In order to develop novel antitumor d rugs,1,5-bis(2-hydroxybenzylidene)-thiocarbohydrazide(HL)and its Ag ?Complex([Ag2L]·NO3)have been prepared and characterize d by elemental analysis,IR,UV,1 H NMR and molar co...In order to develop novel antitumor d rugs,1,5-bis(2-hydroxybenzylidene)-thiocarbohydrazide(HL)and its Ag ?Complex([Ag2L]·NO3)have been prepared and characterize d by elemental analysis,IR,UV,1 H NMR and molar conductance,respectively.The inhibitory effects of them on five tumor cell lines,including HL-60,Bel-7402,EJ,HCT-8and A431 have been measured by using MTT(Dimethoxyneotetrazolium)colorimetric assay and SRB(Sulforhodamine B)assay.The result indicated that the Ag Complex has str onger inhibitory effect on the five t umor cell lines than the ligand,especially showed very stro ng effect on HL-60cell and Bel-7402c ell.When the exposure concentration of the complex was 10-5mol·L-1,The inhibitory rate is over 96%.展开更多
The title compound was synthesized by the reaction of 3-benzoxybenzaldehyde with 2-hydroxybenzoylhydrazine in ethanol and characterized by IR,UV,1H NMR spectra and elemental analysis.The single crystal structure was d...The title compound was synthesized by the reaction of 3-benzoxybenzaldehyde with 2-hydroxybenzoylhydrazine in ethanol and characterized by IR,UV,1H NMR spectra and elemental analysis.The single crystal structure was determined by X-ray diffraction analysis.The crystal belongs to Monoclinic system,space group Cc with cell constant,a=0.48217（11） nm,b=3.2212（7） nm,c=1.0992（3） nm,β=101.755（5）.,V=1.6714（7） nm3,Z=4,μ=0.090mm-1,DC=1.321 g/cm3,F（000）=696.The crystal measurement showed that the molecule was not coplanar.The crystal structure involving in intermolecular and intermolecular hydrogen bonds was observed,and the intermolecular hydrogen bonds are linked along the c-axis direction to form a chain.The title molecule was calculated by quantum chemistry at the RHF/6-31G level,frontier orbitals electronic densities and charge distribution were discussed.展开更多
4-溴-2-(溴甲基)苯甲醛是合成1,2-二氢酞嗪化合物的重要中间体。以4-溴-2-甲基苯腈为原料,通过溴代、还原得两步反应得到目标化合物4-溴-2-(溴甲基)苯甲醛。确定了溴代反应最佳条件:N-溴代丁二酰亚胺(24.0mmol)、过氧苯甲酰(4.0mmol),...4-溴-2-(溴甲基)苯甲醛是合成1,2-二氢酞嗪化合物的重要中间体。以4-溴-2-甲基苯腈为原料,通过溴代、还原得两步反应得到目标化合物4-溴-2-(溴甲基)苯甲醛。确定了溴代反应最佳条件:N-溴代丁二酰亚胺(24.0mmol)、过氧苯甲酰(4.0mmol),反应体系在CCl4中回流反应8h。还原反应最佳条件:二异丁基氢化铝(DIBAL-H)(12.0mmol),反应溶剂二氯甲烷,室温反应3h。两步反应总收率85.4%,产物及中间体结构通过1 H NMR、13 C NMR和电喷雾电离质谱(ESI-MS)进行了表征。展开更多
文摘In order to develop novel antitumor d rugs,1,5-bis(2-hydroxybenzylidene)-thiocarbohydrazide(HL)and its Ag ?Complex([Ag2L]·NO3)have been prepared and characterize d by elemental analysis,IR,UV,1 H NMR and molar conductance,respectively.The inhibitory effects of them on five tumor cell lines,including HL-60,Bel-7402,EJ,HCT-8and A431 have been measured by using MTT(Dimethoxyneotetrazolium)colorimetric assay and SRB(Sulforhodamine B)assay.The result indicated that the Ag Complex has str onger inhibitory effect on the five t umor cell lines than the ligand,especially showed very stro ng effect on HL-60cell and Bel-7402c ell.When the exposure concentration of the complex was 10-5mol·L-1,The inhibitory rate is over 96%.
文摘The title compound was synthesized by the reaction of 3-benzoxybenzaldehyde with 2-hydroxybenzoylhydrazine in ethanol and characterized by IR,UV,1H NMR spectra and elemental analysis.The single crystal structure was determined by X-ray diffraction analysis.The crystal belongs to Monoclinic system,space group Cc with cell constant,a=0.48217（11） nm,b=3.2212（7） nm,c=1.0992（3） nm,β=101.755（5）.,V=1.6714（7） nm3,Z=4,μ=0.090mm-1,DC=1.321 g/cm3,F（000）=696.The crystal measurement showed that the molecule was not coplanar.The crystal structure involving in intermolecular and intermolecular hydrogen bonds was observed,and the intermolecular hydrogen bonds are linked along the c-axis direction to form a chain.The title molecule was calculated by quantum chemistry at the RHF/6-31G level,frontier orbitals electronic densities and charge distribution were discussed.
文摘4-溴-2-(溴甲基)苯甲醛是合成1,2-二氢酞嗪化合物的重要中间体。以4-溴-2-甲基苯腈为原料,通过溴代、还原得两步反应得到目标化合物4-溴-2-(溴甲基)苯甲醛。确定了溴代反应最佳条件:N-溴代丁二酰亚胺(24.0mmol)、过氧苯甲酰(4.0mmol),反应体系在CCl4中回流反应8h。还原反应最佳条件:二异丁基氢化铝(DIBAL-H)(12.0mmol),反应溶剂二氯甲烷,室温反应3h。两步反应总收率85.4%,产物及中间体结构通过1 H NMR、13 C NMR和电喷雾电离质谱(ESI-MS)进行了表征。
