Epstein-Barr virus (EBV) infects over 90% of the global population, establishing latent infections in most individuals. Under specific conditions like inflammation and immune suppression, EBV can be reactivated, leadi...Epstein-Barr virus (EBV) infects over 90% of the global population, establishing latent infections in most individuals. Under specific conditions like inflammation and immune suppression, EBV can be reactivated, leading to the initiation and progression of related diseases. While inflammation is known to induce EBV reactivation, the precise mechanisms underlying this phenomenon remain unclear. Chemokine (C-X-C motif) ligand (CXCL10), a key inflammatory factor, plays a significant role in various infectious diseases. In this study, we investigated how CXCL10 levels regulate the transition between the latent and lytic replication phases of the EBV lifecycle using cell culture, Western blot, fluorescent quantitative PCR, immunofluorescence, and flow cytometric apoptosis assays. Our findings indicate that CXCL10 induces EBV transition from latency to lytic replication through its receptor CXCR3 by regulating the downstream effector, exostosis-like glycosyltransferase 1. Additionally, CXCL10 activates the JAK2/STAT3 pathway. This study confirms the role of CXCL10 in promoting EBV lytic replication, providing crucial insights into the pathogenic mechanisms of inflammation-triggered EBV reactivation.展开更多
In this article, 88 cases of cervical spondylosis were treated with warming-needle moxi-bustion and Tuina, and the fair clinical effect was obtained with the total effective rate of 90. 9 %. TheX-ray manifestations of...In this article, 88 cases of cervical spondylosis were treated with warming-needle moxi-bustion and Tuina, and the fair clinical effect was obtained with the total effective rate of 90. 9 %. TheX-ray manifestations of 65 cases before and after the treatment were observed and it has been foundthat the clinical symptoms could also be remarkedly improved or cured even if the X-ray examinationremained unchanged.展开更多
文章利用实验结果分析了 5 4 HC0 4的阈值电压在不同剂量率下随总剂量的变化关系 ,对若干种加速实验方法进行了比较 ,认为 1 0 ke V X射线源可以作为对 MOS器件进行快速的加速实验性能测试的辐照源。从环境安全考虑 ,1 0 ke V X射线源...文章利用实验结果分析了 5 4 HC0 4的阈值电压在不同剂量率下随总剂量的变化关系 ,对若干种加速实验方法进行了比较 ,认为 1 0 ke V X射线源可以作为对 MOS器件进行快速的加速实验性能测试的辐照源。从环境安全考虑 ,1 0 ke V X射线源易于屏蔽 ,可以用于硅片级的参数测试 ,且花费远远小于封装后的器件在60 Co源上的性能测试 。展开更多
文摘Epstein-Barr virus (EBV) infects over 90% of the global population, establishing latent infections in most individuals. Under specific conditions like inflammation and immune suppression, EBV can be reactivated, leading to the initiation and progression of related diseases. While inflammation is known to induce EBV reactivation, the precise mechanisms underlying this phenomenon remain unclear. Chemokine (C-X-C motif) ligand (CXCL10), a key inflammatory factor, plays a significant role in various infectious diseases. In this study, we investigated how CXCL10 levels regulate the transition between the latent and lytic replication phases of the EBV lifecycle using cell culture, Western blot, fluorescent quantitative PCR, immunofluorescence, and flow cytometric apoptosis assays. Our findings indicate that CXCL10 induces EBV transition from latency to lytic replication through its receptor CXCR3 by regulating the downstream effector, exostosis-like glycosyltransferase 1. Additionally, CXCL10 activates the JAK2/STAT3 pathway. This study confirms the role of CXCL10 in promoting EBV lytic replication, providing crucial insights into the pathogenic mechanisms of inflammation-triggered EBV reactivation.
文摘In this article, 88 cases of cervical spondylosis were treated with warming-needle moxi-bustion and Tuina, and the fair clinical effect was obtained with the total effective rate of 90. 9 %. TheX-ray manifestations of 65 cases before and after the treatment were observed and it has been foundthat the clinical symptoms could also be remarkedly improved or cured even if the X-ray examinationremained unchanged.
