AIM: To investigate which surgical techniques and perioperative regimens yielded the best survival rates for diabetic rats undergoing gastric bypass. METHODS: We performed Roux-en-Y gastric bypass with reserved gastri...AIM: To investigate which surgical techniques and perioperative regimens yielded the best survival rates for diabetic rats undergoing gastric bypass. METHODS: We performed Roux-en-Y gastric bypass with reserved gastric volume, a procedure in which gastrointestinal continuity was reestablished while excluding the entire duodenum and proximal jejunal loop. We observed the procedural success rate, long-term survival, and histopathological sequelae associated with a number of technical modifications. These included: use of anatomical markers to precisely identify Treitz's ligament; careful dissection along surgical planes; careful attention to the choice of regional transection sites; reconstruction using full-thickness anastomoses; use of a minimally invasive procedure with prohemostatic pretreatment and hemorrhage control; prevention of hypo-thermic damage; reduction in the length of the procedure; and accelerated surgical recovery using fast-track surgical modalities such as perioperative permissive underfeeding and goal-directed volume therapy. RESULTS: The series of modif ications we adopted reduced operation time from 110.02 ± 12.34 min to 78.39 ± 7.26 min (P < 0.01), and the procedural success rate increased from 43.3% (13/30) to 90% (18/20) (P < 0.01), with a long-term survival of 83.3% (15/18) (P < 0.01). CONCLUSION: Using a number of fast-track and damage control surgical techniques, we have successfully established a stable model of gastric bypass in diabetic rats.展开更多
Objectives:This study aimed to translate the revised 17-item Diabetes Distress Scale(DDS17,2017)into mandarin(simplified)Chinese and validate the Chinese version of DDS17(C-DDS17,2021)among adult patients with type 2 ...Objectives:This study aimed to translate the revised 17-item Diabetes Distress Scale(DDS17,2017)into mandarin(simplified)Chinese and validate the Chinese version of DDS17(C-DDS17,2021)among adult patients with type 2 diabetes in China.Methods:A scale translation and cross-sectional validation study was conducted.The DDS17 was translated into mandarin(simplified)Chinese through a five-step process:authorization,forward translation,synthesis,back translation,and amendment.During this session,59 patients assessed the understandability and readability of the translated scale.From June 7 to September 4,2021,a cross-sectional study that adhered to the COSMIN checklist was conducted with 400 individuals with type 2 diabetes from three Class A tertiary comprehensive hospitals in Beijing,China.The content,construct,convergent,discriminant validity,and reliability(Cronbach’s a coefficient and item-total correlation coefficients)of the C-DDS17 were evaluated.This study was a part of a project registered in the Chinese Clinical Trial Registry(no.ChiCTR2100047071).Results:Among the participants,33.3%(133/400)of them experienced moderate to high diabetes distress.The content validity indices of the C-DDS17 equaled 1.00.The scale yielded a four-factor structure.The average variances extracted were 0.42e0.57,which was lower than squared correla-tions.Cronbach’s a coefficient was 0.88 for the overall scale and ranged from 0.76 to 0.81 for sub-scales.Corrected item-total correlation coefficients ranged from 0.42 to 0.61.The eighth item(“Feeling that I am often failing with my diabetes routine”)was better fit to physician distress than regimen distress but had little influence on the validation results.Conclusions:The C-DDS17 is a reliable and valid instrument for assessing diabetes distress in patients with type 2 diabetes.It is a promising instrument for early identification and management of diabetes distress in clinical practice and trials.展开更多
基金Supported by Scientific Research Fund of Heilongjiang Provincial Education Department, No. 11541200Harbin Medical University First Affi liated Hospital, No. 2007098
文摘AIM: To investigate which surgical techniques and perioperative regimens yielded the best survival rates for diabetic rats undergoing gastric bypass. METHODS: We performed Roux-en-Y gastric bypass with reserved gastric volume, a procedure in which gastrointestinal continuity was reestablished while excluding the entire duodenum and proximal jejunal loop. We observed the procedural success rate, long-term survival, and histopathological sequelae associated with a number of technical modifications. These included: use of anatomical markers to precisely identify Treitz's ligament; careful dissection along surgical planes; careful attention to the choice of regional transection sites; reconstruction using full-thickness anastomoses; use of a minimally invasive procedure with prohemostatic pretreatment and hemorrhage control; prevention of hypo-thermic damage; reduction in the length of the procedure; and accelerated surgical recovery using fast-track surgical modalities such as perioperative permissive underfeeding and goal-directed volume therapy. RESULTS: The series of modif ications we adopted reduced operation time from 110.02 ± 12.34 min to 78.39 ± 7.26 min (P < 0.01), and the procedural success rate increased from 43.3% (13/30) to 90% (18/20) (P < 0.01), with a long-term survival of 83.3% (15/18) (P < 0.01). CONCLUSION: Using a number of fast-track and damage control surgical techniques, we have successfully established a stable model of gastric bypass in diabetic rats.
文摘Objectives:This study aimed to translate the revised 17-item Diabetes Distress Scale(DDS17,2017)into mandarin(simplified)Chinese and validate the Chinese version of DDS17(C-DDS17,2021)among adult patients with type 2 diabetes in China.Methods:A scale translation and cross-sectional validation study was conducted.The DDS17 was translated into mandarin(simplified)Chinese through a five-step process:authorization,forward translation,synthesis,back translation,and amendment.During this session,59 patients assessed the understandability and readability of the translated scale.From June 7 to September 4,2021,a cross-sectional study that adhered to the COSMIN checklist was conducted with 400 individuals with type 2 diabetes from three Class A tertiary comprehensive hospitals in Beijing,China.The content,construct,convergent,discriminant validity,and reliability(Cronbach’s a coefficient and item-total correlation coefficients)of the C-DDS17 were evaluated.This study was a part of a project registered in the Chinese Clinical Trial Registry(no.ChiCTR2100047071).Results:Among the participants,33.3%(133/400)of them experienced moderate to high diabetes distress.The content validity indices of the C-DDS17 equaled 1.00.The scale yielded a four-factor structure.The average variances extracted were 0.42e0.57,which was lower than squared correla-tions.Cronbach’s a coefficient was 0.88 for the overall scale and ranged from 0.76 to 0.81 for sub-scales.Corrected item-total correlation coefficients ranged from 0.42 to 0.61.The eighth item(“Feeling that I am often failing with my diabetes routine”)was better fit to physician distress than regimen distress but had little influence on the validation results.Conclusions:The C-DDS17 is a reliable and valid instrument for assessing diabetes distress in patients with type 2 diabetes.It is a promising instrument for early identification and management of diabetes distress in clinical practice and trials.
