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^(18)F-FDGhPET/CT显像在非小细胞肺癌临床分期中的应用 被引量:1
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作者 张彦彬 朱家瑞 杨志祥 《解放军医学杂志》 CAS CSCD 北大核心 2006年第5期473-475,共3页
目的探讨^(18)F-脱氧葡萄糖hPET/CT(^(18)F-FDGhPET/CT)显像在非小细胞肺癌(NSCLC)临床分期中的应用价值。方法72例NSCLC患者于放疗前行^(18)F-FDGhPET/CT显像检查,进行FDG分期,并将FDG分期和CT分期结果进行比较分析。结果18F-FDGhPET/C... 目的探讨^(18)F-脱氧葡萄糖hPET/CT(^(18)F-FDGhPET/CT)显像在非小细胞肺癌(NSCLC)临床分期中的应用价值。方法72例NSCLC患者于放疗前行^(18)F-FDGhPET/CT显像检查,进行FDG分期,并将FDG分期和CT分期结果进行比较分析。结果18F-FDGhPET/CT显像使27例NSCLC患者分期改变,其中分期升级20例,分期降级7例。14例分期升级者^(18)F-FDGhPET/CT显像检查发现了远处转移灶,其治疗方案由根治性治疗改为姑息性治疗。FDG显像较CT多发现了47个转移淋巴结,并对其进行了放疗;多发现了26个远处转移灶,并对其进行了姑息性放疗。结论^(18)F-FDGhPET/CT显像改变了37.5%(27/72)NSCLC患者的临床分期,影响了其治疗策略及放疗计划,使得治疗更加合理。 展开更多
关键词 非小细胞肺 ^18f-fdg hpet/ct显像 肿瘤分期
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Improved image resolution on thoracic carcinomas by quantitative 18F-FDG coincidence SPECT/CT in comparison to 18F-FDG PET/CT 被引量:2
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作者 Yuming Zheng Chaoling Jin +4 位作者 Huijuan Cui Haojie Dai Jue Yan Pingping Han Bailing Hsu 《The Journal of Biomedical Research》 CAS CSCD 2020年第4期309-317,共9页
Currently,18F-FDG coincidence SPECT(Co-SPECT)/CT scan still serves as an important tool for diagnosis,staging,and evaluation of cancer treatment in developing countries.We implemented full physical corrections(FPC) to... Currently,18F-FDG coincidence SPECT(Co-SPECT)/CT scan still serves as an important tool for diagnosis,staging,and evaluation of cancer treatment in developing countries.We implemented full physical corrections(FPC) to Co-SPECT(quantitative Co-SPECT) to improve the image resolution and contrast along with the capability for image quantitation.FPC included attenuation,scatter,resolution recovery,and noise reduction.A standard NEMA phantom filled with 10:1 F-18 activity concentration ratio in spheres and background was utilized to evaluate image performance.Subsequently,15 patients with histologically confirmed thoracic carcinomas were included to undergo a 18 F-FDG Co-SPECT/CT scan followed by a 18 F-FDG PET/CT scan.Functional parameters as SUVmax,SUVmean,SULpeak,and MTV from both quantitative Co-SPECT and PET were analyzed.Image resolution of Co-SPECT for NEMA phantom was improved to reveal the smallest sphere from a diameter of 28 mm to 22 mm(17 mm for PET).The image contrast was enhanced from 1.7 to 6.32(6.69 for PET) with slightly degraded uniformity in background(3.1% vs.6.7%)(5.6% for PET).Patients’ SUVmax,SUVmean,SULpeak,and MTV measured from quantitative Co-SPECT were overall highly correlated with those from PET(r=0.82-0.88).Adjustment of the threshold of SUVmax and SUV to determine SUVmean and MTV did not further change the correlations with PET(r=0.81-0.88).Adding full physical corrections to Co-SPECT images can significantly improve image resolution and contrast to reveal smaller tumor lesions along with the capability to quantify functional parameters like PET/CT. 展开更多
关键词 18f-fdg coincidence SPEct/ct full physical corrections thoracic carcinomas image quantitation
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应用18F-FDG hPET/CT全身显像诊断颈部淋巴结转移癌的临床效果
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作者 周勤冰 余小忠 《浙江临床医学》 2019年第5期613-615,共3页
目的 探讨颈部淋巴结转移癌患者采用18F-FDG?hPET/CT全身显像的诊断效果及其T/N比值与VEGF、PDGF和MVD的相关性.方法 选择2016年1月至2018年2月颈部淋巴结转移患者39例,入院后患者先行常规影像学检查,然后对患者行18F-FDG?hPET/CT全身... 目的 探讨颈部淋巴结转移癌患者采用18F-FDG?hPET/CT全身显像的诊断效果及其T/N比值与VEGF、PDGF和MVD的相关性.方法 选择2016年1月至2018年2月颈部淋巴结转移患者39例,入院后患者先行常规影像学检查,然后对患者行18F-FDG?hPET/CT全身显像检查,测定患者T/N比值,计算18F-FDG?hPET/CT全身显像与常规影像学诊断灵敏度、特异度、阳性预测值(PPV)与阴性预测值,分析18F-FDG?hPET/CT全身显像在颈部淋巴结转移癌患者中的诊断效果;颈部淋巴结患者手术后取病理组织、癌旁组织,采用免疫组织化学法测定不同病理组织VEGF、PDGF和MVD的表达阳性情况;分析T/N比值与VEGF、PDGF和MVD的相关性.结果 39例颈部淋巴结转移癌患者中,18F-FDG?hPET/CT全身显像发现25例原发灶,阳性率95%置信区间(47%,79%)为95%,最终经病理检查确诊23例,诊断符合率为92.0%.常规影像学检查出22例(其中真阳16例,假阳6例),两种诊断符合率比较差异有统计学意义(P<0.05);18F-FDG?hPET/CT全身显像用于颈部淋巴结转移癌诊断敏感度、特异度、阳性预测值及阴性预测值,均高于常规影像学(P<0.05);颈部淋巴结转移癌患者病灶组织VEGF、PDGF和MVD阳性率,均高于癌旁组织(P<0.05);SPSS?Pearson相关性分析结果表明,18F-FDG?hPET/CT全身显像T/N比值与VEGF、PDGF和MVD均呈负相关(P<0.05).结论 将18F-FDG?hPET/CT全身显像用于颈部淋巴结转移癌患者中能取得理想的诊断效果,且病理组织中VEGF、PDGF和MVD呈高表达,与T/N比值具有一定相关性,能为临床治疗提供依据和参考. 展开更多
关键词 18f-fdg hpet/ct全身显像 颈部淋巴结转移癌 血管内皮生长因子、血小板来源的内皮生长因子 Ⅷ因子测定微血管密度 相关性
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Mucosa-associated lymphoid tissue lymphoma with unusual 18F-FDG hypermetabolism arising at the colorectal anastomosis
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作者 Na-Sha Zhang Fang Shi +1 位作者 Li Kong Hui Zhu 《World Journal of Gastroenterology》 SCIE CAS 2017年第3期551-559,共9页
Mucosa-associated lymphoid tissue (MALT) lymphoma usually originates from the stomach and presents with low ^(18)F-fluorodeoxyglucose (FDG) avidity with average maximum standard uptake value of 3.6. Colorectal MALT ly... Mucosa-associated lymphoid tissue (MALT) lymphoma usually originates from the stomach and presents with low ^(18)F-fluorodeoxyglucose (FDG) avidity with average maximum standard uptake value of 3.6. Colorectal MALT lymphoma is a rare entity that contributes to 1.6% of all MALT lymphomas and < 0.2% of large intestinal malignancies. The case reported herein firstly revealed stage Ⅱ MALT lymphoma with unexpected higher ^(18)F-FDG avidity of 18.9 arising at the colorectal anastomosis in a patient with a surgical history for sigmoid adenocarcinoma, which was strongly suspected as local recurrence before histopathological and immunohistochemical examinations. After accurate diagnosis, the patient received four cycles of standard R-CVP regimen (rituximab, cyclophosphamide, vincristine and prednisone), combined target therapy and chemotherapy, instead of radiotherapy recommended by National Comprehensive Cancer Network guidelines. He tolerated the treatment well and reached complete remission. 展开更多
关键词 Colorectal ANASTOMOSIS Mucosa-associated LYMPHOID tissue lymphoma ETIOPATHOGENESIS UNUSUAL 18f-fdg HYPERMETABOLISM 18f-fdg-PET/ct imaging Patient-tailored treatment
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