The presence of toxic elements in manganese slag(MSG)poses a threat to the environment due to potential pollution.Utilizing CO_(2) curing on MS offers a promising approach to immobilize toxic substances within this ma...The presence of toxic elements in manganese slag(MSG)poses a threat to the environment due to potential pollution.Utilizing CO_(2) curing on MS offers a promising approach to immobilize toxic substances within this material,thereby mitigating their release into the natural surroundings.This study investigates the impact of CO_(2) cured MS on various rheological parameters,including slump flow,plastic viscosity(η),and yield shear stress(τ).Additionally,it assesses flexural and compressive strengths(f_(t) and f_(cu)),drying shrinkage rates(DSR),durability indicators(chloride ion migration coefficient(CMC),carbonization depth(CD)),and the leaching behavior of heavy metal elements.Microscopic examination via scanning electron microscopy(SEM)is employed to elucidate the underlying mechanisms.The results indicate that CO_(2) curing significantly enhances the slump flow of ultra-high performance concrete(UHPC)by up to 51.2%.Moreover,it reduces UHPC’sηandτby rates ranging from 0%to 52.7%and 0%to 40.2%,respectively.The DSR exhibits a linear increase corresponding to the mass ratio of CO_(2) cured MS.Furthermore,CO_(2) curing enhances both f_(t) and f_(cu) of UHPC by up to 28.7%and 17.6%,respectively.The electrical resistance is also improved,showing an increase of up to 53.7%.The relationship between mechanical strengths and electrical resistance follows a cubic relationship.The CO_(2) cured MS demonstrates a notable decrease in the CMC and CD by rates ranging from 0%to 52.6%and 0%to 26.1%,respectively.The reductions of leached chromium(Cr)and manganese(Mn)are up to 576.3%and 1312.7%,respectively.Overall,CO_(2) curing also enhances the compactness of UHPC,thereby demonstrating its potential to improve both mechanical and durability properties.展开更多
目的 分析2型糖尿病(Diabetes Mellitus Type 2, T2DM)患者采用基于行动研究法的饮食护理取得的效果。方法 选取2022年10月—2023年9月于江南大学附属医院就诊的98例T2DM患者为研究对象,参照随机数表法分为对照组和研究组。对照组49例,...目的 分析2型糖尿病(Diabetes Mellitus Type 2, T2DM)患者采用基于行动研究法的饮食护理取得的效果。方法 选取2022年10月—2023年9月于江南大学附属医院就诊的98例T2DM患者为研究对象,参照随机数表法分为对照组和研究组。对照组49例,采取常规饮食护理;研究组49例,在对照组基础上联合基于行动研究法的饮食护理。比较两组饮食依从性、血糖值与糖尿病特异性生活质量测定量表(Diabetes Specific Quality of Life Scale, DSQL)评分。结果 研究组的总依从率高于对照组,差异有统计学意义(P<0.05);干预12周后,研究组的餐后2 h血糖为(8.25±1.42)mmol/L,空腹血糖为(6.01±0.89)mmol/L,低于对照组的(9.88±1.50)、(7.37±0.90)mmol/L,差异有统计学意义(P均<0.05);研究组DSQL评分高于对照组,差异有统计学意义(P<0.05)。结论 T2DM患者采用基于行动研究法的饮食护理能够提高饮食依从性,有效控制血糖值,保障生活质量。展开更多
目的:通过网络药理学和分子对接初步揭示了青黛抗2型糖尿病的作用机制。方法:从中药系统药理学数据库与分析平台(TCMSP)中根据吸收和代谢情况选出青黛的有效成分及成分所对应的靶点,将靶点转换成对应的基因,取青黛和2型糖尿病的交集基因...目的:通过网络药理学和分子对接初步揭示了青黛抗2型糖尿病的作用机制。方法:从中药系统药理学数据库与分析平台(TCMSP)中根据吸收和代谢情况选出青黛的有效成分及成分所对应的靶点,将靶点转换成对应的基因,取青黛和2型糖尿病的交集基因做PPI蛋白互作网络图,通过David数据库进行基因本体(GO)和京都基因与基因组百科全书(KEGG)分析,最后采用分子对接验证。结果:筛选得到青黛的活性成分9个、交集基因204个,通过蛋白互作分析发现“STAT3、JUN、MAPK3”可能有治疗2型糖尿病的作用,KEGG富集发现,且可能通过positive regulation of transcription from RNA polymerase II promotor、response to drug、positive regulation of gene expression等信号通路进行调控。分子对接结果表明青黛中的Bisindigotin、Indican、Isovitexin等活性成分与“STAT3、JUN、MAPK3”有比较强的结合能力。结论:青黛可能是通过Bisindigotin、Indican、Isovitexin等成分调控positive regulation of transcription from RNA polymerase II promotor等相关信号通路上的STAT3、JUN、MAPK3等基因发挥治疗2型糖尿病的作用。展开更多
基金supported by Hebei Province Higher Education Science and Technology Research Project(No.ZC2024031).
文摘The presence of toxic elements in manganese slag(MSG)poses a threat to the environment due to potential pollution.Utilizing CO_(2) curing on MS offers a promising approach to immobilize toxic substances within this material,thereby mitigating their release into the natural surroundings.This study investigates the impact of CO_(2) cured MS on various rheological parameters,including slump flow,plastic viscosity(η),and yield shear stress(τ).Additionally,it assesses flexural and compressive strengths(f_(t) and f_(cu)),drying shrinkage rates(DSR),durability indicators(chloride ion migration coefficient(CMC),carbonization depth(CD)),and the leaching behavior of heavy metal elements.Microscopic examination via scanning electron microscopy(SEM)is employed to elucidate the underlying mechanisms.The results indicate that CO_(2) curing significantly enhances the slump flow of ultra-high performance concrete(UHPC)by up to 51.2%.Moreover,it reduces UHPC’sηandτby rates ranging from 0%to 52.7%and 0%to 40.2%,respectively.The DSR exhibits a linear increase corresponding to the mass ratio of CO_(2) cured MS.Furthermore,CO_(2) curing enhances both f_(t) and f_(cu) of UHPC by up to 28.7%and 17.6%,respectively.The electrical resistance is also improved,showing an increase of up to 53.7%.The relationship between mechanical strengths and electrical resistance follows a cubic relationship.The CO_(2) cured MS demonstrates a notable decrease in the CMC and CD by rates ranging from 0%to 52.6%and 0%to 26.1%,respectively.The reductions of leached chromium(Cr)and manganese(Mn)are up to 576.3%and 1312.7%,respectively.Overall,CO_(2) curing also enhances the compactness of UHPC,thereby demonstrating its potential to improve both mechanical and durability properties.
文摘目的 分析2型糖尿病(Diabetes Mellitus Type 2, T2DM)患者采用基于行动研究法的饮食护理取得的效果。方法 选取2022年10月—2023年9月于江南大学附属医院就诊的98例T2DM患者为研究对象,参照随机数表法分为对照组和研究组。对照组49例,采取常规饮食护理;研究组49例,在对照组基础上联合基于行动研究法的饮食护理。比较两组饮食依从性、血糖值与糖尿病特异性生活质量测定量表(Diabetes Specific Quality of Life Scale, DSQL)评分。结果 研究组的总依从率高于对照组,差异有统计学意义(P<0.05);干预12周后,研究组的餐后2 h血糖为(8.25±1.42)mmol/L,空腹血糖为(6.01±0.89)mmol/L,低于对照组的(9.88±1.50)、(7.37±0.90)mmol/L,差异有统计学意义(P均<0.05);研究组DSQL评分高于对照组,差异有统计学意义(P<0.05)。结论 T2DM患者采用基于行动研究法的饮食护理能够提高饮食依从性,有效控制血糖值,保障生活质量。
文摘目的:通过网络药理学和分子对接初步揭示了青黛抗2型糖尿病的作用机制。方法:从中药系统药理学数据库与分析平台(TCMSP)中根据吸收和代谢情况选出青黛的有效成分及成分所对应的靶点,将靶点转换成对应的基因,取青黛和2型糖尿病的交集基因做PPI蛋白互作网络图,通过David数据库进行基因本体(GO)和京都基因与基因组百科全书(KEGG)分析,最后采用分子对接验证。结果:筛选得到青黛的活性成分9个、交集基因204个,通过蛋白互作分析发现“STAT3、JUN、MAPK3”可能有治疗2型糖尿病的作用,KEGG富集发现,且可能通过positive regulation of transcription from RNA polymerase II promotor、response to drug、positive regulation of gene expression等信号通路进行调控。分子对接结果表明青黛中的Bisindigotin、Indican、Isovitexin等活性成分与“STAT3、JUN、MAPK3”有比较强的结合能力。结论:青黛可能是通过Bisindigotin、Indican、Isovitexin等成分调控positive regulation of transcription from RNA polymerase II promotor等相关信号通路上的STAT3、JUN、MAPK3等基因发挥治疗2型糖尿病的作用。
