BACKGROUND Early quantitative assessment of liver fat content is essential for patients with fatty liver disease.Mounting evidence has shown that magnetic resonance(MR)technique has high accuracy in the quantitative a...BACKGROUND Early quantitative assessment of liver fat content is essential for patients with fatty liver disease.Mounting evidence has shown that magnetic resonance(MR)technique has high accuracy in the quantitative analysis of fatty liver,and is suitable for monitoring the therapeutic effect on fatty liver.However,many packaging methods and postprocessing functions have puzzled radiologists in clinical applications.Therefore,selecting a quantitative MR imaging technique for patients with fatty liver disease remains challenging.AIM To provide information for the proper selection of commonly used quantitative MR techniques to quantify fatty liver.METHODS We completed a systematic literature review of quantitative MR techniques for detecting fatty liver,following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol.Studies were retrieved from PubMed,Embase,and Cochrane Library databases,and their quality was assessed using the Quality Assessment of Diagnostic Studies criteria.The Reference Citation Analysis database(https://www.referencecitationanalysis.com)was used to analyze citation of articles which were included in this review.RESULTS Forty studies were included for spectroscopy,two-point Dixon imaging,and multiple-point Dixon imaging comparing liver biopsy to other imaging methods.The advantages and disadvantages of each of the three techniques and their clinical diagnostic performances were analyzed.CONCLUSION The proton density fat fraction derived from multiple-point Dixon imaging is a noninvasive method for accurate quantitative measurement of hepatic fat content in the diagnosis and monitoring of fatty liver progression.展开更多
目的观察依达拉奉对急性脑梗死患者磁共振氢质子波谱(1H magnetic resonance spectroscopy,1H MRS)的影响,评价依达拉奉治疗急性脑梗死的疗效。方法选择发病24h内的急性脑梗死患者66例,随机分为依达拉奉组(35例)及对照组(31例)。对2组...目的观察依达拉奉对急性脑梗死患者磁共振氢质子波谱(1H magnetic resonance spectroscopy,1H MRS)的影响,评价依达拉奉治疗急性脑梗死的疗效。方法选择发病24h内的急性脑梗死患者66例,随机分为依达拉奉组(35例)及对照组(31例)。对2组治疗前及4周后美国国立卫生研究院脑卒中量表评分(NIHSS评分)、N-乙酰天冬氨酸(NAA),N-乙酰天冬氨酸与肌酸(Cr)比值(NAA/Cr)进行比较。结果4周后依达拉奉组NIHSS评分(5.71±1.74)较对照组(7.26±2.87)降低明显,差异有统计学意义(P<0.05)。4周后NAA、NAA/Cr值对照组(514±118、1.67±0.23)和依达拉奉组(613±169、1.82±0.28)均较治疗前(对照组345±108、1.34±0.18;治疗组336±115、1.32±0.19)升高,但依达拉奉组升高明显,差异有统计学意义(P<0.05)。结论依达拉奉是一种有效的治疗急性脑梗死的神经保护剂。展开更多
In the present study we investigated structural and metabolic modifications of the brain in the Ts65Dn mouse model of Down syndrome(DS)using both in vivo magnetic resonance imaging(MRI)and proton magnetic resonance sp...In the present study we investigated structural and metabolic modifications of the brain in the Ts65Dn mouse model of Down syndrome(DS)using both in vivo magnetic resonance imaging(MRI)and proton magnetic resonance spectroscopy(MRS). MRI was performed for further texture analysis and changes in texture parameters, including mean grey levels, contrast and homogeneity, and they were found in Ts65Dn compared to diploid littermates (2n). These phenotypic changes were different in the hippocampus and cerebellum, since in Ts65Dn mean grey levels increased in the cerebellum and decreased in the hippocampus. In addition, proton NMR spectra revealed differences in metabolite ratios. Levels of N-acetylaspartate(NAA)and glutamate(Glu), were lower compared to total creatine levels (CX), in the Ts65Dn brain. However, the most striking finding was an increase in the concentration of myo-inositol(Ins)and choline(Cho)in the hippocampus, whereas the Ins concentration was reduced in the cerebellum. Overall, these data illustrate that MRI and MRS are valuable assesment tools sufficiently sensitive to detect associated changes in different brain areas, thus providing new insight into the causative role of dosage-sensitive genes in the Ts65Dn DS mouse model.展开更多
人类免疫缺陷病毒(HIV)感染血清抗体阳性后能迅速进入大脑导致HIV相关神经认知疾病(HAND)。HAND的临床前期诊断较为困难,而无创磁共振成像(MRI)检查有成为生物标记物的潜能。本文综述一些神经成像技术在HIV阳性个体的应用,包括质子磁共...人类免疫缺陷病毒(HIV)感染血清抗体阳性后能迅速进入大脑导致HIV相关神经认知疾病(HAND)。HAND的临床前期诊断较为困难,而无创磁共振成像(MRI)检查有成为生物标记物的潜能。本文综述一些神经成像技术在HIV阳性个体的应用,包括质子磁共振波谱(1 H MRS)、基于体素形态学分析(VBM)、扩散张量成像(DTI)和功能磁共振成像(fMRI)。这些神经成像方法可以用于早期检测和干预不同程度HAND,研究HAND功能、结构损伤及其发生机制,监测高效抗逆转录病毒治疗(HAART)疗效,基于神经成像可以找到评估HAND早期、敏感的可视化生物标记物。展开更多
基金Supported by Beijing Municipal Science and Technology Commission,No.Z171100000417056Key Support Project of Guo Zhong Health Care of China General Technology Group,No.SGGK202201001。
文摘BACKGROUND Early quantitative assessment of liver fat content is essential for patients with fatty liver disease.Mounting evidence has shown that magnetic resonance(MR)technique has high accuracy in the quantitative analysis of fatty liver,and is suitable for monitoring the therapeutic effect on fatty liver.However,many packaging methods and postprocessing functions have puzzled radiologists in clinical applications.Therefore,selecting a quantitative MR imaging technique for patients with fatty liver disease remains challenging.AIM To provide information for the proper selection of commonly used quantitative MR techniques to quantify fatty liver.METHODS We completed a systematic literature review of quantitative MR techniques for detecting fatty liver,following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol.Studies were retrieved from PubMed,Embase,and Cochrane Library databases,and their quality was assessed using the Quality Assessment of Diagnostic Studies criteria.The Reference Citation Analysis database(https://www.referencecitationanalysis.com)was used to analyze citation of articles which were included in this review.RESULTS Forty studies were included for spectroscopy,two-point Dixon imaging,and multiple-point Dixon imaging comparing liver biopsy to other imaging methods.The advantages and disadvantages of each of the three techniques and their clinical diagnostic performances were analyzed.CONCLUSION The proton density fat fraction derived from multiple-point Dixon imaging is a noninvasive method for accurate quantitative measurement of hepatic fat content in the diagnosis and monitoring of fatty liver progression.
文摘目的观察依达拉奉对急性脑梗死患者磁共振氢质子波谱(1H magnetic resonance spectroscopy,1H MRS)的影响,评价依达拉奉治疗急性脑梗死的疗效。方法选择发病24h内的急性脑梗死患者66例,随机分为依达拉奉组(35例)及对照组(31例)。对2组治疗前及4周后美国国立卫生研究院脑卒中量表评分(NIHSS评分)、N-乙酰天冬氨酸(NAA),N-乙酰天冬氨酸与肌酸(Cr)比值(NAA/Cr)进行比较。结果4周后依达拉奉组NIHSS评分(5.71±1.74)较对照组(7.26±2.87)降低明显,差异有统计学意义(P<0.05)。4周后NAA、NAA/Cr值对照组(514±118、1.67±0.23)和依达拉奉组(613±169、1.82±0.28)均较治疗前(对照组345±108、1.34±0.18;治疗组336±115、1.32±0.19)升高,但依达拉奉组升高明显,差异有统计学意义(P<0.05)。结论依达拉奉是一种有效的治疗急性脑梗死的神经保护剂。
文摘In the present study we investigated structural and metabolic modifications of the brain in the Ts65Dn mouse model of Down syndrome(DS)using both in vivo magnetic resonance imaging(MRI)and proton magnetic resonance spectroscopy(MRS). MRI was performed for further texture analysis and changes in texture parameters, including mean grey levels, contrast and homogeneity, and they were found in Ts65Dn compared to diploid littermates (2n). These phenotypic changes were different in the hippocampus and cerebellum, since in Ts65Dn mean grey levels increased in the cerebellum and decreased in the hippocampus. In addition, proton NMR spectra revealed differences in metabolite ratios. Levels of N-acetylaspartate(NAA)and glutamate(Glu), were lower compared to total creatine levels (CX), in the Ts65Dn brain. However, the most striking finding was an increase in the concentration of myo-inositol(Ins)and choline(Cho)in the hippocampus, whereas the Ins concentration was reduced in the cerebellum. Overall, these data illustrate that MRI and MRS are valuable assesment tools sufficiently sensitive to detect associated changes in different brain areas, thus providing new insight into the causative role of dosage-sensitive genes in the Ts65Dn DS mouse model.
文摘人类免疫缺陷病毒(HIV)感染血清抗体阳性后能迅速进入大脑导致HIV相关神经认知疾病(HAND)。HAND的临床前期诊断较为困难,而无创磁共振成像(MRI)检查有成为生物标记物的潜能。本文综述一些神经成像技术在HIV阳性个体的应用,包括质子磁共振波谱(1 H MRS)、基于体素形态学分析(VBM)、扩散张量成像(DTI)和功能磁共振成像(fMRI)。这些神经成像方法可以用于早期检测和干预不同程度HAND,研究HAND功能、结构损伤及其发生机制,监测高效抗逆转录病毒治疗(HAART)疗效,基于神经成像可以找到评估HAND早期、敏感的可视化生物标记物。
