本文报道了Υ酸(7—氨基—1—萘酚—3—磺酸,简称H_2Υ)、邻菲咯啉(phen)的9种稀土(RE)三元固体配合物的制备方法,通过化学和元素分析确定了它们的化学组成,并测定了三元配合物的摩尔电导、磁化率;还用红外光谱、紫外光谱、核磁共振谱...本文报道了Υ酸(7—氨基—1—萘酚—3—磺酸,简称H_2Υ)、邻菲咯啉(phen)的9种稀土(RE)三元固体配合物的制备方法,通过化学和元素分析确定了它们的化学组成,并测定了三元配合物的摩尔电导、磁化率;还用红外光谱、紫外光谱、核磁共振谱、热谱及 x 射线粉末衍射进行了研究.展开更多
A simple,highly effective hydrogenation of chiral BINOL to provide H_4-BINOL in multigram scale with good yield（up to 78% yield） was developed.A series of heterogeneous catalysts was tested in the hydrogenation;;the...A simple,highly effective hydrogenation of chiral BINOL to provide H_4-BINOL in multigram scale with good yield（up to 78% yield） was developed.A series of heterogeneous catalysts was tested in the hydrogenation;;the best result was obtained with 5%Pd/ C in EtOH under the H_2 pressure of 50 bar for 2 h.This method is a more useful method for practical synthesis of optically pure H4- BINOL than other available methods.展开更多
The'electrochemical reduction characteristics of α-nitronaphthalene in sulfuric acidsolution were first reported in this paper. The results showed that the 1-amino-5-naphthol can beprepared by electrodeduction f...The'electrochemical reduction characteristics of α-nitronaphthalene in sulfuric acidsolution were first reported in this paper. The results showed that the 1-amino-5-naphthol can beprepared by electrodeduction from α-nitronaphthalene and reduction peak corresponding to thereaction of α-nitronaphthalene to 1-amino-3-naphthol was in the range of -0.40~0.60V(vs, D.H.E )on the amalgamated copper cathode in the presence of SnCl2 additives. The mechanism of α-nitronaphthalene electroreduction to 1-amino-5-naphthol was also investigated, the overallelectroreduction reaction was composed of two intermediate steps and two intermediate productsexisted in solution. The electrochemical reduction mechanism was similar to that of nitrobenzeneto para-aminophenol.展开更多
Agreen regioselective synthesis of some new and known 9-aryl-5,9-dihydropyrimido[4,5-d][l,2,4]triazolo[1,5-a]pyrimidine-6,8（4H,7H）-diones has been described via the microwave-assisted one-pot reaction of 3-amino-1H-...Agreen regioselective synthesis of some new and known 9-aryl-5,9-dihydropyrimido[4,5-d][l,2,4]triazolo[1,5-a]pyrimidine-6,8（4H,7H）-diones has been described via the microwave-assisted one-pot reaction of 3-amino-1H-1,2,4-triazoles,aromatic aldehydes and barbituric acids under solvent- and catalyst-free conditions.This operationally simple procedure is less laborious and provides a better scope than previously reported procedures.展开更多
Background C-Jun N-terminal kinase （JNK） signaling pathway plays a critical role in cerebral ischemia. Although the mechanistic basis for this activation of JNK1/2 is uncertain, oxidative stress may play a role. The...Background C-Jun N-terminal kinase （JNK） signaling pathway plays a critical role in cerebral ischemia. Although the mechanistic basis for this activation of JNK1/2 is uncertain, oxidative stress may play a role. The purpose of this study was to investigate whether the activation of JNK1/2 is associated with the production of endogenous nitric oxide （NO）. Methods Ischemia and reperfusion （I/R） was induced by cerebral four-vessel occlusion. Sprague-Dawley （SD） rats were divided into 6 groups： sham group, I/R group, neuronal nitric oxide synthase （nNOS） inhibitor （7-nitroindazole, 7-NI） given group, inducible nitric oxide synthase （iNOS） inhibitor （2-amino-5,6-dihydro-methylthiazine, AMT） given group, sodium chloride control group, and 1% dimethyl sulfoxide （DMSO） control group. The levels of protein expression and phospho-JNK1/2 were detected by Western blotting and the survival hippocampus neurons in CA1 zone were observed by cresyl violet staining. Results The study illustrated two peaks of JNK1/2 activation occurred at 30 minutes and 3 days during reperfusion. 7-NI inhibited JNK1/2 activation during the early reperfusion, whereas AMT preferably attenuated JNK1/2 activation during the later reperfusion. Administration of 7-NI and AMT can decrease I/R-induced neuronal loss in hippocampal CA1 region. Conclusion JNK1/2 activation is associated with endogenous NO in response to ischemic insult.展开更多
A variety of 2-arylnaphtho[ 1,2-d]oxazole derivatives were efficiently synthesized in moderate to high yields by the reaction of aromatic aldehydes with 1-amino-2-naphthol derivatives in the presence of triethylamine ...A variety of 2-arylnaphtho[ 1,2-d]oxazole derivatives were efficiently synthesized in moderate to high yields by the reaction of aromatic aldehydes with 1-amino-2-naphthol derivatives in the presence of triethylamine in refluxing ethanol in air. Seven new 2-arylnaphtho[1,2-d]oxazole derivatives were obtained and characterized by the spectral data and elemental analysis. In addition, the X-ray crystal structures of 2-[4-（N,N-dimethylamino）phenyl]naphtho[ 1,2-d] oxzole （3d） and 1, 1＇-bis（naphtho[ 1,2-d]oxazol-2-yl）ferrocene （3n） have been determined.展开更多
By capitalizing on the capability of photoredox catalysis to generate reactive radical intermediate under mild conditions, we established a photocatalytic cross-coupling protocol that could deliver both derivatives fr...By capitalizing on the capability of photoredox catalysis to generate reactive radical intermediate under mild conditions, we established a photocatalytic cross-coupling protocol that could deliver both derivatives from 1-bromo-2-naphthols in combination with 2-naphthols or 2-naphthylamines. This distinct activation mode could overcome structural or electronic limitation associated with conventional coupling pathways. Additionally, a novel kinetic resolution protocol of unprotected BINOLs has been established with azodicarboxylates via chiral phosphoric acid(CPA) catalysis. Selectivity factor of up to 175 could be achieved and delivered to both enantiomers in atropisomerically enriched form after a simple work-up.展开更多
基金supported by the Science and Technology Department of Zhejiang Province(no.2008C21041)was partially supported by the NSFC(no.20572101)
文摘A simple,highly effective hydrogenation of chiral BINOL to provide H_4-BINOL in multigram scale with good yield（up to 78% yield） was developed.A series of heterogeneous catalysts was tested in the hydrogenation;;the best result was obtained with 5%Pd/ C in EtOH under the H_2 pressure of 50 bar for 2 h.This method is a more useful method for practical synthesis of optically pure H4- BINOL than other available methods.
文摘The'electrochemical reduction characteristics of α-nitronaphthalene in sulfuric acidsolution were first reported in this paper. The results showed that the 1-amino-5-naphthol can beprepared by electrodeduction from α-nitronaphthalene and reduction peak corresponding to thereaction of α-nitronaphthalene to 1-amino-3-naphthol was in the range of -0.40~0.60V(vs, D.H.E )on the amalgamated copper cathode in the presence of SnCl2 additives. The mechanism of α-nitronaphthalene electroreduction to 1-amino-5-naphthol was also investigated, the overallelectroreduction reaction was composed of two intermediate steps and two intermediate productsexisted in solution. The electrochemical reduction mechanism was similar to that of nitrobenzeneto para-aminophenol.
文摘Agreen regioselective synthesis of some new and known 9-aryl-5,9-dihydropyrimido[4,5-d][l,2,4]triazolo[1,5-a]pyrimidine-6,8（4H,7H）-diones has been described via the microwave-assisted one-pot reaction of 3-amino-1H-1,2,4-triazoles,aromatic aldehydes and barbituric acids under solvent- and catalyst-free conditions.This operationally simple procedure is less laborious and provides a better scope than previously reported procedures.
基金This work was supported by a grant from the Project of China Postdoctoral Science Foundation （No. 20100480568）.
文摘Background C-Jun N-terminal kinase （JNK） signaling pathway plays a critical role in cerebral ischemia. Although the mechanistic basis for this activation of JNK1/2 is uncertain, oxidative stress may play a role. The purpose of this study was to investigate whether the activation of JNK1/2 is associated with the production of endogenous nitric oxide （NO）. Methods Ischemia and reperfusion （I/R） was induced by cerebral four-vessel occlusion. Sprague-Dawley （SD） rats were divided into 6 groups： sham group, I/R group, neuronal nitric oxide synthase （nNOS） inhibitor （7-nitroindazole, 7-NI） given group, inducible nitric oxide synthase （iNOS） inhibitor （2-amino-5,6-dihydro-methylthiazine, AMT） given group, sodium chloride control group, and 1% dimethyl sulfoxide （DMSO） control group. The levels of protein expression and phospho-JNK1/2 were detected by Western blotting and the survival hippocampus neurons in CA1 zone were observed by cresyl violet staining. Results The study illustrated two peaks of JNK1/2 activation occurred at 30 minutes and 3 days during reperfusion. 7-NI inhibited JNK1/2 activation during the early reperfusion, whereas AMT preferably attenuated JNK1/2 activation during the later reperfusion. Administration of 7-NI and AMT can decrease I/R-induced neuronal loss in hippocampal CA1 region. Conclusion JNK1/2 activation is associated with endogenous NO in response to ischemic insult.
基金Project supported by the National Natural Science Foundation of China （No. 20472074） and the Innovation found for 0utstanding Scholars of Henan Province （No. 0621001100）.
文摘A variety of 2-arylnaphtho[ 1,2-d]oxazole derivatives were efficiently synthesized in moderate to high yields by the reaction of aromatic aldehydes with 1-amino-2-naphthol derivatives in the presence of triethylamine in refluxing ethanol in air. Seven new 2-arylnaphtho[1,2-d]oxazole derivatives were obtained and characterized by the spectral data and elemental analysis. In addition, the X-ray crystal structures of 2-[4-（N,N-dimethylamino）phenyl]naphtho[ 1,2-d] oxzole （3d） and 1, 1＇-bis（naphtho[ 1,2-d]oxazol-2-yl）ferrocene （3n） have been determined.
基金supported by the National Natural Science Foundation of China (21825105)the Guangdong Provincial Key Laboratory of Catalysis (2020B121201002)+3 种基金the Guangdong Innovative Program (2019BT02Y335)the Shenzhen Special Funds (JCYJ20190812-112603598, JCYJ20210324120205016)the Shenzhen Nobel Prize Scientists Laboratory Project (C17213101)the SUSTech Special Fund for the Construction of High-Level Universities (G02216302)。
文摘By capitalizing on the capability of photoredox catalysis to generate reactive radical intermediate under mild conditions, we established a photocatalytic cross-coupling protocol that could deliver both derivatives from 1-bromo-2-naphthols in combination with 2-naphthols or 2-naphthylamines. This distinct activation mode could overcome structural or electronic limitation associated with conventional coupling pathways. Additionally, a novel kinetic resolution protocol of unprotected BINOLs has been established with azodicarboxylates via chiral phosphoric acid(CPA) catalysis. Selectivity factor of up to 175 could be achieved and delivered to both enantiomers in atropisomerically enriched form after a simple work-up.
