of ECDs. This study addresses these issues by developing anewconstitutivemodel that is both easily understandable and user-friendly for FEAsoftware. By utilizing numericalresults obtained from electromagnetic FEA, a novel power law constitutive model is proposed to capture thenonlinear behavior of ECDs. The effectiveness of the power law constitutive model is validated throughmechanicalproperty tests and numerical seismic analysis. Furthermore, a detailed description of the application process ofthe power law constitutive model in ANSYS FEA software is provided. To facilitate the preliminary design ofECDs, an analytical derivation of energy dissipation and parameter optimization for ECDs under harmonicmotionis performed. The results demonstrate that the power law constitutive model serves as a viable alternative forconducting dynamic analysis using FEA and optimizing parameters for ECDs.
基金National Key Research and Development Program of China,Grant/Award Number:2021YFC2301403 and 2022YFF0711000。
文摘Background:This study aimed to construct and characterize a humanized influenza mouse model expressing hST6GAL1.Methods:Humanized fragments,consisting of the endothelial cell-specific K18 promoter,human ST6GAL1-encoding gene,and luciferase gene,were microinjected into the fertilized eggs of mice.The manipulated embryos were transferred into the oviducts of pseudopregnant female mice.The offspring were identified using PCR.Mice exhibiting elevated expression of the hST6GAL1 gene were selectively bred for propagation,and in vivo analysis was performed for screening.Expression of the humanized gene was tested by performing immunohistochemical(IHC)analysis.Hematologic and biochemical analyses using the whole blood and serum of humanized hST6GAL1 mice were performed.Results:Successful integration of the human ST6GAL1 gene into the mouse genome led to the overexpression of human SiaT ST6GAL1.Seven mice were identified as carrying copies of the humanized gene,and the in vivo analysis indicated that hST6GAL1gene expression in positive mice mirrored influenza virus infection characteristics.The IHC results revealed that hST6GAL1 was expressed in the lungs of humanized mice.Moreover,the hematologic and biochemical parameters of the positive mice were within the normal range.Conclusion:A humanized influenza mouse model expressing the hST6GAL1 gene was successfully established and characterized.
文摘This study aims to thoroughly investigate the axial power peaking factors (PPF) within the low-enriched uranium (LEU) core of the Ghana Research Reactor-1 (GHARR-1). This study uses advanced simulation tools, like the MCNPX code for analysing neutron behavior and the PARET/ANL code for understanding power variations, to get a clearer picture of the reactor’s performance. The analysis covers the initial six years of GHARR-1’s operation and includes projections for its whole 60-year lifespan. We closely observed the patterns of both the highest and average PPFs at 21 axial nodes, with measurements taken every ten years. The findings of this study reveal important patterns in power distribution within the core, which are essential for improving the safety regulations and fuel management techniques of the reactor. We provide a meticulous approach, extensive data, and an analysis of the findings, highlighting the significance of continuous monitoring and analysis for proactive management of nuclear reactors. The findings of this study not only enhance our comprehension of nuclear reactor safety but also carry significant ramifications for sustainable energy progress in Ghana and the wider global context. Nuclear engineering is essential in tackling global concerns, such as the demand for clean and dependable energy sources. Research on optimising nuclear reactors, particularly in terms of safety and efficiency, is crucial for the ongoing advancement and acceptance of nuclear energy.
文摘Atmospheric models are physical equations based on the ideal gas law. Applied to the atmosphere, this law yields equations for water, vapor (gas), ice, air, humidity, dryness, fire, and heat, thus defining the model of key atmospheric parameters. The distribution of these parameters across the entire planet Earth is the origin of the formation of the climatic cycle, which is a normal climatic variation. To do this, the Earth is divided into eight (8) parts according to the number of key parameters to be defined in a physical representation of the model. Following this distribution, numerical models calculate the constants for the formation of water, vapor, ice, dryness, thermal energy (fire), heat, air, and humidity. These models vary in complexity depending on the indirect trigonometric direction and simplicity in the sum of neighboring models. Note that the constants obtained from the equations yield 275.156˚K (2.006˚C) for water, 273.1596˚K (0.00963˚C) for vapor, 273.1633˚K (0.0133˚C) for ice, 0.00365 in/s for atmospheric dryness, 1.996 in<sup>2</sup>/s for humidity, 2.993 in<sup>2</sup>/s for air, 1 J for thermal energy of fire, and 0.9963 J for heat. In summary, this study aims to define the main parameters and natural phenomena contributing to the modification of planetary climate. .
基金supported in part by the National Key Research and Development Program of China(No.2017YFE0300104)in part by National Natural Science Foundation of China(No.51821005)。
文摘The China Fusion Engineering Test Reactor plans to build a 200 k V/25 A acceleration grid power supply(AGPS)for the negative-ion-based neutral beam injector prototype system.The AGPS uses a rectifier-inverter-isolated step-up structure.There is a DC bus between the rectifier and the inverter.In order to limit DC bus voltage ripple and transient fluctuations,a large number of capacitors are used,which degrades the reliability of the power supply and occupies a large amount of space.This work finds that due to the difference in the turn-off time of the rectifier and the inverter,the capacitance mainly depends on the rectifier current when the inverter is turned off.On this basis,an active power filter(APF)scheme is proposed to absorb the current.To enhance the dynamic response ability of the APF,model predictive control is adopted.In this paper,the circuit structure of the APF is introduced,the prediction model is deduced,the corresponding control strategy and signal detection method are proposed,and the simulation and experimental results show that APF can track the transient current of the DC bus and reduce the voltage fluctuation significantly.
基金supported by the No. 4 National Project in 2022 of the Ministry of Emergency Response (2022YJBG04)the International Clean Energy Talent Program (201904100014)。
文摘Photovoltaic(PV) power generation is characterized by randomness and intermittency due to weather changes.Consequently, large-scale PV power connections to the grid can threaten the stable operation of the power system. An effective method to resolve this problem is to accurately predict PV power. In this study, an innovative short-term hybrid prediction model(i.e., HKSL) of PV power is established. The model combines K-means++, optimal similar day approach,and long short-term memory(LSTM) network. Historical power data and meteorological factors are utilized. This model searches for the best similar day based on the results of classifying weather types. Then, the data of similar day are inputted into the LSTM network to predict PV power. The validity of the hybrid model is verified based on the datasets from a PV power station in Shandong Province, China. Four evaluation indices, mean absolute error, root mean square error(RMSE),normalized RMSE, and mean absolute deviation, are employed to assess the performance of the HKSL model. The RMSE of the proposed model compared with those of Elman, LSTM, HSE(hybrid model combining similar day approach and Elman), HSL(hybrid model combining similar day approach and LSTM), and HKSE(hybrid model combining K-means++,similar day approach, and LSTM) decreases by 66.73%, 70.22%, 65.59%, 70.51%, and 18.40%, respectively. This proves the reliability and excellent performance of the proposed hybrid model in predicting power.
基金supported by the KIZ-CUHK Joint Lab of Bioresources and Molecular Research of Common Diseases(4750378)the VC Discretionary Fund provided to the Hong Kong Branch of Chinese Academy of Science Center for Excellence in Animal Evolution and Genetics(Acc 8601011)partially by the State Key Laboratory CUHKJinan MOE Key Laboratory for Regenerative medicine(2622009)。
文摘Parkinson’s disease(PD)relates to defective mitochondrial quality control in the dopaminergic motor network.Genetic studies have revealed that PINK1 and Parkin mutations are indicative of a heightened propensity to PD onset,pinpointing mitophagy and inflammation as the culprit pathways involved in neuronal loss in the substantia nigra(SNpc).In a reciprocal manner,LRRK2 functions in the regulation of basal flux and inflammatory responses responsible for PINK1/Parkin-dependent mitophagy activation.Pharmacological intervention in these diseasemodifying pathways may facilitate the development of novel PD therapeutics,despite the current lack of an established drug evaluation model.As such,we reviewed the feasibility of employing the versatile global Pink1knockout(KO)rat model as a self-sufficient,spontaneous PD model for investigating both disease etiology and drug pharmacology.These rats retain clinical features encompassing basal mitophagic flux changes with PD progression.We demonstrate the versatility of this PD rat model based on the incorporation of additional experimental insults to recapitulate the proinflammatory responses observed in PD patients.
基金Supported by SSFC(04BTJ002),the National Natural Science Foundation of China(10371016) and the Post-Doctorial Grant in Southeast University.
文摘This paper presents an approach for estimating power of the score test, based on an asymptotic approximation to the power of the score test under contiguous alternatives. The method is applied to the problem of power calculations for the score test of heteroscedasticity in European rabbit data (Ratkowsky, 1983). Simulation studies are presented which indicate that the asymptotic approximation to the finite-sample situation is good over a wide range of parameter configurations.
文摘The classical minimization of power losses in transmission lines is dominated by artificial intelligence techniques, which do not guarantee global optimum amidst local minima. Revolutionary and evolutionary techniques are encumbered with sophisticated transformations, which weaken the techniques. Power loss minimization is crucial to the efficient design and operation of power transmission lines. Minimization of losses is one way to meet steady grid supply, especially at peak demand. Thus, this paper has presented a gradient technique to obtain optimal variables and values from the power loss model, which efficiently minimizes power losses by modifying the traditional power loss model that combines Ohm and Corona losses. Optimality tests showed that the unmodified model does not support the minimization of power losses on transmission lines as the Hessian matrix portrayed the maximization of power losses. However, the modified model is consistent with the gradient method of optimization, which yielded optimum variables and values from the power loss model developed in this study. The unmodified (modified) models for Bujagali-Kawanda 220 kV and Masaka West-Mbarara North 132 kV transmission lines in Uganda showed maximum power losses of 0.406 (0.391) and 0.452 (0.446) kW/km/phase respectively. These results indicate that the modified model is superior to the unmodified model in minimizing power losses in the transmission lines and should be implemented for the efficient design and operation of power transmission lines within and outside Uganda for the same transmission voltages.
文摘At present,the database cache model of power information system has problems such as slow running speed and low database hit rate.To this end,this paper proposes a database cache model for power information systems based on deep machine learning.The caching model includes program caching,Structured Query Language(SQL)preprocessing,and core caching modules.Among them,the method to improve the efficiency of the statement is to adjust operations such as multi-table joins and replacement keywords in the SQL optimizer.Build predictive models using boosted regression trees in the core caching module.Generate a series of regression tree models using machine learning algorithms.Analyze the resource occupancy rate in the power information system to dynamically adjust the voting selection of the regression tree.At the same time,the voting threshold of the prediction model is dynamically adjusted.By analogy,the cache model is re-initialized.The experimental results show that the model has a good cache hit rate and cache efficiency,and can improve the data cache performance of the power information system.It has a high hit rate and short delay time,and always maintains a good hit rate even under different computer memory;at the same time,it only occupies less space and less CPU during actual operation,which is beneficial to power The information system operates efficiently and quickly.
基金supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China(20120143110001)the General Education Program Requirements in the Humanities and Social Sciences of China(11YJC630155)the Youth Foundation of Hubei Province of China(Q20121203)
文摘The morbidity problem of the GM(1,1) power model in parameter identification is discussed by using multiple and rotation transformation of vectors. Firstly we consider the morbidity problem of the special matrix and prove that the condition number of the coefficient matrix is determined by the ratio of lengths and the included angle of the column vector, which could be adjusted by multiple and rotation transformation to turn the matrix to a well-conditioned one. Then partition the corresponding matrix of the GM(1,1) power model in accordance with the column vector and regulate the matrix to a well-conditioned one by multiple and rotation transformation of vectors, which completely solve the instability problem of the GM(1,1) power model. Numerical results show that vector transformation is a new method in studying the stability problem of the GM(1,1) power model.
基金supported by the Special Research Project on Power Planning of the Guangdong Power Grid Co.,Ltd.
文摘To accommodate wind power as safely as possible and deal with the uncertainties of the output power of winddriven generators,a min-max-min two-stage robust optimization model is presented,considering the unit commitment,source-network load collaboration,and control of the load demand response.After the constraint functions are linearized,the original problem is decomposed into the main problem and subproblem as a matrix using the strong dual method.The minimum-maximum of the original problem was continuously maximized using the iterative method,and the optimal solution was finally obtained.The constraint conditions expressed by the matrix may reduce the calculation time,and the upper and lower boundaries of the original problem may rapidly converge.The results of the example show that the injected nodes of the wind farms in the power grid should be selected appropriately;otherwise,it is easy to cause excessive accommodation of wind power at some nodes,leading to a surge in reserve costs and the load demand response is continuously optimized to reduce the inverse peak regulation characteristics of wind power.Thus,the most economical optimization scheme for the worst scenario of the output power of the generators is obtained,which proves the economy and reliability of the two-stage robust optimization method.
基金supported by the Natural Science Foundation of Fujian Province,China(No.2022J01566).
文摘The in-core self-powered neutron detector(SPND)acts as a key measuring device for the monitoring of parameters and evaluation of the operating conditions of nuclear reactors.Prompt detection and tolerance of faulty SPNDs are indispensable for reliable reactor management.To completely extract the correlated state information of SPNDs,we constructed a twin model based on a generalized regression neural network(GRNN)that represents the common relationships among overall signals.Faulty SPNDs were determined because of the functional concordance of the twin model and real monitoring sys-tems,which calculated the error probability distribution between the model outputs and real values.Fault detection follows a tolerance phase to reinforce the stability of the twin model in the case of massive failures.A weighted K-nearest neighbor model was employed to reasonably reconstruct the values of the faulty signals and guarantee data purity.The experimental evaluation of the proposed method showed promising results,with excellent output consistency and high detection accuracy for both single-and multiple-point faulty SPNDs.For unexpected excessive failures,the proposed tolerance approach can efficiently repair fault behaviors and enhance the prediction performance of the twin model.