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Synthesis, Structural Characterization and Antimicrobial Activity of a Novel Cobalt(II) Complex Based on 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One
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作者 Emeline Sorelle Mefouegang Claudelle Sybilline Anensong Djadock +5 位作者 Golngar Djimassingar Gabriel Tchuente Kamsu Donald Raoul Tchuifon Tchuifon Alain Charly Tagne Kuate Dirk Bockfeld Jean Ngoune 《Journal of Materials Science and Chemical Engineering》 2023年第8期109-126,共18页
New cobalt(II) complex, [Co(O<sub>2</sub>C<sub>15</sub>H<sub>11</sub>N<sub>2</sub>S)<sub>2</sub>(OH<sub>2</sub>)<sub>2</sub>]∙2H<s... New cobalt(II) complex, [Co(O<sub>2</sub>C<sub>15</sub>H<sub>11</sub>N<sub>2</sub>S)<sub>2</sub>(OH<sub>2</sub>)<sub>2</sub>]∙2H<sub>2</sub>O (1∙2H<sub>2</sub>O), has been synthesized upon reaction of cobalt chloride hexahydrate (Co(Cl)<sub>2</sub>∙6H<sub>2</sub>O) with 3-methyl-1-Phenyl-4-(2-thienoyl)-pyrazol-5-one (referred as HL) in ethanol at room temperature. Single crystal X-ray diffraction (XRD), spectroscopic methods, and microelemental analyses were used to characterize 1∙2H<sub>2</sub>O. Compound 1∙2H<sub>2</sub>O crystallizes in the orthorhombic crystal system with a Pbca space group and with the cobalt atom being pseudo-octahedral coordinated. The broth microdilution technique was used to screen the free ligand (HL) and the complex (1∙2H<sub>2</sub>O) for antimicrobial activities. HL has a low activity (MIC > 100 μg/mL) on all microorganisms, whereas compound 1∙2H<sub>2</sub>O displayed moderate activity (10 ∙2H<sub>2</sub>O exhibited bactericidal and fungicidal activity respectively on all the bacteria and yeasts tested. These findings reveal that the antimicrobial activity of HL was enhanced upon coordination to Co(II) ion against all microorganisms (bacteria and fungus). 展开更多
关键词 COBALT ACYLPYRAZOLONE X-Ray Diffraction Antimicrobial Activity 3-methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One
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Synthesis, Structural Characterization and Antimicrobial Activity of a Novel Cobalt(II) Complex Based on 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One
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作者 Emeline Sorelle Mefouegang Claudelle Sybilline Anensong Djadock +5 位作者 Golngar Djimassingar Gabriel Tchuente Kamsu Donald Raoul Tchuifon Tchuifon Alain Charly Tagne Kuate Dirk Bockfeld Jean Ngoune 《Journal of Modern Physics》 2023年第8期109-126,共12页
New cobalt(II) complex, [Co(O<sub>2</sub>C<sub>15</sub>H<sub>11</sub>N<sub>2</sub>S)<sub>2</sub>(OH<sub>2</sub>)<sub>2</sub>]∙2H<s... New cobalt(II) complex, [Co(O<sub>2</sub>C<sub>15</sub>H<sub>11</sub>N<sub>2</sub>S)<sub>2</sub>(OH<sub>2</sub>)<sub>2</sub>]∙2H<sub>2</sub>O (1∙2H<sub>2</sub>O), has been synthesized upon reaction of cobalt chloride hexahydrate (Co(Cl)<sub>2</sub>∙6H<sub>2</sub>O) with 3-methyl-1-Phenyl-4-(2-thienoyl)-pyrazol-5-one (referred as HL) in ethanol at room temperature. Single crystal X-ray diffraction (XRD), spectroscopic methods, and microelemental analyses were used to characterize 1∙2H<sub>2</sub>O. Compound 1∙2H<sub>2</sub>O crystallizes in the orthorhombic crystal system with a Pbca space group and with the cobalt atom being pseudo-octahedral coordinated. The broth microdilution technique was used to screen the free ligand (HL) and the complex (1∙2H<sub>2</sub>O) for antimicrobial activities. HL has a low activity (MIC > 100 μg/mL) on all microorganisms, whereas compound 1∙2H<sub>2</sub>O displayed moderate activity (10 ∙2H<sub>2</sub>O exhibited bactericidal and fungicidal activity respectively on all the bacteria and yeasts tested. These findings reveal that the antimicrobial activity of HL was enhanced upon coordination to Co(II) ion against all microorganisms (bacteria and fungus). 展开更多
关键词 COBALT ACYLPYRAZOLONE X-Ray Diffraction Antimicrobial Activity 3-methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One
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Synthesis and Crystal Structure of Ethyl 3-(4-Chlorophenyl)-3,4-dihydro-6-methyl-4-oxo-2-(pyrrolidin-1-yl)furo[2,3-d]pyrimidine-5-carboxylate 被引量:2
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作者 胡扬根 徐靖 丁明武 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2009年第6期689-692,共4页
The crystal structure of the title compound ethyl 3-(4-chlorophenyl)-3,4-dihydro-6- methyl-4-oxo-2-(pyrrolidin-1-yl)furo[2,3-d]pyrimidine-5-carboxylate (C20H20ClN3O4, Mr= 401.84) has been prepared and determined... The crystal structure of the title compound ethyl 3-(4-chlorophenyl)-3,4-dihydro-6- methyl-4-oxo-2-(pyrrolidin-1-yl)furo[2,3-d]pyrimidine-5-carboxylate (C20H20ClN3O4, Mr= 401.84) has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n with a = 20.6215(9), b = 8.5311(4), c = 21.6886(9) A^°, β = 91.607(1)°, V = 3814.0(3)A^°^3, Z = 8, Dc = 1.400 g/cm^3, F(000) = 1680, μ = 0.233 mm^-1, R = 0.0718 and wR = 0.1545 for 6717 observed reflections with I 〉 2σ(I). X-ray diffraction analysis reveals two crystallographically independent molecules in the asymmetric unit. 展开更多
关键词 crystal structure ethyl 3-(4-ehlorophenyl)-3 4-dihydro-6-methyl-4-oxo-2- pyrrolidin-1-yl)furo[2 3-d]pyrimidine-5-earboxylate aza-Wittig reaction synthesis
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Dissolution Properties of 2-(Dinitromethylene)-5-methyl-1,3-diazacyclopentane in Dimethyl Sulfoxide and N-Methyl Pyrrolidone 被引量:2
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作者 XIAO Li-bai XING Xiao-ling +4 位作者 ZHAO Feng-qi XU Kang-zheng YAO Er-gang TAN Yi HAO Hai-xia 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2012年第4期743-746,共4页
The molar enthalpies of dissolution for 2-(dinitromethylene)-5-methyl-1,3-diazacyclopentane(DNMDZ) in dimethyl sulfoxide(DMSO) and N-methyl pyrrolidone(NMP) were measured using an RD496-2000 Calvet microcalori... The molar enthalpies of dissolution for 2-(dinitromethylene)-5-methyl-1,3-diazacyclopentane(DNMDZ) in dimethyl sulfoxide(DMSO) and N-methyl pyrrolidone(NMP) were measured using an RD496-2000 Calvet microcalorimeter at 298.15 K under atmospheric pressure.Empirical formulae for the calculation of the molar enthalpies of dissolution(Δ diss H) were obtained from the experimental data of the dissolution processes of DNMDZ in DMSO or NMP.The relationships between the rate constant(k) and the molality(b) and between the reaction order(n) and the molality(b) were determined.The corresponding kinetic equations describing the two dissolution processes were dα/dt=10^-2.16(1-α) ^1.01 for the dissolution of DNMDZ in DMSO,and dα/dt=10^-2.02(1-α)^ 0.85 for the dissolution of DNMDZ in NMP,respectively. 展开更多
关键词 2-(Dinitromethylene)-5-methyl-1 3-diazacyclopentane DISSOLUTION Kinetics DIMETHYLSULFOXIDE N-Methyl pyrrolidone
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Synthesis and Crystal Structure of Trans-4-[(5-(2,4-Dichlorophenoxy)-3-methyl-1-phenyl-1H-pyrazol-4-yl)methyleneamino]-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one 被引量:4
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作者 孙凤梅 田孟魁 +1 位作者 杨靖华 连照勋 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2008年第7期789-792,共4页
The title compound trans-4-[(5-(2,4-dichlorophenoxy)-3-methyl- 1-phenyl-1H-pyrazol-4-yl)methyleneamino]- 1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one 3 (C28H23Cl2N5O2, Mr = 532.41) has been synthesized and its... The title compound trans-4-[(5-(2,4-dichlorophenoxy)-3-methyl- 1-phenyl-1H-pyrazol-4-yl)methyleneamino]- 1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one 3 (C28H23Cl2N5O2, Mr = 532.41) has been synthesized and its crystal structure was determined by single-crystal X-ray diffraction analysis. It crystallizes in triclinic, space group P1- with a = 8.9438(4), b = 11.6065(5), c = 14.2215(6)A, α = 112.566(1), β = 92.324(2), γ = 102.91(1)°, V= 1315.65(10) A^3, Z = 2, Dc = 1.344 g/cm^3,μ(MoKa) = 0.282 mm^-1, λ = 0.71073 A, F(000) = 552, the final R = 0.0587 and wR = 0.1578 for 5071 observed reflections (I 〉 2σ(I)). X-ray analysis reveals that the product is a thermodynamically stable trans isomer. Intra- and intermolecular C( 12)-H(12)…O(1) and C(28)-H(28)...O(1)# 1 hydrogen bonds were observed in the title compound. 展开更多
关键词 trans-4-[ 5-2 4-dichlorophenoxy)-3-methyl- 1-phenyl- 1H-pyrazol-4-yl)methylene amino]-1 5-dimethyl-2-phenyl-1 2-dihydropyrazol-3-one synthesis crystal structure
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Photo-induced Coupling Reaction of 1,1-Diphenyl-2,2-dicyanoethylene with 10-Methyl-9,10-dihydroacridine
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作者 HongJIANG YouChengLIU +3 位作者 GuanWuWANG ShiWeiLUO QuanMingWANG ThomasC.W.MAK 《Chinese Chemical Letters》 SCIE CAS CSCD 2004年第2期159-162,共4页
Diphenyl-2, 2-dicyanoethylene reacts with 10-methyl-9, 10-dihydroacridine in deaerated acetonitrile under irradiation with l>320 nm to give the coupling product 1, 1-diphenyl-1-(10-methyl-9-acridinyl)-2, 2-dicyanoe... Diphenyl-2, 2-dicyanoethylene reacts with 10-methyl-9, 10-dihydroacridine in deaerated acetonitrile under irradiation with l>320 nm to give the coupling product 1, 1-diphenyl-1-(10-methyl-9-acridinyl)-2, 2-dicyanoethane, which has been characterized by X-ray crystallographic, MS and NMR analyses. 展开更多
关键词 Photo-induced coupling reaction 1 1-diphenyl-2 2-dicyanoethylene 10-methyl-9 10-dihydroacridine 1 1-diphenyl-1-(10-methyl-9-acridinyl)-2 2-dicyanoethane.
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Syntheses and Crystal Structures of Methyl 2-(4,5-Dibromo-1-methylpyrrole-2-carbonylamino)-3-phenylpropanoate and 4,5-Dibromo-1-methyl-2- trichloroacetylpyrrole
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作者 ZENG Xiang-Chao GU Jian XU Shi-Hai LIU Po-Run 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2006年第2期153-158,共6页
4,5-Dibromo-1-methyl-2-trichloroacetylpyrrole Ⅰ, prepared by the reaction of 1-methyl-2-trichloroacetylpyrrole with Br2 in 98.6 % yield, was condensed with methyl L-2-amino-3- phenylpropanoate to afford methyl 2-(4,... 4,5-Dibromo-1-methyl-2-trichloroacetylpyrrole Ⅰ, prepared by the reaction of 1-methyl-2-trichloroacetylpyrrole with Br2 in 98.6 % yield, was condensed with methyl L-2-amino-3- phenylpropanoate to afford methyl 2-(4,5-dibromo-1-methylpyrrole-2-carboxmido)-3-phenylpropanoate Ⅱ in 90.8% yield. Crystal data for Ⅰ: monoclinic system, space group P21/c with a = 8.595(3), b = 10.900(4), c = 12.321(5) ,A°,β = 92.292(7)°, V = 1153.4(8)A°^3, Dc = 2.213 g/cm^3, F(000) = 728, CTH4Br2Cl3NO, Mr = 384.28, λ = 0.71073 A°, μ(MoKa) = 7.688 mm^-1, Z = 4, R = 0.0338 and wR2 = 0.0840 for 1963 observed reflections with I 〉 2a(I). Crystal data for Ⅱ: monoclinic system, space group P21 with a = 4.886(2), b = 15.921(8), c = 11.635(6) A°,β = 101.803(9)°, V = 885.9(7) A°^3, Dc = 1.665 g/cm^3, F(000) = 440, C16H16Br2N2O3, Mr = 444.13, λ = 0.71073 A°, μ(MoKa) = 4.590 mm^-1, Z = 2, R = 0.0335 and wR2 = 0.0837 for 3191 observed reflections with I 〉 2σ(I). The crystal structure reveals that compound Ⅱ forms the one-dimensional chain structure via the intermolecular hydrogen bonds of N(2)-H…O(1). 展开更多
关键词 methyl 2-(4 5-dibromo-1-methylpyrrole-2-carbonylamino)-3-phenylpropanoate synthesis crystal structure 4 5-dibromo-1-methyl-2-trichloroacetylpyrrole
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Synthesis and Crystal Structure of 4-Bromo-5-ethoxy-3-methyl-5- (naphthalen-1-yl)-1-tosyl-1H-pyrrol-2(5H)-one
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作者 沈如伟 杨誉竹 +2 位作者 曹剑 吴露玲 黄宪 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2007年第12期1505-1508,共4页
The title compound 4-bromo-5-ethoxy-3-methyl-5-(naphthalen-l-yl)-l-tosyl-lH- pyrrol-2(5H)-one 1 (C24H22BrNO4S, Mr = 500.40) has been synthesized and its crystal structure was determined by single-crystal X-ray d... The title compound 4-bromo-5-ethoxy-3-methyl-5-(naphthalen-l-yl)-l-tosyl-lH- pyrrol-2(5H)-one 1 (C24H22BrNO4S, Mr = 500.40) has been synthesized and its crystal structure was determined by single-crystal X-ray diffraction analysis. It crystallizes in monoclinic, space group P21/n with a = 8.8562(15), b = 18.118(3), c = 14.055(2)A, β = 99.855(3)^o, V= 2221.9(6)A3, Z = 4, Dc = 1.496 g/cm^3,μ= 1.975 mm^-1, 2 = 0.71073A, F(000) = 1024, R = 0.0607 and wR = 0.1371. 展开更多
关键词 4-bromo-5-ethoxy-3-methyl-5-(naphthalen-1-y1-1-tosyl-1H-pyrrol-2(5H)-one synthesis crystal structure
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Crystal and Molecular Structure, and Spectral Characteristics of Sodium 3,5-Bis(Hydroxyimino)-1-Methyl-2,4,6-Trioxocyclohexanide
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作者 Olga Kovalchukova Nguyen Dinh Do +6 位作者 Adam Stash Vitaly Bel’sky Paul Strashnov Andrew Alafinov Oleg Volyansky Svetlana Strashnova Konstantin Kobrakov 《Crystal Structure Theory and Applications》 2012年第3期46-51,共6页
Sodium 3,5-bis(hydroxyimino)-1-methyl-2,4,6-trioxocyclohexanide C7H5N2NaO5 (I) has been isolated as the only product of the reaction of nitrosation of methylphloroglucinol. The structure of the titled compound has bee... Sodium 3,5-bis(hydroxyimino)-1-methyl-2,4,6-trioxocyclohexanide C7H5N2NaO5 (I) has been isolated as the only product of the reaction of nitrosation of methylphloroglucinol. The structure of the titled compound has been determined from single crystal X-ray diffraction data. The hydrated C7H5N2NaO52.5H2O crystallizes in the monoclinic space group C2/c, with a(?) 16.408(3);b(?) 12.446(3);c(?) 13.716(3);(o) 126.34(3). The planar organic anion exists in a triketo-dihydroxyimino form with the C–O and C–N distances from 1.220(2) to 1.271(2)?? and from 1.292(2) to 1.293?? respectively. In the IR spectrum of I, the sharp absorption band occurred at 1681 cm-1 due to C=O stretching indicating the strong H-interactions. The correlations of theoretical (DFT-B3LYP/aug-cc-pVDZ) and experimental UV-vis absorption spectra in neutral and alkaline ethanolic solutions showed the existence of hydroxyimino-nitroso tautomerism while ionization of I. 展开更多
关键词 SODIUM 3 5-Bis(Hydroxyimino)-1-methyl-2 4 6-Trioxocyclohexanide CRYSTAL Structure IR SPECTRA Electronic Absorption SPECTRA Quantum Chemical Modeling
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Single-neuron neurodegeneration as a degenerative model for Parkinson’s disease 被引量:2
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作者 Sandro Huenchuguala Juan Segura-Aguilar 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期529-535,共7页
The positive effect of levodopa in the treatment of Parkinson’s disease,although it is limited in time and has severe side effects,has encouraged the scientific community to look for new drugs that can stop the neuro... The positive effect of levodopa in the treatment of Parkinson’s disease,although it is limited in time and has severe side effects,has encouraged the scientific community to look for new drugs that can stop the neurodegenerative process or even regenerate the neuromelanin-containing dopaminergic nigrostriatal neurons.Successful preclinical studies with coenzyme Q10,mitoquinone,isradipine,nilotinib,TCH346,neurturin,zonisamide,deferiprone,prasinezumab,and cinpanemab prompted clinical trials.However,these failed and after more than 50 years levodopa continues to be the key drug in the treatment of the disease,despite its severe side effects after 4–6 years of chronic treatment.The lack of translated successful results obtained in preclinical investigations based on the use of neurotoxins that do not exist in the human body as new drugs for Parkinson’s disease treatment is a big problem.In our opinion,the cause of these failures lies in the experimental animal models involving neurotoxins that do not exist in the human body,such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine,that induce a very fast,massive and expansive neurodegenerative process,which contrasts with the extremely slow one of neuromelanin-containing dopaminergic neurons.The exceedingly slow progress of the neurodegenerative process of the nigrostriatal neurons in idiopathic Parkinson’s patients is due to(i)a degenerative model in which the neurotoxic effect of an endogenous neurotoxin affects a single neuron,(ii)a neurotoxic event that is not expansive and(iii)the fact that the neurotoxin that triggers the neurodegenerative process is produced inside the neuromelanin-containing dopaminergic neurons.The endogenous neurotoxin that fits this degenerative model involving one single neuron at a time is aminochrome,since it(i)is generated within neuromelanin-containing dopaminergic neurons,(ii)does not cause an expansive neurotoxic effect and(iii)triggers all the mechanisms involved in the neurodegenerative process of the nigrostriatal neurons in idiopathic Parkinson’s disease.In conclusion,based on the hypothesis that the neurodegenerative process of idiopathic Parkinson’s disease corresponds to a single-neuron neurodegeneration model,we must search for molecules that increase the expression of the neuroprotective enzymes DT-diaphorase and glutathione transferase M2-2.It has been observed that the activation of the Kelch-like ECH-associated protein 1/nuclear factor(erythroid-derived 2)-like 2 pathway is associated with the transcriptional activation of the DT-diaphorase and glutathione transferase genes. 展开更多
关键词 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine 6-HYDROXYDOPAMINE aminochrome dopaminergic neurons DT-diaphorase exogenous neurotoxins glutathione transferase M2-2
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Synthesis, Reactions and Characterization of 1,1’-(1,4-Phenylenebis(3-amino-6-methyl-1H-pyrazolo[3,4-b]pyridine-4,5-diyl))bis(ethan-1-one)
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作者 Ahmed A. M. Elreedy Hameed M. Alkubaisi Fawzy A. Attaby 《International Journal of Organic Chemistry》 CAS 2016年第1期65-76,共12页
Reaction of 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile) (1) with methyl iodide afforded the 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-(methylthio)nicotinonitrile) (2). Th... Reaction of 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile) (1) with methyl iodide afforded the 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-(methylthio)nicotinonitrile) (2). The reaction of 2 with hydrazine hydrate followed by diazotization reaction af-forded the 1,1’-(1,4-phenylenebis(3-amino-6-methyl-1H-pyrazolo[3,4-b]pyridine-4,5-diyl))bis(e-than-1-one) (3) and 1,1’-(1,4-phenylenebis(3-(chlorodiazenyl)-6-methyl-1H-pyrazolo[3,4-b]-pyridine-4,5-diyl))bis(ethan-1-one) (4) respectively. On the other hand, reaction of 4 with malononitrile, 2-cyanoethanethioamide, ethyl acetoacetate, acetyl acetone, ethyl benzoylacetate, diethylmalonate, ethyl cyanoacetate and phenacylbromide aiming to build up pyrazolotriazine or pyrazole ring on the ring system of 4. Structures of all newly synthesized heterocyclic compounds in the present study were confirmed by considering the data of IR, 1H NMR, mass spectra as well as that of elemental analyses. 展开更多
关键词 Bis-1 2-dihydropyridine-3-carbonitrile Bis-Nicotinonitrile 1 1-(1 4-Phenyl-enebis(3-(chlorodiazenyl)-6-methyl-1H-pyrazolo[3 4-b]pyri-dine-4 5-diyl))bis(ethan-1-one) Bis-dihydropyrido[2 3’:3 4]pyrazolo[5 1-c][1 2 4]triazine-3-carboxylate Bis-1H-pyrazolo[3 4-b]pyridine
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A New Halogenated Biindole and A New Apo-carotenone from Green Alga Chaetomorpha basiretorsa Setchell 被引量:6
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作者 DaYongSHI LiJunHAN +5 位作者 JieSUN ShuaiLI SuJuanWANG YongChunYANG XiaoFAN JianGongSHI 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第6期777-780,共4页
A new halogenated biindole and a new apo-carotenone have been isolated from the ethanolic extract of the green alga Chaetomorpha basiretorsa Sethcell. On the basis of chemical and spectroscopic methods including 2D NM... A new halogenated biindole and a new apo-carotenone have been isolated from the ethanolic extract of the green alga Chaetomorpha basiretorsa Sethcell. On the basis of chemical and spectroscopic methods including 2D NMR technique, their structures have been elucidated as 4,4′-dichloro-5,5′-dibromo-7,7′-dimethoxy-2,2′-bi-1H-indole and 1′S*,4′R*-8-(4′-hydroxy-2′,6′,6′- trimethylcyclohex-2-enyl)-6-methyloct-3E,5E,7E-trien-2-one, respectively. 展开更多
关键词 Green alga Chaetomorpha basiretorsa Sethcell 4 4′-dichloro-5 5′-dibromo-7 7′-di- methoxy-2 2-bi-1H-indole 1′S* 4′R*-8-(4′-hydroxy-2 6′ 6′-trimethylcyclohex-2-enyl)-6-methyl- oct-3E 5E 7E-trien-2-one.
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Synthesis of a New β-Mercaptoalcohol 被引量:1
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作者 Jian Feng GE Li Fen ZHANG +1 位作者 Zong Xuan SHEN Ya Wen ZHANG 《Chinese Chemical Letters》 SCIE CAS CSCD 2001年第7期569-570,共2页
In this letter, (R)-1,1-diphenyl-2-mercapto-3-methyl-1-butanol was synthesized from L-valine and two synthetic routes have been tried.
关键词 R)-1 1-Diphenyl-2-mercapto-3-methyl-1-butanol asymmetric synthesis L-valine.
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Synthesis and Physico-chemical Properties of (Co)polymers of 2-[(2E)-1-methyl-2-buten-1-yl]aniline and Aniline
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作者 A. Andriianova A. Shigapova +3 位作者 Y. Biglova R. Salikhov I. Abdrakhmanov A. Mustafin 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2019年第8期774-782,共9页
A new soluble polymer on 2-[(2 E)-1-methyl-2-buten-1-yl]aniline and its copolymers with aniline basis have been synthesized in various molar ratios. For all samples, the electrical conductivity, morphology, solubility... A new soluble polymer on 2-[(2 E)-1-methyl-2-buten-1-yl]aniline and its copolymers with aniline basis have been synthesized in various molar ratios. For all samples, the electrical conductivity, morphology, solubility, electrochemical properties, as well as spectral and molecular mass characteristics have been studied, and a comparative analysis with polyaniline has been carried out. The substituent introduced into the aniline aromatic ring significantly improves the solubility in typical organic solvents of a high molecular weight product. The morphology of the test compounds depends on the co-monomer ratio. As the content of the substituted aniline in the initial mixture increases, the morphology of the polymer changes from the inherent polyaniline fibrous microstructure to the globular one with irregular substituted polyaniline shapes and sizes. Electrochemical study of the samples revealed that the higher the oxidation potential, the wider the band gap(ranging from 2.00 to 2.15). The electrical conductivity decreases in proportion to the increase in the substituted aniline concentration of the initial co-monomer mixture and amounts to 12.5–35.7 × 10~6 nSm. 展开更多
关键词 Polyaniline 2-[(2E)-1 -methyl-2-buten-1 -yl]aniline Copolymers Solubility Electrochemical properties Electrical conductivity
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Preconcentration/Separation of Some Metal Ions Using Sodium Dodecyl Sulfate Coated Alumina Modified with Bis(5-bromo- 2-hydroxy-benzaldehyde)-2-methyl-1,5-pentane Diimine (BBHBPDI) Prior to Their Flame-AAS Determination
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作者 Ghaedi, Mehrorang Montazerozohori, Mortez +2 位作者 Marahel, Farzaneh Nejati Biareh, Mehdi Soylak, Mostafa 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2011年第10期2141-2147,共7页
Preconcentration/separation of Co(II), Fe(III), Pb(II), Cr(IIl), Cu(II) and Cd(II) ions using bis(5-bromo- 2-hydroxy-benzaldehyde)-2-methy1-1,5-pentane diimine (BBHBPDI) on SDS coated alumina has been ... Preconcentration/separation of Co(II), Fe(III), Pb(II), Cr(IIl), Cu(II) and Cd(II) ions using bis(5-bromo- 2-hydroxy-benzaldehyde)-2-methy1-1,5-pentane diimine (BBHBPDI) on SDS coated alumina has been reported. The influences of the analytical parameters including pH, ligand and SDS amount, type and concentration of eluent and sample volume on metal ions recoveries were investigated. At optimum values of all variables the relative standard deviation are between 2.5-2.7 and preconcentration factor was 375, while recoveries for all understudy metal ions are higher than 95%, determination limits are between 1.5-2.7. The method has been successfully applied to determination of Co(II), Fe(III), Pb(II), Cr(III), Cu(II) and Cd(II) ions content in some real samples. 展开更多
关键词 surfactant coated alumina atomic absorption spectrometry solid phase extraction bis(5-bromo-2-hydroxy-benzaldehyde)-2-methyl- 1 5-pentane diimine 3 - [(1H-indo1-3y1- 3 4 5-trimethyl] - 1H-indole
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HELIX SENSE-SELECTIVE COPOLYMERIZATION OF TRIPHENYLMETHYL METHACRYLATE WITH CHIRAL ANIONIC INITIATORS
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作者 任长玉 陈传福 习复 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 1994年第4期379-384,共6页
Optically active copolymers of pairs of three monomers, triphenyl (methyl methacrylate)and one or two pyridyl substituted methyl methacrylate homologues, were obtained by helix-sense-selective copolymerization using c... Optically active copolymers of pairs of three monomers, triphenyl (methyl methacrylate)and one or two pyridyl substituted methyl methacrylate homologues, were obtained by helix-sense-selective copolymerization using complexes of organolithium with chiral ligand as anionicinitiators in toluene at low temperature. The copolymers obtained with (-)-sparteine (Sp) and(S,S)-(+)-and (R, R)-(-)-2, 3-dimethoxy-1, 4-bis (dimethylamino) butanes((+)-and (-)-DDB) complexes of organolithium showed low optical activity, but PMP complex with N, N-diphenylethyleneamine monolithium amide (PMP-DPEDA-Li) was effective in synthesizingcopolymers of high optical rotation ([α]_D^(25) about+320~1370°)which were comparable to thoseof relative homopolymers with one-handed helical structure. 展开更多
关键词 Phenyl [bis (2-pyridyl) methyl methacrylate (s)-(+)-1-(2pyrrolidinyl-methyl) pyrrolidine (PMP) Anionic asymmetric copolymerization Optically active copolymer
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A New Benzylisoquinoline Alkaloid from Sabia parviflora 被引量:6
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作者 Jin CHEN Bin CHEN +1 位作者 Jun TIAN Feng E WU 《Chinese Chemical Letters》 SCIE CAS CSCD 2002年第5期426-427,共2页
A new benzylisoquinoline alkaloid, 1, 2, 3, 4-tetrahydro-5-hydroxyl-8-methoxyl-2- methyl-4'-methoxyl-benzylisoquinoline, was isolated from the arial parts of Sabia parviflora. Its structure was established on the... A new benzylisoquinoline alkaloid, 1, 2, 3, 4-tetrahydro-5-hydroxyl-8-methoxyl-2- methyl-4'-methoxyl-benzylisoquinoline, was isolated from the arial parts of Sabia parviflora. Its structure was established on the basis of spectral analysis. 展开更多
关键词 Sabia parviflora benzylisoquinoline alkaloid 1 2 3 4-tetrahydro-5-hydroxyl-8- methoxyl-2-methyl-4'-methoxyl-benzylisoquinoline.
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Isatin decreases Bax protein expression in the substantia nigra of a mouse model of Parkinson's disease 被引量:3
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作者 Jiguo Zhang Fang Zhang +1 位作者 Yanlong Qiu Wang Yue 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第26期2022-2025,共4页
The present study observed the action of 1H-indole-2, 3-dione (isatin) on Bax protein expression in the substantia nigra of a Parkinson's disease animal model. Parkinson's disease-like behaviors were induced in C5... The present study observed the action of 1H-indole-2, 3-dione (isatin) on Bax protein expression in the substantia nigra of a Parkinson's disease animal model. Parkinson's disease-like behaviors were induced in C57BL/6J mice treated with 1-methyl-4-phenyl-1,2, 3, 6-tetrahydropyridine (MPTP) Bax protein expression was significantly reduced in isatin (100, 200 mg/kg)-pretreated mice. Results demonstrate that isatin plays a neuroprotective role in mice treated with MPTP by down-regulating Bax protein expression. 展开更多
关键词 1H-indole-2 3-dione (isatin) Parkinson's disease 1-methyl-4-phenyl-1 2 3 6- tetrahydropyridine Bax MOUSE neurodegenerative disease neural regeneration
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A New Bisxanthone from Hypericum japonicum Thunb.ex Murray 被引量:1
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作者 PengFU WeiDongZHANG TingZhaoLI RunHuiLIU HuiLiangLI WeiZHANG HaiShengCHEN 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第6期771-773,共3页
A new bisxanthone, named bijaponicaxanthone C, was isolated from the whole plant of Hypericum japonicum. The structure was elucidated as 6-[1’’,5’’,6’’-trihydroxy-2’’’-(β-hydroxy-β- methylethyl)-2’’’,3... A new bisxanthone, named bijaponicaxanthone C, was isolated from the whole plant of Hypericum japonicum. The structure was elucidated as 6-[1’’,5’’,6’’-trihydroxy-2’’’-(β-hydroxy-β- methylethyl)-2’’’,3’’’-dihydrofuran(5’’’,4’’’,3’’,4’’)xanthone-3’’’-oxyl]-1,3,5-trihydroxy-4-isoprenylxant- hone (1) on the basis of the spectral and chemical evidences. 展开更多
关键词 Hypericum japonicum bisxanthone 6-[1'' 5'' 6''-trihydroxy-2'''--hydroxy-β-methyl- ethyl)-2''' 3'''-dihydrofuran(5''' 4''' 3'' 4'')xanthone-3'''-oxyl]-1 3 5-trihydroxy-4-isoprenylxanthone bijaponicaxanthone C.
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Isolation and structural elucidation of cytotoxic compounds from the root bark of Diospyros quercina (Baill.) endemic to Madagascar
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作者 Fatiany Pierre Ruphin Robijaona Baholy +3 位作者 Randrianarivo Emmanuel Raharisololalao Amelie Marie-Therese Martin Ngbolua Koto-te-Nyiwa 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2014年第3期169-175,共7页
Objective:To isolate and characterize the cytotoxic compounds from Diospyros quercina(Baill.)G.E.Schatz&Lowry(Ebenaceae).Methods:An ethno-botanical survey was conducted in the south of Madagascar from July to Augu... Objective:To isolate and characterize the cytotoxic compounds from Diospyros quercina(Baill.)G.E.Schatz&Lowry(Ebenaceae).Methods:An ethno-botanical survey was conducted in the south of Madagascar from July to August 2010.Bio-guided fractionation assay was carried out on the root bark of Diospyros quercina,using cytotoxicity bioassay on murine P388 leukemia cell lines as model.The structures of the cytotoxic compounds were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry.Results:Biological experiments resulted in the isolation of three bioactive pure compounds(named TR-21,TR-22,and TR-23)which exhibited very good in vitro cytotoxic activities with the IC_(50)values of(0.017 5±0.0060)μg/mL,(0.089±0.005)μg/mL and(1.027±0.070)μg/mL respectively.Thus,they support the claims of traditional healers and suggest the possible correlation between the chemical composition of this plant and its wide use in Malagasy folk medicine to treat cancer.Conclusions:The ability of isolated compounds in this study to inhibit cell growth may represent a rational explanation for the use of Diospyros quercina root bark in treating cancer by Malagasy traditional healers.Further studies are,therefore,necessary to evaluate the in vivo antineoplastic activity of these cytotoxic compounds as effective anticancer drugs. 展开更多
关键词 DIOSPYROS quercinia Cytotoxic activities Isodiospyrin 6’-Ethoxy-1 3’-dihydroxy-4 6-dimethyl-1 2-binaphthyl-2 5’3 8’tetraones (E)-5 6-Dimethyl-2-(2-methyl-3-(prop-1-enyl) phenyl)-2H-Chromene Madagascar
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