Locally advanced pancreatic cancer is associated with a very poor prognosis. This study was performed to evaluate whether patients with locally advanced pancreatic cancer benefit from 125 ^I seed implantation. This re...Locally advanced pancreatic cancer is associated with a very poor prognosis. This study was performed to evaluate whether patients with locally advanced pancreatic cancer benefit from 125 ^I seed implantation. This retrospective study included 224 patients with locally advanced pancreatic cancer, with 137 patients（61.2%） in the implantation（IP） group and 87（38.9%） in the non-implantation（NIP） group. The survival status, complications and objective curative effects were compared between the groups. The average operative time in the IP group was significantly longer than that in the NIP group（243±51 vs. 214±77 min）. The tumor response rates were 9.5% and 0 at the 2nd month after surgery in the IP and NIP groups, respectively（P〈0.05）. The IP group exhibited a trend toward pain relief at the 6th month after surgery. The global health status scores of the IP group were higher than those of the NIP group at the 3rd and 6th month after surgery. The median survival time in the IP group was significantly longer than that in the NIP group. In conclusion, patients with locally advanced pancreatic cancer can benefit from 125 I seed implantation in terms of local tumor control, survival time, pain relief and quality of life.展开更多
Rhabdomyosarcomas(RMSs)are highly malignant soft-tissue sarcomas.Head and neck RMSs often pose unique challenges to treatment because of their closeness to important structures.We here report a rare case of a 1-year-o...Rhabdomyosarcomas(RMSs)are highly malignant soft-tissue sarcomas.Head and neck RMSs often pose unique challenges to treatment because of their closeness to important structures.We here report a rare case of a 1-year-old boy with a 1-month history of right eye swelling and an eye mass.Biopsy of deep tumors in the maxillofacial region supports embryonal RMS.Postoperative positron emission computed tomography showed a 5.0 cm×4.8 cm×4.2 cm malignant tumor in the right maxillary region.In accordance with the international RMS study group guideline,the child was diagnosed with IIIa and TNM stage T2bN1M1 embryonal RMS.The child was treated with a combination of chemotherapy and ^(125)I seed implantation radiotherapy and eventually achieved partial remission.This case report shows that ^(125)I seed implantation is a safe and effective means of delivering radiotherapy to young children with head and neck RMSs.It may be an option for children with RMSs for whom surgery or external radiotherapy is unsuitable.展开更多
文摘Locally advanced pancreatic cancer is associated with a very poor prognosis. This study was performed to evaluate whether patients with locally advanced pancreatic cancer benefit from 125 ^I seed implantation. This retrospective study included 224 patients with locally advanced pancreatic cancer, with 137 patients（61.2%） in the implantation（IP） group and 87（38.9%） in the non-implantation（NIP） group. The survival status, complications and objective curative effects were compared between the groups. The average operative time in the IP group was significantly longer than that in the NIP group（243±51 vs. 214±77 min）. The tumor response rates were 9.5% and 0 at the 2nd month after surgery in the IP and NIP groups, respectively（P〈0.05）. The IP group exhibited a trend toward pain relief at the 6th month after surgery. The global health status scores of the IP group were higher than those of the NIP group at the 3rd and 6th month after surgery. The median survival time in the IP group was significantly longer than that in the NIP group. In conclusion, patients with locally advanced pancreatic cancer can benefit from 125 I seed implantation in terms of local tumor control, survival time, pain relief and quality of life.
基金Beijing Municipal Natural Science Foundation,Grant/Award Number:7222054Beijing Research Ward Project,Grant/Award Number:BCRW202101。
文摘Rhabdomyosarcomas(RMSs)are highly malignant soft-tissue sarcomas.Head and neck RMSs often pose unique challenges to treatment because of their closeness to important structures.We here report a rare case of a 1-year-old boy with a 1-month history of right eye swelling and an eye mass.Biopsy of deep tumors in the maxillofacial region supports embryonal RMS.Postoperative positron emission computed tomography showed a 5.0 cm×4.8 cm×4.2 cm malignant tumor in the right maxillary region.In accordance with the international RMS study group guideline,the child was diagnosed with IIIa and TNM stage T2bN1M1 embryonal RMS.The child was treated with a combination of chemotherapy and ^(125)I seed implantation radiotherapy and eventually achieved partial remission.This case report shows that ^(125)I seed implantation is a safe and effective means of delivering radiotherapy to young children with head and neck RMSs.It may be an option for children with RMSs for whom surgery or external radiotherapy is unsuitable.
