目的 分析X-pert联合核苷酸结合寡聚化结构域蛋白2(NOD2)、自噬相关蛋白16样蛋白1(ATG16L1)在活动性肺结核患者疾病转归评估中的应用价值。方法 前瞻性选取2023年4月至2024年4月池州市人民医院收治的110例活动性肺结核患者为研究对象。...目的 分析X-pert联合核苷酸结合寡聚化结构域蛋白2(NOD2)、自噬相关蛋白16样蛋白1(ATG16L1)在活动性肺结核患者疾病转归评估中的应用价值。方法 前瞻性选取2023年4月至2024年4月池州市人民医院收治的110例活动性肺结核患者为研究对象。所有患者均行抗结核治疗、疾病转归评估,将转归患者60例作为转归组,未转归患者50例作为未转归组。收集两组患者的临床资料(年龄、体重指数、性别、吸烟史、贫血、累及肺野数、肺部空洞病变、利福平耐药)。治疗前行X-pert、NOD2、ATG16L1检测,比较两组X-pert阳性率及NOD2、ATG16L1表达水平。采用多因素Logistics回归分析分析活动性肺结核患者疾病转归的影响因素,采用受试者操作特征(ROC)曲线分析X-pert、NOD2、ATG16L1对活动性肺结核患者疾病转归的预测价值。结果 两组体重指数、吸烟史、贫血、累及肺野数、利福平耐药比较,差异均无统计学意义(P>0.05);与转归组相比,未转归组患者年龄较大[(56.15±19.34)vs.(63.18±12.84)岁],男性(71.67 vs. 90.00)%、肺部空洞病变(11.67 vs. 32.00)%比例较高,差异均有统计学意义(P<0.05)。与转归组相比,未转归组患者X-pert阳性率(75.00 vs. 90.00)%、NOD2[(164.31±15.55)vs.(199.29±24.63)ng/L]、ATG16L1[(8.95±1.1.74)vs.(12.15±2.26)ng/L]表达水平均较高,差异均有统计学意义(P<0.05)。多因素Logistics回归分析结果显示,年龄、性别、肺部空洞病变、X-pert、NOD2、ATG16L1为活动性肺结核患者疾病转归的危险因素(P<0.05)。与X-pert、NOD2、ATG16L1单项诊断相比,X-pert、NOD2、ATG16L1联合检测对活动性肺结核患者疾病转归的预测价值较高(P<0.05)。结论 疾病未转归活动性肺结核患者X-pert阳性率、NOD2、ATG16L1表达水平均高于转归患者,X-pert、NOD2、ATG16L1为活动性肺结核患者疾病转归的危险因素,X-pert联合NOD2、ATG16L1对活动性肺结核患者疾病转归的预测价值较高,为活动性肺结核患者疾病转归评估提供了有效依据。展开更多
Among the numerous transition metal catalysts,manganese-based compounds are considered as promising peroxymonosulfate(PMS)catalysts due to their low cost and environmental friendliness,such as cryptomelane manganese o...Among the numerous transition metal catalysts,manganese-based compounds are considered as promising peroxymonosulfate(PMS)catalysts due to their low cost and environmental friendliness,such as cryptomelane manganese oxide(K_(2-x)Mn_(8)O_(16):abbreviation KMnO).However,the limited catalytic performance of KMnO limits its practical application.In this work,iron-doped KMnO(Fe-KMnO)was prepared by one-step hydrothermal method to optimize its catalytic performance.Compared with KMnO/PMS system,Fe-KMnO/PMS system possessed more excellent removal efficiency of tetracycline(TC).Meanwhile,the Fe-KMnO/PMS system also exhibited good practical application potential and excellent stability.The mechanism of Fe-KMnO activation of PMS was further analyzed in detail.It was found that Fe participated in the redox of high-valent Mn,which promoted the activation of PMS.Moreover,The Fe site as an adsorption site enhanced the TC enrichment ability of the catalyst,reducing the mass transfer resistance and further enhancing the TC removal ability of Fe-KMnO/PMS system.This work not only provides an excellent PMS catalyst,but also offers new insights into the mechanism of PMS activation by bimetallic manganese-based catalysts.展开更多
基金jointly supported by the National Natural Science Foundation of China(No.22273093,No.41905018,No.21903080)the Ministry of Science and Technology of China(No.2022YFF0606500)。
文摘目的 分析X-pert联合核苷酸结合寡聚化结构域蛋白2(NOD2)、自噬相关蛋白16样蛋白1(ATG16L1)在活动性肺结核患者疾病转归评估中的应用价值。方法 前瞻性选取2023年4月至2024年4月池州市人民医院收治的110例活动性肺结核患者为研究对象。所有患者均行抗结核治疗、疾病转归评估,将转归患者60例作为转归组,未转归患者50例作为未转归组。收集两组患者的临床资料(年龄、体重指数、性别、吸烟史、贫血、累及肺野数、肺部空洞病变、利福平耐药)。治疗前行X-pert、NOD2、ATG16L1检测,比较两组X-pert阳性率及NOD2、ATG16L1表达水平。采用多因素Logistics回归分析分析活动性肺结核患者疾病转归的影响因素,采用受试者操作特征(ROC)曲线分析X-pert、NOD2、ATG16L1对活动性肺结核患者疾病转归的预测价值。结果 两组体重指数、吸烟史、贫血、累及肺野数、利福平耐药比较,差异均无统计学意义(P>0.05);与转归组相比,未转归组患者年龄较大[(56.15±19.34)vs.(63.18±12.84)岁],男性(71.67 vs. 90.00)%、肺部空洞病变(11.67 vs. 32.00)%比例较高,差异均有统计学意义(P<0.05)。与转归组相比,未转归组患者X-pert阳性率(75.00 vs. 90.00)%、NOD2[(164.31±15.55)vs.(199.29±24.63)ng/L]、ATG16L1[(8.95±1.1.74)vs.(12.15±2.26)ng/L]表达水平均较高,差异均有统计学意义(P<0.05)。多因素Logistics回归分析结果显示,年龄、性别、肺部空洞病变、X-pert、NOD2、ATG16L1为活动性肺结核患者疾病转归的危险因素(P<0.05)。与X-pert、NOD2、ATG16L1单项诊断相比,X-pert、NOD2、ATG16L1联合检测对活动性肺结核患者疾病转归的预测价值较高(P<0.05)。结论 疾病未转归活动性肺结核患者X-pert阳性率、NOD2、ATG16L1表达水平均高于转归患者,X-pert、NOD2、ATG16L1为活动性肺结核患者疾病转归的危险因素,X-pert联合NOD2、ATG16L1对活动性肺结核患者疾病转归的预测价值较高,为活动性肺结核患者疾病转归评估提供了有效依据。
基金supported by the National Natural Science Foundation of China (21806115)Sichuan Science and Technology Program (2020YJ0149)+1 种基金the Power Construction of China (P42819,DJ-ZDXM-2019-42)the Supported by Sichuan Science and Technology Program (2021ZDZX0012)。
文摘Among the numerous transition metal catalysts,manganese-based compounds are considered as promising peroxymonosulfate(PMS)catalysts due to their low cost and environmental friendliness,such as cryptomelane manganese oxide(K_(2-x)Mn_(8)O_(16):abbreviation KMnO).However,the limited catalytic performance of KMnO limits its practical application.In this work,iron-doped KMnO(Fe-KMnO)was prepared by one-step hydrothermal method to optimize its catalytic performance.Compared with KMnO/PMS system,Fe-KMnO/PMS system possessed more excellent removal efficiency of tetracycline(TC).Meanwhile,the Fe-KMnO/PMS system also exhibited good practical application potential and excellent stability.The mechanism of Fe-KMnO activation of PMS was further analyzed in detail.It was found that Fe participated in the redox of high-valent Mn,which promoted the activation of PMS.Moreover,The Fe site as an adsorption site enhanced the TC enrichment ability of the catalyst,reducing the mass transfer resistance and further enhancing the TC removal ability of Fe-KMnO/PMS system.This work not only provides an excellent PMS catalyst,but also offers new insights into the mechanism of PMS activation by bimetallic manganese-based catalysts.
