This work presents the results of the exact computation of (180)<sup>3</sup> = 5,832,000 third-order mixed sensitivities of the leakage response of a polyethylene-reflected plutonium (PERP) experimental be...This work presents the results of the exact computation of (180)<sup>3</sup> = 5,832,000 third-order mixed sensitivities of the leakage response of a polyethylene-reflected plutonium (PERP) experimental benchmark with respect to the benchmark’s 180 microscopic total cross sections. This computation was made possible by applying the Third-Order Adjoint Sensitivity Analysis Methodology developed by Cacuci. The numerical results obtained in this work revealed that many of the 3<sup>rd</sup>-order sensitivities are significantly larger than their corresponding 1<sup>st</sup>- and 2<sup>nd</sup>-order ones, which is contrary to the widely held belief that higher-order sensitivities are all much smaller and hence less important than the first-order ones, for reactor physics systems. In particular, the largest 3<sup>rd</sup>-order relative sensitivity is the mixed sensitivity <img src="Edit_754b8437-dfdf-487d-af68-c78c637e6d4e.png" width="180" height="24" alt="" />of the PERP leakage response with respect to the lowest energy-group (30) total cross sections of <sup>1</sup>H (“isotope 6”) and <sup>239</sup>Pu (“isotope 1”). These two isotopes are shown in this work to be the two most important parameters affecting the PERP benchmark’s leakage response. By comparison, the largest 1<sup>st</sup>-order sensitivity is that of the PERP leakage response with respect to the lowest energy-group total cross section of isotope <sup>1</sup>H, having the value <img src="Edit_a5cfcc11-6a99-41ee-b844-a5ee84b454b3.png" width="100" height="24" alt="" />, while the largest 2<sup>nd</sup>-order sensitivity is <img src="Edit_05166a2b-97f7-43f1-98ff-b21368c00228.png" width="120" height="22" alt="" />. The 3<sup>rd</sup>-order sensitivity analysis presented in this work is the first ever such analysis in the field of reactor physics. The consequences of the results presented in this work on the uncertainty analysis of the PERP benchmark’s leakage response will be presented in a subsequent work.展开更多
This work extends to third-order previously published work on developing the adjoint sensitivity and uncertainty analysis of the numerical model of a <u>p</u>oly<u>e</u>thylene-<u>r</u...This work extends to third-order previously published work on developing the adjoint sensitivity and uncertainty analysis of the numerical model of a <u>p</u>oly<u>e</u>thylene-<u>r</u>eflected <u>p</u>lutonium (acronym: PERP) OECD/NEA reactor physics benchmark. The PERP benchmark comprises 21,976 imprecisely known (uncertain) model parameters. Previous works have used the adjoint sensitivity analysis methodology to compute exactly and efficiently all of the 21,976 first-order and (21,976)<sup>2</sup> second-order sensitivities of the PERP benchmark’s leakage response to all of the benchmark’s uncertain parameters, showing that the largest and most consequential 1<sup>st</sup>- and 2<sup>nd</sup>-order response sensitivities are with respect to the total microscopic cross sections. These results have motivated extending the previous adjoint-based derivations to third-order, leading to the derivation, in this work, of the exact mathematical expressions of the (180)<sup>3</sup> third-order sensitivities of the PERP leakage response with respect to these total microscopic cross sections. The formulas derived in this work are valid not only for the PERP benchmark but can also be used for computing the 3<sup>rd</sup>-order sensitivities of the leakage response of any nuclear system involving fissionable material and internal or external neutron sources. Subsequent works will use the adjoint-based mathematical expressions obtained in this work to compute exactly and efficiently the numerical values of these (180)<sup>3</sup> third-order sensitivities (which turned out to be very large and consequential) and use them for a third-order uncertainty analysis of the PERP benchmark’s leakage response.展开更多
On Oct.25,2015,the 3rd Work Meeting of the 2nd Editorial Board Committee of China City Planning Review(abbreviated as CCPR hereafter)was convened at the School of Architecture,Tsinghua University in Beijing.The Editor...On Oct.25,2015,the 3rd Work Meeting of the 2nd Editorial Board Committee of China City Planning Review(abbreviated as CCPR hereafter)was convened at the School of Architecture,Tsinghua University in Beijing.The Editorial Board members participated in the meeting.At the meeting,the Editorial Department of CCPR presented a Work Report of the 2nd Editorial Board Committee(2013–2015)and a Work Report of the Editorial Department,followed by open discussions.展开更多
The 3rd plenary session of the 2nd Editorial Committee of Chinese Herbal Medicines (CHM) was held in Nanjing, China, on July 19, 2014. The participants included the associate editors-in-chief of CHM, Prof. Li-da Ta...The 3rd plenary session of the 2nd Editorial Committee of Chinese Herbal Medicines (CHM) was held in Nanjing, China, on July 19, 2014. The participants included the associate editors-in-chief of CHM, Prof. Li-da Tang (China), Prof. De-an Guo (China), Prof. Guido E Pauli (USA), Prof. Pulok Kumar Mukherjee (India), and Prof. Rudolf Bauer (Austria), and some members of CHM Editorial Board, such as Prof. Leslie Gunatilaka (India), Prof. Peter Hylands (UK), Prof. Alexander Shikov (Russia), Prof. Shi-shan Yu (China), Prof. Zheng-tao Wang (China), and Prof. Hong-xi Xu (China), and the editors of Editorial Office of CHM.展开更多
In recent years,as we have a better knowledge and understanding of the biology of non small cell lung carcinoma(NSCLC),which leads us to targeting biomarkers driving the NSCLC carcinogenesis and metastatic potential,w...In recent years,as we have a better knowledge and understanding of the biology of non small cell lung carcinoma(NSCLC),which leads us to targeting biomarkers driving the NSCLC carcinogenesis and metastatic potential,we now have an increased number of options to offer our patients with NSCLC.We also realize the importance of distinguishing squamous and non squamous histology to guide our treatment decisions of NSCLC.The palliative care concomitant with therapies from the very start of the treatment also showed an impact on survival.This review examines the treatment options in all lines of therapy for metastatic NSCLC that have been approved in Canada,the United States,or Europe.展开更多
This work extends to fourth-order previously published work on developing the adjoint sensitivity and uncertainty analysis of the numerical model of a <u>p</u>oly<u>e</u>thylene-<u>r</...This work extends to fourth-order previously published work on developing the adjoint sensitivity and uncertainty analysis of the numerical model of a <u>p</u>oly<u>e</u>thylene-<u>r</u>eflected <u>p</u>lutonium (acronym: PERP) OECD/NEA reactor physics benchmark. The PERP benchmark comprises 7477 imprecisely known (uncertain) model parameters which have nonzero values. These parameters are as follows: 180 microscopic total cross sections;7101 microscopic scattering sections;60 microscopic fission cross sections;60 parameters that characterize the average number of neutrons per fission;60 parameters that characterize the fission spectrum;10 parameters that characterize the fission source;and 6 parameters that characterize the isotope number densities. Previous works have used the adjoint sensitivity analysis methodology to compute exactly and efficiently all of the 7477 first-order and 27,956,503 second-order sensitivities of the PERP benchmark’s leakage response to all of the benchmark’s uncertain parameters. These works showed that largest response sensitivities involve the total microscopic cross sections, which motivated the recent computation of all of the (180)<sup>3</sup> third-order sensitivities of the PERP leakage response with respect to these total microscopic cross sections. It turned out that some of these 3<sup>rd</sup>-order cross sections were far larger than the corresponding 2<sup>nd</sup>-order ones, thereby having the largest impact on the uncertainties induced in the PERP benchmark’s response. This finding has motivated the development of the original 4<sup>th</sup>-order formulas presented in this work, which are valid not only for the PERP benchmark but can also be used for computing the 4<sup>th</sup>-order sensitivities of response of any nuclear system involving fissionable material and internal or external neutron sources. Subsequent works will use the adjoint-based mathematical expressions obtained in this work to compute exactly and efficiently the numerical values of the largest fourth-order sensitivities of the PERP benchmark’s response to the total microscopic cross section and use them for a pioneering fourth-order uncertainty analysis of the PERP benchmark’s response.展开更多
文摘This work presents the results of the exact computation of (180)<sup>3</sup> = 5,832,000 third-order mixed sensitivities of the leakage response of a polyethylene-reflected plutonium (PERP) experimental benchmark with respect to the benchmark’s 180 microscopic total cross sections. This computation was made possible by applying the Third-Order Adjoint Sensitivity Analysis Methodology developed by Cacuci. The numerical results obtained in this work revealed that many of the 3<sup>rd</sup>-order sensitivities are significantly larger than their corresponding 1<sup>st</sup>- and 2<sup>nd</sup>-order ones, which is contrary to the widely held belief that higher-order sensitivities are all much smaller and hence less important than the first-order ones, for reactor physics systems. In particular, the largest 3<sup>rd</sup>-order relative sensitivity is the mixed sensitivity <img src="Edit_754b8437-dfdf-487d-af68-c78c637e6d4e.png" width="180" height="24" alt="" />of the PERP leakage response with respect to the lowest energy-group (30) total cross sections of <sup>1</sup>H (“isotope 6”) and <sup>239</sup>Pu (“isotope 1”). These two isotopes are shown in this work to be the two most important parameters affecting the PERP benchmark’s leakage response. By comparison, the largest 1<sup>st</sup>-order sensitivity is that of the PERP leakage response with respect to the lowest energy-group total cross section of isotope <sup>1</sup>H, having the value <img src="Edit_a5cfcc11-6a99-41ee-b844-a5ee84b454b3.png" width="100" height="24" alt="" />, while the largest 2<sup>nd</sup>-order sensitivity is <img src="Edit_05166a2b-97f7-43f1-98ff-b21368c00228.png" width="120" height="22" alt="" />. The 3<sup>rd</sup>-order sensitivity analysis presented in this work is the first ever such analysis in the field of reactor physics. The consequences of the results presented in this work on the uncertainty analysis of the PERP benchmark’s leakage response will be presented in a subsequent work.
文摘This work extends to third-order previously published work on developing the adjoint sensitivity and uncertainty analysis of the numerical model of a <u>p</u>oly<u>e</u>thylene-<u>r</u>eflected <u>p</u>lutonium (acronym: PERP) OECD/NEA reactor physics benchmark. The PERP benchmark comprises 21,976 imprecisely known (uncertain) model parameters. Previous works have used the adjoint sensitivity analysis methodology to compute exactly and efficiently all of the 21,976 first-order and (21,976)<sup>2</sup> second-order sensitivities of the PERP benchmark’s leakage response to all of the benchmark’s uncertain parameters, showing that the largest and most consequential 1<sup>st</sup>- and 2<sup>nd</sup>-order response sensitivities are with respect to the total microscopic cross sections. These results have motivated extending the previous adjoint-based derivations to third-order, leading to the derivation, in this work, of the exact mathematical expressions of the (180)<sup>3</sup> third-order sensitivities of the PERP leakage response with respect to these total microscopic cross sections. The formulas derived in this work are valid not only for the PERP benchmark but can also be used for computing the 3<sup>rd</sup>-order sensitivities of the leakage response of any nuclear system involving fissionable material and internal or external neutron sources. Subsequent works will use the adjoint-based mathematical expressions obtained in this work to compute exactly and efficiently the numerical values of these (180)<sup>3</sup> third-order sensitivities (which turned out to be very large and consequential) and use them for a third-order uncertainty analysis of the PERP benchmark’s leakage response.
文摘On Oct.25,2015,the 3rd Work Meeting of the 2nd Editorial Board Committee of China City Planning Review(abbreviated as CCPR hereafter)was convened at the School of Architecture,Tsinghua University in Beijing.The Editorial Board members participated in the meeting.At the meeting,the Editorial Department of CCPR presented a Work Report of the 2nd Editorial Board Committee(2013–2015)and a Work Report of the Editorial Department,followed by open discussions.
文摘The 3rd plenary session of the 2nd Editorial Committee of Chinese Herbal Medicines (CHM) was held in Nanjing, China, on July 19, 2014. The participants included the associate editors-in-chief of CHM, Prof. Li-da Tang (China), Prof. De-an Guo (China), Prof. Guido E Pauli (USA), Prof. Pulok Kumar Mukherjee (India), and Prof. Rudolf Bauer (Austria), and some members of CHM Editorial Board, such as Prof. Leslie Gunatilaka (India), Prof. Peter Hylands (UK), Prof. Alexander Shikov (Russia), Prof. Shi-shan Yu (China), Prof. Zheng-tao Wang (China), and Prof. Hong-xi Xu (China), and the editors of Editorial Office of CHM.
文摘In recent years,as we have a better knowledge and understanding of the biology of non small cell lung carcinoma(NSCLC),which leads us to targeting biomarkers driving the NSCLC carcinogenesis and metastatic potential,we now have an increased number of options to offer our patients with NSCLC.We also realize the importance of distinguishing squamous and non squamous histology to guide our treatment decisions of NSCLC.The palliative care concomitant with therapies from the very start of the treatment also showed an impact on survival.This review examines the treatment options in all lines of therapy for metastatic NSCLC that have been approved in Canada,the United States,or Europe.
文摘This work extends to fourth-order previously published work on developing the adjoint sensitivity and uncertainty analysis of the numerical model of a <u>p</u>oly<u>e</u>thylene-<u>r</u>eflected <u>p</u>lutonium (acronym: PERP) OECD/NEA reactor physics benchmark. The PERP benchmark comprises 7477 imprecisely known (uncertain) model parameters which have nonzero values. These parameters are as follows: 180 microscopic total cross sections;7101 microscopic scattering sections;60 microscopic fission cross sections;60 parameters that characterize the average number of neutrons per fission;60 parameters that characterize the fission spectrum;10 parameters that characterize the fission source;and 6 parameters that characterize the isotope number densities. Previous works have used the adjoint sensitivity analysis methodology to compute exactly and efficiently all of the 7477 first-order and 27,956,503 second-order sensitivities of the PERP benchmark’s leakage response to all of the benchmark’s uncertain parameters. These works showed that largest response sensitivities involve the total microscopic cross sections, which motivated the recent computation of all of the (180)<sup>3</sup> third-order sensitivities of the PERP leakage response with respect to these total microscopic cross sections. It turned out that some of these 3<sup>rd</sup>-order cross sections were far larger than the corresponding 2<sup>nd</sup>-order ones, thereby having the largest impact on the uncertainties induced in the PERP benchmark’s response. This finding has motivated the development of the original 4<sup>th</sup>-order formulas presented in this work, which are valid not only for the PERP benchmark but can also be used for computing the 4<sup>th</sup>-order sensitivities of response of any nuclear system involving fissionable material and internal or external neutron sources. Subsequent works will use the adjoint-based mathematical expressions obtained in this work to compute exactly and efficiently the numerical values of the largest fourth-order sensitivities of the PERP benchmark’s response to the total microscopic cross section and use them for a pioneering fourth-order uncertainty analysis of the PERP benchmark’s response.