[Objectives]To investigate the clinical effect of different doses of Xuesaitong combined with autologous platelet-rich gel(APG)on patients with diabetic foot(DF).[Methods]90 patients with diabetic foot admitted to our...[Objectives]To investigate the clinical effect of different doses of Xuesaitong combined with autologous platelet-rich gel(APG)on patients with diabetic foot(DF).[Methods]90 patients with diabetic foot admitted to our hospital from February 2017 to February 2019 were enrolled in the study.According to the random number table method,the subjects were divided into study group A and B and control group C.Group A was given a low dose of Xuesaitong combined with APG,while group B was given high-dose Xuesaitong combined with APG and group C was treated only with APG.Patients in the three groups were observed and the changes of related indexes were detected.[Results]After treatment,with regard to the three groups,the fasting blood glucose,2-h postprandial blood glucose level,HbA1c,TNF-α,Hcy,blood urea nitrogen(BUN),creatinine(Cr)and 24-h urine protein levels were all decreased,yet AT-III level was increased,and granulation tissue coverage and thickness,wound clearance rate were increased,while the repair time of ulcer surface was significantly reduced.The above indexes were all significantly different(P<0.05).Compared with the control group C,the changes of the indexes in the study group A and B were the same as above,and the difference was significant(P<0.05).Compared with the study group A,the level of AT-III in group B was significantly increased(P<0.05),while TNF-α,Hcy,BUN,Cr and 24-h urine protein levels were significantly decreased(P<0.05).There was no significant difference in the other indexes between groups A and B(P>0.05).[Conclusions]Xuesaitong combined with APG could effectively reduce the blood sugar level of DF patients,improve the clinical indexes,promote wound healing,and the high-dose group had more significant advantages and was worthy of promotion.展开更多
【目的】系统评价益气养阴法联合西药治疗肾病综合征的有效性及安全性。【方法】检索中国知网(CNKI)、中国生物医学文献数据库(CBM)、万方(Wangfang)、维普(VIP)、PubMed、Web of Science、Cochrane Library、Embase等国内外主要文献数...【目的】系统评价益气养阴法联合西药治疗肾病综合征的有效性及安全性。【方法】检索中国知网(CNKI)、中国生物医学文献数据库(CBM)、万方(Wangfang)、维普(VIP)、PubMed、Web of Science、Cochrane Library、Embase等国内外主要文献数据库,筛选其中有关益气养阴法联合西药(试验组)对比单纯西药(对照组)治疗肾病综合征的临床随机对照试验(RCTs),采用Cochrane手册中的偏倚风险工具进行文献的质量评价,运用RevMan 5.3软件进行Meta分析。【结果】共纳入18个RCTs,包含1334例患者。Meta分析结果显示,益气养阴法联合西药在提高临床有效率(RR=1.24,95%CI[1.16,1.32],P<0.00001),改善24 h尿蛋白定量(24hUPRO)(MD=-0.92,95%CI[-1.09,-0.75],P<0.00001)、血清白蛋白(ALB)(MD=7.06,95%CI[4.73,9.39],P<0.00001)、尿素氮(BUN)(MD=-1.57,95%CI[-2.01,-1.13],P<0.00001)、血肌酐(SCr)(MD=-12.23,95%CI[-16.58,-7.88],P<0.00001)、总胆固醇(TC)(MD=-1.06,95%CI[-1.69,-0.43],P=0.0009)、甘油三酯(TG)(MD=-0.58,95%CI[-0.94,-0.21],P=0.002)水平,以及降低不良反应发生率(RR=0.50,95%CI[0.40,0.64],P<0.00001)方面优于单纯西药治疗。【结论】益气养阴法联合西药治疗肾病综合征在提高临床疗效及改善24hUPRO、ALB、BUN、SCr、TC、TG方面优于单纯西药治疗,且能降低激素产生的不良反应。因纳入文献较少,文献质量较低,潜在疗效需更多的高质量研究进行验证。展开更多
目的观察芪苓健脾配方颗粒辅助治疗肾病综合征脾肾亏虚证的临床疗效。方法将60例肾病综合征脾肾亏虚证患者采用随机数字表法分为2组,各30例。对照组给予西医常规治疗,治疗组在对照组治疗方法的基础上联合芪苓健脾配方颗粒治疗,2组均以4...目的观察芪苓健脾配方颗粒辅助治疗肾病综合征脾肾亏虚证的临床疗效。方法将60例肾病综合征脾肾亏虚证患者采用随机数字表法分为2组,各30例。对照组给予西医常规治疗,治疗组在对照组治疗方法的基础上联合芪苓健脾配方颗粒治疗,2组均以4周为1个疗程,治疗2个疗程后比较2组的临床疗效、复发率、不良反应发生情况,以及治疗前后中医证候总积分、实验室检查指标[24 h尿蛋白定量(24 h UPQ)、血浆白蛋白(ALB)、总胆固醇(TC)、三酰甘油(TAG)、血肌酐(Scr)]。结果治疗组总有效率为93.33%(28/30),对照组为70.00%(24/30),2组比较差异有统计学意义(P<0.05);治疗组复发率为3.33%(1/30),对照组为20.00%(6/30),2组比较差异有统计学意义(P<0.05)。2组治疗后中医证候总积分、24 h UPQ、TC、TAG均明显降低,ALB明显升高,与同组治疗前比较差异有统计学意义(P<0.01),且治疗组各项指标改善更明显,与对照组治疗后比较差异均有统计学意义(P<0.05或P<0.01)。2组治疗过程中心电图,血、粪常规,肝功能均未见明显异常。结论芪苓健脾配方颗粒可有效改善肾病综合征脾肾亏虚证患者的临床症状,降低复发率,且安全性高,值得临床推广应用。展开更多
基金Applied Basic Research Program of Yunnan Province(2017FH001-081).
文摘[Objectives]To investigate the clinical effect of different doses of Xuesaitong combined with autologous platelet-rich gel(APG)on patients with diabetic foot(DF).[Methods]90 patients with diabetic foot admitted to our hospital from February 2017 to February 2019 were enrolled in the study.According to the random number table method,the subjects were divided into study group A and B and control group C.Group A was given a low dose of Xuesaitong combined with APG,while group B was given high-dose Xuesaitong combined with APG and group C was treated only with APG.Patients in the three groups were observed and the changes of related indexes were detected.[Results]After treatment,with regard to the three groups,the fasting blood glucose,2-h postprandial blood glucose level,HbA1c,TNF-α,Hcy,blood urea nitrogen(BUN),creatinine(Cr)and 24-h urine protein levels were all decreased,yet AT-III level was increased,and granulation tissue coverage and thickness,wound clearance rate were increased,while the repair time of ulcer surface was significantly reduced.The above indexes were all significantly different(P<0.05).Compared with the control group C,the changes of the indexes in the study group A and B were the same as above,and the difference was significant(P<0.05).Compared with the study group A,the level of AT-III in group B was significantly increased(P<0.05),while TNF-α,Hcy,BUN,Cr and 24-h urine protein levels were significantly decreased(P<0.05).There was no significant difference in the other indexes between groups A and B(P>0.05).[Conclusions]Xuesaitong combined with APG could effectively reduce the blood sugar level of DF patients,improve the clinical indexes,promote wound healing,and the high-dose group had more significant advantages and was worthy of promotion.
文摘目的观察芪苓健脾配方颗粒辅助治疗肾病综合征脾肾亏虚证的临床疗效。方法将60例肾病综合征脾肾亏虚证患者采用随机数字表法分为2组,各30例。对照组给予西医常规治疗,治疗组在对照组治疗方法的基础上联合芪苓健脾配方颗粒治疗,2组均以4周为1个疗程,治疗2个疗程后比较2组的临床疗效、复发率、不良反应发生情况,以及治疗前后中医证候总积分、实验室检查指标[24 h尿蛋白定量(24 h UPQ)、血浆白蛋白(ALB)、总胆固醇(TC)、三酰甘油(TAG)、血肌酐(Scr)]。结果治疗组总有效率为93.33%(28/30),对照组为70.00%(24/30),2组比较差异有统计学意义(P<0.05);治疗组复发率为3.33%(1/30),对照组为20.00%(6/30),2组比较差异有统计学意义(P<0.05)。2组治疗后中医证候总积分、24 h UPQ、TC、TAG均明显降低,ALB明显升高,与同组治疗前比较差异有统计学意义(P<0.01),且治疗组各项指标改善更明显,与对照组治疗后比较差异均有统计学意义(P<0.05或P<0.01)。2组治疗过程中心电图,血、粪常规,肝功能均未见明显异常。结论芪苓健脾配方颗粒可有效改善肾病综合征脾肾亏虚证患者的临床症状,降低复发率,且安全性高,值得临床推广应用。
