Novel hexadecyl 3- { 4-[2-hydroxy-3（isopropylamino）propoxy]phenyl }propionate （HPP）was synthesized and its effect on delivery of liposomes into cultured cardiomyocytes was examined. The structure of HPP was charac...Novel hexadecyl 3- { 4-[2-hydroxy-3（isopropylamino）propoxy]phenyl }propionate （HPP）was synthesized and its effect on delivery of liposomes into cultured cardiomyocytes was examined. The structure of HPP was characterized by IH NMR, 1R and MS. The amount of cardiomyocytes uptake of HPP-liposome was 3.9-fold higher than plain-liposome, and the increase was 6.2-fold when hypoxia happens. It indicated that HPP was a potential ligand for liposome targeting to ischemic myocardium.展开更多
A new dimeric Mn（Ⅱ） complex,namely,[Mn（L）（PIP）]_2·H_2O（1）,was synthesized under hydrothermal condition（H_2L = 3-carboxy-1-carboxymethyl-2-oxidopyridinium and PIP = 2-（pyridin-3-yl）-1H-imidazo[4,5-f][1...A new dimeric Mn（Ⅱ） complex,namely,[Mn（L）（PIP）]_2·H_2O（1）,was synthesized under hydrothermal condition（H_2L = 3-carboxy-1-carboxymethyl-2-oxidopyridinium and PIP = 2-（pyridin-3-yl）-1H-imidazo[4,5-f][1,10]phenanthroline）.It crystallizes in triclinic,space group P1 with a = 9.2037（13）,b = 9.6794（13）,c = 14.649（3） A,α = 94.858（3）,β = 94.928（3）,γ = 114.468（2）o,V = 1172.9（3） A^3,Z = 1,C_（52）H_（34）Mn_2N_（12）O_（11）,Mr = 1112.79,Dc = 1.575 g/cm^3,F（000） = 568,μ（Mo Ka） = 0.618 mm^-1,R = 0.0432 and w R = 0.1151.In 1,two L anions bridge two Mn（Ⅱ） atoms to give a dimeric [Mn（L）（PIP）] unit with the Mn···Mn distance of 3.009（2） A.The two PIP ligands are located on both sides of the dimer,which provides suitable π-π stacking interactions between PIP ligands.By these π-π stacking interactions,adjacent dimers are extended into a two-dimensional supramolecular layer.Further,the strong N–H···O hydrogen bond stabilizes the supramolecular layer structure of 1.Moreover,the thermal behavior and luminescent property of 1 have been studied.展开更多
基金This project was supported by the National Natural Science Foundation of China(No.30271548).
文摘Novel hexadecyl 3- { 4-[2-hydroxy-3（isopropylamino）propoxy]phenyl }propionate （HPP）was synthesized and its effect on delivery of liposomes into cultured cardiomyocytes was examined. The structure of HPP was characterized by IH NMR, 1R and MS. The amount of cardiomyocytes uptake of HPP-liposome was 3.9-fold higher than plain-liposome, and the increase was 6.2-fold when hypoxia happens. It indicated that HPP was a potential ligand for liposome targeting to ischemic myocardium.
基金Supported by the Institute Foundation of Siping city(No.2013036)
文摘A new dimeric Mn（Ⅱ） complex,namely,[Mn（L）（PIP）]_2·H_2O（1）,was synthesized under hydrothermal condition（H_2L = 3-carboxy-1-carboxymethyl-2-oxidopyridinium and PIP = 2-（pyridin-3-yl）-1H-imidazo[4,5-f][1,10]phenanthroline）.It crystallizes in triclinic,space group P1 with a = 9.2037（13）,b = 9.6794（13）,c = 14.649（3） A,α = 94.858（3）,β = 94.928（3）,γ = 114.468（2）o,V = 1172.9（3） A^3,Z = 1,C_（52）H_（34）Mn_2N_（12）O_（11）,Mr = 1112.79,Dc = 1.575 g/cm^3,F（000） = 568,μ（Mo Ka） = 0.618 mm^-1,R = 0.0432 and w R = 0.1151.In 1,two L anions bridge two Mn（Ⅱ） atoms to give a dimeric [Mn（L）（PIP）] unit with the Mn···Mn distance of 3.009（2） A.The two PIP ligands are located on both sides of the dimer,which provides suitable π-π stacking interactions between PIP ligands.By these π-π stacking interactions,adjacent dimers are extended into a two-dimensional supramolecular layer.Further,the strong N–H···O hydrogen bond stabilizes the supramolecular layer structure of 1.Moreover,the thermal behavior and luminescent property of 1 have been studied.
