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拉米夫定疗程中慢性乙型肝炎患者血清IL-12水平和Th平衡变化及其意义 被引量:2
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作者 何登明 毛青 +1 位作者 王宇明 谭朝霞 《第三军医大学学报》 CAS CSCD 北大核心 2004年第19期1765-1767,共3页
目的 探讨慢性乙型肝炎患者拉米夫定治疗前后血清IL -12水平和辅助性T细胞 (Th)平衡变化及其临床意义。方法 根据患者对拉米夫定治疗的应答情况分组进行回顾性研究 ,利用双抗体夹心ELISA法检测治疗前后不同时相点血清IL -12、γ干扰素... 目的 探讨慢性乙型肝炎患者拉米夫定治疗前后血清IL -12水平和辅助性T细胞 (Th)平衡变化及其临床意义。方法 根据患者对拉米夫定治疗的应答情况分组进行回顾性研究 ,利用双抗体夹心ELISA法检测治疗前后不同时相点血清IL -12、γ干扰素 (IFHγ)、IL -4水平 ,以与正常对照校对后的IFNγ/IL -4作为Th平衡指标 ,取健康献血员作对照。结果 治疗前血清IL -l2水平低于健康对照 ,Th平衡表现为Th2优势应答 ;治疗后HBeAg阳性完全应答组在治疗的第 3个月有明显的血清IL -12水平高峰 ,Th平衡得以恢复并保持Thl优势应答 ,HBeAg阳性部分应答组和HBeAg阴性组Th平衡仍以Th2 为优势应答。结论 拉米夫定治疗应答和血清IL -12水平及Th平衡的恢复程度有关 ,治疗后慢性乙型肝炎患者抗HBV免疫有所恢复 ,血清lL -l2水平可作为早期预测拉米夫定疗效的免疫学指标 ,治疗后Th平衡的恢复是完全应答实现的保证。 展开更多
关键词 慢性乙型肝炎 拉米夫定 白细胞介素12 th平衡
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鼻息肉组织Th细胞分化诱导因子IL-12和IL-4的表达及临床意义
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作者 王艳 张健 《中国医药科学》 2015年第20期191-193,共3页
目的分析鼻息肉组织中的Th1与Th2细胞和其分化诱导因子IL-12与IL-4的表达,进一步研究鼻息肉组织的T细胞活化程度和组织免疫状态。方法在我院2011年2月~2014年12月鼻息肉患者病例中随机选择41例作为实验组,另选同期行鼻中矫正手术病例41... 目的分析鼻息肉组织中的Th1与Th2细胞和其分化诱导因子IL-12与IL-4的表达,进一步研究鼻息肉组织的T细胞活化程度和组织免疫状态。方法在我院2011年2月~2014年12月鼻息肉患者病例中随机选择41例作为实验组,另选同期行鼻中矫正手术病例41例作为对照组,分析两组患者的Th1与Th2细胞反应的具体特征。结果实验组的Th1、Th2辅助细胞平均百分率、IL-12与IL-4水平均高于对照组,差异有统计学意义(P〈0.05)。鼻息肉病例中,IL-12白细胞介素与Th1辅助细胞平均百分率、IL-4白细胞介素与Th2辅助细胞平均百分率呈正相关关系;IL-12白细胞介素同IL-4白细胞介素呈负相关关系。结论 Th1细胞亚群是鼻息肉组织里的主要细胞群体,感染因素与鼻息肉的发生密切相关;同时由Th2辅助细胞介导产生的变态反应因素与鼻息肉的发生也有关联。 展开更多
关键词 鼻息肉组织 th细胞 IL-12 IL-4 表达
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A Review of Development of Environmental Protection Information during the 12^(th) Five-Year Plan Period and Its Outlook 被引量:1
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作者 Zhang Fujiang 《Meteorological and Environmental Research》 CAS 2017年第3期67-70,共4页
During the 12^(th)Five-Year Plan period,the environmental protection information work made remarkable achievements,and the construction of nationwide air quality monitoring network was completed; the trinitarian monit... During the 12^(th)Five-Year Plan period,the environmental protection information work made remarkable achievements,and the construction of nationwide air quality monitoring network was completed; the trinitarian monitoring system was established,and environmental emergency command ability enhanced significantly. However,the issues of " information island" and " application silo" are still outstanding,and the application and promotion of new technologies make slow progress; the capacity of information system to support environmental protection business is insufficient,and there is no capacity for decision analysis. In the 13^(th)Five-Year Plan period,it is needed to strengthen the application and promotion of new technologies such as cloud computing,big data,Internet of Things,and spatial information,mainly construct and improve " Cloud Computing Based Environmental Protection( CCBEP) ", " big data platform of ecological environment",and then realize the core objective of improving environmental quality. 展开更多
关键词 the 12th Five-Year PLAN PERIOD ENVIRONMENTAL information Review OUTLOOK
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The 12th PAMS/JECSS Workshop
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《Acta Oceanologica Sinica》 SCIE CAS CSCD 2005年第1期F006-F006,共1页
The 12th the Pacific Asian Marginal Seas (PAMS) / Japan and East China Sea Study (JECSS) (PAMS/JEC-SS) Workshop was held on 22-24 November 2003 in Hangzhou, China.More than 100 scientists attended this workshop. There... The 12th the Pacific Asian Marginal Seas (PAMS) / Japan and East China Sea Study (JECSS) (PAMS/JEC-SS) Workshop was held on 22-24 November 2003 in Hangzhou, China.More than 100 scientists attended this workshop. There were 57 oral presentations and 43 post presentations, grouped into 7 themes, namely,(1) Studies of the South China Sea(2) Studies of the Bohai, Huanghai and East China Seas 展开更多
关键词 PAMS JEC the 12th PAMS/JECSS Workshop ORAL
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The 12th Workshop on Antarctic Meteorology and Climate
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作者 Matthew A.LAZZARA Jordan G.POWERS +3 位作者 Carol A.COSTANZA David H.BROMWICH Scott CARPENTIER Steve R.COLWELL 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2018年第7期753-756,共4页
1.Overview The 12th Workshop on Antarctic Meteorology and Climate(WAMC),formerly known as the Antarctic Meteorological Observation,Modeling,and Forecasting(AMOMF)Workshop(AMOMFW),was held at the National Center ... 1.Overview The 12th Workshop on Antarctic Meteorology and Climate(WAMC),formerly known as the Antarctic Meteorological Observation,Modeling,and Forecasting(AMOMF)Workshop(AMOMFW),was held at the National Center for Atmospheric Research(NCAR)in Boulder,Colorado,USA on 26–28 June 2017.The annual workshop dates from 2006,and recent meetings have been the 10th AMOMF Workshop held in 2015 in Cambridge, 展开更多
关键词 AWS the 12th Workshop on Antarctic Meteorology and Climate SH
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Integrating Climate Change Factors into Environmental Planning Innovation of the National 12^(th) Five Year Development Plan towards Climate Change in China
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作者 Yang Xiao Li Yangfan Yin Rongyao Sun Xiang Zhu Xiaodong 《Chinese Journal of Population,Resources and Environment》 2011年第4期42-48,共7页
Effects on sustainable development of climate change have been going further nowadays.National Five Year Development Plan in China should have specific policies on how to take climate change impacts into account throu... Effects on sustainable development of climate change have been going further nowadays.National Five Year Development Plan in China should have specific policies on how to take climate change impacts into account through the environmental planning.Key fields distribute in three levels of natural bearing capacity,production system and human settlements,and include seven aspects:ecosystems,water resources,disasters and risks,low-carbon economy,vulnerable departments,urbanization,and coastland. 展开更多
关键词 climate change environmental planning innovation the 12th Five Year Development Plan
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Achievements Made at the 12th China-LAC Business Summit
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《China's Foreign Trade》 2018年第6期2-2,共1页
Business communities from China and Latin American and Caribbean countries have made achievements at the12th China-LAC Business Summit in Zhuhai,Guangdong Province.The China Council for the Promotion of International ... Business communities from China and Latin American and Caribbean countries have made achievements at the12th China-LAC Business Summit in Zhuhai,Guangdong Province.The China Council for the Promotion of International Trade,host of the summit and trade promotion agencies of Latin American countries jointly issued Zhuhai Declaration on November2. 展开更多
关键词 LAC Achievements Made at the 12th China-LAC Business Summit
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China's Industries in the Beginning of Its 12th Five-Year Plan Period
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作者 金碚 《China Economist》 2012年第6期4-18,共15页
Complex international and domestic economic scenarios and the short cyclical nature of macroeconomic policies characterizes the beginning year of the 12th Five- Year Plan period, it reflects the difficult policy choic... Complex international and domestic economic scenarios and the short cyclical nature of macroeconomic policies characterizes the beginning year of the 12th Five- Year Plan period, it reflects the difficult policy choices that arise among three major regulatory targets ,for growth, structure, and prices. In the transitional period of intertwined challenges, a spirit of commitment and dedication to real industries will allow China to occupy vantage points in world manufacturing and become an industrial power in the real sense. To a certain extent the beginning year of the 12th Five-Year Plan period (2011-2015), while.fraught with challenges and pain, marks a departure from cutthroat competition to quality growth for Chinese enterprises and entrepreneurs. From 2012, China's industrial and market economic systems will both head towards more sophisticated stages of development. China "s industries will develop along environmentally sustainable, delicate, high-end, IT-based and service-oriented paths, while expediting the country's economic restructuring, industrial upgrade capabilities and its pursuit of innovative industrialization, and it will do so with strides more remarkable than ever before in its history. 展开更多
关键词 12th Five-Year Plan new approach of industrialization industrial transformation and upgrade
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Challenges and Opportunities for China's Agricultural and Rural Development in the 12th Five-year Plan Period
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作者 宋洪远 张红奎 +2 位作者 方华 张恒春 赵海 《China Economist》 2011年第1期58-66,共9页
Despite the great progress of rural socioeconomic development in the 11 th Five-year Plan period (2006-2010), China's agriculture and countryside are still.lacing the challenges of a crude development pattern, back... Despite the great progress of rural socioeconomic development in the 11 th Five-year Plan period (2006-2010), China's agriculture and countryside are still.lacing the challenges of a crude development pattern, backward rural development and cities' weak driving effect on the countryside. In the 12th Five-year Plan period (20I 1-2015), China should transform the way agriculture grows and operates; promote rural socioeconomic development; improve urban planning and its functions, institutional innovation, and urban/rural integration to lay a solid foundation for building an all-round well- off society. 展开更多
关键词 12th Five-Year Plan (2011-2015) modern agriculture construction of new socialist countryside integration of rural andurban areas
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Strengthening International Cooperation, Working for World Human Rights Development——Speech at the opening ceremony of the 12th Sino-German Human Rights Symposium, July 13, 2014
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作者 Cui Yuying 《The Journal of Human Rights》 2014年第5期2-4,共3页
The 12th Sino-German Human Rights Symposium opened today in Beijing. On behalf of the State Council Information Office, I would like to express my warmest con- gratulations on the opening of the forum, extend my welco... The 12th Sino-German Human Rights Symposium opened today in Beijing. On behalf of the State Council Information Office, I would like to express my warmest con- gratulations on the opening of the forum, extend my welcome to Ms. Herta Daeubler-Gmelin and other German friends and my gratitude to symposium organizers and all participants for your long-term contribution to communication and exchange in human rights between China and Germany. 展开更多
关键词 Strengthening International Cooperation Speech at the opening ceremony of the 12th Sino-German Human Rights Symposium Working for World Human Rights Development July 13
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Appropriate Attitude and Principle for Strengthening Human Rights Protection——Speech at the opening ceremony of the 12th Sino-German Human Rights Symposium, July 13, 2014
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作者 Huang Mengfu 《The Journal of Human Rights》 2014年第5期4-6,共3页
Since 1999, there have been 11 Sino-German Human Rights symposiums. Due to the concept of peace and development and the principle of dialogue through consultation, non- confrontation and pragmatism with equality, whic... Since 1999, there have been 11 Sino-German Human Rights symposiums. Due to the concept of peace and development and the principle of dialogue through consultation, non- confrontation and pragmatism with equality, which have been upheld by organizers, such symposiums have made great achievements. The dialogue mechanism for human rights topics between China and Germany has helped construct a common, accessible and interactive platform for pushing forward human rights legal advancement in both countries, which has brought about a positive influence on the develop- ment of the human rights cause in the two countries. Strengthening legal construction and ensuring hu- man rights are not only the shared aspiration of all the people in the world, but also the irreversible his- torical trend of human civilization. The symposium, with the theme of international law and human rights protection, encourages participants to discuss and share theories and practices in human rights studies, which makes a significant contribu- tion to enriching the modern human rights concept and building a new type of international cooperation. The international community always pays great attention to the relation- ship between human rights and legal governance. China always abides by international human rights con- ventions including the Universal Declaration of Human Rights, which set up fundamental principles for promoting and ensuring human rights, and has endorsed 26 inter- national human rights conventions such as the International Covenant on Economic, Social and Cultural Rights. Meanwhile, China, through legislation, jurisdiction and admin- istration, brings into full play the active role of international human rights conventions in ensuring hu- man rights in the country. 展开更多
关键词 Appropriate Attitude and Principle for Strengthening Human Rights Protection July 13 Speech at the opening ceremony of the 12th Sino-German Human Rights Symposium
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API 610第12版重要变化解读
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作者 陈超 徐辉 《石油化工设备技术》 CAS 2023年第1期39-44,I0003,共7页
文章介绍了API 610规范的重要性以及升版情况,详细对比了API 610第11版和第12版的区别,并结合工程实际进行了解读。API 610第12版经过10年的总结和提升,更符合工程实际,能够为广大从业者提供更好的选型设计参考。同时,新版本中的一些要... 文章介绍了API 610规范的重要性以及升版情况,详细对比了API 610第11版和第12版的区别,并结合工程实际进行了解读。API 610第12版经过10年的总结和提升,更符合工程实际,能够为广大从业者提供更好的选型设计参考。同时,新版本中的一些要求尚未在实际工程中应用,未来还需各方相互协商、详尽研读、逐步适应。 展开更多
关键词 API610 离心泵 第11版 12
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An Analysis of China's Overall Price Trend During the 12th Five-year Plan Period and Suggestions
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作者 王双正 《China Economist》 2010年第6期120-133,共14页
In this paper,the author first summarizes China’s price operation situation and characteristics since the 1990s,and thenanalyzes inflation shaping factors and types.Based on that,the author raises six inflation early... In this paper,the author first summarizes China’s price operation situation and characteristics since the 1990s,and thenanalyzes inflation shaping factors and types.Based on that,the author raises six inflation early-warning indexes andfully dissects influencing factors of the overall price trend and inflation risks during the 12th Five-year Plan period.Afterthat,the author explains some aspects of price fluctuation that warrants attention during the 12th Five-year Plan period.Finally,the author puts forward policies and suggestions for stabilizing the overall price during the transformation of theeconomic development mode based on our actual situation. 展开更多
关键词 12th Five-year PLAN PERIOD overall PRICE level INFLATION TRANSFORMING ECONOMIC development mode
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IL-12 p35 silenced dendritic cells modulate immune responses by blocking IL-12 signaling through JAK-STAT pathway in T lymphocytes
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作者 Xu, H. Zhang, Y. H. Hua, Y. B. Chen, T. Wang, H. Q. Wu, W. X. 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2007年第5期423-423,共1页
关键词 JAK-STAT路径 淋巴细胞 RNA干涉 细胞因子 移植 免疫 IL-12 P35 基因沉默
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第12届欧洲足球锦标赛决赛阶段各队进球统计与分析 被引量:24
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作者 郭书胜 李书玲 刘涛 《中国体育科技》 北大核心 2005年第3期86-88,99,共4页
通过对第12届欧洲足球锦标赛决赛阶段31场比赛的77个进球情况进行统计分析,结果显示,下半场的进球数高于上半场,比赛的开始时段是进球的低谷,75~90min时段是进球的高峰;进球的主要射门区域是在罚球区内;进球射门方式以脚射为主;中路进... 通过对第12届欧洲足球锦标赛决赛阶段31场比赛的77个进球情况进行统计分析,结果显示,下半场的进球数高于上半场,比赛的开始时段是进球的低谷,75~90min时段是进球的高峰;进球的主要射门区域是在罚球区内;进球射门方式以脚射为主;中路进攻和边路进攻相结合才是进球的有效手段;各位置进球最多的是前锋运动员。 展开更多
关键词 足球 欧洲锦标赛 12 技术分析
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第12届欧洲足球锦标赛冠军希腊队比赛分析与研究 被引量:13
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作者 王君 马成全 郑鹭宾 《中国体育科技》 北大核心 2005年第3期89-91,共3页
采用录像统计、观察法对第12届欧洲足球锦标赛决赛阶段希腊队的所有比赛进行分析研究。结果表明:在第12届欧洲足球锦标赛上,希腊队的比赛阵型以4 4 2为主;希腊队的快速反击进攻简炼、实效,定位球进攻战术手段丰富,成效显著;希腊队的... 采用录像统计、观察法对第12届欧洲足球锦标赛决赛阶段希腊队的所有比赛进行分析研究。结果表明:在第12届欧洲足球锦标赛上,希腊队的比赛阵型以4 4 2为主;希腊队的快速反击进攻简炼、实效,定位球进攻战术手段丰富,成效显著;希腊队的防守采取以紧逼盯人防守为主,结合区域性的防守形成有效的主动型整体防守体系。 展开更多
关键词 足球 欧洲锦标赛 12 进攻 防守 希腊队
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哮喘患儿血清Th_1/Th_2类细胞因子水平及其临床意义的研究 被引量:11
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作者 冯益真 李舒 崔爱华 《山东医药》 CAS 北大核心 2002年第5期21-22,共2页
采用 IL ISA法测定了哮喘发作期和缓解期患儿的血清白介素 - 12 ( IL- 12 )和白介素 - 4 ( IL- 4 )。结果发现 ,发作期哮喘患儿 IL - 12水平 ( 3 5 .2± 11.18pg/ ml)显著低于缓解期 ( 4 2 .75± 13 .3 8pg/ ml)和健康儿 ( 4 5 ... 采用 IL ISA法测定了哮喘发作期和缓解期患儿的血清白介素 - 12 ( IL- 12 )和白介素 - 4 ( IL- 4 )。结果发现 ,发作期哮喘患儿 IL - 12水平 ( 3 5 .2± 11.18pg/ ml)显著低于缓解期 ( 4 2 .75± 13 .3 8pg/ ml)和健康儿 ( 4 5 .4 3±2 9.19pg/ ml) ,P分别 <0 .0 1、0 .0 5。发作期和缓解期哮喘患儿血清 IL - 4阳性率 (分别为 5 5 .5 6%和 3 6.3 6% )均显著高于健康儿 ( 9.1% ) ,P分别 <0 .0 1、0 .0 5。IL- 12和 IL- 4呈显著负相关 ( r=- 0 .3 4 ,P<0 .0 5 )。认为哮喘患儿存在明显的 Th1 / Th2 类细胞因子失衡 ,IL- 12和 IL- 4在哮喘发病中都起重要作用。吸入糖皮质激素等治疗可改变这种失衡状态。 展开更多
关键词 哮喘 白介素-12 白介素-4 th1/th2类细胞 儿童
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第12届亚洲杯足球决赛中、日、韩各队对抗中技术运用情况的对比分析 被引量:12
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作者 秦志辉 《中国体育科技》 北大核心 2002年第2期19-22,共4页
通过对第 12届亚洲杯足球决赛中、日、韩男子足球队同场比赛录像资料的观察统计 ,对中国男子足球队运动员对抗中技术运用能力的现状进行了对比分析。研究结果表明 :中国队运动员在全场比赛时间内保持对抗中有效地完成攻、防技术的稳定... 通过对第 12届亚洲杯足球决赛中、日、韩男子足球队同场比赛录像资料的观察统计 ,对中国男子足球队运动员对抗中技术运用能力的现状进行了对比分析。研究结果表明 :中国队运动员在全场比赛时间内保持对抗中有效地完成攻、防技术的稳定性较差 ;对抗中传、接球技术运用能力明显不足 ;抢截球技术运用的攻防综合效率不高。 展开更多
关键词 足球 亚洲杯 12 男子 技术分析 中国 日本 韩国
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5·12震灾中《人民日报》抗震救灾报道实证分析 被引量:2
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作者 呼东燕 侯蓉英 《防灾科技学院学报》 2008年第3期135-137,共3页
2008年5.12汶川地震灾难造成了重大的人员伤亡,本文将以《人民日报》作为研究样本,选取5月12日到6月12日共32天的报道,通过对抗震救灾报道进行归类、分析、思考,笔者认为《人民日报》在抗震救灾报道中呈现出议程设置进程化、议题选择多... 2008年5.12汶川地震灾难造成了重大的人员伤亡,本文将以《人民日报》作为研究样本,选取5月12日到6月12日共32天的报道,通过对抗震救灾报道进行归类、分析、思考,笔者认为《人民日报》在抗震救灾报道中呈现出议程设置进程化、议题选择多样化、报道公开透明有力等新的特点,充分体现了媒体的社会责任和社会功能,因此本次报道是中国媒体在突发事件报道中新的里程碑。 展开更多
关键词 12地震 《人民日报》 抗震救灾 实证分析
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无创血液动力学检测于妊娠12周预测妊娠期高血压疾病的应用价值 被引量:7
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作者 王玢 《空军医学杂志》 2015年第1期52-54,共3页
目的探讨无创血液动力学检测于妊娠12周预测妊娠期高血压疾病(hypertensive disorders in pregnancy,HDP)的可行性。方法随机选取我院门诊无妊娠合并症及妊娠并发症的孕妇472例,随机分为观察组(233例)和对照组(239例)。观察组于妊娠12... 目的探讨无创血液动力学检测于妊娠12周预测妊娠期高血压疾病(hypertensive disorders in pregnancy,HDP)的可行性。方法随机选取我院门诊无妊娠合并症及妊娠并发症的孕妇472例,随机分为观察组(233例)和对照组(239例)。观察组于妊娠12周行无创血液动力学检测,以时量平均波形曲线下面积(AMP2)≥90%、中心动脉收缩压≥100 mm Hg为妊娠期高血压疾病阳性预测指标。对照组于妊娠20周行平均动脉压检测,以平均动脉压≥85 mm Hg为妊娠期高血压疾病阳性预测指标。结果观察组妊娠12周时量平均波形曲线下面积71.30%~134.51%,均值87.91%±20.93%,中位数85.90%,中心动脉收缩压81.22~115.43 mm Hg,均值(83.76±22.59)mm Hg,中位数83.21 mm Hg,预测发病人数14人,预测发病率6.01%,实际发病人数12人,实际发病率5.15%,敏感度85.71%,特异度99.10%。对照组平均动脉压69.33~106.15 mm Hg,平均值(81.33±18.47)mm Hg,中位数80.27 mm Hg,对照组预测发病人数41人,预测发病率17.67%,实际发病人数13人,实际发病率5.60%,敏感度31.70%,特异度88.66%。2种预测方法的敏感度、特异度相比较,差异均有统计学意义(P<0.05)。结论以时量平均波形曲线下面积≥90%、中心动脉收缩压≥100 mm Hg为阳性预测标准,于妊娠12周采用无创血液动力学检测预测妊娠期高血压疾病具有预测孕周早、敏感度高、特异性强等优点。 展开更多
关键词 无创血液动力学 妊娠12 预测 妊娠期高血压疾病
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