A practical and straightforward protocol has been developed for the preparation of 2-thioxo-2,3-dihydroquinazolin-4（1H）-one derivatives from dithiocarbamate chemistry. The method involves the reaction of anthranilic...A practical and straightforward protocol has been developed for the preparation of 2-thioxo-2,3-dihydroquinazolin-4（1H）-one derivatives from dithiocarbamate chemistry. The method involves the reaction of anthranilic acid derivatives（2-aminobenzoic acid, 2-aminobenzamide and isatoic anhydride）with various dithiocarbamate derivatives using ethanol as solvent. The main advantages of this protocol include practical simplicity, good to high yields, and ease of product isolation, purification and cheapness of the solvent.展开更多
We discovered that a-chymotrypsin has a promiscuous ability to catalyze the cyclocondensation of aromatic and aliphatic aldehydes with 2-aminobenzamides to afford the corresponding 2,3-dihydroquinazolin-4（1H）-ones s...We discovered that a-chymotrypsin has a promiscuous ability to catalyze the cyclocondensation of aromatic and aliphatic aldehydes with 2-aminobenzamides to afford the corresponding 2,3-dihydroquinazolin-4（1H）-ones successfully in high yields（90%–98%） under alcohol solvent. The catalytic activity of a-chymotrypsin was evaluated through investigating the temperature, the enzyme loading and the ratio of substrates in the enzyme-catalyzed reactions. The present method proves to be efficient and environmentally friendly in terms of short reaction time, high yield, green catalyst and the clean products obtained without further purification processes.展开更多
An efficient and eco-friendly method is reported for the synthesis of 2-substituted-2,3-dihydroquinazolin-4（1H）-ones from direct cyclocondensation of anthranilamide with aldehydes and ketones using N-propylsulfamic ...An efficient and eco-friendly method is reported for the synthesis of 2-substituted-2,3-dihydroquinazolin-4（1H）-ones from direct cyclocondensation of anthranilamide with aldehydes and ketones using N-propylsulfamic acid supported onto magnetic Fe304 nanoparticles （MNPs-PSA） as a recoverable and recyclable nanocatalyst in good to excellent yields in water at 70 ℃, The catalyst was readily separated using an external magnet and reusable without significant loss of their catalytic efficiency,展开更多
基金the Chemistry and Chemical Engineering Research Center of Iran is gratefully appreciated
文摘A practical and straightforward protocol has been developed for the preparation of 2-thioxo-2,3-dihydroquinazolin-4（1H）-one derivatives from dithiocarbamate chemistry. The method involves the reaction of anthranilic acid derivatives（2-aminobenzoic acid, 2-aminobenzamide and isatoic anhydride）with various dithiocarbamate derivatives using ethanol as solvent. The main advantages of this protocol include practical simplicity, good to high yields, and ease of product isolation, purification and cheapness of the solvent.
基金the financial support of the National Natural Science Foundation of China (Nos. 21262002, 21462001 and 21465002)the Program for Changjiang Scholars and Innovative Research Team in University (IRT13054)+1 种基金the Natural Science Foundation of Jiangxi No. 20142BAB203008)the Science and Technology Foundation of the Jiangxi Education Department (Nos. KJLD12006, GJJ14466 and KJLD14050)
文摘We discovered that a-chymotrypsin has a promiscuous ability to catalyze the cyclocondensation of aromatic and aliphatic aldehydes with 2-aminobenzamides to afford the corresponding 2,3-dihydroquinazolin-4（1H）-ones successfully in high yields（90%–98%） under alcohol solvent. The catalytic activity of a-chymotrypsin was evaluated through investigating the temperature, the enzyme loading and the ratio of substrates in the enzyme-catalyzed reactions. The present method proves to be efficient and environmentally friendly in terms of short reaction time, high yield, green catalyst and the clean products obtained without further purification processes.
文摘An efficient and eco-friendly method is reported for the synthesis of 2-substituted-2,3-dihydroquinazolin-4（1H）-ones from direct cyclocondensation of anthranilamide with aldehydes and ketones using N-propylsulfamic acid supported onto magnetic Fe304 nanoparticles （MNPs-PSA） as a recoverable and recyclable nanocatalyst in good to excellent yields in water at 70 ℃, The catalyst was readily separated using an external magnet and reusable without significant loss of their catalytic efficiency,
