Objective:To investigate the effect and mechanism of bioactive glass1393 on wound healing in mice with burn injuries.Methods:A benchtop temperature-controlled scald instrument was used to establish a mouse burn wound ...Objective:To investigate the effect and mechanism of bioactive glass1393 on wound healing in mice with burn injuries.Methods:A benchtop temperature-controlled scald instrument was used to establish a mouse burn wound model,which was divided into an injury group(simple scald group)and a bioactive glass 1393treatment group.The wound healing of burn injuries in mice was observed at different times after the operation,and the formation of granulation tissue,collagen deposition and tissue proliferation in the wounds were observed by HE staining,Masson staining and Ki67 staining,and the levels of apoptosis-related proteins and the expression of wnt3a/β-catenin signaling pathway were detected in the wounds by Western blot.Results:Compared with the injury group,the bioactive glass 1393 group accelerated burn wound healing and promoted granulation tissue formation,collagen deposition,and cell proliferation.In addition,compared with the injury group,the bioactive glass 1393 group promoted the expression of Bcl-2 protein,inhibited the expression of Bax protein and up-regulated the expression of Wnt3a andβ-catenin protein.Conclusion:Bioactive glass 1393 promotes burn wound healing in mice by inhibiting apoptosis through modulation of wnt3a/β-catenin signaling pathway.展开更多
Spectral and timing properties of accretion flows on a black hole depend on their density and temperature distributions,which in turn come from the underlying dynamics.Thus,an accurate description of the flow which in...Spectral and timing properties of accretion flows on a black hole depend on their density and temperature distributions,which in turn come from the underlying dynamics.Thus,an accurate description of the flow which includes hydrodynamics and radiative transfer is a must to interpret the observational results.In the case of nonrotating black holes,a pseudo-Newtonian description of surrounding spacetime enables one to make significant progress in predicting spectral and timing properties.This formalism is lacking for spinning black holes.In this paper,we show that there exists an exact form of a"natural"potential derivable from the general relativistic(GR)radial momentum equation.Use of this potential in an otherwise Newtonian set of equations allows to describe transonic flows very accurately as is evidenced by comparing with solutions obtained from the full GR framework.We study the properties of the critical points and the centrifugal pressure supported shocks in the parameter space spanned by the specific energy and angular momentum,and compare with the results of GR hydrodynamics.We show that this potential can safely be used for the entire range of Kerr parameter-1<a<1 for modeling of observational results around spinning black holes.We assume the flow to be inviscid.Thus,it is non-dissipative with constant energy and angular momentum.These assumptions are valid very close to the black hole as the infall timescale is much shorter as compared to the viscous timescale.展开更多
文摘Objective:To investigate the effect and mechanism of bioactive glass1393 on wound healing in mice with burn injuries.Methods:A benchtop temperature-controlled scald instrument was used to establish a mouse burn wound model,which was divided into an injury group(simple scald group)and a bioactive glass 1393treatment group.The wound healing of burn injuries in mice was observed at different times after the operation,and the formation of granulation tissue,collagen deposition and tissue proliferation in the wounds were observed by HE staining,Masson staining and Ki67 staining,and the levels of apoptosis-related proteins and the expression of wnt3a/β-catenin signaling pathway were detected in the wounds by Western blot.Results:Compared with the injury group,the bioactive glass 1393 group accelerated burn wound healing and promoted granulation tissue formation,collagen deposition,and cell proliferation.In addition,compared with the injury group,the bioactive glass 1393 group promoted the expression of Bcl-2 protein,inhibited the expression of Bax protein and up-regulated the expression of Wnt3a andβ-catenin protein.Conclusion:Bioactive glass 1393 promotes burn wound healing in mice by inhibiting apoptosis through modulation of wnt3a/β-catenin signaling pathway.
基金sponsored RESPOND project(ISRO/RES/2/418/18-19)supported in part by the Higher Education Dept.of the Govt.of West Bengal,India。
文摘Spectral and timing properties of accretion flows on a black hole depend on their density and temperature distributions,which in turn come from the underlying dynamics.Thus,an accurate description of the flow which includes hydrodynamics and radiative transfer is a must to interpret the observational results.In the case of nonrotating black holes,a pseudo-Newtonian description of surrounding spacetime enables one to make significant progress in predicting spectral and timing properties.This formalism is lacking for spinning black holes.In this paper,we show that there exists an exact form of a"natural"potential derivable from the general relativistic(GR)radial momentum equation.Use of this potential in an otherwise Newtonian set of equations allows to describe transonic flows very accurately as is evidenced by comparing with solutions obtained from the full GR framework.We study the properties of the critical points and the centrifugal pressure supported shocks in the parameter space spanned by the specific energy and angular momentum,and compare with the results of GR hydrodynamics.We show that this potential can safely be used for the entire range of Kerr parameter-1<a<1 for modeling of observational results around spinning black holes.We assume the flow to be inviscid.Thus,it is non-dissipative with constant energy and angular momentum.These assumptions are valid very close to the black hole as the infall timescale is much shorter as compared to the viscous timescale.
