A new and novel class of bis(heterocycles) viz., bis pyrroles, pyrrolyl pyrazoles and pyrrolyl isoxazoles are prepared from 1-aroyl-2-styrylsulfonylethenes by 1,3-dipolar cycloaddition of tosylmethyl isocyanide, diazo...A new and novel class of bis(heterocycles) viz., bis pyrroles, pyrrolyl pyrazoles and pyrrolyl isoxazoles are prepared from 1-aroyl-2-styrylsulfonylethenes by 1,3-dipolar cycloaddition of tosylmethyl isocyanide, diazomethane, nitrile imines and nitrile oxides. The lead compounds are screened for antimicrobial activity.展开更多
The dynamic kinetic resolution of 2-aroyl-l-tetralones was achieved via asymmetric transfer hydrogenation using （S,S）-RuCl（p-cymene）TsDPEN （TsDPEN=N-（tosyl）-1,2-diphenylethylenediamine） in formic acid/triethyl...The dynamic kinetic resolution of 2-aroyl-l-tetralones was achieved via asymmetric transfer hydrogenation using （S,S）-RuCl（p-cymene）TsDPEN （TsDPEN=N-（tosyl）-1,2-diphenylethylenediamine） in formic acid/triethylamine （5 ： 2, molar ratio）, afforded the desired products in good yields （up to 85%） with diastereomeric ratio up to 〉99 ： 1 and high enantiomeric excesses （up to 〉99%）. The absolute configuration of major the product was con- firmed by X-ray crystal structure analysis.展开更多
文摘A new and novel class of bis(heterocycles) viz., bis pyrroles, pyrrolyl pyrazoles and pyrrolyl isoxazoles are prepared from 1-aroyl-2-styrylsulfonylethenes by 1,3-dipolar cycloaddition of tosylmethyl isocyanide, diazomethane, nitrile imines and nitrile oxides. The lead compounds are screened for antimicrobial activity.
文摘The dynamic kinetic resolution of 2-aroyl-l-tetralones was achieved via asymmetric transfer hydrogenation using （S,S）-RuCl（p-cymene）TsDPEN （TsDPEN=N-（tosyl）-1,2-diphenylethylenediamine） in formic acid/triethylamine （5 ： 2, molar ratio）, afforded the desired products in good yields （up to 85%） with diastereomeric ratio up to 〉99 ： 1 and high enantiomeric excesses （up to 〉99%）. The absolute configuration of major the product was con- firmed by X-ray crystal structure analysis.
