Objective Diminished ovarian reserve(DOR)can lead to early menopause,poor fecundity,and an increased risk of disorders such as osteoporosis,cardiovascular disease,and cognitive impairment,seriously affecting the physi...Objective Diminished ovarian reserve(DOR)can lead to early menopause,poor fecundity,and an increased risk of disorders such as osteoporosis,cardiovascular disease,and cognitive impairment,seriously affecting the physical and mental health of women.There is still no safe and effective strategy or method to combat DOR.We have developed a novel Chinese herbal formula,Tongji anti-ovarian aging 101(TJAOA101),to treat DOR.However,its safety and efficacy need to be further validated.Methods In this prospective and pre-post clinical trial,100 eligible patients aged 18–45 diagnosed with DOR will be recruited.All participants receive TJAOA101 twice a day for 3 months.Then,comparisons before and after treatment will be analyzed,and the outcomes,including anti-mullerian hormone(AMH)and follicle-stimulating hormone(FSH)levels and the antral follicle count(AFC),the recovery rate of menopause,and the Kupperman index(KMI),will be assessed at baseline,every month during medication(the intervention period),and 1,3 months after medication(the follow-up period).Assessments for adverse events will be performed during the intervention and follow-up periods.Conclusion A multicenter,prospective study will be conducted to further confirm the safety and efficacy of TJAOA101 in treating DOR and to provide new therapeutic strategies for improving the quality of life in DOR patients.展开更多
The IEC60870-5-104 protocol lacks an integrated authentication mechanism during plaintext transmission, and is vulnerable to security threats, monitoring, tampering, or cutting off communication connections. In order ...The IEC60870-5-104 protocol lacks an integrated authentication mechanism during plaintext transmission, and is vulnerable to security threats, monitoring, tampering, or cutting off communication connections. In order to verify the security problems of 104 protocol, the 104 master-slave communication implemented DoS attacks, ARP spoofing and Ettercap packet filtering and other man-in-the-middle attacks. DoS attacks may damage the network functions of the 104 communication host, resulting in communication interruption. ARP spoofing damaged the data privacy of the 104 protocol, and Ettercap packet filtering cut off the communication connection between the master and the slave. In order to resist the man-in-the-middle attack, the AES and RSA hybrid encryption signature algorithm and the national secret SM2 elliptic curve algorithm are proposed. AES and RSA hybrid encryption increases the security strength of communication data and realizes identity authentication. The digital signature implemented by the SM2 algorithm can realize identity verification, ensure that the data has not been tampered with, and can ensure the integrity of the data. Both of them improve the communication security of the 104 protocol.展开更多
基金supported by grants from the National Natural Science Foundation of China(No.82001498 and No.82002768)the Natural Science Foundation of Hubei Province(No.2020CFB544)The Clinical Research Pilot Project of Tongji Hospital,Huazhong University of Science and Technology(No.2019CR205).
文摘Objective Diminished ovarian reserve(DOR)can lead to early menopause,poor fecundity,and an increased risk of disorders such as osteoporosis,cardiovascular disease,and cognitive impairment,seriously affecting the physical and mental health of women.There is still no safe and effective strategy or method to combat DOR.We have developed a novel Chinese herbal formula,Tongji anti-ovarian aging 101(TJAOA101),to treat DOR.However,its safety and efficacy need to be further validated.Methods In this prospective and pre-post clinical trial,100 eligible patients aged 18–45 diagnosed with DOR will be recruited.All participants receive TJAOA101 twice a day for 3 months.Then,comparisons before and after treatment will be analyzed,and the outcomes,including anti-mullerian hormone(AMH)and follicle-stimulating hormone(FSH)levels and the antral follicle count(AFC),the recovery rate of menopause,and the Kupperman index(KMI),will be assessed at baseline,every month during medication(the intervention period),and 1,3 months after medication(the follow-up period).Assessments for adverse events will be performed during the intervention and follow-up periods.Conclusion A multicenter,prospective study will be conducted to further confirm the safety and efficacy of TJAOA101 in treating DOR and to provide new therapeutic strategies for improving the quality of life in DOR patients.
文摘The IEC60870-5-104 protocol lacks an integrated authentication mechanism during plaintext transmission, and is vulnerable to security threats, monitoring, tampering, or cutting off communication connections. In order to verify the security problems of 104 protocol, the 104 master-slave communication implemented DoS attacks, ARP spoofing and Ettercap packet filtering and other man-in-the-middle attacks. DoS attacks may damage the network functions of the 104 communication host, resulting in communication interruption. ARP spoofing damaged the data privacy of the 104 protocol, and Ettercap packet filtering cut off the communication connection between the master and the slave. In order to resist the man-in-the-middle attack, the AES and RSA hybrid encryption signature algorithm and the national secret SM2 elliptic curve algorithm are proposed. AES and RSA hybrid encryption increases the security strength of communication data and realizes identity authentication. The digital signature implemented by the SM2 algorithm can realize identity verification, ensure that the data has not been tampered with, and can ensure the integrity of the data. Both of them improve the communication security of the 104 protocol.
