The relationship between gastric mucosal blood flow (GMBF) and gastric acid secretionwere studied in rats by using secretory stimulant (pentagastrin)and inhibitor(cimetidine). GMBFwas measured by Laser Doppler flowmet...The relationship between gastric mucosal blood flow (GMBF) and gastric acid secretionwere studied in rats by using secretory stimulant (pentagastrin)and inhibitor(cimetidine). GMBFwas measured by Laser Doppler flowmetry (LDF) and gastric mucosal pH determined by microglasspH electrode. GMBF increased and gastric mucosal pH decreased significantly after intravenous injec-tion of 6μg/kg of pentagastrin; nevertheless GMBF decreased and gastric mucosal pH increasedmarkedly after intravenous administration of 100mg/kg of cimetidine. This indicates that pentagastrincan increase GMBF and gastric acid secretion, and cimetidine can decrease GMBF and gastric acidsecretion in rats, proving the close relationship between GMBF and gastric acid secretion in rats.展开更多
In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (M...In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (MABP) and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX-2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal (i.p.) administration of etodolac (10 mg/kg);however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.展开更多
目的探讨子午流注择时耳穴压豆治疗对2型糖尿病(T2DM)患者血糖控制、上消症状及失眠状况的影响。方法选取2020年1月至2022年12月河南省中西医结合医院内分泌科收治的138例T2DM患者作为研究对象,依据电脑数表随机抽取法分为西医组(常规...目的探讨子午流注择时耳穴压豆治疗对2型糖尿病(T2DM)患者血糖控制、上消症状及失眠状况的影响。方法选取2020年1月至2022年12月河南省中西医结合医院内分泌科收治的138例T2DM患者作为研究对象,依据电脑数表随机抽取法分为西医组(常规西医干预)46例、中医1组(耳穴压豆干预)46例和中医2组(子午流注择时耳穴压豆干预)46例,连续干预4周。比较三组患者的治疗总有效率、治疗前后的血糖水平[空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(Hb1Ac)]、上消症状、睡眠质量[匹兹堡睡眠治疗指数(PSQI)]、Toll样受体4(TLR4)/细胞核因子κB(NF-κB)炎症信号通路因子[外周血TLR4、NF-κB、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平及不良反应发生情况。结果中医2组、中医1组患者的治疗总有效率分别为93.48%、84.78%,明显高于西医组的71.74%,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的FBG、2 h PBG、Hb1Ac水平分别为(6.36±0.83)mmol/L、(8.18±1.05)mmol/L、(6.13±0.59)%,明显低于中医1组的(7.05±1.02)mmol/L、(9.37±1.16)mmol/L、(6.91±0.83)%及西医组的(7.81±1.10)mmol/L、(10.80±1.44)mmol/L、(7.88±0.75)%,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的口干、多饮症状积分、PSQI各维度评分及总分明显低于中医1组、西医组,中医1组明显低于西医组,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的外周血TLR4、NF-κB蛋白及血清TNF-α、IL-6水平分别为1.26±0.24、1.31±0.25、(26.76±4.38)pg/mL、(17.72±3.34)pg/mL,明显低于中医1组的1.59±0.31、1.53±0.29、(31.54±4.71)pg/mL、(20.53±4.11)pg/mL及西医组的2.02±0.35、2.06±0.37、(34.07±5.23)pg/mL、(23.18±3.62)pg/mL,差异均有统计学意义(P<0.05);三组患者治疗期间的总不良反应发生率比较差异无统计学意义(P>0.05)。结论子午流注择时耳穴压豆治疗T2DM具有一定的治疗效果,其可控制血糖水平,改善上消症状,提高睡眠质量,且具有一定安全性,其治疗机制可能与调节TLR4/NF-κB炎症信号通路有关。展开更多
文摘The relationship between gastric mucosal blood flow (GMBF) and gastric acid secretionwere studied in rats by using secretory stimulant (pentagastrin)and inhibitor(cimetidine). GMBFwas measured by Laser Doppler flowmetry (LDF) and gastric mucosal pH determined by microglasspH electrode. GMBF increased and gastric mucosal pH decreased significantly after intravenous injec-tion of 6μg/kg of pentagastrin; nevertheless GMBF decreased and gastric mucosal pH increasedmarkedly after intravenous administration of 100mg/kg of cimetidine. This indicates that pentagastrincan increase GMBF and gastric acid secretion, and cimetidine can decrease GMBF and gastric acidsecretion in rats, proving the close relationship between GMBF and gastric acid secretion in rats.
文摘In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (MABP) and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX-2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal (i.p.) administration of etodolac (10 mg/kg);however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.
文摘目的探讨子午流注择时耳穴压豆治疗对2型糖尿病(T2DM)患者血糖控制、上消症状及失眠状况的影响。方法选取2020年1月至2022年12月河南省中西医结合医院内分泌科收治的138例T2DM患者作为研究对象,依据电脑数表随机抽取法分为西医组(常规西医干预)46例、中医1组(耳穴压豆干预)46例和中医2组(子午流注择时耳穴压豆干预)46例,连续干预4周。比较三组患者的治疗总有效率、治疗前后的血糖水平[空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(Hb1Ac)]、上消症状、睡眠质量[匹兹堡睡眠治疗指数(PSQI)]、Toll样受体4(TLR4)/细胞核因子κB(NF-κB)炎症信号通路因子[外周血TLR4、NF-κB、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平及不良反应发生情况。结果中医2组、中医1组患者的治疗总有效率分别为93.48%、84.78%,明显高于西医组的71.74%,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的FBG、2 h PBG、Hb1Ac水平分别为(6.36±0.83)mmol/L、(8.18±1.05)mmol/L、(6.13±0.59)%,明显低于中医1组的(7.05±1.02)mmol/L、(9.37±1.16)mmol/L、(6.91±0.83)%及西医组的(7.81±1.10)mmol/L、(10.80±1.44)mmol/L、(7.88±0.75)%,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的口干、多饮症状积分、PSQI各维度评分及总分明显低于中医1组、西医组,中医1组明显低于西医组,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的外周血TLR4、NF-κB蛋白及血清TNF-α、IL-6水平分别为1.26±0.24、1.31±0.25、(26.76±4.38)pg/mL、(17.72±3.34)pg/mL,明显低于中医1组的1.59±0.31、1.53±0.29、(31.54±4.71)pg/mL、(20.53±4.11)pg/mL及西医组的2.02±0.35、2.06±0.37、(34.07±5.23)pg/mL、(23.18±3.62)pg/mL,差异均有统计学意义(P<0.05);三组患者治疗期间的总不良反应发生率比较差异无统计学意义(P>0.05)。结论子午流注择时耳穴压豆治疗T2DM具有一定的治疗效果,其可控制血糖水平,改善上消症状,提高睡眠质量,且具有一定安全性,其治疗机制可能与调节TLR4/NF-κB炎症信号通路有关。
