为研究2-St age PDE中连续超声速射流及结构参数对撞诱导激波聚焦的影响规律,在冷态条件下开展了2-St age PDE中连续超声速射流对撞诱导激波聚焦的试验。分析了喷口宽度、导流环深度、凹面腔开口端与喷管间距、尾喷管角度、射流入射压...为研究2-St age PDE中连续超声速射流及结构参数对撞诱导激波聚焦的影响规律,在冷态条件下开展了2-St age PDE中连续超声速射流对撞诱导激波聚焦的试验。分析了喷口宽度、导流环深度、凹面腔开口端与喷管间距、尾喷管角度、射流入射压力等参数对凹面腔底部峰值压力的影响。结果表明:喷口宽度、导流环深度、凹面腔开口端与喷口间距、射流入射压力越大,凹面腔底部峰值压力越大,激波聚焦效果越好;尾喷管角度越大,凹面腔底部峰值压力越小,激波聚焦效果越差;喷口宽度、导流环深度、射流入射压力对激波聚焦的影响较大。展开更多
目的:探讨西地那非联合苁蓉益肾颗粒治疗2型糖尿病性勃起功能障碍(erectile dysfunction,ED)的疗效及安全性分析。方法:将70例二甲双胍药物控制的2型糖尿病性ED患者随机分为A、B两组,A组35例,服用西地那非;B组35例,联合服用西地那非和...目的:探讨西地那非联合苁蓉益肾颗粒治疗2型糖尿病性勃起功能障碍(erectile dysfunction,ED)的疗效及安全性分析。方法:将70例二甲双胍药物控制的2型糖尿病性ED患者随机分为A、B两组,A组35例,服用西地那非;B组35例,联合服用西地那非和苁蓉益肾颗粒,两组均治疗4周。分别对治疗前后国际勃起功能指数-5评分(international index of erectile function,IIEF-5)、每周性交频率、夫妻双方性生活满意程度进行统计分析,并观察两组患者治疗期间的不良反应。结果:A、B两组在IIEF-5评分、每周性交频率、夫妻双方性生活满意程度方面均较治疗前增加,差异具有统计学意义(P<0.05),但B组治疗后在IIEF-5评分、夫妻双方性生活满意程度高于A组治疗后,差异具有统计学意义(P<0.05)。两组患者治疗期间未发生严重不良反应。结论:西地那非联合苁蓉益肾颗粒治疗2型糖尿病性ED较单用西地那非可显著改善患者的勃起功能,提高夫妻性生活质量,安全、有效。展开更多
Different VSA （Vacuum Swing Adsorption） cycles and process schemes have been evaluated to find suitable process configurations for effectively separating C02 from flue gases from different industrial sectors. The cy...Different VSA （Vacuum Swing Adsorption） cycles and process schemes have been evaluated to find suitable process configurations for effectively separating C02 from flue gases from different industrial sectors. The cycles were studied using an adsorption simulator developed in our research group, which has been suc- cessfully used to predict experimental results over severa~ years. Commercial zeolite APGIlI and granular ac- tivated carbon were used as the adsorbents. Three-bed VSA cycles with- and without-product purge and 2- stage VSA systems have been investigated. It was found that for a feed gas containing 15% CO2 （representing flue gas from power plants）, high CO2 purities and recoveries could be obtained using a three-bed zeolite APGII1 VSA unit for one stage capture, but with more stringent conditions such as deeper vacuum pressures of 1-3 kPa. 2-stage VSA process operated in series allowed us to use simple process steps and operate at more realistic vacuum pressures. With a vacuum pressure of 10 kPa, final C02 purity of 95.3% with a recov- ery of 98.2% were obtained at specific power consumption of 0.55 MJ. （kg CO2） 1 from feed gas containing 15% C02. These numbers compare very well with those obtained from a single stage process operating at I kPa vacuum pressure. The feed CO2 concentration was very influential in determining the desorption pressure necessary to achieve high separation efficiency. For feed gases containing 〉30% CO2, a singlestage VSA capture process operating at moderate vacuum pressure and without a product purge, can achieve very high product purities and recoveries.展开更多
Islets from RIP-PDE3B mice, exhibiting β-cell specific overexpression of the cAMP/cGMP-degrading enzyme phosphodiesterase 3B (PDE3B) and dysregulated insulin secretion, were subjected to microarray analysis. We show ...Islets from RIP-PDE3B mice, exhibiting β-cell specific overexpression of the cAMP/cGMP-degrading enzyme phosphodiesterase 3B (PDE3B) and dysregulated insulin secretion, were subjected to microarray analysis. We show that osteopontin (OPN) mRNA is increased in a dose-dependent manner in islets from RIP-PDE3B mice, as compared to wild-type islets. In addition, in silico analysis shows that PDE3B and OPN are interacting. Furthermore, OPN interacts with protein kinase CK2 ina distinct submodule of the protein-protein interaction network. We studied PDE3B and OPN proteins and, in some cases, also PDE1B and PDE4C, under conditions of relevance for insulin secretion. In the presence of forskolin, PDE inhibitors, insulin, or a protein kinase CK2 inhibitor, similar alterations in protein levels of PDE3B and OPN are shown. In summary, results from using a number of strategies demonstrate a connection between PDE3B and OPNas well as a role for protein kinase CK2 inpancreatic β-cells.展开更多
文摘为研究2-St age PDE中连续超声速射流及结构参数对撞诱导激波聚焦的影响规律,在冷态条件下开展了2-St age PDE中连续超声速射流对撞诱导激波聚焦的试验。分析了喷口宽度、导流环深度、凹面腔开口端与喷管间距、尾喷管角度、射流入射压力等参数对凹面腔底部峰值压力的影响。结果表明:喷口宽度、导流环深度、凹面腔开口端与喷口间距、射流入射压力越大,凹面腔底部峰值压力越大,激波聚焦效果越好;尾喷管角度越大,凹面腔底部峰值压力越小,激波聚焦效果越差;喷口宽度、导流环深度、射流入射压力对激波聚焦的影响较大。
文摘目的:探讨西地那非联合苁蓉益肾颗粒治疗2型糖尿病性勃起功能障碍(erectile dysfunction,ED)的疗效及安全性分析。方法:将70例二甲双胍药物控制的2型糖尿病性ED患者随机分为A、B两组,A组35例,服用西地那非;B组35例,联合服用西地那非和苁蓉益肾颗粒,两组均治疗4周。分别对治疗前后国际勃起功能指数-5评分(international index of erectile function,IIEF-5)、每周性交频率、夫妻双方性生活满意程度进行统计分析,并观察两组患者治疗期间的不良反应。结果:A、B两组在IIEF-5评分、每周性交频率、夫妻双方性生活满意程度方面均较治疗前增加,差异具有统计学意义(P<0.05),但B组治疗后在IIEF-5评分、夫妻双方性生活满意程度高于A组治疗后,差异具有统计学意义(P<0.05)。两组患者治疗期间未发生严重不良反应。结论:西地那非联合苁蓉益肾颗粒治疗2型糖尿病性ED较单用西地那非可显著改善患者的勃起功能,提高夫妻性生活质量,安全、有效。
基金Supported by the Corporate Research Centre for Greenhouse Gas Technology Foundation in Australiathe National Natural Science Foundation of China(51074205)
文摘Different VSA （Vacuum Swing Adsorption） cycles and process schemes have been evaluated to find suitable process configurations for effectively separating C02 from flue gases from different industrial sectors. The cycles were studied using an adsorption simulator developed in our research group, which has been suc- cessfully used to predict experimental results over severa~ years. Commercial zeolite APGIlI and granular ac- tivated carbon were used as the adsorbents. Three-bed VSA cycles with- and without-product purge and 2- stage VSA systems have been investigated. It was found that for a feed gas containing 15% CO2 （representing flue gas from power plants）, high CO2 purities and recoveries could be obtained using a three-bed zeolite APGII1 VSA unit for one stage capture, but with more stringent conditions such as deeper vacuum pressures of 1-3 kPa. 2-stage VSA process operated in series allowed us to use simple process steps and operate at more realistic vacuum pressures. With a vacuum pressure of 10 kPa, final C02 purity of 95.3% with a recov- ery of 98.2% were obtained at specific power consumption of 0.55 MJ. （kg CO2） 1 from feed gas containing 15% C02. These numbers compare very well with those obtained from a single stage process operating at I kPa vacuum pressure. The feed CO2 concentration was very influential in determining the desorption pressure necessary to achieve high separation efficiency. For feed gases containing 〉30% CO2, a singlestage VSA capture process operating at moderate vacuum pressure and without a product purge, can achieve very high product purities and recoveries.
文摘Islets from RIP-PDE3B mice, exhibiting β-cell specific overexpression of the cAMP/cGMP-degrading enzyme phosphodiesterase 3B (PDE3B) and dysregulated insulin secretion, were subjected to microarray analysis. We show that osteopontin (OPN) mRNA is increased in a dose-dependent manner in islets from RIP-PDE3B mice, as compared to wild-type islets. In addition, in silico analysis shows that PDE3B and OPN are interacting. Furthermore, OPN interacts with protein kinase CK2 ina distinct submodule of the protein-protein interaction network. We studied PDE3B and OPN proteins and, in some cases, also PDE1B and PDE4C, under conditions of relevance for insulin secretion. In the presence of forskolin, PDE inhibitors, insulin, or a protein kinase CK2 inhibitor, similar alterations in protein levels of PDE3B and OPN are shown. In summary, results from using a number of strategies demonstrate a connection between PDE3B and OPNas well as a role for protein kinase CK2 inpancreatic β-cells.
