目的探究盆底功能障碍性疾病(pelvic floor dysfunctional disease,PFD)患者血清微小RNA(microRNA,miR)-4429和微小RNA(microRNA,miR)-19-3p水平表达及意义。方法选取2021年6月~2022年6月衡水市第二人民医院收治的PFD患者90例作为PFD组...目的探究盆底功能障碍性疾病(pelvic floor dysfunctional disease,PFD)患者血清微小RNA(microRNA,miR)-4429和微小RNA(microRNA,miR)-19-3p水平表达及意义。方法选取2021年6月~2022年6月衡水市第二人民医院收治的PFD患者90例作为PFD组,分为盆腔器官脱垂(pelvic organ prolapse,POP)组(n=50)、压力性尿失禁(stress urinary incontinence,SUI)组(n=25)和POP并发SUI组(n=15);并选取同期在衡水市第二人民医院检查的健康女性80例为对照组。比较对照组与PFD组分娩方式、既往流产史、PFD家族史等一般资料。比较各组血清miR-4429和miR-19-3p水平。受试者工作特征(receiver operating characteristic,ROC)曲线分析血清miR-4429,miR-19-3p水平对PFD的诊断价值。Logistic回归分析影响PFD的因素。配对样本t检验比较PFD治疗前后血清miR-4429,miR-19-3p水平变化。结果PFD组在分娩方式、既往流产史、PFD家族史方面与对照组相比差异均有统计学意义(t=4.415,6.444,4.707,均P<0.05)。PFD组血清miR-4429水平较对照组降低(0.71±0.19 vs 1.00±0.25),miR-19-3p水平较对照组升高(1.44±0.35 vs 1.01±0.28),差异具有统计学意义(t=8.927,8.772,均P<0.05)。POP组和SUI组血清miR-4429水平高于POP并发SUI组(0.73±0.22,0.74±0.16 vs 0.59±0.16),POP组和SUI组血清miR-19-3p水平低于POP并发SUI组(1.35±0.39,1.41±0.31 vs 1.77±0.56),差异具有统计学意义(t=3.531,3.411;5.003,3.865,均P<0.05)。ROC曲线分析显示,miR-4429,miR-19-3p可辅助评估是否发生PFD的曲线下面积(area under curve,AUC)分别为0.805,0.825,二者联合检测的AUC为0.865。多因素分析显示,miR-19-3p是影响PFD的危险因素,miR-4429是保护因素。经过治疗发现,PFD患者血清miR-4429水平升高(0.93±0.23 vs 0.71±0.19),miR-19-3p水平降低(1.12±0.29 vs 1.44±0.35),差异具有统计学意义(t=6.996,6.679,均P<0.05)。结论PFD患者血清miR-4429水平降低,miR-19-3p水平升高,血清miR-4429,miR-19-3p水平与PFD疾病的发生发展密切相关,可作为预测PFD的评估指标。展开更多
Gliomas are primary brain tumors derived from glial cells of the central nervous system,afflicting both adults and children with distinct characteristics and therapeutic challenges.Recent developments have ushered in ...Gliomas are primary brain tumors derived from glial cells of the central nervous system,afflicting both adults and children with distinct characteristics and therapeutic challenges.Recent developments have ushered in novel clinical and molecular prognostic factors,reshaping treatment paradigms based on classi-fication and grading,determined by histological attributes and cellular lineage.This review article delves into the diverse treatment modalities tailored to the specific grades and molecular classifications of gliomas that are currently being discussed and used clinically in the year 2023.For adults,the therapeutic triad typically consists of surgical resection,chemotherapy,and radiotherapy.In contrast,pediatric gliomas,due to their diversity,require a more tailored approach.Although complete tumor excision can be curative based on the location and grade of the glioma,certain non-resectable cases demand a chemotherapy approach usually involving,vincristine and carboplatin.Addi-tionally,if surgery or chemotherapy strategies are unsuccessful,Vinblastine can be used.Despite recent advancements in treatment methodologies,there remains a need of exploration in the literature,particularly concerning the efficacy of treatment regimens for isocitrate dehydrogenase type mutant astrocytomas and fine-tuned therapeutic approaches tailored for pediatric cohorts.This review article explores into the therapeutic modalities employed for both adult and pediatric gliomas in the context of their molecular classification.展开更多
Gliomas originate from glial cells in the central nervous system.Approximately 80%-85%of malignant brain tumors in adults are gliomas.The most common central nervous system tumor in children is low-grade pediatric gli...Gliomas originate from glial cells in the central nervous system.Approximately 80%-85%of malignant brain tumors in adults are gliomas.The most common central nervous system tumor in children is low-grade pediatric glioma.Diagnosis was determined by histological features until 2016 when the World Health Organization classification integrated molecular data with anatomopathological information to achieve a more integral diagnosis.Molecular characterization has led to better diagnostic and prognostic staging,which in turn has increased the precision of treatment.Current efforts are focused on more effective therapies to prolong survival and improve the quality of life of adult and pediatric patients with glioma.However,improvements in survival have been modest.Currently,clinical guidelines,as well as the article by Mohamed et al accompanying this editorial piece,are adapting treatment recommendations(surgery,chemotherapy,and radiotherapy)according to diagnosis and prognosis guided by molecular biomarkers.Furthermore,this paves the way for the design of clinical trials with new therapies,which is especially important in pediatric gliomas.展开更多
Glioma is one of the most common primary intracranial tumors,characterized by invasive growth and poor prognosis.Actin cytoskeletal rearrangement is an essential event in tumor cell migration.Scinderin(SCIN),an actin ...Glioma is one of the most common primary intracranial tumors,characterized by invasive growth and poor prognosis.Actin cytoskeletal rearrangement is an essential event in tumor cell migration.Scinderin(SCIN),an actin severing and capping protein that regulates the actin cytoskeleton,is involved in the prolif-eration and migration of certain cancer cells.However,its biological role and molecular mechanism in glioma remain unclear.Lin et al explored the role and mechanism of SCIN in gliomas.The results showed that SCIN mechanically affected cytoskeleton remodeling and inhibited the formation of lamellipodia via RhoA/FAK signaling pathway.This study identifies the cancer-promoting role of SCIN and provides a potential therapeutic target for SCIN in glioma treatment.展开更多
文摘目的探究盆底功能障碍性疾病(pelvic floor dysfunctional disease,PFD)患者血清微小RNA(microRNA,miR)-4429和微小RNA(microRNA,miR)-19-3p水平表达及意义。方法选取2021年6月~2022年6月衡水市第二人民医院收治的PFD患者90例作为PFD组,分为盆腔器官脱垂(pelvic organ prolapse,POP)组(n=50)、压力性尿失禁(stress urinary incontinence,SUI)组(n=25)和POP并发SUI组(n=15);并选取同期在衡水市第二人民医院检查的健康女性80例为对照组。比较对照组与PFD组分娩方式、既往流产史、PFD家族史等一般资料。比较各组血清miR-4429和miR-19-3p水平。受试者工作特征(receiver operating characteristic,ROC)曲线分析血清miR-4429,miR-19-3p水平对PFD的诊断价值。Logistic回归分析影响PFD的因素。配对样本t检验比较PFD治疗前后血清miR-4429,miR-19-3p水平变化。结果PFD组在分娩方式、既往流产史、PFD家族史方面与对照组相比差异均有统计学意义(t=4.415,6.444,4.707,均P<0.05)。PFD组血清miR-4429水平较对照组降低(0.71±0.19 vs 1.00±0.25),miR-19-3p水平较对照组升高(1.44±0.35 vs 1.01±0.28),差异具有统计学意义(t=8.927,8.772,均P<0.05)。POP组和SUI组血清miR-4429水平高于POP并发SUI组(0.73±0.22,0.74±0.16 vs 0.59±0.16),POP组和SUI组血清miR-19-3p水平低于POP并发SUI组(1.35±0.39,1.41±0.31 vs 1.77±0.56),差异具有统计学意义(t=3.531,3.411;5.003,3.865,均P<0.05)。ROC曲线分析显示,miR-4429,miR-19-3p可辅助评估是否发生PFD的曲线下面积(area under curve,AUC)分别为0.805,0.825,二者联合检测的AUC为0.865。多因素分析显示,miR-19-3p是影响PFD的危险因素,miR-4429是保护因素。经过治疗发现,PFD患者血清miR-4429水平升高(0.93±0.23 vs 0.71±0.19),miR-19-3p水平降低(1.12±0.29 vs 1.44±0.35),差异具有统计学意义(t=6.996,6.679,均P<0.05)。结论PFD患者血清miR-4429水平降低,miR-19-3p水平升高,血清miR-4429,miR-19-3p水平与PFD疾病的发生发展密切相关,可作为预测PFD的评估指标。
文摘Gliomas are primary brain tumors derived from glial cells of the central nervous system,afflicting both adults and children with distinct characteristics and therapeutic challenges.Recent developments have ushered in novel clinical and molecular prognostic factors,reshaping treatment paradigms based on classi-fication and grading,determined by histological attributes and cellular lineage.This review article delves into the diverse treatment modalities tailored to the specific grades and molecular classifications of gliomas that are currently being discussed and used clinically in the year 2023.For adults,the therapeutic triad typically consists of surgical resection,chemotherapy,and radiotherapy.In contrast,pediatric gliomas,due to their diversity,require a more tailored approach.Although complete tumor excision can be curative based on the location and grade of the glioma,certain non-resectable cases demand a chemotherapy approach usually involving,vincristine and carboplatin.Addi-tionally,if surgery or chemotherapy strategies are unsuccessful,Vinblastine can be used.Despite recent advancements in treatment methodologies,there remains a need of exploration in the literature,particularly concerning the efficacy of treatment regimens for isocitrate dehydrogenase type mutant astrocytomas and fine-tuned therapeutic approaches tailored for pediatric cohorts.This review article explores into the therapeutic modalities employed for both adult and pediatric gliomas in the context of their molecular classification.
文摘Gliomas originate from glial cells in the central nervous system.Approximately 80%-85%of malignant brain tumors in adults are gliomas.The most common central nervous system tumor in children is low-grade pediatric glioma.Diagnosis was determined by histological features until 2016 when the World Health Organization classification integrated molecular data with anatomopathological information to achieve a more integral diagnosis.Molecular characterization has led to better diagnostic and prognostic staging,which in turn has increased the precision of treatment.Current efforts are focused on more effective therapies to prolong survival and improve the quality of life of adult and pediatric patients with glioma.However,improvements in survival have been modest.Currently,clinical guidelines,as well as the article by Mohamed et al accompanying this editorial piece,are adapting treatment recommendations(surgery,chemotherapy,and radiotherapy)according to diagnosis and prognosis guided by molecular biomarkers.Furthermore,this paves the way for the design of clinical trials with new therapies,which is especially important in pediatric gliomas.
文摘Glioma is one of the most common primary intracranial tumors,characterized by invasive growth and poor prognosis.Actin cytoskeletal rearrangement is an essential event in tumor cell migration.Scinderin(SCIN),an actin severing and capping protein that regulates the actin cytoskeleton,is involved in the prolif-eration and migration of certain cancer cells.However,its biological role and molecular mechanism in glioma remain unclear.Lin et al explored the role and mechanism of SCIN in gliomas.The results showed that SCIN mechanically affected cytoskeleton remodeling and inhibited the formation of lamellipodia via RhoA/FAK signaling pathway.This study identifies the cancer-promoting role of SCIN and provides a potential therapeutic target for SCIN in glioma treatment.
