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东北林蛙重组抗菌肽dybowskin-1ST部分理化特性和生物学活性研究 被引量:1
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作者 李玉 刘琦 +3 位作者 王敬之 柴龙会 周旋 肖向红 《野生动物学报》 北大核心 2016年第2期129-133,共5页
目的:对具有广谱抑菌活性的东北林蛙(Rana dybowskii)重组抗菌肽dybowskin-1ST进行热稳定性、酸碱稳定性、局部过敏反应(Arthus反应)及溶血活性分析,为进一步摸清重组肽的理化特性及其应用提供科学依据。方法:将重组抗菌肽dybowsk... 目的:对具有广谱抑菌活性的东北林蛙(Rana dybowskii)重组抗菌肽dybowskin-1ST进行热稳定性、酸碱稳定性、局部过敏反应(Arthus反应)及溶血活性分析,为进一步摸清重组肽的理化特性及其应用提供科学依据。方法:将重组抗菌肽dybowskin-1ST分别置于不同环境温度(25~100℃)及不同酸碱环境(pH2~pH12)中处理4 h,观察其对金黄色葡萄球菌(Staphylococcus aureus)及大肠杆菌(Escherichia coli)的抑菌环直径,确定其稳定性;用不同浓度梯度的重组dybowskin-1ST进行溶血试验和局部过敏反应(Arthus反应)。结果:1.重组dybowskin-1ST在25~100℃温度及pH2~pH12环境下均有抑菌活性,其中,最适环境温度为25℃;重组dybowskin-1ST在pH3~pH7范围对Staphylococcus aureus抑菌活性较强(抑菌环直径为12.77~13.17 mm),在pH3~pH8范围对Escherichia coli抑菌性较强(抑菌环直径为12.63~13.37 mm)。2.溶血试验结果显示,重组dybowskin-1ST对家兔红细胞的溶血率在0.14%~4.4%;小鼠Arthus氏试验观察其腹部皮下重组dybowskin-1ST注射部位红肿不明显,无出血、坏死等炎性反应。结论:实验结果显示重组dybowskin-1 ST具有较好稳定性、低溶血性及低致敏性,为其应用提供科学依据。 展开更多
关键词 东北林蛙 抗菌肽dybowskin-1st 稳定性 局部过敏反应 溶血活性
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东北林蛙皮肤抗菌肽dybowskin-1ST的抗病毒活性分析 被引量:3
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作者 周旋 肖向红 李玉 《野生动物》 2013年第3期171-173,共3页
【目的】检测重组东北林蛙皮肤抗菌肽dybowskin-1ST的抗病毒活性。【方法】将实验分为预防组和治疗组,采用CPE观察法和MTT法检测dybowskin-1ST体外抗蛙虹彩病毒GRV的作用。【结果】预防组dybowskin-1ST对病毒的抑制作用不明显(P>0.0... 【目的】检测重组东北林蛙皮肤抗菌肽dybowskin-1ST的抗病毒活性。【方法】将实验分为预防组和治疗组,采用CPE观察法和MTT法检测dybowskin-1ST体外抗蛙虹彩病毒GRV的作用。【结果】预防组dybowskin-1ST对病毒的抑制作用不明显(P>0.05);治疗组200μg/ml的dybowskin-1ST对病毒有明显的抑制作用(P<0.05),随着浓度降低,100μg/ml和50μg/ml时对病毒抑制作用下降,浓度小于25μg/m1后,对病毒抑制作用不显著(P>0.05)。 展开更多
关键词 东北林蛙 抗菌肽 dybowskin-1st 抗病毒活性
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1st degree acromioclavicular sprain, elevated 1st rib, or both? A case study of a rodeo cowboy
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作者 Mark RLafave Dale JButterwick +1 位作者 Blaine Bugg Dave Roberts 《Open Journal of Therapy and Rehabilitation》 2014年第1期21-24,共4页
Objective: To present a case of a rodeo cowboy who suffered a seemingly routine 1st degree acromioclavicular (AC) sprain. The AC sprain was exacerbated by an elevated 1st rib. Background: Saddle bronc riding is one of... Objective: To present a case of a rodeo cowboy who suffered a seemingly routine 1st degree acromioclavicular (AC) sprain. The AC sprain was exacerbated by an elevated 1st rib. Background: Saddle bronc riding is one of three rough stock events in North American rodeo and the least common event for injury relative to bull riding and bareback riding. Shoulder injury in rodeo rough stock events make up 9.3% of all injuries. Approximately 28% of injuries in rodeo are considered minor sprains. The professional cowboy was thrown from his horse landing on the tip of his shoulder. The cowboy presented with a routine 1st degree AC sprain based on the Tossey and Rockwood definitions. Differential Diagnosis: Due to the mechanism of injury and forces produced with the cowboy being thrown to the ground, elimination of serious neck injury was critical. A scanning examination revealed some neck dysfunction. A cervical rotation, lateral flexion special test confirmed the additional elevated 1st rib in addition to the 1st degree AC sprain. Treatment: A chiropractic adjustment of the 1st rib reduced pain in the AC joint from a 6/10 to 1/10 immediately. Subsequently, the patient iced and was treated with one other 1st rib adjustment at a later date. Uniqueness: There were no cases of 1st degree AC sprains with an associated elevated first rib in the literature. It was very unique to relieve to the patient’s shoulder symptoms so dramatically in a short period of time with manual therapy to the first rib. Conclusions: It is important to follow a thorough history and physical examination of patients who suffer from a 1st degree AC sprain. The use of a scanning examination will help identify the primary source of pain (i.e. neck and/or shoulder). Manual therapy of the 1st rib may be useful in the treatment. 展开更多
关键词 1st degree acromioclavicular sprain elevated 1st rib or both? A case study of a rodeo cowboy
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基于1stOpt神经网络模型的年均径流预测与应用
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作者 张佩 王加虎 +2 位作者 陆冰清 马戎荣 金盛杰 《中国农村水利水电》 北大核心 2014年第7期64-66,71,共4页
针对年均径流预测问题,首先利用1stOpt软件进行逐个影响因子拟合,得到相关影响因子的主次顺序,提取关键因子在基于L-M算法和UGO算法下对年均径流进行多元非线性曲线拟合;另外结合基于L-M算法的改进BP神经网络利用所提取的关键因子进行... 针对年均径流预测问题,首先利用1stOpt软件进行逐个影响因子拟合,得到相关影响因子的主次顺序,提取关键因子在基于L-M算法和UGO算法下对年均径流进行多元非线性曲线拟合;另外结合基于L-M算法的改进BP神经网络利用所提取的关键因子进行径流预测,以北方某河流径流实例进行计算,两种方法效果均优于传统模型,且在多影响因子的情况下,组合模型精度和效果更好,为径流预测提供了一个新的更实用的方法。 展开更多
关键词 径流预测 1stOpt L—M算法 UGO算法BP神经网络
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The 1st International Conference on Datadriven Knowledge Discovery:When Data Science Meets Information Science.June 19–22,2016,Beijing·China 被引量:1
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作者 the jdis editors 《Journal of Data and Information Science》 2016年第3期1-5,共5页
The 1st International Conference on Data-driven Knowledge Discovery: When Data Science Meets Information Science took place at the National Science Library (NSL), Chinese Academy of Sciences (CAS) in Beijing from... The 1st International Conference on Data-driven Knowledge Discovery: When Data Science Meets Information Science took place at the National Science Library (NSL), Chinese Academy of Sciences (CAS) in Beijing from June 19 till June 22, 2016. The Conference was opened by NSL Director Xiangyang Huang, who placed the event within the goals of the Library, and lauded the spirit of intemational collaboration in the area of data science and knowledge discovery. The whole event was an encouraging success with over 370 registered participants and highly enlightening presentations. The Conference was organized by the Journal of Data andlnformation Science (JDIS) to bring the Joumal to the attention of an international and local audience. 展开更多
关键词 DATA BEIJING China The 1st International Conference on Datadriven Knowledge Discovery
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The First-Order Comprehensive Sensitivity Analysis Methodology (1st-CASAM) for Scalar-Valued Responses: I. Theory 被引量:1
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作者 Dan Gabriel Cacuci 《American Journal of Computational Mathematics》 2020年第2期275-289,共15页
This work presents the first-order comprehensive adjoint sensitivity analysis methodology (1st-CASAM) for computing efficiently, exactly, and exhaustively, the first-order sensitivities of scalar-valued responses (res... This work presents the first-order comprehensive adjoint sensitivity analysis methodology (1st-CASAM) for computing efficiently, exactly, and exhaustively, the first-order sensitivities of scalar-valued responses (results of interest) of coupled nonlinear physical systems characterized by imprecisely known model parameters, boundaries and interfaces between the coupled systems. The 1st-CASAM highlights the conclusion that response sensitivities to the imprecisely known domain boundaries and interfaces can arise both from the definition of the system’s response as well as from the equations, interfaces and boundary conditions defining the model and its imprecisely known domain. By enabling, in premiere, the exact computations of sensitivities to interface and boundary parameters and conditions, the 1st-CASAM enables the quantification of the effects of manufacturing tolerances on the responses of physical and engineering systems. Ongoing research will generalize the methodology presented in this work, aiming at computing exactly and efficiently higher-order response sensitivities for coupled systems involving imprecisely known interfaces, parameters, and boundaries. 展开更多
关键词 Adjoint Sensitivity Analysis (1st-CASAM) Response Sensitivities for Coupled Nonlinear Systems Imprecisely Known Interfaces Imprecisely Known Parameters Imprecisely Known Boundaries
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The 1st International conference On Computer Graphics and Spatial Information Systems Beijing, China. August 6~9, 2002 (CircularAnnouncement)
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《Journal of Geographical Sciences》 SCIE CSCD 2001年第4期120-120,共1页
关键词 GIS CAS AUGUST China CircularAnnouncement On Computer Graphics and Spatial Information Systems Beijing The 1st International conference
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The 1st Announcement of the Fourth International Conference on Asian and Pacific Coasts (APAC 2007) Sept. 21~24, 2007, Nanjing, China
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《China Ocean Engineering》 SCIE EI 2006年第3期517-520,共4页
关键词 The 1st Announcement of the Fourth International Conference on Asian and Pacific Coasts In NANJING Sept APAC 2007 China
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Preliminary Announcement for the 1st Pacific Rim International Conference on Advanced Materials and Processing(PRICM-1)
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《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 1990年第5期378-378,共1页
The Joint Conference Organizing Committee of The Chinese Society of Metals(CSM),The Japan Insti-tute of Metals(JIM),The Korean Institute of Metals(KIM)and The Minerals,Metals & Materials Society(TMS)announces The ... The Joint Conference Organizing Committee of The Chinese Society of Metals(CSM),The Japan Insti-tute of Metals(JIM),The Korean Institute of Metals(KIM)and The Minerals,Metals & Materials Society(TMS)announces The First Pacific Rim International Conference on Advanced Materials and Processing(PRICM-1)which will be held in Hangzhou,China,in the last week of June,1992 lasting about four days.It is agreed that the PRICM-1 will be organized by The Chinese Society of Metals. 展开更多
关键词 Co PRICM-1 Preliminary Announcement for the 1st Pacific Rim International Conference on Advanced Materials and Processing
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Contribution to Improving the Management of Sewage Sludge in the Western Region: Case of Bafoussam 1st
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作者 Félicite Obono Mba Ngongang Sanou 《Journal of Geoscience and Environment Protection》 2022年第3期111-119,共9页
Sanitation is a particularly sensitive issue in the world, especially in Africa where local communities are plagued by the problem of managing sludge which is causing a lot of damage in Africa and mainly in Cameroon. ... Sanitation is a particularly sensitive issue in the world, especially in Africa where local communities are plagued by the problem of managing sludge which is causing a lot of damage in Africa and mainly in Cameroon. This study aims to contribute to improving the management of sewage sludge in the municipality of Bafoussam 1st. For this study, the methodology used is field survey. The questionnaire was submitted to 120 households in the commune of Bafoussam 1st, in particular, we take into account knowledge of the health and environmental risks that can result from improper handling of sludge and its treatment. The results show that the most widespread sanitation system is traditional latrines. Similarly, 79.19% of those surveyed dump, the sludge collected at the landfill against only 14.28% who dump it in fields and 6.53% have no idea about the fate of the sludge from their sanitary facilities. It should also be noted that 55.83% of the people surveyed are not aware of the health and environmental risks of untreated sewage sludge and therefore do not take the precautions to avoid it. Subsequently, 93.75% of respondents say that the current landfill would be a nuisance and the main nuisances identified are water pollution and subsequent fish poisoning. Physico-chemical analyzes of the sludge revealed values much higher than the values provided for by the WHO standards. Thus, total nitrogen and phosphate ions represented respectively 97 mg/L and 47 mg/L against 35 and 30.4 mg/L for the standard;COD and BOD<sub>5</sub> represented respectively 3250 mg/L and 1100 mg/L against 150 and 40 mg/L provided by the WHO standards. It follows the temperature and the MES which gave values of 32.7&#176;C and 1750 mg/L, values much higher than the standard (30&#176;C and 50 mg/L). 展开更多
关键词 Sewage Sludge MANAGEMENT Treatment SANITATION Bafoussam 1st
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The First Announcement of the 1st International Symposium on Geospatial Health
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《中国寄生虫学与寄生虫病杂志》 CAS CSCD 北大核心 2006年第B12期84-84,共1页
关键词 The First Announcement of the 1st International Symposium on Geospatial Health
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Constitution of the ICC China——Adopted by the 1st Congress of the ICC China
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《China's Foreign Trade》 1995年第5期15-16,共2页
Chapter Ⅰ General Provisions Article 1 This body bears the name of the ICC China (hereinafter referred to as the ICCC) and is the National Committee of the International Chamber of Commerce (the ICC) in the People’s... Chapter Ⅰ General Provisions Article 1 This body bears the name of the ICC China (hereinafter referred to as the ICCC) and is the National Committee of the International Chamber of Commerce (the ICC) in the People’s Republic of China. Article 2 The ICCC represents the Chinese business community in the International Chamber of Commerce and represents the ICC in China. It aims at promoting the 展开更多
关键词 ICC Adopted by the 1st Congress of the ICC China Constitution of the ICC China
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Meet the 1st International Conference on Hydropower Technology & Key Equipment 2006 in the golden autumn of Beijing
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《Electricity》 2006年第3期35-35,共1页
Co-hosted by China Society for Hydropower Engineering and China Three Gorges Project Corporation, co-organized by China Hydropower Engineering Consulting Group Corporation , SINOHYDRO Corporation, China Gezhouba (Grou... Co-hosted by China Society for Hydropower Engineering and China Three Gorges Project Corporation, co-organized by China Hydropower Engineering Consulting Group Corporation , SINOHYDRO Corporation, China Gezhouba (Group) Corporation and China Institute of Water Resources and Hydropower Research, organized by China Electric Power Information Center Beijing Zhongdianqiuzhen T&DCo., Ltd., supported by State Electricity Regulatory Commission of China, State Grid Corporation of China, China Southern Power Grid Co., Ltd., China 展开更多
关键词 Co Meet the 1st International Conference on Hydropower Technology Key Equipment 2006 in the golden autumn of Beijing
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The 1st batch of SP's key laboratories named
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《Electricity》 2001年第4期7-7,共1页
关键词 SP The 1st batch of SP’s key laboratories named
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12,000 plus IPR infringement cases unearthed in 1st half of 2006
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《中国专利与商标》 2006年第4期51-,共1页
On August 28, the 2006 Beijing International Publishing Forum was held in Kempinski Hotel, Beijing Lufthansa Center. Yu Yongzhan, Deputy Director of General Administration of Press and Publication (GAPP), introduced a... On August 28, the 2006 Beijing International Publishing Forum was held in Kempinski Hotel, Beijing Lufthansa Center. Yu Yongzhan, Deputy Director of General Administration of Press and Publication (GAPP), introduced at the forum that governments at all 展开更多
关键词 IPR plus IPR infringement cases unearthed in 1st half of 2006
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Annual check-ups for overseas funded firms Will Begin March 1st
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《China's Foreign Trade》 2002年第2期52-52,共1页
关键词 Annual check-ups for overseas funded firms Will Begin March 1st
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Airbus to Build 1st Plane in China by'08
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《China's Foreign Trade》 2006年第6期30-,共1页
  Airbus SAS, the world's largest maker of commercial aircraft,said it will make its first A320aircraft in China by the end of 2008 as it seeks to boost capacity amid demand for single-aisle planes, according to...   Airbus SAS, the world's largest maker of commercial aircraft,said it will make its first A320aircraft in China by the end of 2008 as it seeks to boost capacity amid demand for single-aisle planes, according to the report of Xinhua on Feb. 23.…… 展开更多
关键词 Airbus to Build 1st Plane in China by’08
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The Document for Proposing Haiyang Nuclear Power Station 1st Phase Project in Shandong Province Submitted Formally to SPC
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《Electricity》 1997年第3期48-48,共1页
关键词 PROJECT The Document for Proposing Haiyang Nuclear Power Station 1st Phase Project in Shandong Province Submitted Formally to SPC
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ASUS BC-08B1ST
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《个人电脑》 2009年第6期72-72,共1页
作为ASUS的BD—Combo系列产品中的最新款.BC-0881ST具有8x读取BD—ROM、BD—R盘片的能力.在BD读取速度方面处于比较领先的位置。
关键词 ASUS BC-08B1st 光驱 产品设计 性能
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ASUS DRW-22B1ST
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《个人电脑》 2009年第6期70-70,共1页
DRW-22B1ST采用短机身设计.并且在上盖上设有导流凹槽.以便控制因光盘高速转动产生的气流和噪音。
关键词 ASUS DRW-22B1st 光驱 产品设计 性能
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