C_(10)H_8N_2O_2S_2, Mr=252. 32,monoclinic,P2_(1/c),a=7.165(5).b=7.659(3),c=19.543(8)A,β=96. 76(5)°,V=1065.0(9) A,Z=4,D_c=1. 57 g/cm￣3.The structure was solved by direct methods and refined to final R(R_w)=0.051...C_(10)H_8N_2O_2S_2, Mr=252. 32,monoclinic,P2_(1/c),a=7.165(5).b=7.659(3),c=19.543(8)A,β=96. 76(5)°,V=1065.0(9) A,Z=4,D_c=1. 57 g/cm￣3.The structure was solved by direct methods and refined to final R(R_w)=0.051(0.057) for 1446 observed reflections with I≥3σ(Ⅰ).The sulfur-sulfur bond length is found to be 2. 019(2) A with a dihedral angle CSSC of 93.29°.展开更多
Hydroxy-phenyl)-5-(2-methyl-phenyl)-6-ethoxycarbonyl-cyclohexen-2-one has been synthesized and characterized by elemental analysis, IR, UV, H NMR and MS, and its crystal 1 structure was determined by X-ray single-crys...Hydroxy-phenyl)-5-(2-methyl-phenyl)-6-ethoxycarbonyl-cyclohexen-2-one has been synthesized and characterized by elemental analysis, IR, UV, H NMR and MS, and its crystal 1 structure was determined by X-ray single-crystal diffraction method. The crystal belongs to the monoclinic system, space group P21/c with a = 14.6298(13), b = 5.8623(5), c = 22.255(2) ?, β = 105.855(2)o, V = 1836.0(3) ?3, Mr = 350.40, Z = 4, Dc = 1.268 g/cm3, F(000) = 744, μ(MoKα) = 0.086 mm-1, R = 0.0680 and wR = 0.1498. The crystal analysis results show that the cyclohexene unit of the title compound has a quasi-chair conformation, and a centrosymmetric dimer with a 16-membered ring is produced by the intermolecular hydrogen bonds.展开更多
The zinc 3-hydroxy-2-mercaptopyridine complex was prepared by self-assemby reaction of Zn(NO3)2 and 3-hydroxy-2-mercaptopyridine (hmp). Single-crystal X-ray diffraction analysis indicates that it crystallizes in a tet...The zinc 3-hydroxy-2-mercaptopyridine complex was prepared by self-assemby reaction of Zn(NO3)2 and 3-hydroxy-2-mercaptopyridine (hmp). Single-crystal X-ray diffraction analysis indicates that it crystallizes in a tetragonal system, space group (No. 122) with a = 13.4562(6), c = 13.6860(8) , V = 2478.1(2) 3, Z = 8, Mr = 317.67, Dc = 1.703 g/cm3, m(Mo-Ka) = 2.308 mm-1 and F(000) = 1280. R = 0.0289 and wR = 0.0676 for 1040 observed reflections (I > 2s(I)). The crystal structure consists of a neutral molecule with a distorted tetrahedral cis-ZnS2O2 core, in which the mononuclear Zn2+ ion is coordinated by two O and two S atoms from two hmp ligands with the average bond distances of 2.301(1) ?for ZnS and 1.986(3) ?for ZnO. The 1H . NMR and IR spectra of the compound are discussed.展开更多
To improve the stability and pharmacokinetic properties,prodrugs of L-ddG（L-2＇,3＇-dideoxy-guanosine）and L-D4G （L-2＇,3＇-dihydro-2＇,3＇-dideoxyguanosine）modified with a series of substituted amino groups at C-6...To improve the stability and pharmacokinetic properties,prodrugs of L-ddG（L-2＇,3＇-dideoxy-guanosine）and L-D4G （L-2＇,3＇-dihydro-2＇,3＇-dideoxyguanosine）modified with a series of substituted amino groups at C-6 position of the purine base were designed and synthesized and their anti-HIV activities were evaluated.Compounds 7d and 8g exhibited moderate activity and showed EC_（50）of 42μmol/L and 55μmol/L,respectively.展开更多
In this article, AHPS (3 - allyloxy- 2 -hydrory- 1 -Propanesulfonate salt) wassynthesized to use in emulsifier-Ne emulsion polymerization of BA/BMa/MMA systemfor high solid content latexes. Storage stability klow beha...In this article, AHPS (3 - allyloxy- 2 -hydrory- 1 -Propanesulfonate salt) wassynthesized to use in emulsifier-Ne emulsion polymerization of BA/BMa/MMA systemfor high solid content latexes. Storage stability klow behavior of the latexes,morphology of the obtained latex particles, dynamic viscoelastic behavior, tensilestrength and water resistance properties of the resulted copolymers were investigated.The experimental results show that with the addition of AHPS, stability of the emulsionis greatly improved that there appears no apparent precipitation dunring thepolymerization and storage at room temperature for 6 months and at -10℃ for fourmonths. Flow of the latexes follows the Bingham body laws, diameter of the latexparticles is about 0.6μn, of which is larger than that of by conventional emulsionpolymerization(0.12μm). In addition, not only water resistance of the copolymersobtained by emulsifier-free emulsion polymerization is greatly improved, but alsotensile strength is obviously enhanced.展开更多
文摘C_(10)H_8N_2O_2S_2, Mr=252. 32,monoclinic,P2_(1/c),a=7.165(5).b=7.659(3),c=19.543(8)A,β=96. 76(5)°,V=1065.0(9) A,Z=4,D_c=1. 57 g/cm￣3.The structure was solved by direct methods and refined to final R(R_w)=0.051(0.057) for 1446 observed reflections with I≥3σ(Ⅰ).The sulfur-sulfur bond length is found to be 2. 019(2) A with a dihedral angle CSSC of 93.29°.
基金This work was financially supported by the Education Committee of Hunan Province (02C465)Hunan Provincial Key Discipline and Hunan Provincial General College Leader of Learning
文摘Hydroxy-phenyl)-5-(2-methyl-phenyl)-6-ethoxycarbonyl-cyclohexen-2-one has been synthesized and characterized by elemental analysis, IR, UV, H NMR and MS, and its crystal 1 structure was determined by X-ray single-crystal diffraction method. The crystal belongs to the monoclinic system, space group P21/c with a = 14.6298(13), b = 5.8623(5), c = 22.255(2) ?, β = 105.855(2)o, V = 1836.0(3) ?3, Mr = 350.40, Z = 4, Dc = 1.268 g/cm3, F(000) = 744, μ(MoKα) = 0.086 mm-1, R = 0.0680 and wR = 0.1498. The crystal analysis results show that the cyclohexene unit of the title compound has a quasi-chair conformation, and a centrosymmetric dimer with a 16-membered ring is produced by the intermolecular hydrogen bonds.
基金the Innovative Project (No. IP01007)the Introduction of Overseas Elitists Program (No. IB990168) of the Chinese Academy of Sciences
文摘The zinc 3-hydroxy-2-mercaptopyridine complex was prepared by self-assemby reaction of Zn(NO3)2 and 3-hydroxy-2-mercaptopyridine (hmp). Single-crystal X-ray diffraction analysis indicates that it crystallizes in a tetragonal system, space group (No. 122) with a = 13.4562(6), c = 13.6860(8) , V = 2478.1(2) 3, Z = 8, Mr = 317.67, Dc = 1.703 g/cm3, m(Mo-Ka) = 2.308 mm-1 and F(000) = 1280. R = 0.0289 and wR = 0.0676 for 1040 observed reflections (I > 2s(I)). The crystal structure consists of a neutral molecule with a distorted tetrahedral cis-ZnS2O2 core, in which the mononuclear Zn2+ ion is coordinated by two O and two S atoms from two hmp ligands with the average bond distances of 2.301(1) ?for ZnS and 1.986(3) ?for ZnO. The 1H . NMR and IR spectra of the compound are discussed.
基金National Natural Science Foundation of China (Grant No.20472006 and 20832001)
文摘To improve the stability and pharmacokinetic properties,prodrugs of L-ddG（L-2＇,3＇-dideoxy-guanosine）and L-D4G （L-2＇,3＇-dihydro-2＇,3＇-dideoxyguanosine）modified with a series of substituted amino groups at C-6 position of the purine base were designed and synthesized and their anti-HIV activities were evaluated.Compounds 7d and 8g exhibited moderate activity and showed EC_（50）of 42μmol/L and 55μmol/L,respectively.
文摘In this article, AHPS (3 - allyloxy- 2 -hydrory- 1 -Propanesulfonate salt) wassynthesized to use in emulsifier-Ne emulsion polymerization of BA/BMa/MMA systemfor high solid content latexes. Storage stability klow behavior of the latexes,morphology of the obtained latex particles, dynamic viscoelastic behavior, tensilestrength and water resistance properties of the resulted copolymers were investigated.The experimental results show that with the addition of AHPS, stability of the emulsionis greatly improved that there appears no apparent precipitation dunring thepolymerization and storage at room temperature for 6 months and at -10℃ for fourmonths. Flow of the latexes follows the Bingham body laws, diameter of the latexparticles is about 0.6μn, of which is larger than that of by conventional emulsionpolymerization(0.12μm). In addition, not only water resistance of the copolymersobtained by emulsifier-free emulsion polymerization is greatly improved, but alsotensile strength is obviously enhanced.
