Catalyzed Resolutionb racemic 2-methyl-1-butanol was achieved,with max.95%optical purity of chiral alcohol,by candida cycindrace lipase in non-aqueous organic media.Effect of some factors on the resolution was investg...Catalyzed Resolutionb racemic 2-methyl-1-butanol was achieved,with max.95%optical purity of chiral alcohol,by candida cycindrace lipase in non-aqueous organic media.Effect of some factors on the resolution was investgated.The factors included temperature,pH,organic solvents,the amount of added water and the reaction time.展开更多
In liquid–liquid systems, the substrates in the liquids are inaccessible to each other for the reaction. By adding a small quantity of phase transfer catalyst, the reaction can be made accessible and accelerated. The...In liquid–liquid systems, the substrates in the liquids are inaccessible to each other for the reaction. By adding a small quantity of phase transfer catalyst, the reaction can be made accessible and accelerated. The present study involves the phase transfer catalyzed oxidation of 2-methyl-1-butanol by quaternary ammonium permanganate(tricaprylyl methyl ammonium permanganate). The attempt was to compare the kinetics under homogeneous and heterogeneous conditions. Experiments were conducted in a batch reactor to determine the kinetics under homogeneous conditions. A baffled borosilicate agitated reactor was used to find the enhancement factor and the kinetics under heterogeneous conditions. The rate constants determined under both homogeneous and heterogeneous conditions agreed very well. The oxidation was found to be first order with respect to each of the reactants, quaternary ammonium permanganate and the alcohol, resulting in an overall second order rate expression. Aliquat336(tricaprylylmethylammonium chloride) was found to be the best compared with the other catalysts tested(triethylbenzylammonium chloride, tetrabutylammonium bromide, tetrabutylammonium iodide and tetrabutylammonium hydrogen sulfate) and it gave an enhancement factor of 9.8.展开更多
文摘Catalyzed Resolutionb racemic 2-methyl-1-butanol was achieved,with max.95%optical purity of chiral alcohol,by candida cycindrace lipase in non-aqueous organic media.Effect of some factors on the resolution was investgated.The factors included temperature,pH,organic solvents,the amount of added water and the reaction time.
文摘In liquid–liquid systems, the substrates in the liquids are inaccessible to each other for the reaction. By adding a small quantity of phase transfer catalyst, the reaction can be made accessible and accelerated. The present study involves the phase transfer catalyzed oxidation of 2-methyl-1-butanol by quaternary ammonium permanganate(tricaprylyl methyl ammonium permanganate). The attempt was to compare the kinetics under homogeneous and heterogeneous conditions. Experiments were conducted in a batch reactor to determine the kinetics under homogeneous conditions. A baffled borosilicate agitated reactor was used to find the enhancement factor and the kinetics under heterogeneous conditions. The rate constants determined under both homogeneous and heterogeneous conditions agreed very well. The oxidation was found to be first order with respect to each of the reactants, quaternary ammonium permanganate and the alcohol, resulting in an overall second order rate expression. Aliquat336(tricaprylylmethylammonium chloride) was found to be the best compared with the other catalysts tested(triethylbenzylammonium chloride, tetrabutylammonium bromide, tetrabutylammonium iodide and tetrabutylammonium hydrogen sulfate) and it gave an enhancement factor of 9.8.
