The key intermediate, 2-isopropyl-2-(3-methyl-1-benzoxyl-5-phenylsulfonyl-3E-pentenyl)-1, 3-dithiocycllohexane(Ⅲ), for the total synthesis of Sarcophytol-A (1)was prepared through 7 steps from acetone. The key steps ...The key intermediate, 2-isopropyl-2-(3-methyl-1-benzoxyl-5-phenylsulfonyl-3E-pentenyl)-1, 3-dithiocycllohexane(Ⅲ), for the total synthesis of Sarcophytol-A (1)was prepared through 7 steps from acetone. The key steps are nucleophilic addition of 2-1ithio-2-isopropyl-1,3-dithiocyclohexane to aldehyde 5 and double bond migration reaction of allylic alcohol 9 and 10.展开更多
A new halogenated biindole and a new apo-carotenone have been isolated from the ethanolic extract of the green alga Chaetomorpha basiretorsa Sethcell. On the basis of chemical and spectroscopic methods including 2D NM...A new halogenated biindole and a new apo-carotenone have been isolated from the ethanolic extract of the green alga Chaetomorpha basiretorsa Sethcell. On the basis of chemical and spectroscopic methods including 2D NMR technique, their structures have been elucidated as 4,4′-dichloro-5,5′-dibromo-7,7′-dimethoxy-2,2′-bi-1H-indole and 1′S*,4′R*-8-(4′-hydroxy-2′,6′,6′- trimethylcyclohex-2-enyl)-6-methyloct-3E,5E,7E-trien-2-one, respectively.展开更多
An efficient method for the synthesis of novel benzo[b]pyrimido[4′,5′：5,4]thieno[2,3e]-[1,6]naphthyridine-8-one derivatives via Pictet-Spengler cyclization is reported. The reaction of 4-（3-aminopyrimido[4,5-d]thi...An efficient method for the synthesis of novel benzo[b]pyrimido[4′,5′：5,4]thieno[2,3e]-[1,6]naphthyridine-8-one derivatives via Pictet-Spengler cyclization is reported. The reaction of 4-（3-aminopyrimido[4,5-d]thieno-2-yl）quinoline-2-ones, which could be obtained from Thorpe-Ziegler isomerization of 4-bromomethylquinoline-2-ones and 5-cyano-1,6-dihydro-4-methyl-2-phenyl-6-thioxopyrimidine,with aromatic aldehydes in the presence of BF3·OEt2 gives pyrimidothieno[1,6]naphthyridines in good yields.展开更多
基金Supported by the National Natural Science Foundation of China State Educational Commission Foundation of China
文摘The key intermediate, 2-isopropyl-2-(3-methyl-1-benzoxyl-5-phenylsulfonyl-3E-pentenyl)-1, 3-dithiocycllohexane(Ⅲ), for the total synthesis of Sarcophytol-A (1)was prepared through 7 steps from acetone. The key steps are nucleophilic addition of 2-1ithio-2-isopropyl-1,3-dithiocyclohexane to aldehyde 5 and double bond migration reaction of allylic alcohol 9 and 10.
基金supported by national 863 project(Grant No.2004AA625030,2001AA620503)NNSFC(Grant No.20432030)Key Innovative Project of the Academy(Grant No.KZCX3-SW-215).
文摘A new halogenated biindole and a new apo-carotenone have been isolated from the ethanolic extract of the green alga Chaetomorpha basiretorsa Sethcell. On the basis of chemical and spectroscopic methods including 2D NMR technique, their structures have been elucidated as 4,4′-dichloro-5,5′-dibromo-7,7′-dimethoxy-2,2′-bi-1H-indole and 1′S*,4′R*-8-(4′-hydroxy-2′,6′,6′- trimethylcyclohex-2-enyl)-6-methyloct-3E,5E,7E-trien-2-one, respectively.
文摘An efficient method for the synthesis of novel benzo[b]pyrimido[4′,5′：5,4]thieno[2,3e]-[1,6]naphthyridine-8-one derivatives via Pictet-Spengler cyclization is reported. The reaction of 4-（3-aminopyrimido[4,5-d]thieno-2-yl）quinoline-2-ones, which could be obtained from Thorpe-Ziegler isomerization of 4-bromomethylquinoline-2-ones and 5-cyano-1,6-dihydro-4-methyl-2-phenyl-6-thioxopyrimidine,with aromatic aldehydes in the presence of BF3·OEt2 gives pyrimidothieno[1,6]naphthyridines in good yields.
