A novel Ru(Ⅱ) complex [(bpy)2Ru(PBC)](PF6)2 (PBC = N-[4-(9-carbazole)butyl]-2-(2-pyridyl)benzimidazole) has been synthesized and verified by 1↑H NMR, elemental analysis and X-ray crystallography. The c...A novel Ru(Ⅱ) complex [(bpy)2Ru(PBC)](PF6)2 (PBC = N-[4-(9-carbazole)butyl]-2-(2-pyridyl)benzimidazole) has been synthesized and verified by 1↑H NMR, elemental analysis and X-ray crystallography. The crystal (C48H40F12N8P2Ru, Mr = 1119.89) belongs to the triclinic system, space group P1, with a = 13.128(4), b = 13.814(4), c = 14.184(4) A, α = 84.112(6), β = 88.473(6), γ = 78.196(6)°, Z = 2, V = 2504.6(13)A^3, Dc = 1.485 g/cm^3, F(000) = 1132, R = 0.0750 and wR = 0.1896. The Ru atom adopts a distorted-octahedral coordination geometry with the bond distances and bond angles falling in normal ranges. The complex shows an intense metal-to-ligand charge transfer (1MLCT) (dπ(Ru) →π*(L)) transition (ε ~1.2×10^4 dm^3mol^-1cm^-1) at 457 nm in the UV-Vis absorption spectrum and a strong red phosphorescence at 632 nm in the CH3CN solution at ambient temperature. An efficient intramolecular energy transfer process from the carbazole unit to the [(bpy)2Ru(PB)]^2+ emissive center exists by selective optical-simulation. Its electrochemical behavior shows multiplicate redox processes based on the metal center, the grafting carbazole moiety and the 2-(2-pyridyl)benzimidazole unit.展开更多
A novel supramolecular compound,{[2-(2-pyridyl)benzimidazoleH2]2·[BiCl6]·Cl},was synthesized by the hydrothermal reaction of o-phenylenediamine and α-pyridinecarboxylic acid with BiCl3 in 6.0 mol·L-1...A novel supramolecular compound,{[2-(2-pyridyl)benzimidazoleH2]2·[BiCl6]·Cl},was synthesized by the hydrothermal reaction of o-phenylenediamine and α-pyridinecarboxylic acid with BiCl3 in 6.0 mol·L-1 HCl solution,and characterized by elemental analysis,IR,X-ray single-crystal diffraction and photoluminescence spectroscopy.The crystal (C24H22N6Cl7Bi,Mr= 851.61) belongs to the triclinic system,space group P1 with a =7.2887(18),b =9.548(2),c= 12.469(3),α=85.306(4),β=82.814(4),γ=71.349(4)°,Z=1,V=814.9(3)3,Dc=1.735 g/cm3,μ(MoKα)=6.007 mm-1,F(000)=410,R=0.0307 and wR=0.0787.The bismuth ion and six chlorine ions construct a distorted octahedral configuration.The three-dimensional supramolecular network is built from electrostatic attractions,hydrogen bonds and π-π interaction between the BiCl6 anion,Cl anion and [2-(2-pyridyl)benzimidazoleH2] cation.The photoluminescence spectroscopy study shows that the title compound has a blue fluorescent emission at 450 nm in the solid state.展开更多
The reactions of SbCl3 and HgCl2 with 2-(3-pyridyl)benzimidazole (PyBIm) in solution acidified with HCl have been investigated. The PyBIm ligands are protonated into 2-(3-pyridinio)benzimidazolium (H2PyBIm) ca...The reactions of SbCl3 and HgCl2 with 2-(3-pyridyl)benzimidazole (PyBIm) in solution acidified with HCl have been investigated. The PyBIm ligands are protonated into 2-(3-pyridinio)benzimidazolium (H2PyBIm) cations and the corresponding metal ions are bonded with chloride atoms into coordination anions, forming two new coordination compounds, namely, (H2PyBIm)(SbCl5) 1 and (H2PyBIm)2(Hg2Cl8) 2. Both compounds were characterized by X-ray crystallography. Crystal data for 1: triclinic, space group P1^- with a = 5.7030(7), b = 9.0625(11), c = 16.5929(18) A, α = 91.808(7)°, β = 93.234(6), γ = 99.216(7)°, C12H11N3SbCl5, Mr = 496.24, V = 844.44(17) A^3, Z = 2, Dc = 1.952 g/cm^3, μ(MoKα) = 2.419 mm^-1, F(000) = 480, the final R = 0.0496 and wR = 0.1382 for 3433 observed reflections (I 〉 2σ(I)). Crystal data for 2: monoclinic, space group P21/c with a = 7.8061(5), b = 15.8127(9), c = 12.2435(9) , β = 91.955(4)o, C24H22N6Hg2Cl8, Mr = 1079.26, V = 1510.40(17) 3, Z = 2, Dc = 2.373 g/cm3, μ(MoKα) = 10.889 mm-1, F(000) = 1008, the final R = 0.0293 and wR = 0.0562 for 2854 observed reflections (I 〉 2σ(I)). X-ray diffraction analysis reveals that the antimony(III) is five-coordinated, exhibiting a slightly distorted square-pyramidal coordination geometry; while in 2, a dimeric [Hg2Cl8]^4-anion consists of two trigonal bipyramids sharing two common edges. The organic cations and coordination anions are connected into a one-dimensional belt and a two-dimensional sheet through N-H···Cl hydrogen bonding interactions in compounds 1 and 2, respectively; both are further aggregated into 3D frameworks by strong π-π contacts.展开更多
A new method of synthesis of 2-(1,2-diferrocenylvinyl)benz- and azabenzimidazoles (3a-f), (4a-f) and 1’H,3’H(Me)-spiro-[(aza)benzimidazoline-2’,3-(1,2-diferrocenylcyclopropenes)] (5a-f) via reactions of diferroceny...A new method of synthesis of 2-(1,2-diferrocenylvinyl)benz- and azabenzimidazoles (3a-f), (4a-f) and 1’H,3’H(Me)-spiro-[(aza)benzimidazoline-2’,3-(1,2-diferrocenylcyclopropenes)] (5a-f) via reactions of diferrocenyl(methylsulfanyl)cyclopropenylium iodide (1) with aromatic o-diamines (2a-f) in the presence of Et3N (80°C - 82°C) is described. The structures of the resultant compounds are established using IR, 1H and 13C NMR spectroscopy, mass spectrometry and elemental analysis. The structure of one compound, cis-2-(1,2-diferrocenylvinyl)-1-methylbenzimidazole (3b), is confirmed by X-ray diffraction analysis. The electrochemical properties of compounds 3a, 3b, 3d and 5f are investigated using cyclic square wave voltammetry. Two electrochemical processes (I-II), attributed to oxidation of the ferrocene moieties, and the values of E0’(I), E0’(II), DE0’(II-I) and comporportionation constant Kcom are reported. The bioactivities of seven compounds 3a, 3c-f, 5d, 5f are evaluated. Compound 5f is the most active compound with a modest cytotoxic activity against six human cancer cell lines: U-251 (glioma), PC-3 (prostate cancer), K-562 (leukemia), HCT-15 (colon cancer), MCF-7 (breast cancer) and SKLU-1 (lung cancer).展开更多
Three sulfhydryl-reactive fluorescent probes, which contain 2-(1H-benzoimidazol-2-yl)-phenol and maleimide group, were synthesized and their structures were characterized by IR and ^1H NMR. Their photo-physical prop...Three sulfhydryl-reactive fluorescent probes, which contain 2-(1H-benzoimidazol-2-yl)-phenol and maleimide group, were synthesized and their structures were characterized by IR and ^1H NMR. Their photo-physical properties and the specificity to sulfhydryl group in the 2-mercapto-ethanol as well as the L-cysteine adducts were indicated by fluorescence intensity. Preliminary tests revealed that the probes could react selectively with the cysteine molecules, suggesting that these probes might be generally useful in biomedical researches.展开更多
The Iead compound of substituted 2-(4-hydroxyphenyl)benzimidazol were modified by phos-phorylation sulfonation and carboxymethylation. The henzimldazoloamidophosphate (6) (7) have better activi-ty against tobacco mosa...The Iead compound of substituted 2-(4-hydroxyphenyl)benzimidazol were modified by phos-phorylation sulfonation and carboxymethylation. The henzimldazoloamidophosphate (6) (7) have better activi-ty against tobacco mosaic virus (TMV). The benzimldazolophenoxyacetic acid, phenoxysuIfonic acid c0ntaining tri flu0r0methyl, and nitro gr0up have 77% ~85% efflclency f0r wheat rust disease.展开更多
In order to study the effect of 5, 6-Dichloro-l-13-D-ribofuranosyl-benzimidazole (DRB) on the biological characteristics of human laryngeal carcinoma Hep-2 cell line in vitro, Hep-2 cells cultured in vitro were trea...In order to study the effect of 5, 6-Dichloro-l-13-D-ribofuranosyl-benzimidazole (DRB) on the biological characteristics of human laryngeal carcinoma Hep-2 cell line in vitro, Hep-2 cells cultured in vitro were treated with different concentrations of DRB. Changes in cell proliferation, apoptotic rate and invasiveness were detected by MTT assay, flow cytometry (FCM) and matrigel in vitro invasion assay, respectively. It was found that DRB inhibited the proliferation of Hep-2 cells in a dose- and time-dependent manner. After being treated with 0, 10, 20, 40, 80 μmmol/L DRB for 24 h, the apoptotic rate in Hep-2 cells was (0.68±0.19)%, (1.95±0.12)%, (8.51±0.26)%, (11.26±0.17)% and (14.99±0.32)%, respectively. The matrigel in vitro invasion assay revealed that DRB began to inhibit the invasion of Hep-2 cells at the concentration of 5 μmmol/L, and with the increase of DRB concentration, the inhibitory effect was enhanced. It was suggested that DRB could influence the essential biological characteristics of Hep-2 cells, inhibit Hep-2 cells proliferation, reduce invasive ability and induce apoptosis of Hep-2 cells.展开更多
Two new complexes: [Cu(TBZ)(bipy)Cl]Cl[H2O (1) and [Cu(TBZ)(phen)CI]CloH20 (2) [TBZ=2-(4'-thiazolyl)- benzimidazole, phen = 1,10-phenanthroline and bipy =2,2'-bipyridine] have been synthesized and cha...Two new complexes: [Cu(TBZ)(bipy)Cl]Cl[H2O (1) and [Cu(TBZ)(phen)CI]CloH20 (2) [TBZ=2-(4'-thiazolyl)- benzimidazole, phen = 1,10-phenanthroline and bipy =2,2'-bipyridine] have been synthesized and characterized by elemental analysis, molar conductivity, IR, and UV-vis methods. Complex 2, structurally characterized by single-crystal X-ray crystallography, crystallizes in the monoclinic space group P21/c in a unit cell of a = 0.85257(12) nm, b=2.5358(4) nm, c=1.15151(13) nm, β=118.721(8)°, V=2.183.2(5) nm^3, Z=4, Dc=1.624 gocm 3, μ= 1.367 mm^-1. The complexes, free ligands and chloride copper(II) salt were each tested for their ability to inhibit the growth of two gram-positive (B. subtilis and S. aureus) and two gram-negative (Salmonella and E. coli) bacteria. The complexes showed good antibacterial activities against the microorganisms. The interaction between the com- plexes and calf thymus DNA in aqueous solution was investigated adopting electronic absorption spectroscopy, fluorescence spectroscopy, viscosity measurements and cyclic voltammetry. Results suggest that the two complexes can bind to DNA by intercalative mode. In addition, the result of agarose gel electrophoresis suggested that the complexes can cleave the plasmid DNA at physiological pH and room temperature. Mechanistic studies with different inhibiting reagents reveal that hydroxyl radicals, and a singlet oxygen-like copper-oxo species are all involved in the DNA scission process mediated by the complexes.展开更多
Cd(Ⅱ), Co(Ⅱ), Cu(Ⅱ) and Zn(Ⅱ) complexes(1~4) based on 2-(2-pyridyl)benzimidazole(pbm) and 4,4'-oxybisbenzoic acid(H2odc) were synthesized. The formulas of these complexes are [Cd(pbm)(odc)2](1), [Co(pbm)(odc)2...Cd(Ⅱ), Co(Ⅱ), Cu(Ⅱ) and Zn(Ⅱ) complexes(1~4) based on 2-(2-pyridyl)benzimidazole(pbm) and 4,4'-oxybisbenzoic acid(H2odc) were synthesized. The formulas of these complexes are [Cd(pbm)(odc)2](1), [Co(pbm)(odc)2](2), [Cu(pbm)(odc)2](3) and [Zn(pbm)(odc)2](4) confirmed by single-crystal X-ray diffraction analysis, which shows that complexes 1, 2 and 4 belong to monoclinic system with space group P21/n, while complex 3 belongs to monoclinic system with space group P21/c. The binding properties of complexes 1~4 with CT-DNA are evaluated by ultraviolet spectrum, fluorescence spectra and viscosity measurements. The results indicate that complexes 1~4 have strong interaction with CT-DNA binding. These complexes exhibit an electrostatic or groove mode in respect of binding with DNA, which can effectively destroy DNA. And this binding mode may be applied to the interaction between the complexes and cancer cell DNA. Therefore, we hope to provide a theoretical and scientific basis for the research of anti-cancer drugs.展开更多
Complexes[Zn(pbm)(5-hip)_(3)](1),[Zn(pbm)(5-nip)3](2),[Mn(pbm)(H_(3)btc)_(2)(H_(2)O)](3)and[Mn(pbm)(5-nip)_(3)](4),where H2HIPA=5-hydroxyisophthalic acid,H2nip=5-nitroisophthalic acid,H3btc=tri-mesic acid and pbm(pyri...Complexes[Zn(pbm)(5-hip)_(3)](1),[Zn(pbm)(5-nip)3](2),[Mn(pbm)(H_(3)btc)_(2)(H_(2)O)](3)and[Mn(pbm)(5-nip)_(3)](4),where H2HIPA=5-hydroxyisophthalic acid,H2nip=5-nitroisophthalic acid,H3btc=tri-mesic acid and pbm(pyridine benzene chelate material)=2-(2-pyridyl)benzimidazole,were identified via sin-gle-crystal XRD analyses.1,2 and 4 pertain to the monoclinic space group C2/c,while 3 belongs to the triclinic space group P1.The interplay of CT-DNA with those complexes was delineated using ultraviolet,fluorescence,and circular dichroism(CD)spectroscopy and viscosity measurements.Complexes 1,2,3 and 4 interact with CT-DNA in an electrostatic or grooving mode.We wish to offer a theory-wise foundation for developing anti-tumor medi-cines.展开更多
基金Supported by the Natural Science Foundation of Henan Province (No. 102100410221)the Natural Science Foundation of Nanyang Normal University (No. ZX2010012)the Young Core Instructor from the Education Commission of Henan Province
文摘A novel Ru(Ⅱ) complex [(bpy)2Ru(PBC)](PF6)2 (PBC = N-[4-(9-carbazole)butyl]-2-(2-pyridyl)benzimidazole) has been synthesized and verified by 1↑H NMR, elemental analysis and X-ray crystallography. The crystal (C48H40F12N8P2Ru, Mr = 1119.89) belongs to the triclinic system, space group P1, with a = 13.128(4), b = 13.814(4), c = 14.184(4) A, α = 84.112(6), β = 88.473(6), γ = 78.196(6)°, Z = 2, V = 2504.6(13)A^3, Dc = 1.485 g/cm^3, F(000) = 1132, R = 0.0750 and wR = 0.1896. The Ru atom adopts a distorted-octahedral coordination geometry with the bond distances and bond angles falling in normal ranges. The complex shows an intense metal-to-ligand charge transfer (1MLCT) (dπ(Ru) →π*(L)) transition (ε ~1.2×10^4 dm^3mol^-1cm^-1) at 457 nm in the UV-Vis absorption spectrum and a strong red phosphorescence at 632 nm in the CH3CN solution at ambient temperature. An efficient intramolecular energy transfer process from the carbazole unit to the [(bpy)2Ru(PB)]^2+ emissive center exists by selective optical-simulation. Its electrochemical behavior shows multiplicate redox processes based on the metal center, the grafting carbazole moiety and the 2-(2-pyridyl)benzimidazole unit.
基金Supported by the Natural Science Foundation of Henan Province (No. 0611023700)
文摘A novel supramolecular compound,{[2-(2-pyridyl)benzimidazoleH2]2·[BiCl6]·Cl},was synthesized by the hydrothermal reaction of o-phenylenediamine and α-pyridinecarboxylic acid with BiCl3 in 6.0 mol·L-1 HCl solution,and characterized by elemental analysis,IR,X-ray single-crystal diffraction and photoluminescence spectroscopy.The crystal (C24H22N6Cl7Bi,Mr= 851.61) belongs to the triclinic system,space group P1 with a =7.2887(18),b =9.548(2),c= 12.469(3),α=85.306(4),β=82.814(4),γ=71.349(4)°,Z=1,V=814.9(3)3,Dc=1.735 g/cm3,μ(MoKα)=6.007 mm-1,F(000)=410,R=0.0307 and wR=0.0787.The bismuth ion and six chlorine ions construct a distorted octahedral configuration.The three-dimensional supramolecular network is built from electrostatic attractions,hydrogen bonds and π-π interaction between the BiCl6 anion,Cl anion and [2-(2-pyridyl)benzimidazoleH2] cation.The photoluminescence spectroscopy study shows that the title compound has a blue fluorescent emission at 450 nm in the solid state.
基金supported by the Natural Science Foundation of Fujian Province (2007HZ0001-1, 2009HZ0004-1, 2009HZ0006-1 and 2006L2005)
文摘The reactions of SbCl3 and HgCl2 with 2-(3-pyridyl)benzimidazole (PyBIm) in solution acidified with HCl have been investigated. The PyBIm ligands are protonated into 2-(3-pyridinio)benzimidazolium (H2PyBIm) cations and the corresponding metal ions are bonded with chloride atoms into coordination anions, forming two new coordination compounds, namely, (H2PyBIm)(SbCl5) 1 and (H2PyBIm)2(Hg2Cl8) 2. Both compounds were characterized by X-ray crystallography. Crystal data for 1: triclinic, space group P1^- with a = 5.7030(7), b = 9.0625(11), c = 16.5929(18) A, α = 91.808(7)°, β = 93.234(6), γ = 99.216(7)°, C12H11N3SbCl5, Mr = 496.24, V = 844.44(17) A^3, Z = 2, Dc = 1.952 g/cm^3, μ(MoKα) = 2.419 mm^-1, F(000) = 480, the final R = 0.0496 and wR = 0.1382 for 3433 observed reflections (I 〉 2σ(I)). Crystal data for 2: monoclinic, space group P21/c with a = 7.8061(5), b = 15.8127(9), c = 12.2435(9) , β = 91.955(4)o, C24H22N6Hg2Cl8, Mr = 1079.26, V = 1510.40(17) 3, Z = 2, Dc = 2.373 g/cm3, μ(MoKα) = 10.889 mm-1, F(000) = 1008, the final R = 0.0293 and wR = 0.0562 for 2854 observed reflections (I 〉 2σ(I)). X-ray diffraction analysis reveals that the antimony(III) is five-coordinated, exhibiting a slightly distorted square-pyramidal coordination geometry; while in 2, a dimeric [Hg2Cl8]^4-anion consists of two trigonal bipyramids sharing two common edges. The organic cations and coordination anions are connected into a one-dimensional belt and a two-dimensional sheet through N-H···Cl hydrogen bonding interactions in compounds 1 and 2, respectively; both are further aggregated into 3D frameworks by strong π-π contacts.
文摘A new method of synthesis of 2-(1,2-diferrocenylvinyl)benz- and azabenzimidazoles (3a-f), (4a-f) and 1’H,3’H(Me)-spiro-[(aza)benzimidazoline-2’,3-(1,2-diferrocenylcyclopropenes)] (5a-f) via reactions of diferrocenyl(methylsulfanyl)cyclopropenylium iodide (1) with aromatic o-diamines (2a-f) in the presence of Et3N (80°C - 82°C) is described. The structures of the resultant compounds are established using IR, 1H and 13C NMR spectroscopy, mass spectrometry and elemental analysis. The structure of one compound, cis-2-(1,2-diferrocenylvinyl)-1-methylbenzimidazole (3b), is confirmed by X-ray diffraction analysis. The electrochemical properties of compounds 3a, 3b, 3d and 5f are investigated using cyclic square wave voltammetry. Two electrochemical processes (I-II), attributed to oxidation of the ferrocene moieties, and the values of E0’(I), E0’(II), DE0’(II-I) and comporportionation constant Kcom are reported. The bioactivities of seven compounds 3a, 3c-f, 5d, 5f are evaluated. Compound 5f is the most active compound with a modest cytotoxic activity against six human cancer cell lines: U-251 (glioma), PC-3 (prostate cancer), K-562 (leukemia), HCT-15 (colon cancer), MCF-7 (breast cancer) and SKLU-1 (lung cancer).
基金Supported by the National Natural Science Foundation of China(No.20771082)the Natural Science Foundation of Tianjin Municipality, China(No.09JCYBJC05800)the Educational Commission of Tianjin Municipality, China (No.20080509)
文摘Three sulfhydryl-reactive fluorescent probes, which contain 2-(1H-benzoimidazol-2-yl)-phenol and maleimide group, were synthesized and their structures were characterized by IR and ^1H NMR. Their photo-physical properties and the specificity to sulfhydryl group in the 2-mercapto-ethanol as well as the L-cysteine adducts were indicated by fluorescence intensity. Preliminary tests revealed that the probes could react selectively with the cysteine molecules, suggesting that these probes might be generally useful in biomedical researches.
文摘The Iead compound of substituted 2-(4-hydroxyphenyl)benzimidazol were modified by phos-phorylation sulfonation and carboxymethylation. The henzimldazoloamidophosphate (6) (7) have better activi-ty against tobacco mosaic virus (TMV). The benzimldazolophenoxyacetic acid, phenoxysuIfonic acid c0ntaining tri flu0r0methyl, and nitro gr0up have 77% ~85% efflclency f0r wheat rust disease.
基金This project was supported by a grant from the Teaching and Research Award Program for Outstanding Young Teacher in Higher Education Institution of Ministry of Education of China.
文摘In order to study the effect of 5, 6-Dichloro-l-13-D-ribofuranosyl-benzimidazole (DRB) on the biological characteristics of human laryngeal carcinoma Hep-2 cell line in vitro, Hep-2 cells cultured in vitro were treated with different concentrations of DRB. Changes in cell proliferation, apoptotic rate and invasiveness were detected by MTT assay, flow cytometry (FCM) and matrigel in vitro invasion assay, respectively. It was found that DRB inhibited the proliferation of Hep-2 cells in a dose- and time-dependent manner. After being treated with 0, 10, 20, 40, 80 μmmol/L DRB for 24 h, the apoptotic rate in Hep-2 cells was (0.68±0.19)%, (1.95±0.12)%, (8.51±0.26)%, (11.26±0.17)% and (14.99±0.32)%, respectively. The matrigel in vitro invasion assay revealed that DRB began to inhibit the invasion of Hep-2 cells at the concentration of 5 μmmol/L, and with the increase of DRB concentration, the inhibitory effect was enhanced. It was suggested that DRB could influence the essential biological characteristics of Hep-2 cells, inhibit Hep-2 cells proliferation, reduce invasive ability and induce apoptosis of Hep-2 cells.
文摘Two new complexes: [Cu(TBZ)(bipy)Cl]Cl[H2O (1) and [Cu(TBZ)(phen)CI]CloH20 (2) [TBZ=2-(4'-thiazolyl)- benzimidazole, phen = 1,10-phenanthroline and bipy =2,2'-bipyridine] have been synthesized and characterized by elemental analysis, molar conductivity, IR, and UV-vis methods. Complex 2, structurally characterized by single-crystal X-ray crystallography, crystallizes in the monoclinic space group P21/c in a unit cell of a = 0.85257(12) nm, b=2.5358(4) nm, c=1.15151(13) nm, β=118.721(8)°, V=2.183.2(5) nm^3, Z=4, Dc=1.624 gocm 3, μ= 1.367 mm^-1. The complexes, free ligands and chloride copper(II) salt were each tested for their ability to inhibit the growth of two gram-positive (B. subtilis and S. aureus) and two gram-negative (Salmonella and E. coli) bacteria. The complexes showed good antibacterial activities against the microorganisms. The interaction between the com- plexes and calf thymus DNA in aqueous solution was investigated adopting electronic absorption spectroscopy, fluorescence spectroscopy, viscosity measurements and cyclic voltammetry. Results suggest that the two complexes can bind to DNA by intercalative mode. In addition, the result of agarose gel electrophoresis suggested that the complexes can cleave the plasmid DNA at physiological pH and room temperature. Mechanistic studies with different inhibiting reagents reveal that hydroxyl radicals, and a singlet oxygen-like copper-oxo species are all involved in the DNA scission process mediated by the complexes.
文摘Cd(Ⅱ), Co(Ⅱ), Cu(Ⅱ) and Zn(Ⅱ) complexes(1~4) based on 2-(2-pyridyl)benzimidazole(pbm) and 4,4'-oxybisbenzoic acid(H2odc) were synthesized. The formulas of these complexes are [Cd(pbm)(odc)2](1), [Co(pbm)(odc)2](2), [Cu(pbm)(odc)2](3) and [Zn(pbm)(odc)2](4) confirmed by single-crystal X-ray diffraction analysis, which shows that complexes 1, 2 and 4 belong to monoclinic system with space group P21/n, while complex 3 belongs to monoclinic system with space group P21/c. The binding properties of complexes 1~4 with CT-DNA are evaluated by ultraviolet spectrum, fluorescence spectra and viscosity measurements. The results indicate that complexes 1~4 have strong interaction with CT-DNA binding. These complexes exhibit an electrostatic or groove mode in respect of binding with DNA, which can effectively destroy DNA. And this binding mode may be applied to the interaction between the complexes and cancer cell DNA. Therefore, we hope to provide a theoretical and scientific basis for the research of anti-cancer drugs.
文摘Complexes[Zn(pbm)(5-hip)_(3)](1),[Zn(pbm)(5-nip)3](2),[Mn(pbm)(H_(3)btc)_(2)(H_(2)O)](3)and[Mn(pbm)(5-nip)_(3)](4),where H2HIPA=5-hydroxyisophthalic acid,H2nip=5-nitroisophthalic acid,H3btc=tri-mesic acid and pbm(pyridine benzene chelate material)=2-(2-pyridyl)benzimidazole,were identified via sin-gle-crystal XRD analyses.1,2 and 4 pertain to the monoclinic space group C2/c,while 3 belongs to the triclinic space group P1.The interplay of CT-DNA with those complexes was delineated using ultraviolet,fluorescence,and circular dichroism(CD)spectroscopy and viscosity measurements.Complexes 1,2,3 and 4 interact with CT-DNA in an electrostatic or grooving mode.We wish to offer a theory-wise foundation for developing anti-tumor medi-cines.