This study aims at the theoretical and practical evidence for prevention of restenosis in vitro.Vascular smooth muscle cell(VSMC)model was established using adherent cell culture methods.The proliferation of VSMC was ...This study aims at the theoretical and practical evidence for prevention of restenosis in vitro.Vascular smooth muscle cell(VSMC)model was established using adherent cell culture methods.The proliferation of VSMC was investigated by the cell counting method and 3H-TDR implementation test.The results are as follows.(1) For ^125I-seeds,the inhibition rate was 29.3% at 74B1(P<0.05),35.2% at 148Bq(P<0.05)and 42.4% at 370Bq(P<0.05),For ^103Pd-implanted stents,the inhibition rate was 14.7% at 4.44MBq(P<0.05),24.0% at 5.92MBq(P<0.05) and 38.0%at 7.4MBq(p<0.05),There was no significant difference between the blank tests and non-radioactive tests.(2) 48 hours exposure from ^125I-seeds at 148Bq or ^103Pd-implanted stents at 7.4MBq did not result in VSMC's morphological alteration,but that from ^125I-seeds at 370Bq caused morphological changes,Both ^125I-seeds and ^103Pd0-implanted stents inhibit the VSMC DNA synthesis in vitro.The inhibition effects are significantly related to their exposure duration and doses.展开更多
放射性光子源如103Pd和125I已被广泛用于前列腺和眼睛的植入治疗中。本文使用MCNP4C软件计算美国医学物理学家协会(American association of physicists in medicine,AAPM)推荐的103Pd和125I的剂量学特征。由AAPM推荐的剂量学参量如剂...放射性光子源如103Pd和125I已被广泛用于前列腺和眼睛的植入治疗中。本文使用MCNP4C软件计算美国医学物理学家协会(American association of physicists in medicine,AAPM)推荐的103Pd和125I的剂量学特征。由AAPM推荐的剂量学参量如剂量率常数、径向剂量函数、各项异性函数通过Monte Carlo计算得到,在材料固体水WT1(solid water)中,125I的剂量率常数为0.99,103Pd的为0.682,而在材料Water中,125I剂量率为1.01。与前研究工作者Reners的计算结果相比125I的剂量率一致,而103Pd剂量率和各向异性函数结果相差较大,这些差异是使用不同Monte Carlo代码截面数据引起的。展开更多
文摘This study aims at the theoretical and practical evidence for prevention of restenosis in vitro.Vascular smooth muscle cell(VSMC)model was established using adherent cell culture methods.The proliferation of VSMC was investigated by the cell counting method and 3H-TDR implementation test.The results are as follows.(1) For ^125I-seeds,the inhibition rate was 29.3% at 74B1(P<0.05),35.2% at 148Bq(P<0.05)and 42.4% at 370Bq(P<0.05),For ^103Pd-implanted stents,the inhibition rate was 14.7% at 4.44MBq(P<0.05),24.0% at 5.92MBq(P<0.05) and 38.0%at 7.4MBq(p<0.05),There was no significant difference between the blank tests and non-radioactive tests.(2) 48 hours exposure from ^125I-seeds at 148Bq or ^103Pd-implanted stents at 7.4MBq did not result in VSMC's morphological alteration,but that from ^125I-seeds at 370Bq caused morphological changes,Both ^125I-seeds and ^103Pd0-implanted stents inhibit the VSMC DNA synthesis in vitro.The inhibition effects are significantly related to their exposure duration and doses.
文摘放射性光子源如103Pd和125I已被广泛用于前列腺和眼睛的植入治疗中。本文使用MCNP4C软件计算美国医学物理学家协会(American association of physicists in medicine,AAPM)推荐的103Pd和125I的剂量学特征。由AAPM推荐的剂量学参量如剂量率常数、径向剂量函数、各项异性函数通过Monte Carlo计算得到,在材料固体水WT1(solid water)中,125I的剂量率常数为0.99,103Pd的为0.682,而在材料Water中,125I剂量率为1.01。与前研究工作者Reners的计算结果相比125I的剂量率一致,而103Pd剂量率和各向异性函数结果相差较大,这些差异是使用不同Monte Carlo代码截面数据引起的。
