Association of the glycemic background patterns and the diabetes management efficacy in poorly controlled type 2 diabetes

BACKGROUND Inadequate glycemic control in patients with type 2 diabetes(T2DM)is a major public health problem and a significant risk factor for the progression of diabetic complications.AIM To evaluate the effects of intensive and supportive glycemic management strategies over a 12-month period in individuals with T2DM with glycated hemoglobin(HbA1c)≥10%and varying backgrounds of glycemic control.METHODS This prospective observational study investigated glycemic control in patients with poorly controlled T2DM over 12 months.Participants were categorized into four groups based on prior glycemic history:Newly diagnosed,previously well controlled with recent worsening,previously off-target but now worsening,and HbA1c consistently above 10%.HbA1c levels were monitored quarterly,and patients received medical,educational,and dietary support as needed.The analysis focused on the success rates of good glycemic control and the associated factors within each group.RESULTS The study showed significant improvements in HbA1c levels in all participants.The most significant improvement was observed in individuals newly diagnosed with diabetes:65%achieved an HbA1c target of≤7%.The results varied between participants with different glycemic control histories,followed by decreasing success rates:39%in participants with previously good glycemic control,21%in participants whose glycemic control had deteriorated compared to before,and only 10%in participants with persistently poor control,with mean HbA1c levels of 6.3%,7.7%,8.2%,and 9.7%,respectively.After one year,65.2%of the“newly diagnosed patients”,39.3%in the“previously controlled group”,21.9%in the“previously off-target but now worsened'”group and 10%in the“poorly controlled from the start”group had achieved HbA1c levels of 7 and below.CONCLUSION In poorly controlled diabetes,the rate at which treatment goals are achieved is associated with the glycemic background characteristics,emphasizing the need for tailored strategies.Therefore,different and comprehensive treatment approaches are needed for patients with persistent uncontrolled diabetes.

Adaptive Control Based on Neural Networks for an Uncertain 2-DOF Helicopter System With Input Deadzone and Output Constraints

In this paper, a study of control for an uncertain2-degree of freedom(DOF) helicopter system is given. The2-DOF helicopter is subject to input deadzone and output constraints. In order to cope with system uncertainties and input deadzone, the neural network technique is introduced because of its capability in approximation. In order to update the weights of the neural network, an adaptive control method is utilized to improve the system adaptability. Furthermore, the integral barrier Lyapunov function(IBLF) is adopt in control design to guarantee the condition of output constraints and boundedness of the corresponding tracking errors. The Lyapunov direct method is applied in the control design to analyze system stability and convergence. Finally, numerical simulations are conducted to prove the feasibility and effectiveness of the proposed control based on the model of Quanser's 2-DOF helicopter.

Study of Interval Type-2 Fuzzy Controller for the Twin-tank Water Level System

For dealing with large static error due to poor immunity of the traditional fuzzy control, a novel interval type-2 fuzzy control system is proposed. By extending the typical membership functions to interval type-2 membership functions, the proposed control system can efficiently reduce the uncertain disturbance from real environment without increasing the design complexity. The simulation results on the water tank level control system showed that the proposed method succeeded in better static and dynamic control with stronger robust performance than the traditional fuzzy control method.

Novel l_2-l_∞ controller design for LPV discrete time-delay systems

One of the first attempts to derive energy-to-peak performance criteria and state-feedback controller design problem for linear parameter-varying discrete time systems with time delay is provided. Firstly, we present a parameter-dependent l 2-l ∞ performance criterion using a parameter-dependent Lyapunov function. Upon the conditions addressed, an improved parameter-dependent l 2-l ∞ performance criterion is established by the introduction of a slack variable, which exhibits a kind of decoupling between Lyapunov functions and system matrices. This kind of decoupling enables us to obtain more easily tractable conditions for analysis and synthesis problems. Then, the corresponding parameter-dependent state-feedback controller design is investigated upon these performance criteria, with sufficient conditions obtained for the existence of admissible controllers in terms of parameterized linear matrix inequalities. Finally, a numerical example is provided to illustrate the feasibility and advantage of the proposed controller design procedure.

Design and Comparison of H∞/H2 Controllers for Frigate Rudder Roll Stabilization

Roll motion of ships can be distinguished in two parts:an unavoidable part due to their natural movement while turning and an unwanted and avoidable part that is due to encounter with waves and rough seas in general.For the attenuation of the unwanted part of roll motion,ways have been developed such as addition of controllable fins and changes in shape.This paper investigates the effectiveness of augmenting the rudder used for rejecting part of the unwanted roll,while maintaining steering and course changing ability.For this purpose,a controller is designed,which acts through intentional superposition of fast,compared with course change,movements of rudder,in order to attenuate the high-frequency roll effects from encountering rough seas.The results obtained by simulation to exogenous disturbance support the conclusion that the roll stabilization for displacement can be effective at least when displacement hull vessels are considered.Moreover,robust stability and performance is verified for the proposed control scheme over the entire operating range of interest.

Type-2 Fuzzy Logic Controllers Based Genetic Algorithm for the Position Control of DC Motor

Type-2 fuzzy logic systems have recently been utilized in many control processes due to their ability to model uncertainty. This research article proposes the position control of (DC) motor. The proposed algorithm of this article lies in the application of a genetic algorithm interval type-2 fuzzy logic controller (GAIT2FLC) in the design of fuzzy controller for the position control of DC Motor. The entire system has been modeled using MATLAB R11a. The performance of the proposed GAIT2FLC is compared with that of its corresponding conventional genetic algorithm type-1 FLC in terms of several performance measures such as rise time, peak overshoot, settling time, integral absolute error (IAE) and integral of time multiplied absolute error (ITAE) and in each case, the proposed scheme shows improved performance over its conventional counterpart. Extensive simulation studies are conducted to compare the response of the given system with the conventional genetic algorithm type-1 fuzzy controller to the response given with the proposed GAIT2FLC scheme.

Study on the Interactivity of Controlled and Automatic Information Processing in L2 Reading

L2 reading is not only an important channel for people to obtain information and knowledge,but also the main way for people to learn a foreign language.Reading information processing can be divided into controlled processing and automatic processing.Controlled information processing is a conscious and resource-intensive processing model,while automatic information processing is an unconscious and automatic processing model.This study investigates the characteristics and interactivity of controlled and automatic information processing in L2 reading,and explores the roles of controlled and automatic information processing strategies in improving L2 reading ability.The findings are as follows:(a)controlled and automatic information processing is interactive in L2 reading;and(b)the uses of controlled and automatic information processing strategies are beneficial to the improvement of the reading ability of L2 learners.This study has important theoretical and practical value in improving the efficiency of L2 reading teaching and learning.

LMI Approach to Robust H_∞/H_2 Controller Design with Regional Poles Constraint of a Pump-Motor System

The time domain guideposts requirements of a pump-motor system is transfered into a series of constraints which express the robust performance upper bound and regional poles limits of the closed loop system. Then the servo system control problem is transferred into the problem of robust performance optimizing under regional poles constrains described by linear matrix inequality （LMI）. These LMIs are easy to solve through the Matlab LMI-toolbox. Simulations indicate that the controller has excellent dynamic, static and disturbance rejection performance, and the control system is robust and has perfect H2 performance to the bounded external torque disturbance.

Controllability and Observability of 2-DOF Permanent Magnet Maglev System with Linear Control

A new type of 2-DOF(degree of freedom) magnetic levitation system for multi-DOF levitation is proposed. In this system, the force of permanent magnets are used for levitation and controlled by adjusting the reluctance of the magnetic circuit. Using permanent magnets, the feature of this system is effective for saving energy and avoiding heat generation. First, the principle of the levitation system and typical reluctance control methods are described. Second, an experimental device based on the principle is introduced. Finally, the feasibility of this system is considered from linear control theory.

Hardware Type 2 Fuzzy Logic Position Controller Based on Karnik-Mendel Algorithms

This paper presents an analysis of the KM （Karnik-Mendel） algorithms performance under real time implementation using 3 types： the non-iterative, the iterative and the enhanced, and their feasibility for real-time interval type 2 fuzzy logic control system applications. The results are also compared against NT （Nie-Tan） method that is one of the fastest and simplest defuzzification methods. Because the DC （direct current） servo-motor is one of the most used motors in different industrial applications and the model of the motor is nonlinear, this motor was selected for validating the implementation in real time hardware. This DC motor is a perfect option for studying the real time performance of KM algorithms in order to show up its limits and possibilities for real-time control system applications. These methodologies are implemented in National Instruments LabVIEW FPGA （field programmable gate array） module hardware which is one of the most used platforms in the industry. The results show that the E-KM （enhanced KM） algorithm and the NT method present good results for implementing real-time control applications in real time hardware. Although fuzzy logic type 2 is a good option for working with nonlinear and noise from the sensors, the defuzzification method has to react in a short period of time in order to allow good control response. Hence, a complete study of defuzzification is needed for improving the real time implementations of fuzzy type 2.

Application of Dorzagliatin in peritoneal dialysis patients with type 2 diabetes mellitus:A case report

BACKGROUND Treating diabetes in dialysis patients remains a challenge,with many hypoglycemic drugs requiring dose adjustments or avoidance in these patients.CASE SUMMARY This report describes an 83-year-old female patient with a 30-year history of type 2 diabetes(T2DM)who had struggled to control her blood sugar for more than a year.She had a history of high blood pressure for 30 years,had undergone continuous ambulatory peritoneal dialysis for more than two years,was 163 cm tall,weighed 77 kg,and had a body mass index of 28.98 kg/m2.Despite intensive insulin therapy at a daily dose of 150 units,adding Dorzagliatin at a dosage of 75 mg orally twice daily led to immediate blood sugar improvement and a gradual reduction in insulin dosage.After one month of follow-up,the fasting plasma glucose was 6-8 mmol/L,and the 2-hour postprandial glucose was 8-12 mmol/L.CONCLUSION To our knowledge,this report is the first to use Dorzagliatin to treat type 2 diabetes peritoneal dialysis patients with challenging glucose control.Dorzagliatin,a novel glucokinase activator primarily metabolized by the liver,exhibits no pharmacokinetic differences among patients with varying degrees of chronic kidney disease.It has a high plasma protein binding rate and may not be cleared by peritoneal dialysis,potentially offering a new glycemic control option for Type 2 diabetic patients on peritoneal dialysis.

Impact of community public health care on treatment effect,health cognition,and self-management in patients with type 2 diabetes

BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T2DM).Based on conven-tional nursing methods,community home care has important clinical significance in controlling blood sugar and disease progression.AIM To explore the impact of community public health nursing on treatment effect,health cognition,and self-management in patients with T2DM.METHODS One hundred patients with T2DM were selected as the research subjects.The patients were divided into either a conventional nursing group or community nursing(CN)group using the random number table method.The conventional nursing group(50 cases)received routine care,while the CN group(50 cases)received community public health care in addition to routine care as that for the conventional nursing group.The rate of excellent and good blood glucose control,fasting blood glucose before and after care,2-h postprandial blood glucose,health cognition,and self-management ability,and patient satisfaction were compared between the two groups.RESULTS The CN group had a higher rate of excellent blood sugar control than the conventional nursing group(88%vs 70%,P<0.05).Before care,there was no significant difference in fasting blood glucose or 2-h postprandial blood glucose between the two groups of patients(P>0.05).After nursing,fasting blood glucose and 2-h postprandial blood glucose were reduced to varying degrees in both groups,and both blood glucose levels in the CN group were lower than those of the conventional nursing group(P<0.05).Compared with the scores before care,the cognitive level score for diabetes and self-management ability score improved after care in both groups.The cognitive level and self-management ability of patients in the CN group were higher than those of the conventional nursing group(P<0.05).The overall satisfaction of the CN group was better than that of the conventional nursing group(98%vs 86%,P<0.05).CONCLUSION Community public health care based on conventional care of T2DM can achieve better blood sugar control,and improve patients’health cognitive level and self-management ability.

Trajectory tracking control based on linear active disturbance rejection controller for 6-DOF robot manipulator

The trajectory tracking control for a 6-DOF robot manipulator with multiple inputs and outputs,non-linearity and strong coupling is studied.Firstly,a dynamical model for the 6-DOF robot manipulator is designed.From the view point of practical engineering,considering the model uncertainties and external disturbances,the robot manipulator is divided into 6 independent joint subsystems,and a linear active disturbance rejection controller(LADRC)is developed to track trajectory for each subsystem respectively.LADRC has few parameters that are easy to be adjusted in engineering.Linear expansion state observer(LESO)as the uncertainty observer is able to estimate the general uncertainties effectively.Eventually,the validity and robustness of the proposed method adopted in 6-DOF robot manipulator are demonstrated via numerical simulations and 6-DOF robot manipulator experiments,which is of practical value in engineering application.

A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

Non-Fragile Controller Design for 2-D Discrete Uncertain Systems Described by the Roesser Model

This paper is concerned with the design problem of non-fragile controller for a class of two-dimensional (2-D) discrete uncertain systems described by the Roesser model. The parametric uncertainties are assumed to be norm-bounded. The aim of this paper is to design a memoryless non-fragile state feedback control law such that the closed-loop system is asymptotically stable for all admissible parameter uncertainties and controller gain variations. A new linear matrix inequality (LMI) based sufficient condition for the existence of such controllers is established. Finally, a numerical example is provided to illustrate the applicability of the proposed method.

Designing mixed <i>H</i>₂/<i>H</i>_&infin;structure specified controllers using Particle Swarm Optimization (PSO) algorithm

This paper proposes an efficient method for designing accurate structure-specified mixed H2/H∞ optimal controllers for systems with uncertainties and disturbance using particle swarm (PSO) algorithm. It is designed to find a suitable controller that minimizes the performance index of error signal subject to an unequal constraint on the norm of the closed-loop system. Although the mixed H2/H∞ for the output feedback approach control is considered as a robust and optimal control technique, the design process normally comes up with a complex and non-convex optimization problem, which is difficult to solve by the conventional optimization methods. The PSO can efficiently solve design problems of multi-input-multi-output (MIMO) optimal control systems, which is very suitable for practical engineering designs. It is used to search for parameters of a structure-specified controller, which satisfies mixed performance index. The simulation and experimental results show high feasibility, robustness and practical value compared with the conventional proportional-integral-derivative (PID) and proportional-Integral (PI) controller, and the proposed algorithm is also more efficient compared with the genetic algorithm (GA).

Simulation and Implementation of Real-Time Vision-Based Control System for 2-DoF Robotic Arm Using PID with Hardware-in-the-Loop

Microsoft Kinect sensor has shown the research community that it's more than just an interactive gaming device, due to its multi-functional abilities and high reliability. In this work, online HIL (Hardware-in-the-Loop) experimental data are used to apply human motion imitation to a 2-degree of freedom Lego Mind storm NXT robotic arm. A model simulation of the dc motor used in this experiment is also present in this paper. The acquired input data from the Kinect sensor are processed in a closed loop PID controller with feedback from motors encoders. The applied algorithms solve the overlapping input problem, conducting a simultaneous control of both shoulder and elbow joints, and solving the overlapping input problem as well. The work in this paper is presented as a prototype to assure the applicability of the algorithms, for further development.

基于控糖效果及胰岛素抵抗变化情况探究化浊疏肝祛瘀法联合穴位贴敷在2型糖尿病前期患者中的应用价值

目的基于控糖效果及胰岛素抵抗变化情况探究化浊疏肝祛瘀法联合穴位贴敷在2型糖尿病前期(T2DM)患者中的应用价值。方法选择张家口市中医院2021年5月—2023年5月收治的118例2型糖尿病前期患者。按随机数字表法分为对照组与观察组各59例,对照组给予生活方式干预,观察组给予生活方式干预+化浊疏肝祛瘀汤+穴位贴敷治疗。对比两组疗效、中医证候积分、控糖效果、胰岛素抵抗变化情况。结果干预后,观察组的疗效等级及有效率均优于对照组(P<0.05);两组各主次证候积分均较降低(P<0.05),且观察组的倦怠乏力、纳呆便溏、头身困重、脘腹胀满、口淡无味或黏腻的积分均低于对照组(P<0.05);两组空腹血糖(FPG)、餐后2 h血糖(2 h PG)、血红蛋白(HbAlc)降低(P<0.05),且观察组均低于对照组(P<0.05);两组胰岛素抵抗指数(HOMA-IR)均降低、胰岛β细胞功能指数(HOMA-β)均升高(P<0.05),且观察组的HOMA-IR低于对照组、HOMA-β高于对照组(P<0.05)。干预期间,观察组患者未出现肝肾降低情况及不良反应。结论化浊疏肝祛瘀汤联合中药贴敷治疗糖尿病前期疗效确切,可明显改善患者症状,降低血糖及胰岛素抵抗,改善胰岛β细胞功能,且安全性较好。

一种球面2-DOF冗余驱动并联机器人的优化设计

提出了一种基于兼顾全域性能指标和局域性能指标相对性能综合最优的机器人机构尺寸优化设计方法,运用VB、Matlab软件编写优化程序,并通过范例给出了该优化程序的使用方法,实现了球面2-DOF冗余驱动并联机器人机构在不同应用场合下兼顾不同性能的尺寸优化设计。

Effect of Carbon Dioxide (CO_2) Controlled Atmosphere on Superoxide Dismutase (SOD) Activity of Three Storage Pests in Chinese Medicinal Materials

[ Objective ] The paper was to study the effect of controlled atmosphere stress of carbon dioxide （ CO2 ） on Superoxide dismutase （SOD） activity of in- sect, so as to analyze the biological mechanism of the action of controlled atmosphere stress on insect. [ Method] Using nitrotetrazolium blue chloride （NBT） light reduction method, SOD activity of drugstore beetle （ Stegobium panlceum ）, cigarette beetle （ Lasioderma serricorne） and coffee bean beetle （Araecerus fasciculatus） was studied, and the stress response of the enzyme under controlled atmosphere stress of CO2 was analyzed. [ Result ] SOD activity of drugstore beetle, cigarette beetle and coffee bean beetle exposed to controlled atmosphere stress of high concentrations of CO2 for 3 and 6 h had certain degree of increase, and the activity sig- nificantly increased from 2.011±0.954,2.664±0.218 and 1.458±0.718 to 3. 135±0. 105,3.050±0.673 and 2.975±0.229 U/（per pest · 30 min） after treat- ment for 6 h. [ Conclusion] Controlled atmosphere stress of high concentrations of CO2 had certain activation effect on SOD activity of storage pest in Chinese me- dicinal material within the context of sub-lethal events. The results could enrich the insecticidal mechanism of controlled atmosphere and theoretical system of analy- sis on insect resistance to controlled atmosphere.