目的:探讨胰高血糖素样肽-1(GLP-1)受体激动剂联合门冬胰岛素30对2型糖尿病患者控糖效果及体重的影响。方法:选取116例2型糖尿病患者为研究对象,随机数字表法分成研究组(A组,n=58)和对照组(B组,n=58)两组。B组予以门冬胰岛素30治疗方案,...目的:探讨胰高血糖素样肽-1(GLP-1)受体激动剂联合门冬胰岛素30对2型糖尿病患者控糖效果及体重的影响。方法:选取116例2型糖尿病患者为研究对象,随机数字表法分成研究组(A组,n=58)和对照组(B组,n=58)两组。B组予以门冬胰岛素30治疗方案,A组则采用门冬胰岛素30联合利拉鲁肽治疗方案,均持续治疗24周后观察疗效。比对两组患者治疗前后控糖指标、脂质生化指标及体重指数(BMI)等变化情况,记录其甲级血糖控制率、血糖总控制率及低血糖发生率差异。结果:1治疗6个月后,两组患者除HDL-C水平较治疗前对比无统计学意义(P>0.05)外,FBG、2 h PG、Hb A1c等控糖指标,TG、TC、LDL-C等脂质生化指标及BMI水平均较治疗前显著降低,其中A组降幅大于B组,差异具有统计学意义(P<0.05);2A组甲级控制率及血糖总控制率分别为70.7%和100.0%,均显著高于B组的37.9%和93.1%(P<0.05);3两组患者治疗期间均无严重不良反应及严重低血糖事件发生,其中A组轻微低血糖发生率为6.9%(4/58),显著低于B组的24.1%(14/58),差异具有统计学意义(P<0.05)。结论:将门冬胰岛素30联合GLP-1受体激动剂方案应用于2型糖尿病患者的临床治疗中,疗效确切,血糖控制效果良好,能有效改善其血脂水平、抑制体重发展,于患者预后提升有利。展开更多
Objective: To observe tissue distribution and cell localization of TNF α mRNA and its protein and study their role in the pathogenesis of liver injury in burn rats. Methods: An animal model of rats subjected to 2...Objective: To observe tissue distribution and cell localization of TNF α mRNA and its protein and study their role in the pathogenesis of liver injury in burn rats. Methods: An animal model of rats subjected to 20% TBSA Ⅲ degree burns combined with intraperitoneal injection of lipopolysaccharide (LPS) was used for this experiment. The changes of hepatic morphology and functions and serum TNF α content and expression and localization of liver TNF α and TNF α mRNA were determined with light microscope (LM) and electron microscope (EM), quantitative analysis, immunohistochemistry (IHC) and in situ hybridization (ISH). Results: It showed that there were sinusoid reaction, KCs activation and degeneration, necrosis of HCs, and platelets aggregation, fibrins deposition and PMNs attachment in sinusoid. The activity of ALT was obviously elevated and ALB content was slightly decreased. The serum content of TNF α showed peak at 3 hours. TNF α was mainly localized in sinusoid endothelial cells (SECs) and Kupffer cells (KCs), and TNF α mRNA was mainly distributed in KCs, polymorphonuclears neutrophils (PMNs) and macrophages (MPs). Conclusions: It suggests that TNF α mRNA and its protein expression and localization are coincident with the pathological changes of liver injury. TNF α is one of the key cytokines in the pathogenesis of liver injury in burn rats with endotoxemia.展开更多
文摘目的:探讨胰高血糖素样肽-1(GLP-1)受体激动剂联合门冬胰岛素30对2型糖尿病患者控糖效果及体重的影响。方法:选取116例2型糖尿病患者为研究对象,随机数字表法分成研究组(A组,n=58)和对照组(B组,n=58)两组。B组予以门冬胰岛素30治疗方案,A组则采用门冬胰岛素30联合利拉鲁肽治疗方案,均持续治疗24周后观察疗效。比对两组患者治疗前后控糖指标、脂质生化指标及体重指数(BMI)等变化情况,记录其甲级血糖控制率、血糖总控制率及低血糖发生率差异。结果:1治疗6个月后,两组患者除HDL-C水平较治疗前对比无统计学意义(P>0.05)外,FBG、2 h PG、Hb A1c等控糖指标,TG、TC、LDL-C等脂质生化指标及BMI水平均较治疗前显著降低,其中A组降幅大于B组,差异具有统计学意义(P<0.05);2A组甲级控制率及血糖总控制率分别为70.7%和100.0%,均显著高于B组的37.9%和93.1%(P<0.05);3两组患者治疗期间均无严重不良反应及严重低血糖事件发生,其中A组轻微低血糖发生率为6.9%(4/58),显著低于B组的24.1%(14/58),差异具有统计学意义(P<0.05)。结论:将门冬胰岛素30联合GLP-1受体激动剂方案应用于2型糖尿病患者的临床治疗中,疗效确切,血糖控制效果良好,能有效改善其血脂水平、抑制体重发展,于患者预后提升有利。
文摘Objective: To observe tissue distribution and cell localization of TNF α mRNA and its protein and study their role in the pathogenesis of liver injury in burn rats. Methods: An animal model of rats subjected to 20% TBSA Ⅲ degree burns combined with intraperitoneal injection of lipopolysaccharide (LPS) was used for this experiment. The changes of hepatic morphology and functions and serum TNF α content and expression and localization of liver TNF α and TNF α mRNA were determined with light microscope (LM) and electron microscope (EM), quantitative analysis, immunohistochemistry (IHC) and in situ hybridization (ISH). Results: It showed that there were sinusoid reaction, KCs activation and degeneration, necrosis of HCs, and platelets aggregation, fibrins deposition and PMNs attachment in sinusoid. The activity of ALT was obviously elevated and ALB content was slightly decreased. The serum content of TNF α showed peak at 3 hours. TNF α was mainly localized in sinusoid endothelial cells (SECs) and Kupffer cells (KCs), and TNF α mRNA was mainly distributed in KCs, polymorphonuclears neutrophils (PMNs) and macrophages (MPs). Conclusions: It suggests that TNF α mRNA and its protein expression and localization are coincident with the pathological changes of liver injury. TNF α is one of the key cytokines in the pathogenesis of liver injury in burn rats with endotoxemia.
