Spinal cord injury often leads to severe motor and sensory deficits,and prognosis using the currently available therapies remains poor.Therefore,we aimed to explore a novel therapeutic approach for improving the progn...Spinal cord injury often leads to severe motor and sensory deficits,and prognosis using the currently available therapies remains poor.Therefore,we aimed to explore a novel therapeutic approach for improving the prognosis of spinal cord injury.In this study,we implanted oscillating field stimulation devices and transplanted neural stem cells into the thoracic region(T9–T10)of rats with a spinal cord contusion.Basso-Beattie-Bresnahan scoring revealed that oscillating field stimulation combined with neural stem cells transplantation promoted motor function recovery following spinal cord injury.In addition,we investigated the regulation of oscillating field stimulation on the miR-124/Tal1 axis in neural stem cells.Transfection of lentivirus was performed to investigate the role of Tal1 in neurogenesis of neural stem cells induced by oscillating field stimulation.Quantitative reverse transcription-polymerase chain reaction,immunofluorescence and western blotting showed that oscillating field stimulation promoted neurogenesis of neural stem cells in vitro and in vivo.Hematoxylin and eosin staining showed that oscillating field stimulation combined with neural stem cells transplantation alleviated cavities formation after spinal cord injury.Taking the results together,we concluded that oscillating field stimulation decreased miR-124 expression and increased Tal1 content,thereby promoting the neurogenesis of neural stem cells.The combination of oscillating field stimulation and neural stem cells transplantation improved neurogenesis,and thereby promoted structural and functional recovery after spinal cord injury.展开更多
During initial studies of ECRH in the HL-1M tokamak, non-standard central MHD activities,such as saturated sawtooth, partially saturated sawtooth, double sawtooth, and the strong m = 1 bursts have been observed while ...During initial studies of ECRH in the HL-1M tokamak, non-standard central MHD activities,such as saturated sawtooth, partially saturated sawtooth, double sawtooth, and the strong m = 1 bursts have been observed while changing the heating location, the ECRH power, the plasma density. Complete suppression of sawtooth is achieved for the duration of the ECRH, when the heating power is applied on the high-field side of low-density plasma, and exceeds a threshold value of power. The m = 1 bursts riding on the ramp phase of sawtooth can only be excited when the ECRH location is near the q = 1 surface on the high field side. The conditions under which the various relaxation activities are produced or suppressed are described. Experimental results imply that the energetic electrons generated during ECRH are responsible for the modification/or stabilization/or excitation of the instability. Near the q = 1 surface, the passing electrons play the role of reducing the shear and tending to stabilize the sawtooth activity, while the barely-trapped electrons play the role of enhancing or driving an internal kink instability.展开更多
We firstly detected the Earth's free toroidal oscillations excited by three large earthquakes in Japan,2011,Chile,2010 and Indonesia,2005 from the observed data of the JCZ-1 seismometer at Wuhan Seismic Station. T...We firstly detected the Earth's free toroidal oscillations excited by three large earthquakes in Japan,2011,Chile,2010 and Indonesia,2005 from the observed data of the JCZ-1 seismometer at Wuhan Seismic Station. The eigenperiods of basic modes (0T2 - 0T67 ) and first modes (1T2 ～ 1T50 ) were detected,and their error ratios were less than 0. 5% by comparing the observed eigenvalues with the theoretical eigenvalues in PREM. We supplemented some modes- 0T11,0T15 , 0T19 , 1T4 , 1T5 and 1T14 ,which were not mentioned in PREM,and also observed the spectral line multi-peak phenomenon from 0T2, 0T6 , 0T7 and 0T8 . These results show that the JCZ-1 seismometer is able to precisely observe the Earth's long period toroidal free oscillations.展开更多
Connections between the spring Antarctic Oscillation （AAO） and the East Asian summer monsoon （EASM） in two reanalysis datasets-NCEP-1 （NCEP/NCAR Reanalysis 1） and ERA-40 （ECMWF 40- year Reanalysis）-are investi...Connections between the spring Antarctic Oscillation （AAO） and the East Asian summer monsoon （EASM） in two reanalysis datasets-NCEP-1 （NCEP/NCAR Reanalysis 1） and ERA-40 （ECMWF 40- year Reanalysis）-are investigated in this study. Both show significant correlation between AAO and EASM rainfall over the Yangtze River valley, especially after about 1985. Though ERA-40 shows weaker anomalous signals connecting AAO and EASM over southern high latitudes than NCEP-1, both datasets reveal similar connecting patterns between them. A wave-train-like pattern appears in the upper levels, from southern high latitudes through east of Australia and from the Maritime Continent to East Asia. In positive AAO years, the cross equatorial southeasterly flow over the Maritime Continent in the lower levels is strengthened, the specific humidity of the whole atmosphere over East Asia increases, and convective activity is enhanced; thus the summer rainfall over East Asia increases. The spring AAO-EASM connection may be better represented in ERA-40.展开更多
Using observational data and the pre-industrial simulations of 19 models from the Coupled Model Intercomparison Project Phase 5（CMIP5）, the El Ni o（EN） and La Ni a（LN） events in positive and negative Pacific Dec...Using observational data and the pre-industrial simulations of 19 models from the Coupled Model Intercomparison Project Phase 5（CMIP5）, the El Ni o（EN） and La Ni a（LN） events in positive and negative Pacific Decadal Oscillation（PDO） phases are examined. In the observational data, with EN（LN） events the positive（negative） SST anomaly in the equatorial eastern Pacific is much stronger in positive（negative） PDO phases than in negative（positive） phases. Meanwhile,the models cannot reasonably reproduce this difference. Besides, the modulation of ENSO frequency asymmetry by the PDO is explored. Results show that, in the observational data, EN is 300% more（58% less） frequent than LN in positive（negative）PDO phases, which is significant at the 99% confidence level using the Monte Carlo test. Most of the CMIP5 models exhibit results that are consistent with the observational data.展开更多
ABSTRACT The authors explored the connection and transition chains of the Northern Oscillation （NO） and the North Pacific Oscilla tion （NPO）, the Southern Oscillation （SO）, and the Antarctic Oscillation （AAO）...ABSTRACT The authors explored the connection and transition chains of the Northern Oscillation （NO） and the North Pacific Oscilla tion （NPO）, the Southern Oscillation （SO）, and the Antarctic Oscillation （AAO） on the interannual timescale in a companion paper. In this study, the connection between the transition chains of the four oscillations （the NO and NPO, the SO and AAO） and the El Nifio/La Nifia cycle were examined. It was found that during the transitions of the four oscillations, alternate anticyclonic/cyclonic correlation centers propagated from the Western Pacific to the Eastern Pacific along both sides of the equator. Between the anticyclonic/cyclonic correlation centers, the zonal wind anomalies also moved eastwardly, favoring the advection of sea surface temperature anomalies from the tropical Western Pacific to the Eastern Pacific. When the anti cyclonic anomalies arrived in the Eastern Pacific, the positive phase of NO/SO and La Nifia were established and vice versa. Thus, in 4-6 years, with an entire transition chain of the four oscillations, an E1 Nifio/La Nifia cycle completed. The eastward propagation of the covarying anomalies of the sea level pressure, zonal wind, and sea surface temperature was critical to the transition chains of the four oscillations and the cycle of E1 Nifio/La Nifia. Based on their close link, a new empirical prediction method of the timing of E1 Nifio by the transition chains of the four oscillations was proposed. The assessment provided confidence in the ability of the new method to supply information regarding the long-term variations of the ocean and atmosphere in the tropical Pacific.展开更多
The investigation of runaway electrons is expanded by different methods. The aim of this study is to show sawtooth oscillations of hard x-ray emission and with the help of sawtooth oscillations to obtain radial diffus...The investigation of runaway electrons is expanded by different methods. The aim of this study is to show sawtooth oscillations of hard x-ray emission and with the help of sawtooth oscillations to obtain radial diffusion coefficient and magnetic fluctuations. In the same way, the hard x-ray spectral evaluation is compared in several time intervals and it is shown that during discharge, the energy of the runaway electrons is less than 200？keV. Also, for typical plasmas, population of runaway electrons is measured at seven time intervals of 5ms and temporal evaluation of runaway electron mean energy. The sawtooth-like shape is observed in the hard x-ray range （10–1000？keV）. By the sawtooth oscillation method, the RE diffusion coefficient in radial transport in the IR-T1 plasma is Dr～0.5Dr～0.5m^2s^-1. The magnetic field fluctuation due to magnetic diffusion DmDm is given as br/Bt～10^-4.展开更多
从北斗卫星信号覆盖范围、卫星授时精度、可扩展的用户容限等方面分析了将北斗授时应用于我国电力系统同步相量测量装置的可行性。北斗授时接收机输出的北斗1 pps(one pulse per second)信号存在较大的随机误差,但不存在累计误差;高精...从北斗卫星信号覆盖范围、卫星授时精度、可扩展的用户容限等方面分析了将北斗授时应用于我国电力系统同步相量测量装置的可行性。北斗授时接收机输出的北斗1 pps(one pulse per second)信号存在较大的随机误差,但不存在累计误差;高精度晶振时钟信号不存在随机误差,在较短时间内累计误差也很小。根据两者误差的特点,建立误差数学模型,提出了利用高精度晶振在线修正北斗1 pps随机误差的方法。运用该技术将修正后的秒脉冲校准时间信息为同步相量测量装置提供精确的时间标签。展开更多
基金supported by the National Natural Science Foundation of China,Nos.81471273(to JQ),and 81472088(to CLS)the Natural Science Research Projects in Colleges and Universities of Anhui Province,No.KJ2020ZD23(to JQ)the Natural Science Foundation of Anhui Province,No.2208085MH210(to JQ)。
文摘Spinal cord injury often leads to severe motor and sensory deficits,and prognosis using the currently available therapies remains poor.Therefore,we aimed to explore a novel therapeutic approach for improving the prognosis of spinal cord injury.In this study,we implanted oscillating field stimulation devices and transplanted neural stem cells into the thoracic region(T9–T10)of rats with a spinal cord contusion.Basso-Beattie-Bresnahan scoring revealed that oscillating field stimulation combined with neural stem cells transplantation promoted motor function recovery following spinal cord injury.In addition,we investigated the regulation of oscillating field stimulation on the miR-124/Tal1 axis in neural stem cells.Transfection of lentivirus was performed to investigate the role of Tal1 in neurogenesis of neural stem cells induced by oscillating field stimulation.Quantitative reverse transcription-polymerase chain reaction,immunofluorescence and western blotting showed that oscillating field stimulation promoted neurogenesis of neural stem cells in vitro and in vivo.Hematoxylin and eosin staining showed that oscillating field stimulation combined with neural stem cells transplantation alleviated cavities formation after spinal cord injury.Taking the results together,we concluded that oscillating field stimulation decreased miR-124 expression and increased Tal1 content,thereby promoting the neurogenesis of neural stem cells.The combination of oscillating field stimulation and neural stem cells transplantation improved neurogenesis,and thereby promoted structural and functional recovery after spinal cord injury.
文摘During initial studies of ECRH in the HL-1M tokamak, non-standard central MHD activities,such as saturated sawtooth, partially saturated sawtooth, double sawtooth, and the strong m = 1 bursts have been observed while changing the heating location, the ECRH power, the plasma density. Complete suppression of sawtooth is achieved for the duration of the ECRH, when the heating power is applied on the high-field side of low-density plasma, and exceeds a threshold value of power. The m = 1 bursts riding on the ramp phase of sawtooth can only be excited when the ECRH location is near the q = 1 surface on the high field side. The conditions under which the various relaxation activities are produced or suppressed are described. Experimental results imply that the energetic electrons generated during ECRH are responsible for the modification/or stabilization/or excitation of the instability. Near the q = 1 surface, the passing electrons play the role of reducing the shear and tending to stabilize the sawtooth activity, while the barely-trapped electrons play the role of enhancing or driving an internal kink instability.
基金sponsored by the Key Program of National Natural Science Foundation of China ( 40730317)
文摘We firstly detected the Earth's free toroidal oscillations excited by three large earthquakes in Japan,2011,Chile,2010 and Indonesia,2005 from the observed data of the JCZ-1 seismometer at Wuhan Seismic Station. The eigenperiods of basic modes (0T2 - 0T67 ) and first modes (1T2 ～ 1T50 ) were detected,and their error ratios were less than 0. 5% by comparing the observed eigenvalues with the theoretical eigenvalues in PREM. We supplemented some modes- 0T11,0T15 , 0T19 , 1T4 , 1T5 and 1T14 ,which were not mentioned in PREM,and also observed the spectral line multi-peak phenomenon from 0T2, 0T6 , 0T7 and 0T8 . These results show that the JCZ-1 seismometer is able to precisely observe the Earth's long period toroidal free oscillations.
基金supported by Na-tional Basic Research Program of China (973 Program)under Grant No 2009CB421406the Chinese Academy of Sciences under Grant KZCX2-YW-Q1-02the Na-tional Natural Science Foundation of China under Grants Nos 40875048, 40620130113, and 40631005
文摘Connections between the spring Antarctic Oscillation （AAO） and the East Asian summer monsoon （EASM） in two reanalysis datasets-NCEP-1 （NCEP/NCAR Reanalysis 1） and ERA-40 （ECMWF 40- year Reanalysis）-are investigated in this study. Both show significant correlation between AAO and EASM rainfall over the Yangtze River valley, especially after about 1985. Though ERA-40 shows weaker anomalous signals connecting AAO and EASM over southern high latitudes than NCEP-1, both datasets reveal similar connecting patterns between them. A wave-train-like pattern appears in the upper levels, from southern high latitudes through east of Australia and from the Maritime Continent to East Asia. In positive AAO years, the cross equatorial southeasterly flow over the Maritime Continent in the lower levels is strengthened, the specific humidity of the whole atmosphere over East Asia increases, and convective activity is enhanced; thus the summer rainfall over East Asia increases. The spring AAO-EASM connection may be better represented in ERA-40.
基金supported by the National Key R&D Program of China (Grant No.2017YFA0604201)the National Natural Science Foundation of China (Grant Nos.41576019,41606027 and 41706028)the China Postdoctoral Science Foundation (Grant No.2015M571095)
文摘Using observational data and the pre-industrial simulations of 19 models from the Coupled Model Intercomparison Project Phase 5（CMIP5）, the El Ni o（EN） and La Ni a（LN） events in positive and negative Pacific Decadal Oscillation（PDO） phases are examined. In the observational data, with EN（LN） events the positive（negative） SST anomaly in the equatorial eastern Pacific is much stronger in positive（negative） PDO phases than in negative（positive） phases. Meanwhile,the models cannot reasonably reproduce this difference. Besides, the modulation of ENSO frequency asymmetry by the PDO is explored. Results show that, in the observational data, EN is 300% more（58% less） frequent than LN in positive（negative）PDO phases, which is significant at the 99% confidence level using the Monte Carlo test. Most of the CMIP5 models exhibit results that are consistent with the observational data.
基金The project supported by the Natural Science Foundation of Inner Mongolia under Grant No. 200408020113 and National Natural Science Foundation of China under Grant No. 40564001
基金supported by the National Key Technologies R&D Program of China (Grant No.2009BAC51B02)the National Basic Research Program of China (Grant NO.2012CB957803)
文摘ABSTRACT The authors explored the connection and transition chains of the Northern Oscillation （NO） and the North Pacific Oscilla tion （NPO）, the Southern Oscillation （SO）, and the Antarctic Oscillation （AAO） on the interannual timescale in a companion paper. In this study, the connection between the transition chains of the four oscillations （the NO and NPO, the SO and AAO） and the El Nifio/La Nifia cycle were examined. It was found that during the transitions of the four oscillations, alternate anticyclonic/cyclonic correlation centers propagated from the Western Pacific to the Eastern Pacific along both sides of the equator. Between the anticyclonic/cyclonic correlation centers, the zonal wind anomalies also moved eastwardly, favoring the advection of sea surface temperature anomalies from the tropical Western Pacific to the Eastern Pacific. When the anti cyclonic anomalies arrived in the Eastern Pacific, the positive phase of NO/SO and La Nifia were established and vice versa. Thus, in 4-6 years, with an entire transition chain of the four oscillations, an E1 Nifio/La Nifia cycle completed. The eastward propagation of the covarying anomalies of the sea level pressure, zonal wind, and sea surface temperature was critical to the transition chains of the four oscillations and the cycle of E1 Nifio/La Nifia. Based on their close link, a new empirical prediction method of the timing of E1 Nifio by the transition chains of the four oscillations was proposed. The assessment provided confidence in the ability of the new method to supply information regarding the long-term variations of the ocean and atmosphere in the tropical Pacific.
文摘The investigation of runaway electrons is expanded by different methods. The aim of this study is to show sawtooth oscillations of hard x-ray emission and with the help of sawtooth oscillations to obtain radial diffusion coefficient and magnetic fluctuations. In the same way, the hard x-ray spectral evaluation is compared in several time intervals and it is shown that during discharge, the energy of the runaway electrons is less than 200？keV. Also, for typical plasmas, population of runaway electrons is measured at seven time intervals of 5ms and temporal evaluation of runaway electron mean energy. The sawtooth-like shape is observed in the hard x-ray range （10–1000？keV）. By the sawtooth oscillation method, the RE diffusion coefficient in radial transport in the IR-T1 plasma is Dr～0.5Dr～0.5m^2s^-1. The magnetic field fluctuation due to magnetic diffusion DmDm is given as br/Bt～10^-4.
