Preparation and Electrochemical Properties of 3-Pyridinyl-6-aryl-1,2,4-triazolo [3,4-b][1, 3,4]thiadiazoles

A series of 3-pyridinyl-6-aryl-l, 2, 4-triazolo[3, 4-b][1, 3, 4]thiadiazoles(PATT) were prepared, the structures were confirmed by IR and H NMR spectra. The results of cyclic 1 voltammetry measurements imply that all these compounds have a higher electron affinity (EA) than 2-(4-biphenyl)-5-(4-tert-butyl phenyl)-1, 3, 4-oxadiazole (PBD) which implies that PATT could be acting as better electron acceptors than widely used electron transporting material PBD.

A facile synthesis of 2,3-dihydro-2-aryl-4(1H)-quinazolinones catalyzed by scandium(Ⅲ) triflate

2,3-Dihydro-2-aryl-4（1H）-quinazolinones were prepared in good yields via condensation of o-aminobenzamide with aldehydes promoted by a catalytic amount of Sc（OTf）3 under mild conditions.

Synthesis of 5-Aryl-1, 2-dihydro-1-pyrrolizinones

In order to search for new potent anti-inflammatory and analgesic agents in pyrrolizinones, the title compounds were designed and synthesized. A series of the compounds were prepared with two different synthetic schemes. Some of the compounds showed remarkable anti-inflammatory and/or analgesic activities on mice.

Synthesis and Crystal Structure of 1,2-Dis(1,3-diphenylpropan-2-yl)disulfane

A novel compound of 1,2-dis（1,3-diphenylpropan-2-yl）disulfane（C30H30S2,Mr=454.27）was synthesized in ethanol with 1,3-diphenyl-2-propanone as raw materials,giving high yield of product（90%）.Its structure was determined by IR,1H NMR,MS,elemental analysis and X-ray diffraction.The crystal belongs to monoclinic,space group C2 with a=18.727（3）,b=6.5179（9）,c=13.7576（18）,β=131.0610（10）o,V=1266.2（3）3,Z=2,Dc=2.136 g/cm3,μ=1.078 mm-1,F（000）=843,R=0.0490 and wR=0.1247 for 3211 observed reflections with I2（I）.X-ray analysis reveals that the molecule is not symmetrical.There exist no classical hydrogen bonds andπ-πstacking interactions.Moreover,the thermal stability of compound 3 was investigated.

Synthesis of Some Hexahydroquinazolinones Using K₃AlF₆(Al₂O₃/KF) as an Efficient Catalyst in Some Hexahydroquinazolinone Derivatives

A protocol for the synthesis of some 4-Aryl-1,3,4,6,7,8-hexahydroquinazolin-2,5(1H,6H)-diones (HHQs) was developed by means of a three-component condensation reaction of an aromatic aldehyde, 1,3-cylohexadione and urea in the presence of K3AlF6 (Al2O3/KF) as catalyst. This reaction is carried out under different conditions including 1) solvent free;2) reflux in acetonitrile;3) reflux in ethanol;4) reflux in chloroform;and 5) reflux in water. In all conditions, the desired products are obtained in high yields after relatively short reaction times. Nevertheless, the reactions proceed faster and in higher yields when they were carried out in acetonitrile. This adopted protocol for some Biginelli-type products has offered the advantages of reusability of the catalyst, high yields and ease of separation of pure products. Furthermore, the catalyst is easily prepared, stabilized and efficiently used under reaction conditions.

Sulfuric acid {[3-(3-silicapropyl)sulfanyl]propyl}ester a recyclable catalyst for the synthesis of 2-aryl- 1-arylmethyl- 1H- 1,3-benzimidazole derivatives

A highly selective synthesis of 2-aryl-1-arylmethyl-1H-1,3-benzimidazoles from the reaction of o-phenylenediamine and aromatic aldehydes in the presence of sulfuric acid{[3-(3-silicapropyl)sulfanyl]propyl}ester(SASPSPE)in water and at 80℃in good to excellent yields.

Synthesis of 2-Aryl-l-arylmethyl-lH-1,3-benzimidazole Derivatives Using Silica-bonded PropyI-S-sulfonic Acid as Recyclable Solid Acid Catalyst

A highly selective synthesis of 2-aryl-l-arylmethyl-lH-1,3-benzimidazoles from the reaction of o-phenylene- diamine and aromatic aldehydes in the presence of silica-bonded propyl-S-sulfonic acid （SBSSA） at 80℃ in water in good to excellent yields was developed.

An Efficient Copper-Catalyzed One-Pot Synthesis of 1-Aryl-1,2,3-triazoles from Arylboronic Acids in Water under Mild Conditions

A convenient method for one-pot two-step 1,3-dipolar cycloadditon reaction of arylboronic acid, sodium azide followed with terminal alkynes in the presence of 2-pyrrolecarbaldiminato-Cu（Ⅱ） complexes catalyst is reported. Various 1-aryl-1,2,3-triazoles were prepared in 63%-97% yields in water at 30℃ without any additives and avoiding the isolation of unstable aryl azides.

Improved microwave-assisted catalyst-free synthesis of9-aryl-5,9-dihydropyrimido[4,5-d][1,2,4]triazolo[1,5-a]pyrimidine-6,8(4H,7H)-dione derivatives

Agreen regioselective synthesis of some new and known 9-aryl-5,9-dihydropyrimido[4,5-d][l,2,4]triazolo[1,5-a]pyrimidine-6,8（4H,7H）-diones has been described via the microwave-assisted one-pot reaction of 3-amino-1H-1,2,4-triazoles,aromatic aldehydes and barbituric acids under solvent- and catalyst-free conditions.This operationally simple procedure is less laborious and provides a better scope than previously reported procedures.

Synthesis and Antibacterial Activities of N- [（1-Aryl-3-phenyl-pyrazol- 4-yl）methylene]-2-（halo-o-hydroxyphenyl）hydrazide Derivatives

A series of novel N-[（1-aryl-3-phenyl-pyrazol-4-yl）methylene]-2-（halo-o-hydroxyphenyl）hydrazide derivatives was synthesized and the antibacterial activity of each of them was evaluated. The supposed reaction mechanism of acquiring compounds 3a--3d is that catalytic activity is enhanced by the electron-donating groups of the first phenyl ring while decreased by electron-withdrawing groups of that ring. The result of preliminary bioassay shows that the lowest minimal inhibitory concentration（MIC） of the title compounds against Escherichia coli is 2 ℃g/mL. MIC values against Monilia albiean and Staphloeoeeus aureus are as low as 4 ~g/mL. They will be a series of potential antibacterial compounds against fungi and gram-negative bacteria.

An environmentally friendly synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives catalyzed by tungstate sulfuric acid

An efficient three-component synthesis of 6-amino-4-aryl-5-cyano-3-metriyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazoles via a reaction between 3-methyl-1-phenyl-2-pyrazolin-5-one,aromatic aldehydes and malononitrile using tungstate sulfuric acid as a catalyst was described.Mild conditions,good to excellent yields,easily available catalyst and easy work-up are the key features of this method.

Synthesis of 3,3,5,5-tetrabenzyl-1,2,4-trithiol and 1,2-dis(1,3-arylpropan-2-yl)disulfane

Novel sulfur-containing compounds （3a-3c, 4a-4c） were obtained in ethanol with 1,3-diphenyl-2- propanone as the starting material. The advantages of this procedure were mild reaction conditions, simple protocol, and high yields. The structures of the products were characterized by IR, 1H NMR, MS and elementary analysis. The crystal of the new compound 4a belongs to monoclinic, space group C2 with a=18.727（3）, b=6.5179（9）, c=13.7576（18） A, fl=131.0610（10）°, V=I266.2（3）A3, Z=2, Dc=2.136g/cm3, μ=1.078mm 1, F（000）=843, R=0.0490 and wR=0.1247 for 3211 observed reflection with I 〉 2σ（I）. X-ray analysis reveals that the molecule is not symmetrical, the molecular structure is stabilized by weak π-π stacking interactions, and no classical hydrogen bonds can be observed.