Eight new brominated 2＇（4＇）-nitro-3-hydroxy diphenyl ethers have been designed and synthesized. The structures of new compounds were confirmed by ^1H NMR, IR and HRMS. The bioactivity tests showed that these compo...Eight new brominated 2＇（4＇）-nitro-3-hydroxy diphenyl ethers have been designed and synthesized. The structures of new compounds were confirmed by ^1H NMR, IR and HRMS. The bioactivity tests showed that these compounds possessed antibacterial activities against the tested bacteria. These new compounds cannot be transformed into dioxins when they were manufactured and used.展开更多
A new method is proposed to determine the amplification factor for 2-hydroxy ethylperoxy radicals （HOC2H4O2·） in chemical amplifier. The radical source comes from the reaction of excess ethene with HO· rad...A new method is proposed to determine the amplification factor for 2-hydroxy ethylperoxy radicals （HOC2H4O2·） in chemical amplifier. The radical source comes from the reaction of excess ethene with HO· radicals generated in the photolysis of water vapor at the wave length of 185 nm in air in a flow tube. This produces a radical source which contains equal amount of HO2·and HOC2H4O2·. The amplification factor is derived from the slopes of the lines between produced NO2 in chemical amplifier and total initial radical concentrations measured for the source of HO2· and that of the same amount of HO2· and HOC2H4O2· respectively. The amplification factor of HOC2H4O2· was similar to that of HO2·, indicating that HOC2H4O2· can be measured with the same sensitivity as HO2· by chemical amplifier.展开更多
Diphenyl-2, 2-dicyanoethylene reacts with 10-methyl-9, 10-dihydroacridine in deaerated acetonitrile under irradiation with l>320 nm to give the coupling product 1, 1-diphenyl-1-(10-methyl-9-acridinyl)-2, 2-dicyanoe...Diphenyl-2, 2-dicyanoethylene reacts with 10-methyl-9, 10-dihydroacridine in deaerated acetonitrile under irradiation with l>320 nm to give the coupling product 1, 1-diphenyl-1-(10-methyl-9-acridinyl)-2, 2-dicyanoethane, which has been characterized by X-ray crystallographic, MS and NMR analyses.展开更多
Cerebrovascular accident（CVA）or stroke is one of the world＇s leading causes of death and permanent disability.The high social and medical costs associated with this pathology mean there is an urgent need to find ef...Cerebrovascular accident（CVA）or stroke is one of the world＇s leading causes of death and permanent disability.The high social and medical costs associated with this pathology mean there is an urgent need to find effective therapies.Occlusion of the middle cerebral artery（MCAO）,mainly by clots,is the origin of most CVAs in humans.展开更多
The optically active R-4-phenyl-2-hydroxy butyrates were prepared by esterification of the racemic acid or transesterification of the racemic ester catalyzed by lipase from Candida cyclindra (CCL) in organic media.
The interaction of N-(2-methyl thiophenyl)-2-hydroxy-1-naphthaldimine (NMTHN) with tin dioxide nanoparticles (SnO2 NPs) has been investigated by spectroscopic tools such as absorption and fluorescence spectroscopy. Ab...The interaction of N-(2-methyl thiophenyl)-2-hydroxy-1-naphthaldimine (NMTHN) with tin dioxide nanoparticles (SnO2 NPs) has been investigated by spectroscopic tools such as absorption and fluorescence spectroscopy. Absorption spectroscopy reveals the formation of ground state complex. Fluorescence spectroscopy has been used to study the signatures of fluorescence quenching. SnO2 NPs are found to quench the intrinsic fluorescence of NMTHN via static and dynamic quenching. The deviation from linearity in the Stern-Volmer plot has been observed.展开更多
A novel compound of 1,2-dis（1,3-diphenylpropan-2-yl）disulfane（C30H30S2,Mr=454.27）was synthesized in ethanol with 1,3-diphenyl-2-propanone as raw materials,giving high yield of product（90%）.Its structure was dete...A novel compound of 1,2-dis（1,3-diphenylpropan-2-yl）disulfane（C30H30S2,Mr=454.27）was synthesized in ethanol with 1,3-diphenyl-2-propanone as raw materials,giving high yield of product（90%）.Its structure was determined by IR,1H NMR,MS,elemental analysis and X-ray diffraction.The crystal belongs to monoclinic,space group C2 with a=18.727（3）,b=6.5179（9）,c=13.7576（18）,β=131.0610（10）o,V=1266.2（3）3,Z=2,Dc=2.136 g/cm3,μ=1.078 mm-1,F（000）=843,R=0.0490 and wR=0.1247 for 3211 observed reflections with I2（I）.X-ray analysis reveals that the molecule is not symmetrical.There exist no classical hydrogen bonds andπ-πstacking interactions.Moreover,the thermal stability of compound 3 was investigated.展开更多
The oxidative carbonylation of phenol to diphenyl carbonate catalyzed by Pd Co, Pd Cu and Pd Mn catalyst systems has been studied with the addition of other components such as benzoquinone, Bu 2NBr and molecular sieve...The oxidative carbonylation of phenol to diphenyl carbonate catalyzed by Pd Co, Pd Cu and Pd Mn catalyst systems has been studied with the addition of other components such as benzoquinone, Bu 2NBr and molecular sieve. The results show that Bu 2NBr plays a very important role and Pd Mn catalyst has the highest activity among the three kinds of the catalysts studied. When the reaction is catalyzed by Pd Mn catalyst at n (PdCl 2)∶ n (Mn(OAc) 2)∶ n (Bu 4NBr)∶ n (benzoquinone)=1∶1∶ 10∶ 25, t =100 ℃, P =2 5 MPa( P CO / P O 2 =4∶1), reaction time 8 h, the yield of DPC is 7 23%. The yield of DPC is found to be increased with increase in total pressure of reactor and could be reached to 10 20% at total pressure of 3 5 MPa.展开更多
A convenient synthesis of optically active α, α -diphenyl-2-pyrrolidinemethanol (1)starting from L-proline, based on different N-protections, was described. Different N-pro-tections had no effect on the optical puri...A convenient synthesis of optically active α, α -diphenyl-2-pyrrolidinemethanol (1)starting from L-proline, based on different N-protections, was described. Different N-pro-tections had no effect on the optical purity of compound 1, but gave different chemical yields. The yield was the lowest when PhCH2, was employed for N-protection. An investiga-tion on the effect of N-protection on the chemical yield and the optical purity of compound 1led to a convenient preparation of the new chiral oxazolidinone 3. The structure of 3 was identified with 1H NMR, 13C NMR, MS and IR.展开更多
文摘Eight new brominated 2＇（4＇）-nitro-3-hydroxy diphenyl ethers have been designed and synthesized. The structures of new compounds were confirmed by ^1H NMR, IR and HRMS. The bioactivity tests showed that these compounds possessed antibacterial activities against the tested bacteria. These new compounds cannot be transformed into dioxins when they were manufactured and used.
文摘A new method is proposed to determine the amplification factor for 2-hydroxy ethylperoxy radicals （HOC2H4O2·） in chemical amplifier. The radical source comes from the reaction of excess ethene with HO· radicals generated in the photolysis of water vapor at the wave length of 185 nm in air in a flow tube. This produces a radical source which contains equal amount of HO2·and HOC2H4O2·. The amplification factor is derived from the slopes of the lines between produced NO2 in chemical amplifier and total initial radical concentrations measured for the source of HO2· and that of the same amount of HO2· and HOC2H4O2· respectively. The amplification factor of HOC2H4O2· was similar to that of HO2·, indicating that HOC2H4O2· can be measured with the same sensitivity as HO2· by chemical amplifier.
文摘Diphenyl-2, 2-dicyanoethylene reacts with 10-methyl-9, 10-dihydroacridine in deaerated acetonitrile under irradiation with l>320 nm to give the coupling product 1, 1-diphenyl-1-(10-methyl-9-acridinyl)-2, 2-dicyanoethane, which has been characterized by X-ray crystallographic, MS and NMR analyses.
文摘Cerebrovascular accident（CVA）or stroke is one of the world＇s leading causes of death and permanent disability.The high social and medical costs associated with this pathology mean there is an urgent need to find effective therapies.Occlusion of the middle cerebral artery（MCAO）,mainly by clots,is the origin of most CVAs in humans.
文摘The optically active R-4-phenyl-2-hydroxy butyrates were prepared by esterification of the racemic acid or transesterification of the racemic ester catalyzed by lipase from Candida cyclindra (CCL) in organic media.
文摘The interaction of N-(2-methyl thiophenyl)-2-hydroxy-1-naphthaldimine (NMTHN) with tin dioxide nanoparticles (SnO2 NPs) has been investigated by spectroscopic tools such as absorption and fluorescence spectroscopy. Absorption spectroscopy reveals the formation of ground state complex. Fluorescence spectroscopy has been used to study the signatures of fluorescence quenching. SnO2 NPs are found to quench the intrinsic fluorescence of NMTHN via static and dynamic quenching. The deviation from linearity in the Stern-Volmer plot has been observed.
基金Supported by the Natural Science Foundation of Hubei Province(No.2012FFB01103)the Hubei Provincial Department of Education(No.Q20131905)+2 种基金the National Natural Science Foundation of China(No.21262011)the Fund of Ethnic Affairs Commission of China(No.12HBZ010)the Team Research for Excellent Mid-aged and Young Teachers of Higher Education of Hubei Province(T201006)
文摘A novel compound of 1,2-dis（1,3-diphenylpropan-2-yl）disulfane（C30H30S2,Mr=454.27）was synthesized in ethanol with 1,3-diphenyl-2-propanone as raw materials,giving high yield of product（90%）.Its structure was determined by IR,1H NMR,MS,elemental analysis and X-ray diffraction.The crystal belongs to monoclinic,space group C2 with a=18.727（3）,b=6.5179（9）,c=13.7576（18）,β=131.0610（10）o,V=1266.2（3）3,Z=2,Dc=2.136 g/cm3,μ=1.078 mm-1,F（000）=843,R=0.0490 and wR=0.1247 for 3211 observed reflections with I2（I）.X-ray analysis reveals that the molecule is not symmetrical.There exist no classical hydrogen bonds andπ-πstacking interactions.Moreover,the thermal stability of compound 3 was investigated.
文摘The oxidative carbonylation of phenol to diphenyl carbonate catalyzed by Pd Co, Pd Cu and Pd Mn catalyst systems has been studied with the addition of other components such as benzoquinone, Bu 2NBr and molecular sieve. The results show that Bu 2NBr plays a very important role and Pd Mn catalyst has the highest activity among the three kinds of the catalysts studied. When the reaction is catalyzed by Pd Mn catalyst at n (PdCl 2)∶ n (Mn(OAc) 2)∶ n (Bu 4NBr)∶ n (benzoquinone)=1∶1∶ 10∶ 25, t =100 ℃, P =2 5 MPa( P CO / P O 2 =4∶1), reaction time 8 h, the yield of DPC is 7 23%. The yield of DPC is found to be increased with increase in total pressure of reactor and could be reached to 10 20% at total pressure of 3 5 MPa.
文摘A convenient synthesis of optically active α, α -diphenyl-2-pyrrolidinemethanol (1)starting from L-proline, based on different N-protections, was described. Different N-pro-tections had no effect on the optical purity of compound 1, but gave different chemical yields. The yield was the lowest when PhCH2, was employed for N-protection. An investiga-tion on the effect of N-protection on the chemical yield and the optical purity of compound 1led to a convenient preparation of the new chiral oxazolidinone 3. The structure of 3 was identified with 1H NMR, 13C NMR, MS and IR.
