Catalyzed Resolutionb racemic 2-methyl-1-butanol was achieved,with max.95%optical purity of chiral alcohol,by candida cycindrace lipase in non-aqueous organic media.Effect of some factors on the resolution was investg...Catalyzed Resolutionb racemic 2-methyl-1-butanol was achieved,with max.95%optical purity of chiral alcohol,by candida cycindrace lipase in non-aqueous organic media.Effect of some factors on the resolution was investgated.The factors included temperature,pH,organic solvents,the amount of added water and the reaction time.展开更多
The racemic amine (±)-2-methyl-1-phenyl propylamine(4)was obtained from benzene(1)and isobutyryl chloride(2).Enantiomers of(4)(up to 99%e.e.)were resolved with(S)-(+)-mandelic acid[(+)-(5)]and(R)-(-)-mandelic aci...The racemic amine (±)-2-methyl-1-phenyl propylamine(4)was obtained from benzene(1)and isobutyryl chloride(2).Enantiomers of(4)(up to 99%e.e.)were resolved with(S)-(+)-mandelic acid[(+)-(5)]and(R)-(-)-mandelic acid[(-)-(5)]as resolving reagents in a mixed solvent of ethyl acetate/hexane.The struchure of (4)was characterized by IR,NMR and MS spectra.展开更多
A new method of synthesis of 2 methyl 1 benzyl benzimidazole starting from 2 methyl benzimdazole and benzyl bromide was reported with KF Al 2O 3 as catlyst and DMF as solution.The influence of some reaction condition ...A new method of synthesis of 2 methyl 1 benzyl benzimidazole starting from 2 methyl benzimdazole and benzyl bromide was reported with KF Al 2O 3 as catlyst and DMF as solution.The influence of some reaction condition on yield was also tested,and the optimum conditions were obtained,the molecular ratio of catlyst and 2 methyl benzimdazole and benzyl bromide 1∶1∶1 05,the reaction temperature 20-25,and the yield 70 8%.展开更多
文摘Catalyzed Resolutionb racemic 2-methyl-1-butanol was achieved,with max.95%optical purity of chiral alcohol,by candida cycindrace lipase in non-aqueous organic media.Effect of some factors on the resolution was investgated.The factors included temperature,pH,organic solvents,the amount of added water and the reaction time.
文摘The racemic amine (±)-2-methyl-1-phenyl propylamine(4)was obtained from benzene(1)and isobutyryl chloride(2).Enantiomers of(4)(up to 99%e.e.)were resolved with(S)-(+)-mandelic acid[(+)-(5)]and(R)-(-)-mandelic acid[(-)-(5)]as resolving reagents in a mixed solvent of ethyl acetate/hexane.The struchure of (4)was characterized by IR,NMR and MS spectra.
文摘A new method of synthesis of 2 methyl 1 benzyl benzimidazole starting from 2 methyl benzimdazole and benzyl bromide was reported with KF Al 2O 3 as catlyst and DMF as solution.The influence of some reaction condition on yield was also tested,and the optimum conditions were obtained,the molecular ratio of catlyst and 2 methyl benzimdazole and benzyl bromide 1∶1∶1 05,the reaction temperature 20-25,and the yield 70 8%.
