Atmospheric models are physical equations based on the ideal gas law. Applied to the atmosphere, this law yields equations for water, vapor (gas), ice, air, humidity, dryness, fire, and heat, thus defining the model o...Atmospheric models are physical equations based on the ideal gas law. Applied to the atmosphere, this law yields equations for water, vapor (gas), ice, air, humidity, dryness, fire, and heat, thus defining the model of key atmospheric parameters. The distribution of these parameters across the entire planet Earth is the origin of the formation of the climatic cycle, which is a normal climatic variation. To do this, the Earth is divided into eight (8) parts according to the number of key parameters to be defined in a physical representation of the model. Following this distribution, numerical models calculate the constants for the formation of water, vapor, ice, dryness, thermal energy (fire), heat, air, and humidity. These models vary in complexity depending on the indirect trigonometric direction and simplicity in the sum of neighboring models. Note that the constants obtained from the equations yield 275.156˚K (2.006˚C) for water, 273.1596˚K (0.00963˚C) for vapor, 273.1633˚K (0.0133˚C) for ice, 0.00365 in/s for atmospheric dryness, 1.996 in<sup>2</sup>/s for humidity, 2.993 in<sup>2</sup>/s for air, 1 J for thermal energy of fire, and 0.9963 J for heat. In summary, this study aims to define the main parameters and natural phenomena contributing to the modification of planetary climate. .展开更多
AIM:To investigate the possible role of chitinase3-like-1(CHI3L1)in the progression of colitis-associated carcinoma(CAC).METHODS:Thirty-four Balb/c mice were randomly assigned to five groups,including the control,CAC ...AIM:To investigate the possible role of chitinase3-like-1(CHI3L1)in the progression of colitis-associated carcinoma(CAC).METHODS:Thirty-four Balb/c mice were randomly assigned to five groups,including the control,CAC control,CAC+caffeine,colitis control and colitis+caffeine.Three animals were sacrificed every two weeks for blinded macroscopic inspection,histological analysis,and total RNA extraction.An immunofluorescent assay was performed using specimens from the colitis control and colitis+caffeine groups to investigate whether the protective effect of caffeine was associated with less oxidative DNA damage.In vitro,HT29 cells prestimulated with different concentrations of recombinant CHI3L1 protein and H2O2 were loaded with the DCFHDA fluorescent probe to determine the effect of CHI3L1on intracellular reactive oxygen species production.RESULTS:CHI3L1 mRNA was increased during the progression of colon carcinogenesis.Tumors were mostly located in the distal end of the colon where the expression of CHI3L1 was higher than in the proximal colon.Caffeine-treated mice developed fewer tumors and milder inflammation than untreated mice.CHI3L1protein increased reactive oxygen species in HT29 cells when exposed to H2O2.CONCLUSION:Caffeine reduces tumor incidence by decreasing oxidative DNA damage.CHI3L1 may contribute to CAC by increasing reactive oxygen species production.展开更多
An improved procedure for the preparation of China, BAD(P)H model. (S_s)- 1 -benzyl-3- (p-tolylsulfinyl)-1.4-dihydropyridine with satisfactary chemical yield and excellent enantiopurity is reported.
在101.32 k Pa下,用改进的Othmer釜测定了含离子液体1-乙基-3-甲基咪唑三氟甲磺酸盐([emim]OTf)的乙酸乙酯-乙腈物系的等压汽液平衡数据;采用NRTL方程对实验数据进行关联,关联效果良好。实验结果表明,加入[emim]OTf后,乙酸乙酯-乙腈二...在101.32 k Pa下,用改进的Othmer釜测定了含离子液体1-乙基-3-甲基咪唑三氟甲磺酸盐([emim]OTf)的乙酸乙酯-乙腈物系的等压汽液平衡数据;采用NRTL方程对实验数据进行关联,关联效果良好。实验结果表明,加入[emim]OTf后,乙酸乙酯-乙腈二组分物系汽液平衡线发生偏离,[emim]OTf含量越高,偏离程度越大;[emim]OTf具有明显的盐析效应,当[emim]·OTf的含量达到5%(x)时,就可消除乙酸乙酯-乙腈物系的共沸点;[emim]OTf可作为乙酸乙酯-乙腈萃取精馏的萃取剂。展开更多
文摘Atmospheric models are physical equations based on the ideal gas law. Applied to the atmosphere, this law yields equations for water, vapor (gas), ice, air, humidity, dryness, fire, and heat, thus defining the model of key atmospheric parameters. The distribution of these parameters across the entire planet Earth is the origin of the formation of the climatic cycle, which is a normal climatic variation. To do this, the Earth is divided into eight (8) parts according to the number of key parameters to be defined in a physical representation of the model. Following this distribution, numerical models calculate the constants for the formation of water, vapor, ice, dryness, thermal energy (fire), heat, air, and humidity. These models vary in complexity depending on the indirect trigonometric direction and simplicity in the sum of neighboring models. Note that the constants obtained from the equations yield 275.156˚K (2.006˚C) for water, 273.1596˚K (0.00963˚C) for vapor, 273.1633˚K (0.0133˚C) for ice, 0.00365 in/s for atmospheric dryness, 1.996 in<sup>2</sup>/s for humidity, 2.993 in<sup>2</sup>/s for air, 1 J for thermal energy of fire, and 0.9963 J for heat. In summary, this study aims to define the main parameters and natural phenomena contributing to the modification of planetary climate. .
基金Supported by National Natural Science Foundation of China,No.81170341
文摘AIM:To investigate the possible role of chitinase3-like-1(CHI3L1)in the progression of colitis-associated carcinoma(CAC).METHODS:Thirty-four Balb/c mice were randomly assigned to five groups,including the control,CAC control,CAC+caffeine,colitis control and colitis+caffeine.Three animals were sacrificed every two weeks for blinded macroscopic inspection,histological analysis,and total RNA extraction.An immunofluorescent assay was performed using specimens from the colitis control and colitis+caffeine groups to investigate whether the protective effect of caffeine was associated with less oxidative DNA damage.In vitro,HT29 cells prestimulated with different concentrations of recombinant CHI3L1 protein and H2O2 were loaded with the DCFHDA fluorescent probe to determine the effect of CHI3L1on intracellular reactive oxygen species production.RESULTS:CHI3L1 mRNA was increased during the progression of colon carcinogenesis.Tumors were mostly located in the distal end of the colon where the expression of CHI3L1 was higher than in the proximal colon.Caffeine-treated mice developed fewer tumors and milder inflammation than untreated mice.CHI3L1protein increased reactive oxygen species in HT29 cells when exposed to H2O2.CONCLUSION:Caffeine reduces tumor incidence by decreasing oxidative DNA damage.CHI3L1 may contribute to CAC by increasing reactive oxygen species production.
基金the National Natural Science Foundation of China ! 29672031 Fang Min FU of Chengdu institute of or
文摘An improved procedure for the preparation of China, BAD(P)H model. (S_s)- 1 -benzyl-3- (p-tolylsulfinyl)-1.4-dihydropyridine with satisfactary chemical yield and excellent enantiopurity is reported.
文摘在101.32 k Pa下,用改进的Othmer釜测定了含离子液体1-乙基-3-甲基咪唑三氟甲磺酸盐([emim]OTf)的乙酸乙酯-乙腈物系的等压汽液平衡数据;采用NRTL方程对实验数据进行关联,关联效果良好。实验结果表明,加入[emim]OTf后,乙酸乙酯-乙腈二组分物系汽液平衡线发生偏离,[emim]OTf含量越高,偏离程度越大;[emim]OTf具有明显的盐析效应,当[emim]·OTf的含量达到5%(x)时,就可消除乙酸乙酯-乙腈物系的共沸点;[emim]OTf可作为乙酸乙酯-乙腈萃取精馏的萃取剂。
